Citations for
1STK4, TIIAC
MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.
Park E, Kim MS, Song JH, Roh KH, Lee R, Kim TS.
Biochem Biophys Res Commun 489(1):56-62. doi: 10.1016/j.bbrc.2017.05.094. Epub 2017 May 17. 2017
2STK3, STK4
Structure of MST2 SARAH domain provides insights into its interaction with RAPL.
Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L, Zhang Z, Zhou Z, Zhang M.
J Struct Biol 185(3):366-74. doi: 10.1016/j.jsb.2014.01.008. Epub 2014 Jan 25. Erratum in: J Struct Biol. 2014 Apr;186(1):204. Hao, Qiao [corr 2014
3STK3, STK4
Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis.
Du X, Dong Y, Shi H, Li J, Kong S, Shi D, Sun LV, Xu T, Deng K, Tao W.
PLoS One 9(3):e90701. doi: 10.1371/journal.pone.0090701. eCollection 2014. 2014
4EZH2, SAFB, STK4
Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2.
Mukhopadhyay NK, Kim J, You S, Morello M, Hager MH, Huang WC, Ramachandran A, Yang J, Cinar B, Rubin MA, Adam RM, Oesterreich S, Di Vizio D, Freeman MR.
Oncogene ncogene. 2013 Jul 29. doi: 10.1038/onc.2013.294. [Epub ahead of print] 2013
5STK3, STK4
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
Rawat SJ, Creasy CL, Peterson JR, Chernoff J.
J Biol Chem 288(12):8762-71. doi: 10.1074/jbc.M112.414524. Epub 2013 Feb 5. 2013
6STK3, STK4
Functional role of Mst1/Mst2 in embryonic stem cell differentiation.
Li P, Chen Y, Mak KK, Wong CK, Wang CC, Yuan P.
PLoS One 8(11):e79867. doi: 10.1371/journal.pone.0079867. eCollection 2013. 2013
7STK4, TIIAC
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival.
Nehme NT, Pachlopnik Schmid J, Debeurme F, André-Schmutz I, Lim A, Nitschke P, Rieux-Laucat F, Lutz P, Picard C, Mahlaoui N, Fischer A, de Saint Basile G.
Blood 119(15):3458-68. Epub 2011 Dec 14. 2012
8ABL1, STK3, STK4
Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway.
Liu W, Wu J, Xiao L, Bai Y, Qu A, Zheng Z, Yuan Z.
PLoS One 7(5):e36562. doi: 10.1371/journal.pone.0036562. Epub 2012 May 9. 2012
9STK3, STK4
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.
Mou F, Praskova M, Xia F, Van Buren D, Hock H, Avruch J, Zhou D.
J Exp Med 209(4):741-59. doi: 10.1084/jem.20111692. Epub 2012 Mar 12. 2012
10PPARG, SAV1, STK3, STK4
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ.
Park BH, Kim DS, Won GW, Jeon HJ, Oh BC, Lee Y, Kim EG, Lee YH.
PLoS One 7(1):e30983. doi: 10.1371/journal.pone.0030983. Epub 2012 Jan 26. 2012
11STK4, TIIAC
The phenotype of human STK4 deficiency.
Abdollahpour H, Appaswamy G, Kotlarz D, Diestelhorst J, Beier R, Schäffer AA, Gertz EM, Schambach A, Kreipe HH, Pfeifer D, Engelhardt KR, Rezaei N, Grimbacher B, Lohrmann S, Sherkat R, Klein C.
Blood 119(15):3450-7. doi: 10.1182/blood-2011-09-378158. Epub 2012 Jan 31. 2012
12RASSF1, STK3, STK4
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
Guo C, Zhang X, Pfeifer GP.
J Biol Chem 286(8):6253-61. Epub 2011 Jan 3. 2011
13PMAIP1, STK4
Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
Valis K, Prochazka L, Boura E, Chladova J, Obsil T, Rohlena J, Truksa J, Dong LF, Ralph SJ, Neuzil J.
Cancer Res 71(3):946-54. Epub 2011 Jan 18. 2011
14MICAL1, STK38, STK4
MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ.
Mol Cell Biol 31(17):3603-15. Epub 2011 Jul 5. 2011
15RASSF2, STK4
Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.
Song H, Oh S, Oh HJ, Lim DS.
Biochem Biophys Res Commun 391(1):969-73. Epub 2009 Dec 4.PMID: 19962960 2010
16RASSF5, STK4
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
Park J, Kang SI, Lee SY, Zhang XF, Kim MS, Beers LF, Lim DS, Avruch J, Kim HS, Lee SB.
J Biol Chem 285(45):35029-38. Epub 2010 Sep 1. 2010
17H2AFX, STK4
MST1 promotes apoptosis through phosphorylation of histone H2AX.
Wen W, Zhu F, Zhang J, Keum YS, Zykova T, Yao K, Peng C, Zheng D, Cho YY, Ma WY, Bode AM, Dong Z.
J Biol Chem 285(50):39108-16. Epub 2010 Oct 4. 2010
18MST2, MST3, STK26, STK4
Structural comparison of human mammalian ste20-like kinases.
Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH.
PLoS One 5(8):e11905. 2010
19STK4
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.
Katagiri K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T.
EMBO J 28(9):1319-31. Epub 2009 Apr 2. 2009
20SAV1, STK4
The human WW45 protein enhances MST1-mediated apoptosis in vivo.
Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, Leng Y, Gardner K, Judge SI, Li QQ, Hu J, Gong J.
Int J Mol Med 23(3):357-62. 2009
21STK4, TNNI3
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.
You B, Yan G, Zhang Z, Yan L, Li J, Ge Q, Jin JP, Sun J.
Biochem J 418(1):93-101.PMID: 18986304 2009
22SAV1, STK4
A crucial role of WW45 in developing epithelial tissues in the mouse.
Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, Lim DS.
EMBO J 27(8):1231-42. Epub 2008 Mar 27. 2008
23STK4
Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region.
Anand R, Kim AY, Brent M, Marmorstein R.
Biochemistry 47(25):6719-26.PMID: 18510339 2008
24MOBKL1A, MOBKL1B, STK3, STK4
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
Praskova M, Xia F, Avruch J.
Curr Biol 18(5):311-21.PMID: 18328708 2008
25STK4
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR.
EMBO J 26(21):4523-34. Epub 2007 Oct 11. 2007
26STK4
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
Jang SW, Yang SJ, Srinivasan S, Ye K.
J Biol Chem 282(42):30836-44. Epub 2007 Aug 28. 2007
27SAV1, STK3, STK4
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Callus BA, Verhagen AM, Vaux DL.
FEBS J 273(18):4264-76. Epub 2006 Aug 23. 2006
28RASSF1, STK4
Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.
Oh HJ, Lee KK, Song SJ, Jin MS, Song MS, Lee JH, Im CR, Lee JO, Yonehara S, Lim DS.
Cancer Res 66(5):2562-9. 2006
29STK4
Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis.
De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA.
Blood 99(9):3432-8. 2002
30STK4
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.
Glantschnig H, Rodan GA, Reszka AA.
J Biol Chem 277(45):42987-96. Epub 2002 Sep 09. 2002
31PRG1, STK4, GADD45GIP1
Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene.
Horikoshi N, Cong J, Kley N, Shenk T.
Biochem Biophys Res Commun 261(3):864-9. 1999
32STK4
Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.
Taylor LK, Wang HC, Erikson RL.
Proc Natl Acad Sci U S A 93(19):10099-104. 1996
33STK4
Cloning and characterization of a human protein kinase with homology to Ste20.
Creasy CL, Chernoff J.
J Biol Chem 270(37):21695-700. 1995
34STK3, STK4
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases.
Creasy CL, Chernoff J.
Gene 167(1-2):303-6. 1995