Citations for
1AGO2, SUMO1, SUMO2
SUMOylation of Argonaute-2 regulates RNA interference activity.
Josa-Prado F, Henley JM, Wilkinson KA.
Biochem Biophys Res Commun 464(4):1066-71. doi: 10.1016/j.bbrc.2015.07.073. Epub 2015 Jul 17. 2015
2SUMO1, SUMO2, TRIM5
TRIM5α is a SUMO substrate.
Dutrieux J, Portilho DM, Arhel NJ, Hazan U, Nisole S.
Retrovirology 12:28. doi: 10.1186/s12977-015-0155-7. 2015
3LMNA, SUMO1
Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations.
Simon DN, Domaradzki T, Hofmann WA, Wilson KL.
Mol Biol Cell 24(3):342-50. doi: 10.1091/mbc.E12-07-0527. Epub 2012 Dec 14. 2013
4CLOCK, SUMO1
CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.
Li S, Wang M, Ao X, Chang AK, Yang C, Zhao F, Bi H, Liu Y, Xiao L, Wu H.
Oncogene 32(41):4883-91. doi: 10.1038/onc.2012.518. 2013
5PIAS1, SUMO1, UBE2I
Identification of a non-covalent ternary complex formed by PIAS1, SUMO1, and UBC9 proteins involved in transcriptional regulation.
Mascle XH, Lussier-Price M, Cappadocia L, Estephan P, Raiola L, Omichinski JG, Aubry M.
J Biol Chem 288(51):36312-27. doi: 10.1074/jbc.M113.486845. Epub 2013 Oct 30. 2013
6RANBP2, RANGAP1, SUMO1, SUMO2, UBE2I
Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.
Gareau JR, Reverter D, Lima CD.
J Biol Chem 287(7):4740-51. doi: 10.1074/jbc.M111.321141. Epub 2011 Dec 22. 2012
7PRDM1, SUMO1
SUMOylation of Blimp-1 is critical for plasma cell differentiation.
Ying HY, Su ST, Hsu PH, Chang CC, Lin IY, Tseng YH, Tsai MD, Shih HM, Lin KI.
EMBO Rep 13(7):631-7. doi: 10.1038/embor.2012.60. 2012
8PCNA, SUMO1
Role of SUMO modification of human PCNA at stalled replication fork.
Gali H, Juhasz S, Morocz M, Hajdu I, Fatyol K, Szukacsov V, Burkovics P, Haracska L.
Nucleic Acids Res 40(13):6049-59. Epub 2012 Mar 28. 2012
9GLP1R, SUMO1
SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion.
Rajan S, Torres J, Thompson MS, Philipson LH.
Am J Physiol Endocrinol Metab 302(6):E714-23. doi: 10.1152/ajpendo.00486.2011. Epub 2012 Jan 10. 2012
10PGRMC1, SUMO1
Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells.
Peluso JJ, Lodde V, Liu X.
Endocrinology 153(8):3929-39. doi: 10.1210/en.2011-2096. Epub 2012 Jun 19. 2012
11DPP8, DPP9, SUMO1, SUMO2, UBA2
A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.
Pilla E, Möller U, Sauer G, Mattiroli F, Melchior F, Geiss-Friedlander R.
J Biol Chem 287(53):44320-9. doi: 10.1074/jbc.M112.397224. Epub 2012 Nov 14. 2012
12CYBB, SUMO1
SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.
Kim HJ, Yun J, Lee J, Hong H, Jeong J, Kim E, Bae YS, Lee KJ.
Biochem Biophys Res Commun 410(3):555-62. Epub 2011 Jun 12. 2011
13NKX2-5, SUMO1
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP.
PLoS One 6(9):e24812. Epub 2011 Sep 12. 2011
14SUMO1
Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model.
McMillan LE, Brown JT, Henley JM, Cimarosti H.
Neurosci Lett 502(3):201-8. Epub 2011 Aug 4. 2011
15BHLHE40, SUMO1
SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.
Hong Y, Xing X, Li S, Bi H, Yang C, Zhao F, Liu Y, Ao X, Chang AK, Wu H.
PLoS One 6(8):e23046. Epub 2011 Aug 1. 2011
16SUMO1
SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases.
Pandey D, Chen F, Patel A, Wang CY, Dimitropoulou C, Patel VS, Rudic RD, Stepp DW, Fulton DJ.
Arterioscler Thromb Vasc Biol 31(7):1634-42. Epub 2011 Apr 28. 2011
17ATP2A2, SUMO1
SUMO1-dependent modulation of SERCA2a in heart failure.
Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E, Park WJ, Hajjar RJ.
Nature 477(7366):601-5. doi: 10.1038/nature10407. 2011
18SUMO1, SUMO2, SUMO3, SUMO4
SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.
Xie Y, Rubenstein EM, Matt T, Hochstrasser M.
Genes Dev 24(9):893-903. Epub 2010 Apr 13. 2010
19EIF4E, HDAC2, SUMO1, SUMO2, SUMO3, SUMO4
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.
Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J.
J Biol Chem 285(24):18139-43. Epub 2010 Apr 26.PMID: 20421305 2010
20SUMO1, SUMO2
Human SUMO fusion systems enhance protein expression and solubility.
Wang Z, Li H, Guan W, Ling H, Wang Z, Mu T, Shuler FD, Fang X.
Protein Expr Purif 73(2):203-8. Epub 2010 May 10.PMID: 20457256 2010
21KLF4, SUMO1
A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.
Du JX, McConnell BB, Yang VW.
J Biol Chem 285(36):28298-308. Epub 2010 Jun 28. 2010
22PAX6, SUMO1
Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.
Yan Q, Gong L, Deng M, Zhang L, Sun S, Liu J, Ma H, Yuan D, Chen PC, Hu X, Liu J, Qin J, Xiao L, Huang XQ, Zhang J, Li DW.
Proc Natl Acad Sci U S A 107(49):21034-9. Epub 2010 Nov 17. 2010
23PIAS1, PIAS4, SUMO1, SUMO2, SUMO3
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP.
Nature 462(7275):935-9. 2009
24SUMO1, SUMO2, SUMO3, SUMO4
Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.
Yang W, Paschen W.
Biochem Biophys Res Commun 382(1):215-8. Epub 2009 Mar 9.PMID: 19275883 2009
25SUMO1
SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate.
Song T, Li G, Jing G, Jiao X, Shi J, Zhang B, Wang L, Ye X, Cao F.
Biochem Biophys Res Commun 377(4):1265-8. Epub 2008 Nov 5. 2008
26SUMO1, SUMO2, SUMO3
Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.
Zhu J, Zhu S, Guzzo CM, Ellis NA, Sung KS, Choi CY, Matunis MJ.
J Biol Chem 283(43):29405-15. Epub 2008 Aug 15.PMID: 18708356 2008
27UBE3A, SUMO1, APP
Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes.
Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP.
Hum Mol Genet 15(6):853-69. Epub 2006 Jan 30. 2006
28SUMO1, PIAS2
Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta.
Liu ST, Wang WH, Hong YR, Chuang JY, Lu PJ, Chang LK.
Virus Res 119(2):163-70. Epub 2006 Feb 3. 2006
29SUMO1
SUMO1 haploinsufficiency leads to cleft lip and palate.
Alkuraya FS, Saadi I, Lund JJ, Turbe-Doan A, Morton CC, Maas RL.
Science 313(5794):1751. 2006
30SENP1, SUMO1, SUMO2, SUMO3
Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.
Xu Z, Au SW.
Biochem J 386(Pt 2):325-30. 2005
31BLM, SUMO1, SUMO2, SUMO3, SUMO4
Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
Eladad S, Ye TZ, Hu P, Leversha M, Beresten S, Matunis MJ, Ellis NA.
Hum Mol Genet 14(10):1351-65. Epub 2005 Apr 13. 2005
32RNF4, SUMO1
SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies.
H�kli M, Karvonen U, J�nne OA, Palvimo JJ.
Exp Cell Res 304(1):224-33. Epub 2004 Nov 23.PMID: 15707587 2005
33SUMO1, TAB2
A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.
Owerbach D, Pina L, Gabbay KH.
Diabetes 53(7):1890-3. 2004
34PIAS1, RANBP2, SUMO1
The nucleoporin RanBP2 has SUMO1 E3 ligase activity.
Pichler A, Gast A, Seeler JS, Dejean A, Melchior F.
Cell 108(1):109-20. 2002
35PCNA, SUMO1
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S.
Nature 419(6903):135-41. 2002
36SUMO1
Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein.
Li W, Hesabi B, Babbo A, Pacione C, Liu J, Chen DJ, Nickoloff JA, Shen Z.
Nucleic Acids Res 28(5):1145-1153. 2000
37ABI2, AOX1, BMPR2, CASP10, CASP8, CD28, CFLAR, CLK1, CTLA4, DAZAP2, MAGI2, ORC2, PPH1, PSMA2, SATB2, SUMO1, TRAK2
A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension.
Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC.
Genomics 68(2):220-8. 2000
38SUMO1
SUMO-1 conjugation to human DNA topoisomerase II isozymes.
Mao Y, Desai SD, Liu LF.
J Biol Chem 275(34):26066-73. 2000
39ETV6, UBE2I, SUMO1
Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies.
Chakrabarti SR, Sood R, Nandi S, Nucifora G.
Proc Natl Acad Sci U S A 97(24):13281-5. 2000
40SAE1, UBA2, SUMO1
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1.
Desterro JM, et al.
J Biol Chem 274(15):10618-24. 1999
41SAE1, UBA2, SUMO1
Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.
Gong L, et al.
FEBS Lett 448(1):185-9. 1999
42SUMO1
Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.
Kim YH, et al.
Proc Natl Acad Sci U S A 96(22):12350-5 1999
43SUMO1
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.
Gostissa M, et al.
EMBO J 18(22):6462-6471 1999
44SUMO1
SUMO-1 modification activates the transcriptional response of p53.
Rodriguez MS, et al.
EMBO J 18(22):6455-6461 1999
45SUMO1, UBL1P1, UBL1P2
The ubiquitin-homology gene PIC1 : characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes.
Howe K, Williamson J, Boddy N, Sheer D, Freemont P, Solomon E.
Genomics 47(1):92-100. 1998
46NFKBIA, SUMO1
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
Desterro JM, et al.
Mol Cell 2(2):233-9. 1998
47PML, SUMO1
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.
Muller S, et al.
EMBO J 17(1):61-70. 1998
48SUMO2, SUMO1
Characterization of a second member of the sentrin family of ubiquitin-like proteins.
Kamitani T, Kito K, Nguyen HP, Fukuda-Kamitani T, Yeh ET.
J Biol Chem 273(18):11349-53. 1998
49PML, SUMO1
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
Sternsdorf T, et al.
J Cell Biol 139(7):1621-34. 1997
50UBA2, SUMO1, RANBP2, RANGAP1
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Mahajan R, et al.
Cell 88(1):97-107. 1997
51SUMO1
Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.
Kamitani T, et al.
J Biol Chem 272(22):14001-4. 1997
52SUMO1, UBL1P1
UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins.
Shen Z, et al.
Genomics 36 : 271-279. 1996
53SUMO1
Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
Okura T, et al.
J Immunol 157 : 4277-4281. 1996
54RANGAP1, SUMO1
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
Matunis MJ, et al.
J Cell Biol 135(6 Pt 1):1457-70. 1996
55PML, SUMO1
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS
Oncogene. 13(5):971-82 1996