| 1 | SIRT2, STK11
|
| SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.
|
| Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YB, Zhao X, Hao DL, Zhang ZQ, Zou MH, Liu DP, Chen HZ.
|
| Circulation 136(21):2051-2067. doi: 10.1161/CIRCULATIONAHA.117.028728. Epub 2017 Sep 25.
2017
|
| 2 | PJS1, STK11
|
| Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 gene.
|
| Masuda K, Kobayashi Y, Kimura T, Umene K, Misu K, Nomura H, Hirasawa A, Banno K, Kosaki K, Aoki D, Sugano K.
|
| Hum Genome Var 3:16002. doi: 10.1038/hgv.2016.2. eCollection 2016.
2016
|
| 3 | CRTC3, STK11
|
| Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3.
|
| Shan T, Xiong Y, Zhang P, Li Z, Jiang Q, Bi P, Yue F, Yang G, Wang Y, Liu X, Kuang S.
|
| Nat Commun 7:12205. doi: 10.1038/ncomms12205.
2016
|
| 4 | BMPR1A, BMPR1B, STK11
|
| The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
|
| Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH, Moustakas A.
|
| Oncotarget 7(2):1120-43. doi: 10.18632/oncotarget.6683.
2016
|
| 5 | MAP3K11, PRKAA1, STK11
|
| MLK3 phophorylates AMPK independently of LKB1.
|
| Luo L, Jiang S, Huang D, Lu N, Luo Z.
|
| PLoS One 10(4):e0123927. doi: 10.1371/journal.pone.0123927. eCollection 2015.
2015
|
| 6 | BHLHE40, PRKAA1, STK11
|
| DEC1 negatively regulates AMPK activity via LKB1.
|
| Sato F, Muragaki Y, Zhang Y.
|
| Biochem Biophys Res Commun 467(4):711-6. doi: 10.1016/j.bbrc.2015.10.077. Epub 2015 Oct 20.
2015
|
| 7 | STK11
|
| LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.
|
| Men Y, Zhang A, Li H, Zhang T, Jin Y, Li H, Zhang J, Gao J.
|
| PLoS One 10(8):e0135841. doi: 10.1371/journal.pone.0135841. eCollection 2015.
2015
|
| 8 | STK11
|
| A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.
|
| Ritho J, Arold ST, Yeh ET.
|
| Cell Rep 12(5):734-42. doi: 10.1016/j.celrep.2015.07.002. Epub 2015 Jul 23.
2015
|
| 9 | STK11
|
| Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.
|
| Swisa A, Granot Z, Tamarina N, Sayers S, Bardeesy N, Philipson L, Hodson DJ, Wikstrom JD, Rutter GA, Leibowitz G, Glaser B, Dor Y.
|
| J Biol Chem 290(34):20934-46. doi: 10.1074/jbc.M115.639237. Epub 2015 Jul 2.
2015
|
| 10 | STK11
|
| LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
|
| Walsh NC, Waters LR, Fowler JA, Lin M, Cunningham CR, Brooks DG, Rehg JE, Morse HC 3rd, Teitell MA.
|
| EMBO Rep 16(6):753-68. doi: 10.15252/embr.201439505. Epub 2015 Apr 26.
2015
|
| 11 | STK11
|
| LKB1 couples glucose metabolism to insulin secretion in mice.
|
| Fu A, Robitaille K, Faubert B, Reeks C, Dai XQ, Hardy AB, Sankar KS, Ogrel S, Al-Dirbashi OY, Rocheleau JV, Wheeler MB, MacDonald PE, Jones R, Screaton RA.
|
| Diabetologia 58(7):1513-22. doi: 10.1007/s00125-015-3579-7. Epub 2015 Apr 16.
2015
|
| 12 | STK11
|
| Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles.
|
| Shan T, Zhang P, Bi P, Kuang S.
|
| J Cell Physiol 230(5):1033-41. doi: 10.1002/jcp.24831.
2015
|
| 13 | SIK3, STK11
|
| Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila.
|
| Choi S, Lim DS, Chung J.
|
| PLoS Genet 11(5):e1005263. doi: 10.1371/journal.pgen.1005263. eCollection 2015 May.
2015
|
| 14 | PRKAA1, STK11
|
| LKB1 and AMPK differentially regulate pancreatic β-cell identity.
|
| Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, Nguyen-Tu MS, Kantor C, Swisa A, Dor Y, Gorman T, Ferrer J, Thorens B, Reimann F, Gribble F, McGinty JA, Chen L, French PM, Birzele F, Hildebrandt T, Uphues I, Rutter GA.
|
| FASEB J 28(11):4972-85. doi: 10.1096/fj.14-257667. Epub 2014 Jul 28.
2014
|
| 15 | STK11
|
| LKB1 suppresses proliferation and invasion of prostate cancer through hedgehog signaling pathway.
|
| Xu P, Cai F, Liu X, Guo L.
|
| Int J Clin Exp Pathol 7(12):8480-8. eCollection 2014.
2014
|
| 16 | STK11
|
| The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.
|
| Pooya S, Liu X, Kumar VB, Anderson J, Imai F, Zhang W, Ciraolo G, Ratner N, Setchell KD, Yoshida Y, Jankowski MP, Dasgupta B.
|
| Nat Commun 5:4993. doi: 10.1038/ncomms5993. Erratum in: Nat Commun. 2015;6:6075. Yutaka, Yoshida [corrected to Yoshida, Yutaka].
2014
|
| 17 | STK11
|
| Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity.
|
| Lai LP, Lotinun S, Bouxsein ML, Baron R, McMahon AP.
|
| Bone 69:98-108. doi: 10.1016/j.bone.2014.09.010. Epub 2014 Sep 18.
2014
|
| 18 | SIK1, SIK2, SIK3, STK11
|
| The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.
|
| Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K.
|
| Nat Commun 5:4535. doi: 10.1038/ncomms5535.
2014
|
| 19 | STK11
|
| Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis.
|
| Shan T, Zhang P, Liang X, Bi P, Yue F, Kuang S.
|
| Stem Cells 32(11):2893-907. doi: 10.1002/stem.1788.
2014
|
| 20 | PLK1, STK11
|
| Liver kinase B1 regulates the centrosome via PLK1.
|
| Werle K, Chen J, Xu HG, Zhao RX, He Q, Lu C, Cui R, Liang J, Li YL, Xu ZX.
|
| Cell Death Dis 5:e1157. doi: 10.1038/cddis.2014.135.
2014
|
| 21 | PARD3B, STK11
|
| The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.
|
| Huo Y, Macara IG.
|
| Nat Cell Biol 16(6):529-37. doi: 10.1038/ncb2969. Epub 2014 May 25. Erratum in: Nat Cell Biol. 2014 Jul;16(7):716.
2014
|
| 22 | NUAK1, STK11
|
| Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture.
|
| Courchet J, Lewis TL Jr, Lee S, Courchet V, Liou DY, Aizawa S, Polleux F.
|
| Cell 153(7):1510-25. doi: 10.1016/j.cell.2013.05.021.
2013
|
| 23 | PTK2, STK11
|
| LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.
|
| Kline ER, Shupe J, Gilbert-Ross M, Zhou W, Marcus AI.
|
| J Biol Chem 288(24):17663-74. doi: 10.1074/jbc.M112.444620. Epub 2013 May 1.
2013
|
| 24 | STK11
|
| Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1.
|
| Tanner CB, Madsen SR, Hallowell DM, Goring DM, Moore TM, Hardman SE, Heninger MR, Atwood DR, Thomson DM.
|
| Am J Physiol Endocrinol Metab 305(8):E1018-29. doi: 10.1152/ajpendo.00227.2013. Epub 2013 Aug 27.
2013
|
| 25 | SIK2, SIK3, STK11
|
| The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.
|
| Walkinshaw DR, Weist R, Kim GW, You L, Xiao L, Nie J, Li CS, Zhao S, Xu M, Yang XJ.
|
| J Biol Chem 288(13):9345-62. doi: 10.1074/jbc.M113.456996. Epub 2013 Feb 7.
2013
|
| 26 | ARHGEF18, STK11
|
| LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.
|
| Xu X, Jin D, Durgan J, Hall A.
|
| Mol Cell Biol 33(14):2671-82. doi: 10.1128/MCB.00154-13.
2013
|
| 27 | FOXO3, FOXO4, NFYC, SP1, STK11
|
| Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.
|
| Lützner N, De-Castro Arce J, Rösl F.
|
| PLoS One 7(3):e32590. Epub 2012 Mar 6.
2012
|
| 28 | HPN, STK11
|
| Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.
|
| Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.
|
| Proc Natl Acad Sci U S A 109(7):E388-97. doi: 10.1073/pnas.1120421109. Epub 2012 Jan 20.
2012
|
| 29 | CRTC1, STK11
|
| Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.
|
| Gu Y, Lin S, Li JL, Nakagawa H, Chen Z, Jin B, Tian L, Ucar DA, Shen H, Lu J, Hochwald SN, Kaye FJ, Wu L.
|
| Oncogene 31(4):469-79. doi: 10.1038/onc.2011.247. Epub 2011 Jun 27.
2012
|
| 30 | PAK1, STK11, STRADA
|
| STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.
|
| Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.
|
| J Biol Chem 287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6.
2012
|
| 31 | PJS1, STK11
|
| Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.
|
| Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM.
|
| Hum Mol Genet 21(20):4394-405. Epub 2012 Jul 12.
2012
|
| 32 | DCLER1C, PRKAA2, STK11
|
| The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1-AMPK complex.
|
| Nakagawa K, Uehata Y, Natsuizaka M, Kohara T, Darmanin S, Asaka M, Takeda H, Kobayashi M.
|
| Biochem Biophys Res Commun 427(4):790-5. doi: 10.1016/j.bbrc.2012.09.140. Epub 2012 Oct 5.
2012
|
| 33 | STK11
|
| Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.
|
| Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I.
|
| J Cell Biol 199(7):1117-30. doi: 10.1083/jcb.201208080.
2012
|
| 34 | STK11
|
| The role of LKB1 and AMPK in cellular responses to stress and damage.
|
| Alexander A, Walker CL.
|
| FEBS Lett 585(7):952-7. Epub 2011 Mar 12. Review.
2011
|
| 35 | STK11
|
| Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.
|
| Gill RK, Yang SH, Meerzaman D, Mechanic LE, Bowman ED, Jeon HS, Roy Chowdhuri S, Shakoori A, Dracheva T, Hong KM, Fukuoka J, Zhang JH, Harris CC, Jen J.
|
| Oncogene 30(35):3784-91. doi: 10.1038/onc.2011.98. Epub 2011 May 2.
2011
|
| 36 | LAT, PLCG1, STK11
|
| LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
|
| Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H, Liu X.
|
| EMBO J 30(10):2083-93. doi: 10.1038/emboj.2011.116. Epub 2011 Apr 12.
2011
|
| 37 | CAB39, STK11
|
| MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.
|
| Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE.
|
| Mol Cell 37(5):620-32.PMID: 20227367 2010
|
| 38 | LOX, STK11
|
| LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.
|
| Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y, Fang Z, Wu J, Han X, Zhang J, Sun Y, Wu G, Padera R, Chen H, Wong KK, Ge G, Ji H.
|
| Proc Natl Acad Sci U S A 107(44):18892-7. Epub 2010 Oct 18.
2010
|
| 39 | MTOR, STK11
|
| Primary cilia regulate mTORC1 activity and cell size through Lkb1.
|
| Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Gödel M, Müller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, Kuehn EW.
|
| Nat Cell Biol. 12(11):1115-22. 2010
|
| 40 | STK11
|
| Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.
|
| Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA.
|
| Nature. 468(7324):701-4. 2010
|
| 41 | STK11
|
| Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
|
| Nakada D, Saunders TL, Morrison SJ.
|
| Nature. 468(7324):653-8. 2010
|
| 42 | STK11
|
| The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.
|
| Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N.
|
| Nature. 468(7324):659-63. 2010
|
| 43 | CAMKK2, PRKAB1, STK11
|
| Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
|
| Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG.
|
| Biochem J 426(1):109-18.
2010
|
| 44 | NUAK1, STK11
|
| New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
|
| Zagórska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, Prescott AR, Alessi DR.
|
| Sci Signal 3(115):ra25. doi: 10.1126/scisignal.2000616.
2010
|
| 45 | STK11, STRADA
|
| STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.
|
| Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB.
|
| J Clin Invest 120(5):1591-602. doi: 10.1172/JCI41592. Epub 2010 Apr 26.
2010
|
| 46 | STK11
|
| Characterization of an alternative splice variant of LKB1.
|
| Denison FC, Hiscock NJ, Carling D, Woods A.
|
| J Biol Chem 284(1):67-76. Epub 2008 Oct 14.
2009
|
| 47 | BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
|
| Microtubule assembly, organization and dynamics in axons and dendrites.
|
| Conde C, Caceres A.
|
| Nat Rev Neurosci. 10(5):319-32. 2009
|
| 48 | STK11
|
| Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.
|
| Xie Z, Dong Y, Zhang J, Scholz R, Neumann D, Zou MH.
|
| Mol Cell Biol 29(13):3582-96. Epub 2009 May 4.
2009
|
| 49 | STK11
|
| LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells.
|
| Taliaferro-Smith L, Nagalingam A, Zhong D, Zhou W, Saxena NK, Sharma D.
|
| Oncogene 28(29):2621-33. Epub 2009 Jun 1. 2009
|
| 50 | CAB39, STK11
|
| Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
|
| Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.
|
| Science 326(5960):1707-11. Epub 2009 Nov 5.
2009
|
| 51 | PRKAB1, STK11
|
| LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
|
| Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H.
|
| Physiol Rev 89(3):777-98. Review.PMID: 19584313 2009
|
| 52 | STK11
|
| Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction.
|
| Ikeda Y, Sato K, Pimentel DR, Sam F, Shaw RJ, Dyck JR, Walsh K.
|
| J Biol Chem 284(51):35839-49. Epub .PMID: 19828446 2009
|
| 53 | CAB 39, STK11, STRADA
|
| ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
|
| Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.
|
| PLoS Biol 7(6):e1000126. Epub 2009 Jun 9.PMID: 19513107 2009
|
| 54 | CAB39, STK11, STK26, STRADA
|
| Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
|
| ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.
|
| Dev Cell 16(4):551-62.PMID: 19386264 2009
|
| 55 | STK11
|
| Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.
|
| Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice LC, Ewens KG, Spielman RS, Leppert PC, Myers ER; Reproductive Medicine Network.
|
| J Clin Endocrinol Metab 93(3):792-800. Epub 2007 Nov 13. 2008
|
| 56 | APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
|
| Inherited susceptibility to common cancers.
|
| Foulkes WD.
|
| N Engl J Med 359(20):2143-53. No abstract available.
2008
|
| 57 | SIRT1, STK11, STRADA
|
| SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
|
| Lan F, Cacicedo JM, Ruderman N, Ido Y.
|
| J Biol Chem 283(41):27628-35. Epub 2008 Aug 7.
2008
|
| 58 | STK11, STRADA, XPO1, XPO7
|
| STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
|
| Dorfman J, Macara IG.
|
| Mol Biol Cell 19(4):1614-26. Epub 2008 Feb 6.
2008
|
| 59 | BRSK2,STK11
|
| LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
|
| Barnes AP, Lilley BN, Pan YA, Plummer LJ, Powell AW, Raines AN, Sanes JR, Polleux F.
|
| Cell 129(3):549-63. 2007
|
| 60 | LYK5,STK11
|
| LKB1/STRAD promotes axon initiation during neuronal polarization.
|
| Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo MM.
|
| Cell 129(3):565-77. 2007
|
| 61 | STK11
|
| LKB1 modulates lung cancer differentiation and metastasis.
|
| Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, JŠnne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK.
|
| Nature 448(7155):807-10. Epub 2007 Aug 5. 2007
|
| 62 | PJS1, STK11
|
| Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.
|
| Mehenni H, Resta N, Guanti G, Mota-Vieira L, Lerner A, Peyman M, Chong KA, Aissa L, Ince A, Cosme A, Costanza MC, Rossier C, Radhakrishna U, Burt RW, Picard D.
|
| Dig Dis Sci 52(8):1924-33. Epub 2007 Apr 3.
2007
|
| 63 | STK11, WDR6
|
| Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
|
| Xie X, Wang Z, Chen Y.
|
| Mol Cell Biochem 301(1-2):115-22. Epub 2007 Jan 10.
2007
|
| 64 | STK11
|
| LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning.
|
| Asada N, Sanada K, Fukada Y.
|
| J Neurosci 27(43):11769-75.PMID: 17959818 2007
|
| 65 | CAB39, STK11, STRADA
|
| Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
|
| Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
|
| Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.PMID: 17921699 2007
|
| 66 | CAB39, STK11, STRADA
|
| Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.
|
| Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.
|
| Mol Biotechnol 36(3):220-31.PMID: 17873408 2007
|
| 67 | STK11, TP53, TUSC3
|
| Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
|
| Guervós MA, Marcos CA, Hermsen M, Nuño AS, Suárez C, Llorente JL.
|
| Cell Oncol 29(4):327-34.
2007
|
| 68 | STK11, STRADA
|
| Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.
|
| Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.
|
| Cancer Biol Ther 6(10):1627-31. Epub 2007 Jul 24.
2007
|
| 69 | PJS1, STK11
|
| An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus.
|
| Chow E, Meldrum CJ, Crooks R, Macrae F, Spigelman AD, Scott RJ.
|
| Clin Genet 70(5):409-14. 2006
|
| 70 | STK11, PJS1
|
| LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.
|
| Volikos E, Robinson J, Aittomaki K, Mecklin JP, Jarvinen H, Westerman AM, de Rooji FW, Vogel T, Moeslein G, Launonen V, Tomlinson IP, Silver AR, Aaltonen LA.
|
| J Med Genet 43(5):e18. 2006
|
| 71 | STK11
|
| A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
|
| Qiu W, Schšnleben F, Thaker HM, Goggins M, Su GH.
|
| Oncogene 25(20):2937-42. 2006
|
| 72 | STK11
|
| Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential.
|
| Zhuang ZG, Di GH, Shen ZZ, Ding J, Shao ZM.
|
| Mol Cancer Res 4(11):843-9.
2006
|
| 73 | PJS1, STK11, SMARCA4, LYK5, CAB39
|
| Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
|
| Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Naatsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Makela TP, Launonen V.
|
| Br J Cancer 92(6):1126-9. 2005
|
| 74 | STK11, PJS1
|
| A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer.
|
| Shinmura K, Goto M, Tao H, Shimizu S, Otsuki Y, Kobayashi H, Ushida S, Suzuki K, Tsuneyoshi T, Sugimura H.
|
| Clin Genet 67(1):81-6. 2005
|
| 75 | STK11, LYK5, PJS1
|
| Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
|
| Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H, Billaud M.
|
| Hum Mol Genet 14(10):1283-92. Epub 2005 Mar 30. 2005
|
| 76 | STK11, PJS1
|
| STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
|
| Schumacher V, Vogel T, Leube B, Driemel C, Goecke T, Moslein G, Royer-Pokora B.
|
| J Med Genet 42(5):428-35. No abstract available. 2005
|
| 77 | PTEN, STK11
|
| LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
|
| Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE.
|
| Hum Mol Genet 14(15):2209-19. Epub 2005 Jun 29. 2005
|
| 78 | STK11, PJS1
|
| Mutations in the human LKB1/STK11 gene.
|
| Launonen V.
|
| Hum Mutat 26(4):291-7. 2005
|
| 79 | STK11, CRTC2
|
| The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
|
| Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.
|
| Science 310(5754):1642-6. Epub 2005 Nov 24. 2005
|
| 80 | STK11
|
| Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
|
| Lin-Marq N, Borel C, Antonarakis SE.
|
| Mol Genet Genomics 273(2):184-96. Epub 2005 Feb 25. 2005
|
| 81 | STK11
|
| Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.
|
| Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR.
|
| FEBS Lett. 579(6):1417-23. 2005
|
| 82 | PJS1, STK11
|
| Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome.
|
| Le Meur N, Martin C, Saugier-Veber P, Joly G, Lemoine F, Moirot H, Rossi A, Bachy B, Cabot A, Joly P, Frebourg T.
|
| Eur J Hum Genet 12(5):415-8. 2004
|
| 83 | STK11, PJS1
|
| De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome.
|
| Hernan I, Roig I, Martin B, Gamundi MJ, Martinez-Gimeno M, Carballo M.
|
| Clin Genet 66(1):58-62. 2004
|
| 84 | STK11
|
| Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas.
|
| Kim CJ, Cho YG, Park JY, Kim TY, Lee JH, Kim HS, Lee JW, Song YH, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS.
|
| Eur J Cancer 40(1):136-41. 2004
|
| 85 | STK11
|
| Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
|
| Fernandez P, Carretero J, Medina PP, Jimenez AI, Rodriguez-Perales S, Paz MF, Cigudosa JC, Esteller M, Lombardia L, Morente M, Sanchez-Verde L, Sotelo T, Sanchez-Cespedes M.
|
| Oncogene 23(29):5084-91. 2004
|
| 86 | STK11
|
| LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
|
| Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR.
|
| EMBO J. 23(4):833-4 2004
|
| 87 | STK11, STRADA
|
| Analysis of the LKB1-STRAD-MO25 complex.
|
| Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.
|
| J Cell Sci. 117(Pt 26):6365-75. 2004
|
| 88 | EPN1, NLRP11, NLRP4, NLRP5, PTPRH, STK11, ZNF444
|
| Mapping of a translocation breakpoint in a Peutz-Jeghers hamartoma to the putative PJS locus at 19q13.4 and mutation analysis of candidate genes in polyp and STK11-negative PJS cases.
|
| Hearle N, Lucassen A, Wang R, Lim W, Ross F, Wheeler R, Moore I, Shipley J, Houlston R.
|
| Genes Chromosomes Cancer 41(2):163-9.PMID: 15287029 2004
|
| 89 | STK11
|
| Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
|
| Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G.
|
| J Biol Chem. 279(13):12804-11. 2004
|
| 90 | STK11
|
| The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
|
| Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.
|
| Proc Natl Acad Sci U S A. 101(10):3329-35. 2004
|
| 91 | LYK5, STK11, STRADA
|
| Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
|
| Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.
|
| EMBO J 22(12):3062-72. 2003
|
| 92 | STK11
|
| LKB1, a protein kinase regulating cell proliferation and polarity.
|
| Boudeau J, Sapkota G, Alessi DR.
|
| FEBS Lett 546(1):159-65. Review. 2003
|
| 93 | MARK3, STK11
|
| Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
|
| Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D.
|
| Oncogene 22(30):4752-6. 2003
|
| 94 | Cdc37, HSP90AA1, STK11
|
| Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
|
| Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR.
|
| Biochem J. 370(Pt 3):849-57 2003
|
| 95 | STK11
|
| An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation.
|
| Liu WK, Chien CY, Chou CK, Su JY.
|
| J Biomed Sci. 10(2):242-52. 2003
|
| 96 | CAB39, STK11
|
| MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
|
| Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.
|
| EMBO J 22(19):5102-14. 2003
|
| 97 | STK11
|
| Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis.
|
| Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H.
|
| Proc Natl Acad Sci U S A 99(13):8903-8. 2002
|
| 98 | STK11
|
| Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients.
|
| Scott RJ, Crooks R, Meldrum CJ, Thomas L, Smith CJ, Mowat D, McPhillips M, Spigelman AD.
|
| Clin Genet 62(4):282-7. 2002
|
| 99 | STK11
|
| Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
|
| Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.
|
| Nature 419(6903):162-7. 2002
|
| 100 | STK11
|
| Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
|
| Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM.
|
| Cancer Res. 62(8):2261-6. 2002
|
| 101 | STK11
|
| Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.
|
| Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP.
|
| Proc Natl Acad Sci U S A. 99(19):12327-32. 2002
|
| 102 | STK11
|
| Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
|
| Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR.
|
| Biochem J. 368(Pt 2):507-16. 2002
|
| 103 | STK11
|
| Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).
|
| Abed AA, Gunther K, Kraus C, Hohenberger W, Ballhausen WG.
|
| Hum Mutat 18(5):397-410. 2001
|
| 104 | STK11IP, SMAD4, STK11
|
| LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
|
| Smith DP, Rayter SI, Niederlander C, Spicer J, Jones CM, Ashworth A.
|
| Hum Mol Genet 10(25):2869-77. 2001
|
| 105 | SMARCA4, STK11
|
| LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest.
|
| Marignani PA, Kanai F, Carpenter CL.
|
| J Biol Chem. 276(35):32415-8. 2001
|
| 106 | STK11
|
| Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.
|
| Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Mäkelä TP.
|
| Science. 293(5533):1323-6. 2001
|
| 107 | STK11
|
| The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
|
| Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J.
|
| Mol Cell. 7(6):1307-19. 2001
|
| 108 | STK11
|
| Germline mutation screening of the STK11/LKB1 gene in familial breast cancer with LOH on 19p.
|
| Chen J, Lindblom A.
|
| Clin Genet 57(5):394-7. 2000
|
| 109 | STK11
|
| Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients.
|
| Yoon KA, Ku JL, Choi HS, Heo SC, Jeong SY, Park YJ, Kim NK, Kim JC, Jung PM, Park JG.
|
| Br J Cancer 82(8):1403-6. 2000
|
| 110 | CTNNB1, STK11
|
| Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.
|
| Miyaki M, Iijima T, Hosono K, Ishii R, Yasuno M, Mori T, Toi M, Hishima T, Shitara N, Tamura K, Utsunomiya J, Kobayashi N, Kuroki T, Iwama T.
|
| Cancer Res 60(22):6311-3. 2000
|
| 111 | PJS1, STK11
|
| Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
|
| Ylikorkala A, Avizienyte E, Tomlinson IP, Tiainen M, Roth S, Loukola A, Hemminki A, Johansson M, Sistonen P, Markie D, Neale K, Phillips R, Zauber P, Twama T, Sampson J, Jarvinen H, Makela TP, Aaltonen LA.
|
| Hum Mol Genet 8 : 45-51. 1999
|
| 112 | PJS1, STK11
|
| Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
|
| Wang ZJ, et al.
|
| J Med Genet 36(5):365-8. 1999
|
| 113 | PJS1, STK11
|
| LKB1 somatic mutations in sporadic tumors.
|
| Avizienyte E, et al.
|
| Am J Pathol 154(3):677-81. 1999
|
| 114 | STK11, PJS1
|
| Somatic mutations in the Peutz-Jegners (LKB1/STKII) gene in sporadic malignant melanomas.
|
| Rowan A, et al.
|
| J Invest Dermatol 112(4):509-11. 1999
|
| 115 | STK11
|
| Mutational analysis of STK11 gene in ovarian carcinomas.
|
| Nishioka Y, et al.
|
| Jpn J Cancer Res 90(6):629-32 1999
|
| 116 | STK11, PJS1
|
| STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.
|
| Jiang CY, et al.
|
| Clin Genet 56(2):136-41 1999
|
| 117 | PTEN, STK11
|
| PTEN and LKB1 genes in laryngeal tumours.
|
| Chen RW, Avizienyte E, Roth S, Elivo I, Makittie AA, Aaltonen LM, Aaltonen LA.
|
| J Med Genet 36(12):943-4. No abstract available 1999
|
| 118 | PJS1, STK11
|
| A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
|
| Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA.
|
| Nature 391(6663):184-7. 1998
|
| 119 | STK11
|
| Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.
|
| Avizienyte E, et al.
|
| Cancer Res 58 : 2087-2090. 1998
|
| 120 | PTEN, STK11
|
| Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
|
| Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I.
|
| Am J Pathol 153 : 363-366. 1998
|
| 121 | PJS1, STK11
|
| Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
|
| Dong SM, et al.
|
| Cancer Res 58 : 3787-3790. 1998
|
| 122 | PJS1, STK11
|
| Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
|
| Mehenni H, Gehrig C, Nezu J, Oku A, Shimane M, Rossier C, Guex N, Blouin JL, Scott HS, Antonarakis SE.
|
| Am J Hum Genet 63 : 1641-1650. 1998
|
| 123 | PJS1, STK11
|
| STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
|
| Resta N, et al.
|
| Cancer Res 58 : 4799-4801. 1998
|