| 1 | CFTR, SHC1, SYK
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| A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane.
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| Loureiro CA, Pinto FR, Barros P, Matos P, Jordan P.
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| Cell Mol Life Sci ell Mol Life Sci. 2020 Jan 23. doi: 10.1007/s00018-020-03448-4. [Epub ahead of print]
2020
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| 2 | BLNK, NIBAN3, PLCG2, SYK
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| The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis
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| Hong R, Lai N, Ouchida R, Xiong E, Zhou Y, Min Q, Liu J, Tang Y, Hikida M, Tsubata T, Wang Y, Wang JY.
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| Eur J Immunol. Jun;49(6):911-917. doi: 10.1002/eji.201847985. Epub 2019 Mar 28. 2019
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| 3 | GP6, SYK, UBASH3B
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| TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
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| Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY.
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| J Biol Chem 291(43):22427-22441. Epub 2016 Sep 8. Erratum in: J Biol Chem. 2017 Mar 10;292(10 ):4360.
2016
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| 4 | IFNB1, IL10, SYK, TLR4
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| Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.
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| Yin H, Zhou H, Kang Y, Zhang X, Duan X, Alnabhan R, Liang S, Scott DA, Lamont RJ, Shang J, Wang H.
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| Biochim Biophys Acta 1860(3):588-98. doi: 10.1016/j.bbagen.2015.12.012. Epub 2015 Dec 17.
2016
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| 5 | SYK, ZAP70
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| SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling.
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| Hauck F, Blumenthal B, Fuchs S, Lenoir C, Martin E, Speckmann C, Vraetz T, Mannhardt-Laakmann W, Lambert N, Gil M, Borte S, Audrain M, Schwarz K, Lim A, Schamel WW, Fischer A, Ehl S, Rensing-Ehl A, Picard C, Latour S.
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| Clin Immunol 161(2):103-9. doi: 10.1016/j.clim.2015.07.002. Epub 2015 Jul 14.
2015
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| 6 | BCL2L1, SYK
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| Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.
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| Wang WH, Childress MO, Geahlen RL.
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| Mol Cell Biol 34(20):3788-99. doi: 10.1128/MCB.00937-14. Epub 2014 Aug 4.
2014
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| 7 | ITK, LCP2, SYK
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| Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.
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| Hussain A, Mohammad DK, Gustafsson MO, Uslu M, Hamasy A, Nore BF, Mohamed AJ, Smith CI.
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| J Biol Chem 288(10):7338-50. doi: 10.1074/jbc.M112.374967. Epub 2013 Jan 4.
2013
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| 8 | CLEC4E, SAP130, SYK
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| Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke.
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| Suzuki Y, Nakano Y, Mishiro K, Takagi T, Tsuruma K, Nakamura M, Yoshimura S, Shimazawa M, Hara H.
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| Sci Rep 3:3177. doi: 10.1038/srep03177.
2013
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| 9 | PRKCB, SYK
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| Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms.
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| Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP.
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| J Biol Chem 288(40):29160-9. doi: 10.1074/jbc.M113.464107. Epub 2013 Aug 19.
2013
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| 10 | SYK, ZAP70
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| Zap70 inhibits Syk-mediated osteoclast function.
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| Zou W, Croke M, Fukunaga T, Broekelmann TJ, Mecham RP, Teitelbaum SL.
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| J Cell Biochem 114(8):1871-8. doi: 10.1002/jcb.24531.
2013
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| 11 | CLEC1B, SYK
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| CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
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| Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis E Sousa C, Tybulewicz VL, Watson SP.
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| Blood 119(7):1747-56. Epub 2011 Dec 20.
2012
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| 12 | SELPLG, SYK
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| Ezrin-radixin-moesin-binding sequence of PSGL-1 glycoprotein regulates leukocyte rolling on selectins and activation of extracellular signal-regulated kinases.
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| Spertini C, Baïsse B, Spertini O.
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| J Biol Chem 287(13):10693-702. doi: 10.1074/jbc.M111.318022. Epub 2012 Feb 6.
2012
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| 13 | SIGLEC15, SYK, TNFRSF11A, TNFSF1, TYROBP
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| Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
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| Ishida-Kitagawa N, Tanaka K, Bao X, Kimura T, Miura T, Kitaoka Y, Hayashi K, Sato M, Maruoka M, Ogawa T, Miyoshi J, Takeya T.
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| J Biol Chem 287(21):17493-502. doi: 10.1074/jbc.M111.324194. Epub 2012 Mar 26.
2012
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| 14 | IKZF1, SYK
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| Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.
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| Uckun FM, Ma H, Zhang J, Ozer Z, Dovat S, Mao C, Ishkhanian R, Goodman P, Qazi S.
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| Proc Natl Acad Sci U S A 109(44):18072-7. doi: 10.1073/pnas.1209828109. Epub 2012 Oct 15.
2012
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| 15 | CFTR, CSNK2A1, SYK
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| Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.
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| Luz S, Kongsuphol P, Mendes AI, Romeiras F, Sousa M, Schreiber R, Matos P, Jordan P, Mehta A, Amaral MD, Kunzelmann K, Farinha CM.
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| Mol Cell Biol 31(22):4392-404. doi: 10.1128/MCB.05517-11. Epub 2011 Sep 19.
2011
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| 16 | BTK, KAT2A, SYK
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| GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.
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| Kikuchi H, Kuribayashi F, Takami Y, Imajoh-Ohmi S, Nakayama T.
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| Biochem Biophys Res Commun 405(4):657-61. Epub 2011 Jan 31.
2011
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| 17 | SWAP70, SYK
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| SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70.
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| Pearce G, Audzevich T, Jessberger R.
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| Blood 117(5):1574-84. Epub 2010 Dec 1.
2011
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| 18 | BCAR1, SYK
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| Identification of BCAR-1 as a new substrate of Syk tyrosine kinase through a determination of amino acid sequence preferences surrounding the substrate tyrosine residue.
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| Kim JY, Huh K, Jung R, Kim TJ.
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| Immunol Lett 135(1-2):151-7. Epub 2010 Oct 31.
2011
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| 19 | SYK
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| Alternative splicing of SYK regulates mitosis and cell survival.
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| Prinos P, Garneau D, Lucier JF, Gendron D, Couture S, Boivin M, Brosseau JP, Lapointe E, Thibault P, Durand M, Tremblay K, Gervais-Bird J, Nwilati H, Klinck R, Chabot B, Perreault JP, Wellinger RJ, Elela SA.
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| Nat Struct Mol Biol 18(6):673-9. Epub 2011 May 8.
2011
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| 20 | SYK
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| SYK inhibition and response prediction in diffuse large B-cell lymphoma.
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| Cheng S, Coffey G, Zhang XH, Shaknovich R, Song Z, Lu P, Pandey A, Melnick AM, Sinha U, Wang YL.
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| Blood 118(24):6342-52. doi: 10.1182/blood-2011-02-333773. Epub 2011 Oct 24.
2011
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| 21 | CLEC1B, SYK
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| CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses.
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| Mourão-Sá D, Robinson MJ, Zelenay S, Sancho D, Chakravarty P, Larsen R, Plantinga M, Van Rooijen N, Soares MP, Lambrecht B, Reis e Sousa C.
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| Eur J Immunol 41(10):3040-53. doi: 10.1002/eji.201141641. Epub 2011 Aug 17.
2011
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| 22 | AGT, FLT1, SYK
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| Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation.
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| Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM, Malik KU.
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| Am J Physiol Heart Circ Physiol 301(3):H1043-55. doi: 10.1152/ajpheart.01018.2010. Epub 2011 Jun 3.
2011
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| 23 | BCL10, CARD9, MALT1, SYK
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| The SYK tyrosine kinase: a crucial player in diverse biological functions.
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| Mócsai A, Ruland J, Tybulewicz VL.
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| Nat Rev Immunol 10(6):387-402. Review. 2010
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| 24 | SYK, UBASH3B, USH3B
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| Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate.
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| Chen X, Ren L, Kim S, Carpino N, Daniel JL, Kunapuli SP, Tsygankov AY, Pei D.
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| J Biol Chem 285(41):31268-76. Epub 2010 Jul 29.PMID: 20670933 2010
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| 25 | GP6, SYK, UBASH3B
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| A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
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| Thomas DH, Getz TM, Newman TN, Dangelmaier CA, Carpino N, Kunapuli SP, Tsygankov AY, Daniel JL.
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| Blood 116(14):2570-8. Epub 2010 Jun 28.PMID: 20585042 2010
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| 26 | SYK
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| Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.
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| Heizmann B, Reth M, Infantino S.
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| Proc Natl Acad Sci U S A 107(43):18563-8. Epub 2010 Oct 12.
2010
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| 27 | CLEC1B, SRC, SYK
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| CLEC-2 activates Syk through dimerization.
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| Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.
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| Blood 115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.
2010
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| 28 | SYK, USP25
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| Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.
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| Cholay M, Reverdy C, Benarous R, Colland F, Daviet L.
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| Exp Cell Res 316(4):667-75. doi: 10.1016/j.yexcr.2009.10.023. Epub 2009 Nov 10.
2010
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| 29 | SYK
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| Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
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| Van Ziffle JA, Lowell CA.
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| Blood 114(23):4871-82. Epub 2009 Oct 1.
2009
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| 30 | SYK
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| Therapeutic prospect of Syk inhibitors.
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| Ruzza P, Biondi B, Calderan A.
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| Expert Opin Ther Pat 19(10):1361-76. Review.
2009
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| 31 | IL4R, SYK
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| IL-4R(alpha), a new member that associates with Syk kinase: implication in IL-4-induced human neutrophil functions.
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| Ennaciri J, Girard D.
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| J Immunol 183(8):5261-9. doi: 10.4049/jimmunol.0900109. Epub 2009 Sep 25. Erratum in: J Immunol. 2010 Feb 1;184(3):1654.
2009
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| 32 | SYK, TRAIP
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| The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells.
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| Zhou Q, Geahlen RL.
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| Oncogene 28(10):1348-56. doi: 10.1038/onc.2008.493. Epub 2009 Jan 19.
2009
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| 33 | SYK
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| Molecular mechanism of the Syk activation switch.
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| Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.
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| J Biol Chem 283(47):32650-9. Epub 2008 Sep 25.
2008
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| 34 | FCGR3A, SYK
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| Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk.
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| Yamashita T, Suzuki R, Backlund PS, Yamashita Y, Yergey AL, Rivera J.
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| J Biol Chem 283(42):28584-94. Epub 2008 Aug 19. 2008
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| 35 | SYK, TREM2, TYROBP
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| Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.
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| Helming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E.
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| Sci Signal 1(43):ra11.
2008
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| 36 | BLNK, SYK
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| SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk.
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| Abudula A, Grabbe A, Brechmann M, Polaschegg C, Herrmann N, Goldbeck I, Dittmann K, Wienands J.
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| J Biol Chem 282(39):29059-66. Epub 2007 Aug 6. 2007
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| 37 | SYK
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| Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis.
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| Chakraborty G, Rangaswami H, Jain S, Kundu GC.
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| J Biol Chem 281(16):11322-31. Epub 2006 Feb 10. 2006
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| 38 | SYK
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| Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.
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| Wang L, Duke L, Zhang PS, Arlinghaus RB, Symmans WF, Sahin A, Mendez R, Dai JL.
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| Cancer Res 63(15):4724-30. Erratum in: Cancer Res. 2003 Oct 15;63(20):7004. 2003
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| 39 | SYK
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| Genomic studies of the spleen protein tyrosine kinase locus reveal a complex promoter structure and several genetic variants.
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| Goodman PA, Jurana B, Wood CM, Uckun F.
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| Leuk Lymphoma 43(8):1627-35. 2002
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| 40 | BLNK, BTK, SYK
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| BLNK mediates Syk-dependent Btk activation.
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| Baba Y, Hashimoto S, Matsushita M, Watanabe D, Kishimoto T, Kurosaki T, Tsukada S.
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| Proc Natl Acad Sci U S A 98(5):2582-6. 2001
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| 41 | SYK
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| The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells.
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| Coopman PJ, Do MT, Barth M, Bowden ET, Hayes AJ, Basyuk E, Blancato JK, Vezza PR, McLeskey SW, Mangeat PH, Mueller SC.
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| Nature 406(6797):742-7. 2000
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| 42 | SYK, ZAP70
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| Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans.
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| Ku G, et al.
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| Immunogenetics 40 : 300-302. 1994
|