1 | PMSE, STRADA
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| Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.
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| Parker WE, Orlova KA, Parker WH, Birnbaum JF, Krymskaya VP, Goncharov DA, Baybis M, Helfferich J, Okochi K, Strauss KA, Crino PB.
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| Sci Transl Med 5(182):182ra53. doi: 10.1126/scitranslmed.3005271.
2013
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2 | PAK1, STK11, STRADA
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| STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.
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| Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.
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| J Biol Chem 287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6.
2012
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3 | STK11, STRADA
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| STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.
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| Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB.
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| J Clin Invest 120(5):1591-602. doi: 10.1172/JCI41592. Epub 2010 Apr 26.
2010
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4 | BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
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| Microtubule assembly, organization and dynamics in axons and dendrites.
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| Conde C, Caceres A.
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| Nat Rev Neurosci. 10(5):319-32. 2009
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5 | CAB 39, STK11, STRADA
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| ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
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| Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.
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| PLoS Biol 7(6):e1000126. Epub 2009 Jun 9.PMID: 19513107 2009
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6 | CAB39, STK11, STK26, STRADA
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| Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
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| ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.
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| Dev Cell 16(4):551-62.PMID: 19386264 2009
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7 | SIRT1, STK11, STRADA
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| SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
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| Lan F, Cacicedo JM, Ruderman N, Ido Y.
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| J Biol Chem 283(41):27628-35. Epub 2008 Aug 7.
2008
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8 | STK11, STRADA, XPO1, XPO7
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| STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
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| Dorfman J, Macara IG.
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| Mol Biol Cell 19(4):1614-26. Epub 2008 Feb 6.
2008
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9 | CAB39, STK11, STRADA
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| Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
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| Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
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| Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.PMID: 17921699 2007
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10 | CAB39, STK11, STRADA
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| Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.
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| Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.
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| Mol Biotechnol 36(3):220-31.PMID: 17873408 2007
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11 | PMSE, STRADA
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| Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5.
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| Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH.
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| Brain 130(Pt 7):1929-41. Epub 2007 May 23.
2007
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12 | STK11, STRADA
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| Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
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| Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
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| Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.
2007
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13 | STK11, STRADA
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| Analysis of the LKB1-STRAD-MO25 complex.
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| Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.
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| J Cell Sci. 117(Pt 26):6365-75. 2004
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14 | LYK5, STK11, STRADA
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| Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
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| Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.
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| EMBO J 22(12):3062-72. 2003
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