| 1 | STUB1
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| Regulation of STUB1 expression and its biological significance in mouse Sertoli cells.
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| Li T, Zheng C, Han WJ, Chen ZZ.
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| Syst Biol Reprod Med. Mar 26:1-15. doi: 10.1080/19396368.2022.2027554. Epub ahead of print. 2022
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| 2 | SCA48, SCAR16, STUB1
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| Genetic Dominant Variants in STUB1, Segregating in Families with SCA48, Display In Vitro Functional Impairments Indistinctive from Recessive Variants Associated with SCAR16.
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| Pakdaman Y, Berland S, Bustad HJ, Erdal S, Thompson BA, James PA, Power KN, Ellingsen S, Krooni M, Berge LI, Sexton A, Bindoff LA, Knappskog PM, Johansson S, Aukrust I.
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| Int J Mol Sci. May 30;22(11):5870. doi: 10.3390/ijms22115870. 2021
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| 3 | SCA48, STUB1
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| Clinical and functional characterization of a novel STUB1 frameshift mutation in autosomal dominant spinocerebellar ataxia type 48 (SCA48).
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| Chen HY, Hsu CL, Lin HY, Lin YF, Tsai SF, Ho YJ, Li YR, Tsai JW, Teng SC, Lin CH.
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| J Biomed Sci. Sep 26;28(1):65. doi: 10.1186/s12929-021-00763-1 2021
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| 4 | OTUD3, STUB1
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| Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer
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| Zhang P, Li C, Li H, Yuan L, Dai H, Peng Z, Deng Z, Chang Z, Cui CP, Zhang L.
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| Cell Death Differ. Nov;27(11):3177-3195. doi: 10.1038/s41418-020-0571-7. Epub 2020 Jun 1. 2020
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| 5 | SCA48, STUB1
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| Clinical and pathologic phenotype of a large family with heterozygous STUB1 mutation
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| Mol MO, van Rooij JGJ, Brusse E, Verkerk AJMH, Melhem S, den Dunnen WFA, Rizzu P, Cupidi C, van Swieten JC, Donker Kaat L.
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| Neurol Genet. Mar 23;6(3):e417. doi: 10.1212/NXG.0000000000000417. 2020
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| 6 | ARNTL, STUB1
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| The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1
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| Ullah K, Chen S, Lu J, Wang X, Liu Q, Zhang Y, Long Y, Hu Z, Xu G.
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| J Biol Chem. Apr 3;295(14):4696-4708. doi: 10.1074/jbc.RA119.011280. Epub 2020 Feb 10. Erratum in: J Biol Chem. 2020 Aug 7;295(32):11378. 2020
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| 7 | CFTR, DNAJA1, DNAJA2, HSPA4, HSPA8, STUB1
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| Hsp70 and DNAJA2 limit CFTR levels through degradation.
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| Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC.
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| PLoS One 14(8):e0220984. doi: 10.1371/journal.pone.0220984. eCollection 2019.
2019
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| 8 | STUB1, TFEB
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| STUB1 regulates TFEB-induced autophagy-lysosome pathway
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| Sha Y, Rao L, Settembre C, Ballabio A, Eissa NT.
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| EMBO J. Sep 1;36(17):2544-2552. doi: 10.15252/embj.201796699. Epub 2017 Jul 28. 2017
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| 9 | RUNX1, RUNX1T1, STUB1
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| The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1
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| Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S.
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| J Biol Chem. Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. 2017
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| 10 | STUB1
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| Transcription factor RFX1 is ubiquitinated by E3 ligase STUB1 in systemic lupus erythematosus
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| Guo Y, Zhao M, Lu Q.
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| Clin Immunol. Aug;169:1-7. doi: 10.1016/j.clim.2016.06.003. Epub 2016 Jun 6. 2016
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| 11 | SCAR16, STUB1
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| Autosomal recessive cerebellar ataxia of adult onset due to STUB1 mutations.
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| Depondt C, Donatello S, Simonis N, Rai M, van Heurck R, Abramowicz M, D'Hooghe M, Pandolfo M.
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| Neurology 82(19):1749-50. doi: 10.1212/WNL.0000000000000416. Epub 2014 Apr 9.
2014
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| 12 | SCAR16, STUB1
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| Phenotype and frequency of STUB1 mutations: next-generation screenings in Caucasian ataxia and spastic paraplegia cohorts.
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| Synofzik M, Schüle R, Schulze M, Gburek-Augustat J, Schweizer R, Schirmacher A, Krägeloh-Mann I, Gonzalez M, Young P, Züchner S, Schöls L, Bauer P.
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| Orphanet J Rare Dis 9:57. doi: 10.1186/1750-1172-9-57.
2014
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| 13 | EIF5A, STUB1
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| CHIP/Stub1 interacts with eIF5A and mediates its degradation.
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| Shang Y, Zhao X, Tian B, Wang Y, Ren F, Jia B, Zhai Y, Chen W, He D, Chang Z.
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| Cell Signal 26(5):1098-104. doi: 10.1016/j.cellsig.2014.01.030. Epub 2014 Feb 6.
2014
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| 14 | FMR1, STUB1
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| Regulation of fragile X mental retardation 1 protein by C-terminus of Hsc70-interacting protein depends on its phosphorylation status.
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| Choi YN, Jeong DH, Lee JS, Yoo SJ.
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| Biochem Biophys Res Commun 453(1):192-7. doi: 10.1016/j.bbrc.2014.09.099. Epub 2014 Sep 28.
2014
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| 15 | MAPT, STUB1
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| Involvement of endoplasmic reticulum stress in tauopathy.
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| Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M.
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| Biochem Biophys Res Commun 430(2):500-4. doi: 10.1016/j.bbrc.2012.12.007. Epub 2012 Dec 10.
2013
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| 16 | KATNA1, STUB1, USP47
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| USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth.
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| Yang SW, Oh KH, Park E, Chang HM, Park JM, Seong MW, Ka SH, Song WK, Park DE, Baas PW, Jeon YJ, Chung CH.
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| J Neurosci 33(31):12728-38. doi: 10.1523/JNEUROSCI.0698-13.2013.
2013
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| 17 | CARD11, STUB1
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| STUB1 is essential for T-cell activation by ubiquitinating CARMA1.
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| Wang S, Li Y, Hu YH, Song R, Gao Y, Liu HY, Shu HB, Liu Y.
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| Eur J Immunol 43(4):1034-41. doi: 10.1002/eji.201242554. Epub 2013 Feb 15.
2013
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| 18 | HSPA8, STUB1
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| The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.
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| Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER.
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| Biochemistry 52(32):5354-64. doi: 10.1021/bi4009209. Epub 2013 Aug 2.
2013
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| 19 | GHR, STUB1, UBE2N
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| Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis.
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| Slotman JA, da Silva Almeida AC, Hassink GC, van de Ven RH, van Kerkhof P, Kuiken HJ, Strous GJ.
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| J Biol Chem 287(19):15533-43. doi: 10.1074/jbc.M111.302521. Epub 2012 Mar 20.
2012
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| 20 | FBXO2, FBXO6, RTN4R, RTN4RL2, STUB1
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| The Nogo receptor 2 is a novel substrate of Fbs1.
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| Kern F, Sarg B, Stasyk T, Hess D, Lindner H.
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| Biochem Biophys Res Commun 417(3):977-81. doi: 10.1016/j.bbrc.2011.12.050. Epub 2011 Dec 20.
2012
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| 21 | HDAC6, STUB1
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| Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation.
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| Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, Petrucelli L.
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| Hum Mol Genet 21(13):2936-45. doi: 10.1093/hmg/dds125. Epub 2012 Apr 5.
2012
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| 22 | RNF168, RNF8, STUB1, TRAF6, UBE2N
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| Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
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| Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.
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| J Biol Chem 287(28):23900-10. doi: 10.1074/jbc.M112.359653. Epub 2012 May 15.
2012
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| 23 | STUB1
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| CHIP-dependent p53 regulation occurs specifically during cellular senescence.
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| Sisoula C, Trachana V, Patterson C, Gonos ES.
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| Free Radic Biol Med 50(1):157-65. Epub 2010 Oct 23.
2011
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| 24 | AIFM1, STUB1, USP2
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| Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.
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| Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH.
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| Cell Death Differ 18(8):1326-36. doi: 10.1038/cdd.2011.3. Epub 2011 Feb 4.
2011
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| 25 | STUB1, TRAF2
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| Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion.
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| Jang KW, Lee KH, Kim SH, Jin T, Choi EY, Jeon HJ, Kim E, Han YS, Chung JH.
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| J Cell Biochem 112(12):3612-20. doi: 10.1002/jcb.23292.
2011
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| 26 | SENP3, STUB1
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| Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90.
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| Yan S, Sun X, Xiang B, Cang H, Kang X, Chen Y, Li H, Shi G, Yeh ET, Wang B, Wang X, Yi J.
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| EMBO J 29(22):3773-86. Epub 2010 Oct 5.
2010
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| 27 | STUB1
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| CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity.
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| Lee JH, Khadka P, Baek SH, Chung IK.
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| J Biol Chem 285(53):42033-45. Epub 2010 Oct 19.
2010
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| 28 | STUB1
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| CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates.
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| Stankiewicz M, Nikolay R, Rybin V, Mayer MP.
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| FEBS J 277(16):3353-67. Epub 2010 Jul 8.
2010
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| 29 | NHLRC1, STUB1
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| Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease.
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| Rao SN, Sharma J, Maity R, Jana NR.
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| J Biol Chem 285(2):1404-13. Epub 2009 Nov 5. 2010
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| 30 | STUB1, UBE2D1, UBE2N
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| Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes.
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| Graf C, Stankiewicz M, Nikolay R, Mayer MP.
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| Biochemistry 49(10):2121-9. doi: 10.1021/bi901829f.
2010
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| 31 | STUB1
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| CHIP functions an E3 ubiquitin ligase of Runx1.
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| Shang Y, Zhao X, Xu X, Xin H, Li X, Zhai Y, He D, Jia B, Chen W, Chang Z.
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| Biochem Biophys Res Commun 386(1):242-6. Epub 2009 Jun 12.
2009
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| 32 | STUB1
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| CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation.
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| Chen L, Kong X, Fu J, Xu Y, Fang S, Hua P, Luo L, Yin Z.
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| Cell Immunol 258(1):38-43. Epub 2009 Apr 10.
2009
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| 33 | STUB1
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| The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
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| Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie SH, Kobayashi Y, Seino Y, Kawano M, Kawabe Y, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J.
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| Nat Cell Biol 11(3):312-9. Epub 2009 Feb 8.
2009
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| 34 | RAF1, STUB1, XIAP
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| X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
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| Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K.
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| Nat Cell Biol 10(12):1447-55. Epub 2008 Nov 16. Erratum in: Nat Cell Biol. 2009 Jan;11(1):110. 2008
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| 35 | STUB1
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| Chaperone functions of the E3 ubiquitin ligase CHIP.
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| Rosser MF, Washburn E, Muchowski PJ, Patterson C, Cyr DM.
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| J Biol Chem 282(31):22267-77. Epub 2007 Jun 1. 2007
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| 36 | STUB1
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| Co-chaperone CHIP promotes aggregation of ataxin-1.
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| Choi JY, Ryu JH, Kim HS, Park SG, Bae KH, Kang S, Myung PK, Cho S, Park BC, Lee do H.
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| Mol Cell Neurosci 34(1):69-79. Epub 2006 Nov 28. 2007
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| 37 | FBXO2, STUB1
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| A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.
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| Nelson RF, Glenn KA, Miller VM, Wen H, Paulson HL.
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| J Biol Chem 281(29):20242-51. Epub 2006 May 8.
2006
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| 38 | BAG2, STUB1
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| BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
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| Arndt V, Daniel C, Nastainczyk W, Alberti S, Hohfeld J.
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| Mol Biol Cell 16(12):5891-900. Epub 2005 Oct 5. 2005
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| 39 | STUB1
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| CHIP interacts with heat shock factor 1 during heat stress.
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| Kim SA, Yoon JH, Kim DK, Kim SG, Ahn SG.
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| FEBS Lett 579(29):6559-63. Epub 2005 Nov 2. 2005
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| 40 | BAG2, HSPA4, STUB1
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| Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
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| Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C.
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| J Biol Chem 280(46):38673-81. Epub 2005 Sep 16. 2005
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| 41 | HSPA4, MAPT, STUB1
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| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
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| Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M.
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| Hum Mol Genet 13(7):703-14. Epub 2004 Feb 12. 2004
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| 42 | STUB1
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| CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.
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| Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu XY, Chang Z.
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| Mol Cell Biol 24(2):856-64. 2004
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| 43 | STUB1
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| A new gun in town: the U box is a ubiquitin ligase domain.
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| Patterson C.
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| Sci STKE 2002(116):PE4. Review. 2002
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| 44 | STUB1
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| Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.
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| Prodromou C, Siligardi G, O'Brien R, Woolfson DN, Regan L, Panaretou B, Ladbury JE, Piper PW, Pearl LH.
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| EMBO J 18(3):754-62 1999
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| 45 | DNAJB1, STUB1
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| Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.
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| Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C.
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| Mol Cell Biol 19(6):4535-45 1999
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| 46 | CWC27, HSPH1, MBD2, SDCCAG1, SDCCAG3, SDCCAG8, STARD10, STUB1, TSHZ1, USH1C, UTP14A, WNK2
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| Characterization of human colon cancer antigens recognized by autologous antibodies.
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| Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, TureciO, Sahin U, Pfreundschuh M, Old LJ.
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| Int J Cancer 76(5):652-8. 1998
|