| 1 | HAP1, SYN1
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| Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.
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| Mackenzie KD, Lumsden AL, Guo F, Duffield MD, Chataway T, Lim Y, Zhou XF, Keating DJ.
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| J Neurochem 138(5):710-21. doi: 10.1111/jnc.13703.
2016
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| 2 | ELDX, SYN1
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| X-linked focal epilepsy with reflex bathing seizures: Characterization of a distinct epileptic syndrome.
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| Nguyen DK, Rouleau I, Sénéchal G, Ansaldo AI, Gravel M, Benfenati F, Cossette P.
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| Epilepsia pilepsia. 2015 Jun 19. doi: 10.1111/epi.13042. [Epub ahead of print]
2015
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| 3 | SYN1
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| Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.
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| Vasin A, Zueva L, Torrez C, Volfson D, Littleton JT, Bykhovskaia M.
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| J Neurosci 34(32):10554-63. doi: 10.1523/JNEUROSCI.5074-13.2014.
2014
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| 4 | CDK5, SYN1
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| Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
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| Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F.
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| J Neurosci 34(21):7266-80. doi: 10.1523/JNEUROSCI.3973-13.2014.
2014
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| 5 | PRICKLE1, SYN1
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| PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
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| Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, Pieper AA, Britt JK, Wemmie JA, Rudd DS, Wassink T, El-Shanti H, Mefford HC, Carvill GL, Manak JR, Bassuk AG.
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| PLoS One 8(12):e80737. doi: 10.1371/journal.pone.0080737. eCollection 2013.
2013
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| 6 | REST, SP1, SYN1
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| Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation.
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| Paonessa F, Latifi S, Scarongella H, Cesca F, Benfenati F.
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| J Biol Chem 288(5):3227-39. doi: 10.1074/jbc.M112.399782. Epub 2012 Dec 18.
2013
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| 7 | SYN1
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| Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I.
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| Giannandrea M, Guarnieri FC, Gehring NH, Monzani E, Benfenati F, Kulozik AE, Valtorta F.
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| PLoS One 8(6):e67724. doi: 10.1371/journal.pone.0067724. Print 2013.
2013
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| 8 | SYN1
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| Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
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| Fornasiero EF, Raimondi A, Guarnieri FC, Orlando M, Fesce R, Benfenati F, Valtorta F.
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| J Neurosci 32(35):12214-27. doi: 10.1523/JNEUROSCI.1554-12.2012.
2012
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| 9 | SYN1
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| Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
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| Orenbuch A, Shalev L, Marra V, Sinai I, Lavy Y, Kahn J, Burden JJ, Staras K, Gitler D.
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| J Neurosci 32(12):3969-80. doi: 10.1523/JNEUROSCI.5058-11.2012.
2012
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| 10 | SYN1
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| SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function.
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| Fassio A, Patry L, Congia S, Onofri F, Piton A, Gauthier J, Pozzi D, Messa M, Defranchi E, Fadda M, Corradi A, Baldelli P, Lapointe L, St-Onge J, Meloche C, Mottron L, Valtorta F, Khoa Nguyen D, Rouleau GA, Benfenati F, Cossette P.
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| Hum Mol Genet 20(12):2297-307. Epub 2011 Mar 25.
2011
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| 11 | APC, CTNNB1, DISC1, DLG4, FZD1, GSK3B, NEUROD1, PRICKLE1, SFRP1, SYN1, WNT1, WNT3, WNT3A, WNT5A, WNT7A
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| Emerging roles of Wnts in the adult nervous system.
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| Inestrosa NC, Arenas E.
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| Nat Rev Neurosci. 11(2):77-86. 2010
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| 12 | ACSL4, AFF2, AGTR2, ARHGEF6, ARX, ATRX, DLG3, ESMR, FTSJ1, GDI1, IL1RAPL1, KDM5C, MECP2, MRX68, MRX89, MRX90, MRXS31, NLGN3, NLGN4X, OPHN1, PQBP1, RPS6KA3, RTTM, SLC16A2, SLC6A8, SYN1, TSPAN7, ZNF41
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| X linked mental retardation: a clinical guide.
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| Raymond FL.
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| J Med Genet 43(3):193-200. Epub 2005 Aug 23. 2006
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| 13 | SYN1, PCMT1
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| Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain.
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| Reissner KJ, Paranandi MV, Luc TM, Doyle HA, Mamula MJ, Lowenson JD, Aswad DW.
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| J Biol Chem 281(13):8389-98. Epub 2006 Jan 27. 2006
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| 14 | ACAP3, ARL15, C14orf139, C15orf29, C16orf45, C17orf61, C4orf17, C8orf30A, CAPNS1, CCDC109B, CCDC137, CCDC137P, CCDC92, CETN3, CRELD1, CXorf26, DAGLB, FAM131A, FAM135B, FAM173A, IGSF21, IK, KBTBD7, KIAA1875, MED31, NDUFB9, RABIF, SYN1
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| A human protein-protein interaction network: a resource for annotating the proteome.
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| Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toks�z E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE.
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| Cell 122(6):957-68. 2005
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| 15 | SYN1, ELDX
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| Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy.
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| Garcia CC, Blair HJ, Seager M, Coulthard A, Tennant S, Buddles M, Curtis A, Goodship JA.
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| J Med Genet 41(3):183-6. 2004
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| 16 | SYN1
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| S100A1 codistributes with synapsin I in discrete brain areas and inhibits the F-actin-bundling activity of synapsin I.
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| Benfenati F, Ferrari R, Onofri F, Arcuri C, Giambanco I, Donato R.
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| J Neurochem. 89(5):1260-70. 2004
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| 17 | SYN1
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| Synapsin is a novel Rab3 effector protein on small synaptic vesicles. II. Functional effects of the Rab3A-synapsin I interaction.
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| Giovedì S, Darchen F, Valtorta F, Greengard P, Benfenati F.
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| J Biol Chem. 279(42):43769-79. 2004
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| 18 | SYN1
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| Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
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| Sakurada K, Kato H, Nagumo H, Hiraoka H, Furuya K, Ikuhara T, Yamakita Y, Fukunaga K, Miyamoto E, Matsumura F, Matsuo YI, Naito Y, Sasaki Y.
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| J Biol Chem. 277(47):45473-9. 2002
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| 19 | SYN1
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| Synapsin I identified as a novel brain-specific autoantigen.
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| Gitlits VM, Sentry JW, Matthew LS, Smith AI, Toh BH.
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| J Investig Med 49(3):276-83. 2001
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| 20 | SYN1
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| Specificity of the binding of synapsin I to Src homology 3 domains.
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| Onofri F, Giovedi S, Kao HT, Valtorta F, Bongiorno Borbone L, De Camilli P, Greengard P, Benfenati F.
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| J Biol Chem. 275(38):29857-67. 2000
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| 21 | SYN1, SYN2, SYN3, SYN4, TIMP1, TIMP2, TIMP3, TIMP4
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| Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human.
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| Pohar N, et al.
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| Genomics 57(2):293-6. 1999
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| 22 | SYN1, SYN2
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| Synapsins as major neuronal Ca2+/S100A1-interacting proteins.
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| Heierhorst J, Mitchelhill KI, Mann RJ, Tiganis T, Czernik AJ, Greengard P, Kemp BE.
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| Biochem J 344 Pt 2:577-83. 1999
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| 23 | SYN1
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| Homo- and heterodimerization of synapsins.
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| Hosaka M, Südhof TC.
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| J Biol Chem. 274(24):16747-53. 1999
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| 24 | SYN1, SYN2, SYN3
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| A third member of the synapsin gene family.
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| Kao HT, et al.
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| Proc Natl Acad Sci U S A 95 : 4667-4672. 1998
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| 25 | SYN1, SYN2, SYN3
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| Synapsin III, a novel synapsin with an unusual regulation by Ca2+.
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| Hosaka M, et al.
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| J Biol Chem 273(22):13371-4. 1998
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| 26 | SYN1
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| Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice.
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| Chin LS, Li L, Ferreira A, Kosik KS, Greengard P.
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| Proc Natl Acad Sci U S A. 92(20):9230-4. 1995
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| 27 | SYN1
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| An integrated physical, genetic and transcriptional map in Xp11.23. (abstr)
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| Coleman MP, et al.
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| Cytogenet Cell Genet 67 : 333. 1994
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| 28 | SYN1
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| Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.
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| Derry JMJ, et al.
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| Genomics 12 : 632-638. 1992
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| 29 | SYN1
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| Structure and function of the synapsins.
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| Valtorta F, et al.
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| J Biol Chem 267 : 7195-7198. 1992
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| 30 | ARAF, SYN1
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| A highly polymorphic dinucleotide repeat on the proximal short arm of the human X chromosome : linkage mapping of the synapsin I/A-raf-I genes.
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| Kirchgessner CU, et al.
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| Am J Hum Genet 49 : 184-191. 1991
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| 31 | SYN1
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| Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes.
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| Yang-Feng TL, et al.
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| Proc Natl Acad Sci U S A 83 : 8679-8683. 1986
|