Citations for
1PMSE, STRADA
Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.
Parker WE, Orlova KA, Parker WH, Birnbaum JF, Krymskaya VP, Goncharov DA, Baybis M, Helfferich J, Okochi K, Strauss KA, Crino PB.
Sci Transl Med 5(182):182ra53. doi: 10.1126/scitranslmed.3005271. 2013
2PAK1, STK11, STRADA
STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.
Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.
J Biol Chem 287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6. 2012
3STK11, STRADA
STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.
Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB.
J Clin Invest 120(5):1591-602. doi: 10.1172/JCI41592. Epub 2010 Apr 26. 2010
4BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
Microtubule assembly, organization and dynamics in axons and dendrites.
Conde C, Caceres A.
Nat Rev Neurosci. 10(5):319-32. 2009
5CAB 39, STK11, STRADA
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.
PLoS Biol 7(6):e1000126. Epub 2009 Jun 9.PMID: 19513107 2009
6CAB39, STK11, STK26, STRADA
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.
Dev Cell 16(4):551-62.PMID: 19386264 2009
7SIRT1, STK11, STRADA
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
Lan F, Cacicedo JM, Ruderman N, Ido Y.
J Biol Chem 283(41):27628-35. Epub 2008 Aug 7. 2008
8STK11, STRADA, XPO1, XPO7
STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
Dorfman J, Macara IG.
Mol Biol Cell 19(4):1614-26. Epub 2008 Feb 6. 2008
9CAB39, STK11, STRADA
Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.PMID: 17921699 2007
10CAB39, STK11, STRADA
Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.
Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.
Mol Biotechnol 36(3):220-31.PMID: 17873408 2007
11PMSE, STRADA
Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5.
Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH.
Brain 130(Pt 7):1929-41. Epub 2007 May 23. 2007
12STK11, STRADA
Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24. 2007
13STK11, STRADA
Analysis of the LKB1-STRAD-MO25 complex.
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.
J Cell Sci. 117(Pt 26):6365-75. 2004
14LYK5, STK11, STRADA
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.
EMBO J 22(12):3062-72. 2003