| 1 | SNAP25, STX1A, STXBP1
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| Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25.
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| Santos TC, Wierda K, Broeke JH, Toonen RF, Verhage M.
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| J Neurosci 37(17):4525-4539. doi: 10.1523/JNEUROSCI.3352-16.2017. Epub 2017 Mar 27.
2017
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| 2 | STX1A, STXBP1
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| A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion.
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| Kavanagh DM, Smyth AM, Martin KJ, Dun A, Brown ER, Gordon S, Smillie KJ, Chamberlain LH, Wilson RS, Yang L, Lu W, Cousin MA, Rickman C, Duncan RR.
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| Nat Commun 5:5774. doi: 10.1038/ncomms6774.
2014
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| 3 | CADPS, STX1A, UNC13A
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| Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.
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| Parsaud L, Li L, Jung CH, Park S, Saw NM, Park S, Kim MY, Sugita S.
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| J Biol Chem 288(32):23050-63. doi: 10.1074/jbc.M113.494088. Epub 2013 Jun 25.
2013
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| 4 | PTPRT, STX1A, STXBP1
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| PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue.
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| Lim SH, Moon J, Lee M, Lee JR.
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| Biochem Biophys Res Commun 439(1):40-6. doi: 10.1016/j.bbrc.2013.08.033. Epub 2013 Aug 17.
2013
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| 5 | STX1A, STXBP1
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| The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane.
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| Martin S, Tomatis VM, Papadopulos A, Christie MP, Malintan NT, Gormal RS, Sugita S, Martin JL, Collins BM, Meunier FA.
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| J Cell Sci 126(Pt 11):2353-60. doi: 10.1242/jcs.126813.
2013
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| 6 | SNAP25, STX1A
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| SNARE proteins synaptobrevin, SNAP-25, and syntaxin are involved in rapid and slow endocytosis at synapses.
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| Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W, Wu LG.
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| Cell Rep 3(5):1414-21. doi: 10.1016/j.celrep.2013.03.010. Epub 2013 May 2.
2013
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| 7 | PLCL1, SNAP25, STX1A
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| PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain.
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| Zhang Z, Takeuchi H, Gao J, Wang D, James DJ, Martin TF, Hirata M.
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| J Biol Chem 288(11):7769-80. doi: 10.1074/jbc.M112.419317. Epub 2013 Jan 22. 2013
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| 8 | APBA1, DYRK1A, STX1A, STXBP1
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| Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.
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| Park JH, Jung MS, Kim YS, Song WJ, Chung SH.
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| J Neurochem 122(5):1081-91. doi: 10.1111/j.1471-4159.2012.07861.x.
2012
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| 9 | CACNA1B, STX1A
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| Bipartite syntaxin 1A interactions mediate CaV2.2 calcium channel regulation.
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| Davies JN, Jarvis SE, Zamponi GW.
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| Biochem Biophys Res Commun 411(3):562-8. Epub 2011 Jul 5.
2011
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| 10 | STX1A
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| Membrane protein sequestering by ionic protein-lipid interactions.
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| van den Bogaart G, Meyenberg K, Risselada HJ, Amin H, Willig KI, Hubrich BE, Dier M, Hell SW, Grubmüller H, Diederichsen U, Jahn R.
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| Nature 479(7374):552-5. doi: 10.1038/nature10545.
2011
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| 11 | STX1A
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| Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A.
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| Chao C, Liang T, Kang Y, Lin X, Xie H, Feng ZP, Gaisano HY.
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| J Mol Cell Cardiol 51(5):790-802. Epub 2011 Aug 22.
2011
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| 12 | STX1A, SYTL4
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| Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.
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| Wang H, Ishizaki R, Kobayashi E, Fujiwara T, Akagawa K, Izumi T.
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| J Biol Chem 286(37):32244-50. Epub 2011 Jul 18.
2011
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| 13 | STX1A, WBS
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| Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex.
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| Gao MC, Bellugi U, Dai L, Mills DL, Sobel EM, Lange K, Korenberg JR.
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| PLoS One 5(4):e10292.
2010
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| 14 | STX1A, STX2
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| Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.
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| Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC.
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| J Biol Chem 284(11):6877-84. Epub 2009 Jan 7.
2009
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| 15 | STX1A
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| Clustering of syntaxin-1A in model membranes is modulated by phosphatidylinositol 4,5-bisphosphate and cholesterol.
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| Murray DH, Tamm LK.
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| Biochemistry 48(21):4617-25.
2009
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| 16 | STX1A
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| Syntaxin 1A is required for normal in utero development.
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| McRory JE, Rehak R, Simms B, Doering CJ, Chen L, Hermosilla T, Duke C, Dyck R, Zamponi GW.
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| Biochem Biophys Res Commun 375(3):372-7. Epub 2008 Aug 17.
2008
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| 17 | KCND3, STX1A
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| Modulation of the K(v)4.3 channel by syntaxin 1A.
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| Ahmed I, Cosen-Binker LI, Leung YM, Gaisano HY, Diamant NE.
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| Biochem Biophys Res Commun 358(3):789-95. Epub 2007 May 4. 2007
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| 18 | VAMP1, SNAP25, STX1A
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| Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage.
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| Sakaba T, Stein A, Jahn R, Neher E.
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| Science 309(5733):491-4. 2005
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| 19 | STX1A
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| Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients.
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| Wu YQ, Bejjani BA, Tsui LC, Mandel A, Osborne LR, Shaffer LG.
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| Am J Med Genet 109(2):121-4. 2002
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| 20 | RNF40, STX1A, UBE2L6
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| Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation.
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| Chin LS, Vavalle JP, Li L.
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| J Biol Chem 277(38):35071-9. 2002
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| 21 | STX1A
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| Molecular determinants of syntaxin 1 modulation of N-type calcium channels.
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| Jarvis SE, Barr W, Feng ZP, Hamid J, Zamponi GW.
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| J Biol Chem 277(46):44399-407. Epub 2002 Sep 06. 2002
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| 22 | CAPZB, HPC2, PCAP, STX1A
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| PCAP is the major known prostate cancer predisposing locus in families from south and west Europe.
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| Cancel-Tassin G, Latil A, Valeri A, Mangin P, Fournier G, Berthon P, Cussenot O.
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| Eur J Hum Genet 9(2):135-42. 2001
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| 23 | STX1A
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| Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents.
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| Naren AP, Di A, Cormet-Boyaka E, Boyaka PN, McGhee JR, Zhou W, Akagawa K, Fujiwara T, Thome U, Engelhardt JF, Nelson DJ, Kirk KL.
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| J Clin Invest 105(3):377-86. 2000
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| 24 | PSEN1, STX1A
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| Identification of syntaxin 1A as a novel binding protein for presenilin-1.
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| Smith SK, Anderson HA, Yu G, Robertson AG, Allen SJ, Tyler SJ, Naylor RL, Mason G, Wilcock GW, Roche PA, Fraser PE, Dawbarn D.
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| Brain Res Mol Brain Res 78(1-2):100-7. 2000
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| 25 | LIMK1, STX1A, WBS
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| Williams syndrome : use of chromosomal microdeletions as a tool to dissect cognitive and physical phenotypes.
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| Tassabehji M, et al.
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| Am J Hum Genet 64 : 118-125. 1999
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| 26 | STX1A
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| Expression analysis and protein localization of the human HPC-1/Syntaxin 1A, a gene deleted in williams syndrome.
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| Botta A, Sangiuolo F, Calza L, Giardino L, Potenza S, Novelli G, Dallapiccola B.
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| Genomics 62(3):525-8 1999
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| 27 | STX1A, STX3, STX6
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| Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1.
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| Martin-Martin B, Nabokina SM, Lazo PA, Mollinedo F.
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| J Leukoc Biol 65(3):397-406. 1999
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| 28 | STX1A, WBS
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| Hemizygous deletion of the HPC-1/syntaxin 1A gene (STX1A) in patients with Williams syndrome.
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| Nakayama T, et al.
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| Cytogenet Cell Genet 82 : 49-51. 1998
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| 29 | STX1A
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| Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2.
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| Nakayama T, Fujiwara T, Miyazawa A, Asakawa S, Shimizu N, Shimizu Y, Mikoshiba K, Akagawa K.
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| Genomics 42(1):173-6. 1997
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| 30 | STX1A, WBS
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| Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.
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| Osborne LR, Soder S, Shi XM, Pober B, Costa T, Scherer SW, Tsui LC.
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| Am J Hum Genet 61(2):449-52. 1997
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