| 1 | NLRP3, SUMO1, SUMO2, SUMO3, TRIM28
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| TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation.
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| Qin Y, Li Q, Liang W, Yan R, Tong L, Jia M, Zhao C, Zhao W.
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| Nat Commun. Aug 9;12(1):4794. doi: 10.1038/s41467-021-25033-4. 2021
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| 2 | PIAS1, SUMO1, SUMO3
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| SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability.
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| Yang N, Liu S, Qin T, Liu X, Watanabe N, Mayo KH, Li J, Li X.
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| Cell Commun Signal. Nov 21;17(1):153. doi: 10.1186/s12964-019-0457-9. 2019
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| 3 | PES1, SUMO1, SUMO2, SUMO3
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| SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination.
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| Li S, Wang M, Qu X, Xu Z, Yang Y, Su Q, Wu H.
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| Oncotarget Aug 2;7(31):50522-50534. doi: 10.18632/oncotarget.10494. 2016
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| 4 | AGO2, SUMO1, SUMO2
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| SUMOylation of Argonaute-2 regulates RNA interference activity.
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| Josa-Prado F, Henley JM, Wilkinson KA.
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| Biochem Biophys Res Commun 464(4):1066-71. doi: 10.1016/j.bbrc.2015.07.073. Epub 2015 Jul 17.
2015
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| 5 | SUMO1, SUMO2, TRIM5
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| TRIM5α is a SUMO substrate.
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| Dutrieux J, Portilho DM, Arhel NJ, Hazan U, Nisole S.
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| Retrovirology 12:28. doi: 10.1186/s12977-015-0155-7.
2015
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| 6 | LMNA, SUMO1
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| Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations.
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| Simon DN, Domaradzki T, Hofmann WA, Wilson KL.
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| Mol Biol Cell 24(3):342-50. doi: 10.1091/mbc.E12-07-0527. Epub 2012 Dec 14.
2013
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| 7 | CLOCK, SUMO1
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| CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.
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| Li S, Wang M, Ao X, Chang AK, Yang C, Zhao F, Bi H, Liu Y, Xiao L, Wu H.
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| Oncogene 32(41):4883-91. doi: 10.1038/onc.2012.518.
2013
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| 8 | PIAS1, SUMO1, UBE2I
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| Identification of a non-covalent ternary complex formed by PIAS1, SUMO1, and UBC9 proteins involved in transcriptional regulation.
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| Mascle XH, Lussier-Price M, Cappadocia L, Estephan P, Raiola L, Omichinski JG, Aubry M.
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| J Biol Chem 288(51):36312-27. doi: 10.1074/jbc.M113.486845. Epub 2013 Oct 30.
2013
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| 9 | RANBP2, RANGAP1, SUMO1, SUMO2, UBE2I
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| Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.
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| Gareau JR, Reverter D, Lima CD.
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| J Biol Chem 287(7):4740-51. doi: 10.1074/jbc.M111.321141. Epub 2011 Dec 22. 2012
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| 10 | PRDM1, SUMO1
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| SUMOylation of Blimp-1 is critical for plasma cell differentiation.
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| Ying HY, Su ST, Hsu PH, Chang CC, Lin IY, Tseng YH, Tsai MD, Shih HM, Lin KI.
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| EMBO Rep 13(7):631-7. doi: 10.1038/embor.2012.60.
2012
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| 11 | PCNA, SUMO1
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| Role of SUMO modification of human PCNA at stalled replication fork.
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| Gali H, Juhasz S, Morocz M, Hajdu I, Fatyol K, Szukacsov V, Burkovics P, Haracska L.
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| Nucleic Acids Res 40(13):6049-59. Epub 2012 Mar 28.
2012
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| 12 | GLP1R, SUMO1
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| SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion.
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| Rajan S, Torres J, Thompson MS, Philipson LH.
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| Am J Physiol Endocrinol Metab 302(6):E714-23. doi: 10.1152/ajpendo.00486.2011. Epub 2012 Jan 10.
2012
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| 13 | PGRMC1, SUMO1
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| Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells.
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| Peluso JJ, Lodde V, Liu X.
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| Endocrinology 153(8):3929-39. doi: 10.1210/en.2011-2096. Epub 2012 Jun 19.
2012
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| 14 | DPP8, DPP9, SUMO1, SUMO2, UBA2
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| A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.
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| Pilla E, Möller U, Sauer G, Mattiroli F, Melchior F, Geiss-Friedlander R.
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| J Biol Chem 287(53):44320-9. doi: 10.1074/jbc.M112.397224. Epub 2012 Nov 14.
2012
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| 15 | CYBB, SUMO1
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| SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.
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| Kim HJ, Yun J, Lee J, Hong H, Jeong J, Kim E, Bae YS, Lee KJ.
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| Biochem Biophys Res Commun 410(3):555-62. Epub 2011 Jun 12.
2011
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| 16 | NKX2-5, SUMO1
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| Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
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| Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP.
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| PLoS One 6(9):e24812. Epub 2011 Sep 12. 2011
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| 17 | SUMO1
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| Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model.
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| McMillan LE, Brown JT, Henley JM, Cimarosti H.
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| Neurosci Lett 502(3):201-8. Epub 2011 Aug 4.
2011
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| 18 | BHLHE40, SUMO1
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| SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.
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| Hong Y, Xing X, Li S, Bi H, Yang C, Zhao F, Liu Y, Ao X, Chang AK, Wu H.
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| PLoS One 6(8):e23046. Epub 2011 Aug 1.
2011
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| 19 | SUMO1
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| SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases.
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| Pandey D, Chen F, Patel A, Wang CY, Dimitropoulou C, Patel VS, Rudic RD, Stepp DW, Fulton DJ.
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| Arterioscler Thromb Vasc Biol 31(7):1634-42. Epub 2011 Apr 28.
2011
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| 20 | ATP2A2, SUMO1
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| SUMO1-dependent modulation of SERCA2a in heart failure.
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| Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E, Park WJ, Hajjar RJ.
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| Nature 477(7366):601-5. doi: 10.1038/nature10407. 2011
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| 21 | SUMO1, SUMO2, SUMO3, SUMO4
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| SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.
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| Xie Y, Rubenstein EM, Matt T, Hochstrasser M.
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| Genes Dev 24(9):893-903. Epub 2010 Apr 13.
2010
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| 22 | EIF4E, HDAC2, SUMO1, SUMO2, SUMO3, SUMO4
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| HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.
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| Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J.
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| J Biol Chem 285(24):18139-43. Epub 2010 Apr 26.PMID: 20421305 2010
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| 23 | SUMO1, SUMO2
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| Human SUMO fusion systems enhance protein expression and solubility.
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| Wang Z, Li H, Guan W, Ling H, Wang Z, Mu T, Shuler FD, Fang X.
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| Protein Expr Purif 73(2):203-8. Epub 2010 May 10.PMID: 20457256 2010
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| 24 | KLF4, SUMO1
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| A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.
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| Du JX, McConnell BB, Yang VW.
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| J Biol Chem 285(36):28298-308. Epub 2010 Jun 28.
2010
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| 25 | PAX6, SUMO1
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| Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.
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| Yan Q, Gong L, Deng M, Zhang L, Sun S, Liu J, Ma H, Yuan D, Chen PC, Hu X, Liu J, Qin J, Xiao L, Huang XQ, Zhang J, Li DW.
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| Proc Natl Acad Sci U S A 107(49):21034-9. Epub 2010 Nov 17.
2010
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| 26 | PIAS1, PIAS4, SUMO1, SUMO2, SUMO3
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| Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
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| Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP.
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| Nature 462(7275):935-9. 2009
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| 27 | SUMO1, SUMO2, SUMO3, SUMO4
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| Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.
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| Yang W, Paschen W.
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| Biochem Biophys Res Commun 382(1):215-8. Epub 2009 Mar 9.PMID: 19275883 2009
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| 28 | SUMO1
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| SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate.
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| Song T, Li G, Jing G, Jiao X, Shi J, Zhang B, Wang L, Ye X, Cao F.
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| Biochem Biophys Res Commun 377(4):1265-8. Epub 2008 Nov 5.
2008
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| 29 | SUMO1, SUMO2, SUMO3
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| Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.
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| Zhu J, Zhu S, Guzzo CM, Ellis NA, Sung KS, Choi CY, Matunis MJ.
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| J Biol Chem 283(43):29405-15. Epub 2008 Aug 15.PMID: 18708356 2008
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| 30 | UBE3A, SUMO1, APP
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| Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes.
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| Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP.
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| Hum Mol Genet 15(6):853-69. Epub 2006 Jan 30. 2006
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| 31 | SUMO1, PIAS2
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| Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta.
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| Liu ST, Wang WH, Hong YR, Chuang JY, Lu PJ, Chang LK.
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| Virus Res 119(2):163-70. Epub 2006 Feb 3. 2006
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| 32 | SUMO1
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| SUMO1 haploinsufficiency leads to cleft lip and palate.
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| Alkuraya FS, Saadi I, Lund JJ, Turbe-Doan A, Morton CC, Maas RL.
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| Science 313(5794):1751. 2006
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| 33 | SENP1, SUMO1, SUMO2, SUMO3
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| Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.
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| Xu Z, Au SW.
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| Biochem J 386(Pt 2):325-30. 2005
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| 34 | BLM, SUMO1, SUMO2, SUMO3, SUMO4
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| Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
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| Eladad S, Ye TZ, Hu P, Leversha M, Beresten S, Matunis MJ, Ellis NA.
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| Hum Mol Genet 14(10):1351-65. Epub 2005 Apr 13. 2005
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| 35 | RNF4, SUMO1
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| SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies.
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| H�kli M, Karvonen U, J�nne OA, Palvimo JJ.
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| Exp Cell Res 304(1):224-33. Epub 2004 Nov 23.PMID: 15707587 2005
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| 36 | SUMO1, TAB2
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| A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.
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| Owerbach D, Pina L, Gabbay KH.
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| Diabetes 53(7):1890-3. 2004
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| 37 | PIAS1, RANBP2, SUMO1
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| The nucleoporin RanBP2 has SUMO1 E3 ligase activity.
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| Pichler A, Gast A, Seeler JS, Dejean A, Melchior F.
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| Cell 108(1):109-20. 2002
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| 38 | PCNA, SUMO1
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| RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
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| Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S.
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| Nature 419(6903):135-41. 2002
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| 39 | SUMO1
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| Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein.
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| Li W, Hesabi B, Babbo A, Pacione C, Liu J, Chen DJ, Nickoloff JA, Shen Z.
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| Nucleic Acids Res 28(5):1145-1153. 2000
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| 40 | ABI2, AOX1, BMPR2, CASP10, CASP8, CD28, CFLAR, CLK1, CTLA4, DAZAP2, MAGI2, ORC2, PPH1, PSMA2, SATB2, SUMO1, TRAK2
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| A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension.
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| Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC.
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| Genomics 68(2):220-8. 2000
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| 41 | SUMO1
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| SUMO-1 conjugation to human DNA topoisomerase II isozymes.
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| Mao Y, Desai SD, Liu LF.
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| J Biol Chem 275(34):26066-73. 2000
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| 42 | ETV6, UBE2I, SUMO1
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| Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies.
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| Chakrabarti SR, Sood R, Nandi S, Nucifora G.
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| Proc Natl Acad Sci U S A 97(24):13281-5. 2000
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| 43 | SAE1, UBA2, SUMO1
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| Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1.
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| Desterro JM, et al.
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| J Biol Chem 274(15):10618-24. 1999
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| 44 | SAE1, UBA2, SUMO1
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| Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.
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| Gong L, et al.
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| FEBS Lett 448(1):185-9. 1999
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| 45 | SUMO1
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| Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.
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| Kim YH, et al.
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| Proc Natl Acad Sci U S A 96(22):12350-5 1999
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| 46 | SUMO1
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| Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.
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| Gostissa M, et al.
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| EMBO J 18(22):6462-6471 1999
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| 47 | SUMO1
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| SUMO-1 modification activates the transcriptional response of p53.
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| Rodriguez MS, et al.
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| EMBO J 18(22):6455-6461 1999
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| 48 | SUMO1, UBL1P1, UBL1P2
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| The ubiquitin-homology gene PIC1 : characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes.
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| Howe K, Williamson J, Boddy N, Sheer D, Freemont P, Solomon E.
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| Genomics 47(1):92-100. 1998
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| 49 | NFKBIA, SUMO1
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| SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
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| Desterro JM, et al.
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| Mol Cell 2(2):233-9. 1998
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| 50 | PML, SUMO1
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| Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.
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| Muller S, et al.
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| EMBO J 17(1):61-70. 1998
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| 51 | SUMO2, SUMO1
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| Characterization of a second member of the sentrin family of ubiquitin-like proteins.
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| Kamitani T, Kito K, Nguyen HP, Fukuda-Kamitani T, Yeh ET.
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| J Biol Chem 273(18):11349-53. 1998
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| 52 | PML, SUMO1
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| Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
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| Sternsdorf T, et al.
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| J Cell Biol 139(7):1621-34. 1997
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| 53 | UBA2, SUMO1, RANBP2, RANGAP1
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| A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
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| Mahajan R, et al.
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| Cell 88(1):97-107. 1997
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| 54 | SUMO1
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| Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.
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| Kamitani T, et al.
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| J Biol Chem 272(22):14001-4. 1997
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| 55 | SUMO1, UBL1P1
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| UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins.
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| Shen Z, et al.
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| Genomics 36 : 271-279. 1996
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| 56 | SUMO1
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| Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
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| Okura T, et al.
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| J Immunol 157 : 4277-4281. 1996
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| 57 | RANGAP1, SUMO1
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| A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
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| Matunis MJ, et al.
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| J Cell Biol 135(6 Pt 1):1457-70. 1996
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| 58 | PML, SUMO1
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| PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
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| Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS
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| Oncogene. 13(5):971-82 1996
|