Citations for
1IFI44L, STAT3, TET2
Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus. 2022 PMID:
Luo S, Wu R, Li Q, Zhang G.
J Immunol Res. May 10;2022:4053038. doi: 10.1155/2022/4053038. 2022
2JMJD1C, STAT3
Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis.
Yin Y, Yang X, Wu S, Ding X, Zhu H, Long X, Wang Y, Zhai S, Chen Y, Che N, Chen J, Wang X.
Nat Immunol. Sep;23(9):1342-1354. doi: 10.1038/s41590-022-01287-y. Epub 2022 Aug 22. 2022
3SH3GL3, STAT3
SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling
Nie Z, Cai S, Wei Z, Li Y, Bian L, Wang C, Wang X, Wang C.
Biochem Biophys Res Commun. Mar 12;544:73-80. doi: 10.1016/j.bbrc.2021.01.040. Epub 2021 Jan 29. 2021
4IL6, MARCHF3, STAT3
The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis.
Lin H, Feng L, Cui KS, Zeng LW, Gao D, Zhang LX, Xu WH, Sun YH, Shu HB, Li S.
Cell Mol Immunol. Dec;18(12):2648-2659. doi: 10.1038/s41423-021-00799-1. Epub 2021 Nov 16. 2021
5HNF1A, SOCS3, STAT3
HNF1α Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway.
Tan J, Xu J, Wei G, Zhang L, Sun L, Wang G, Li F, Jiang F.
J Diabetes Res. May 15;2019:5483946. doi: 10.1155/2019/5483946. eCollection 2019 2019
6STAT3, TMUB1
Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation.
Fu H, Dong R, Zhang Y, Xu J, Liu M, Chen P.
Cell Signal. Mar;55:65-72. doi: 10.1016/j.cellsig.2018.12.013. Epub 2019 Jan 2 2019
7STAT3, ZDHHC19
Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.
Niu J, Sun Y, Chen B, Zheng B, Jarugumilli GK, Walker SR, Hata AN, Mino-Kenudson M, Frank DA, Wu X.
Nature. Sep;573(7772):139-143. doi: 10.1038/s41586-019-1511-x. Epub 2019 Aug 28. 2019
8NFATC1, STAT3
STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription
Yang Y, Chung MR, Zhou S, Gong X, Xu H, Hong Y, Jin A, Huang X, Zou W, Dai Q, Jiang L.
J Biol Chem. Oct 18;294(42):15395-15407. doi: 10.1074/jbc.RA119.010139. Epub 2019 Aug 28. 2019
9METTL8, STAT3
The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway.
Gu H, Do DV, Liu X, Xu L, Su Y, Nah JM, Wong Y, Li Y, Sheng N, Tilaye GA, Yang H, Guo H, Yan J, Fu XY.
Stem Cell Reports 10(6):1807-1820. doi: 10.1016/j.stemcr.2018.03.022. Epub 2018 Apr 26. 2018
10GFAP, OSMR, SMARCA4, STAT3
Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes.
Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa T.
Mol Biol Cell 29(2):209-219. doi: 10.1091/mbc.E17-05-0271. Epub 2017 Nov 15. 2018
11ALDH1A2, STAT3
ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3.
Wang Y, Shao F, Chen L.
Onco Targets Ther. Jan 31;11:599-608. doi: 10.2147/OTT.S145864. 2018
12BCL6, IKZF1, IKZF3, STAT3
Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells.
Read KA, Powell MD, Baker CE, Sreekumar BK, Ringel-Scaia VM, Bachus H, Martin RE, Cooley ID, Allen IC, Ballesteros-Tato A, Oestreich KJ.
J Immunol 199(7):2377-2387. doi: 10.4049/jimmunol.1700106. Epub 2017 Aug 28. 2017
13LEPR, STAT3
STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.
Thiagarajan PS, Zheng Q, Bhagrath M, Mulkearns-Hubert EE, Myers MG, Lathia JD, Reizes O.
Endocr Relat Cancer 24(8):415-426. doi: 10.1530/ERC-16-0349. 2017
14IFNA1, STAT3
A novel anti-viral role for STAT3 in IFN-α signalling responses.
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ.
Cell Mol Life Sci 74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17. 2017
15CXCL1, IL8, STAT3
Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.
Tang AC, Saferali A, He G, Sandford AJ, Strug LJ, Turvey SE.
J Infect Dis 215(2):293-302. doi: 10.1093/infdis/jiw516. 2017
16LOXL3, STAT3
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation
Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE.
Mol Cell. Jan 19;65(2):296-309. doi: 10.1016/j.molcel.2016.12.002. Epub 2017 Jan 5. 2017
17FOXL2, STAT3
Cloning of the promoter region of a human gene, FOXL2, and its regulation by STAT3.
Han Y, Wang T, Sun S, Zhai Z, Tang S.
Mol Med Rep. Sep;16(3):2856-2862. doi: 10.3892/mmr.2017.6914. Epub 2017 Jul 4. 2017
18MAPK14, STAT3, TNFSF18
GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.
Tang X, Tian J, Ma J, Wang J, Qi C, Rui K, Wang Y, Xu H, Lu L, Wang S.
Oncotarget 7(8):8590-600. doi: 10.18632/oncotarget.6535. 2016
19BTG2, STAT3
B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.
Kim S, Hong JW, Park KW.
Mol Cell Biochem 413(1-2):145-53. doi: 10.1007/s11010-015-2648-z. 2016
20SH2D4A, SORBS3, STAT3
Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.
Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S.
Hepatology 64(3):828-42. doi: 10.1002/hep.28684. 2016
21DOCK8, HIES2, STAT3
Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.
Keles S, Charbonnier LM, Kabaleeswaran V, Reisli I, Genel F, Gulez N, Al-Herz W, Ramesh N, Perez-Atayde A, Karaca NE, Kutukculer N, Wu H, Geha RS, Chatila TA.
J Allergy Clin Immunol 138(5):1384-1394.e2. doi: 10.1016/j.jaci.2016.04.023. Epub 2016 May 24. 2016
22SENP3, STAT3
SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.
Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J.
Oncogene 35(45):5826-5838. doi: 10.1038/onc.2016.124. Epub 2016 May 16. 2016
23ARL3, STAT3
A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.
Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, Matsumoto N, Kon S, Sekine Y, Oritani K, Matsuda T.
J Biol Chem 291(21):11161-71. doi: 10.1074/jbc.M116.724849. Epub 2016 Apr 5. 2016
24EFNB1, STAT3
Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury.
Nikolakopoulou AM, Koeppen J, Garcia M, Leish J, Obenaus A, Ethell IM.
ASN Neuro 8(1):1-18. doi: 10.1177/1759091416630220. Print 2016 Jan-Feb. 2016
25NFKB1, STAT3, UACA
Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3.
Dang HV, Sakai T, Pham TA, Tran DH, Yorita K, Shishido Y, Fukui K.
J Biol Chem 290(40):24626-35. doi: 10.1074/jbc.M115.673848. 2015
26MYOCD, STAT3
STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin.
Liao XH, Wang N, Zhao DW, Zheng DL, Zheng L, Xing WJ, Ma WJ, Bao LY, Dong J, Zhang TC.
J Biol Chem 290(32):19641-52. doi: 10.1074/jbc.M114.630111. Epub 2015 Jun 22. 2015
27IL22, STAT3, TYK2
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
Hainzl E, Stockinger S, Rauch I, Heider S, Berry D, Lassnig C, Schwab C, Rosebrock F, Milinovich G, Schlederer M, Wagner M, Schleper C, Loy A, Urich T, Kenner L, Han X, Decker T, Strobl B, Müller M.
J Immunol 195(10):5011-24. doi: 10.4049/jimmunol.1402565. Epub 2015 Oct 2. 2015
28IL21, STAT1, STAT3
Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.
Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ.
Proc Natl Acad Sci U S A 112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13. 2015
29PTPRT, STAT3
PTPRT regulates high-fat diet-induced obesity and insulin resistance.
Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z.
PLoS One 9(6):e100783. doi: 10.1371/journal.pone.0100783. eCollection 2014. 2014
30KLF4, NANOG, STAT3
NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.
Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S, Nichols J, Silva JC.
Curr Biol 24(3):340-6. doi: 10.1016/j.cub.2013.12.040. Epub 2014 Jan 23. 2014
31MAF, RORC, SOX5, STAT3
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H.
J Exp Med 211(9):1857-74. doi: 10.1084/jem.20130791. Epub 2014 Jul 29. 2014
32PTPN2, STAT3, UBL4A
GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.
Wang Y, Ning H, Ren F, Zhang Y, Rong Y, Wang Y, Su F, Cai C, Jin Z, Li Z, Gong X, Zhai Y, Wang D, Jia B, Qiu Y, Tomita Y, Sung JJ, Yu J, Irwin DM, Yang X, Fu X, Chin YE, Chang Z.
Mol Cell 53(5):752-65. doi: 10.1016/j.molcel.2014.01.020. Epub 2014 Feb 13. 2014
33STAT3, UBD
NFκB and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53.
Choi Y, Kim JK, Yoo JY.
Mol Oncol 8(3):642-55. doi: 10.1016/j.molonc.2014.01.007. Epub 2014 Jan 24. 2014
34NHLH2, STAT3
Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).
Al Rayyan N, Zhang J, Burnside AS, Good DJ.
Mol Cell Endocrinol. Mar 25;384(1-2):134-42. doi: 10.1016/j.mce.2014.01.017. Epub 2014 Jan 29. 2014
35GLI1, STAT3
Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME.
J Biol Chem 288(17):11786-94. doi: 10.1074/jbc.M112.438846. Epub 2013 Mar 12. 2013
36STAT3, WASF3
Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility.
Teng Y, Ghoshal P, Ngoka L, Mei Y, Cowell JK.
Carcinogenesis 34(9):1994-9. doi: 10.1093/carcin/bgt167. Epub 2013 May 14. 2013
37NDUFA13, STAT3
Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.
Nallar SC, Kalakonda S, Lindner DJ, Lorenz RR, Lamarre E, Weihua X, Kalvakolanu DV.
J Biol Chem 288(11):7930-41. doi: 10.1074/jbc.M112.440610. Epub 2013 Feb 5. 2013
38NDUFA13, STAT3
Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas.
Zhou T, Chao L, Rong G, Wang C, Ma R, Wang X.
Hum Pathol 44(9):1773-9. doi: 10.1016/j.humpath.2012.12.018. Epub 2013 Apr 22. 2013
39NDUFA13, STAT3
The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain.
Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB.
J Biol Chem 288(7):4723-32. doi: 10.1074/jbc.M112.378984. Epub 2012 Dec 27. 2013
40EGFR, IL6, SOCS3, STAT3
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.
Wang Y, van Boxel-Dezaire AH, Cheon H, Yang J, Stark GR.
Proc Natl Acad Sci U S A 110(42):16975-80. doi: 10.1073/pnas.1315862110. Epub 2013 Sep 30. 2013
41HIC1, STAT3
HIC1 interacts with and modulates the activity of STAT3.
Lin YM, Wang CM, Jeng JC, Leprince D, Shih HM.
Cell Cycle 12(14):2266-76. doi: 10.4161/cc.25365. 2013
42FOXP3, STAT3
FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
Hossain DM, Panda AK, Manna A, Mohanty S, Bhattacharjee P, Bhattacharyya S, Saha T, Chakraborty S, Kar RK, Das T, Chatterjee S, Sa G.
Immunity 39(6):1057-69. doi: 10.1016/j.immuni.2013.11.005. Epub 2013 Dec 5. 2013
43BCL6, STAT3, STAT5B
STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.
Walker SR, Nelson EA, Yeh JE, Pinello L, Yuan GC, Frank DA.
Mol Cell Biol 33(15):2879-90. doi: 10.1128/MCB.01620-12. Epub 2013 May 28. 2013
44EGFR, PTPN2, STAT3
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Shields BJ, Wiede F, Gurzov EN, Wee K, Hauser C, Zhu HJ, Molloy TJ, O'Toole SA, Daly RJ, Sutherland RL, Mitchell CA, McLean CA, Tiganis T.
Mol Cell Biol 33(3):557-70. doi: 10.1128/MCB.01016-12. Epub 2012 Nov 19. 2013
45EIF2AK2, EIF2S1, STAT3
Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy.
Niso-Santano M, Shen S, Adjemian S, Malik SA, Mariño G, Lachkar S, Senovilla L, Kepp O, Galluzzi L, Maiuri MC, Kroemer G.
Autophagy 9(3):415-7. doi: 10.4161/auto.22910. Epub 2012 Dec 7. 2013
46BTG2, IL6, sTAT3
TIS21(/BTG2/PC3) inhibits interleukin-6 expression via downregulation of STAT3 pathway.
Quy LN, Choi YW, Kim YH, Chwae YJ, Park TJ, Lim IK.
Cell Signal 25(12):2391-9. doi: 10.1016/j.cellsig.2013.07.024. 2013
47AR, CCL4, STAT3
Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling.
Fang LY, Izumi K, Lai KP, Liang L, Li L, Miyamoto H, Lin WJ, Chang C.
Cancer Res 73(18):5633-46. doi: 10.1158/0008-5472.CAN-12-3228. Epub 2013 Jul 22. 2013
48NME1, STAT3
Metastasis suppressor Nm23-H1 inhibits STAT3 signaling via a negative feedback mechanism
Gong L, Wu Z, Guo L, Li L, Zhao R, Zhu D, Zhou Q.
Biochem Biophys Res Commun. May 10;434(3):541-6. doi: 10.1016/j.bbrc.2013.03.110. Epub 2013 Apr 10 2013
49GCG, GCGR, STAT3
Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation.
Shiraishi D, Fujiwara Y, Komohara Y, Mizuta H, Takeya M.
Biochem Biophys Res Commun 425(2):304-8. doi: 10.1016/j.bbrc.2012.07.086. Epub 2012 Jul 25. 2012
50HIES, STAT3
Frequent and Widespread Vascular Abnormalities in Human Signal Transducer and Activator of Transcription 3 Deficiency.
Chandesris MO, Azarine A, Ong KT, Taleb S, Boutouyrie P, Mousseaux E, Romain M, Bozec E, Laurent S, Boddaert N, Thumerelle C, Tillie-Leblond I, Hoarau C, Lebranchu Y, Aladjidi N, Tron F, Barlogis V, Body G, Munzer M, Jaussaud R, Suarez F, Clément O, Hermine O, Tedgui A, Lortholary O, Picard C, Mallat Z, Fischer A.
Circ Cardiovasc Genet 5(1):25-34. Epub 2011 Nov 14. 2012
51HIES, STAT3
Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome: Molecular, Cellular, and Clinical Features From a French National Survey.
Chandesris MO, Melki I, Natividad A, Puel A, Fieschi C, Yun L, Thumerelle C, Oksenhendler E, Boutboul D, Thomas C, Hoarau C, Lebranchu Y, Stephan JL, Cazorla C, Aladjidi N, Micheau M, Tron F, Baruchel A, Barlogis V, Palenzuela G, Mathey C, Dominique S, Body G, Munzer M, Fouyssac F, Jaussaud R, Bader-Meunier B, Mahlaoui N, Blanche S, Debré M, Le Bourgeois M, Gandemer V, Lambert N, Grandin V, Ndaga S, Jacques C, Harre C, Forveille M, Alyanakian MA, Durandy A, Bodemer C, Suarez F, Hermine O, Lortholary O, Casanova JL, Fischer A, Picard C.
Medicine (Baltimore) 91(4):e1-e19. 2012
52CDH1, STAT3, ZEB1
Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.
Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su WY, Wang JL, Cui Y, Wang ZH, Fang JY.
J Biol Chem 287(8):5819-32. doi: 10.1074/jbc.M111.295964. Epub 2011 Dec 28. 2012
53CCNB1, SPARC, STAT3
SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.
Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS.
Biochem Biophys Res Commun 417(2):874-9. doi: 10.1016/j.bbrc.2011.12.065. Epub 2011 Dec 20. 2012
54STAT3, TRAF6
The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination.
Wei J, Yuan Y, Jin C, Chen H, Leng L, He F, Wang J.
PLoS One 7(11):e49567. doi: 10.1371/journal.pone.0049567. Epub 2012 Nov 19. 2012
55GREB1, IL6, STAT3
GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer.
Liu M, Wang G, Gomez-Fernandez CR, Guo S.
PLoS One 7(10):e46410. doi: 10.1371/journal.pone.0046410. Epub 2012 Oct 3. 2012
56IGSF3, SIN3A, STAT3
The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
Icardi L, Mori R, Gesellchen V, Eyckerman S, De Cauwer L, Verhelst J, Vercauteren K, Saelens X, Meuleman P, Leroux-Roels G, De Bosscher K, Boutros M, Tavernier J.
Proc Natl Acad Sci U S A 109(30):12058-63. doi: 10.1073/pnas.1206458109. Epub 2012 Jul 10. 2012
57IL6, NFKB1, STAT3
NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells.
Yoon S, Woo SU, Kang JH, Kim K, Shin HJ, Gwak HS, Park S, Chwae YJ.
Oncogene ncogene. 2012 2012
58STAT3
Oncostatin M inhibits TGF-β1-induced CTGF expression via STAT3 in human proximal tubular cells.
Sarközi R, Flucher K, Haller VM, Pirklbauer M, Mayer G, Schramek H.
Biochem Biophys Res Commun 424(4):801-6. doi: 10.1016/j.bbrc.2012.07.042. Epub 2012 Jul 16. 2012
59CTGF, OSM, STAT3
Oncostatin M inhibits TGF-β1-induced CTGF expression via STAT3 in human proximal tubular cells.
Sarközi R, Flucher K, Haller VM, Pirklbauer M, Mayer G, Schramek H.
Biochem Biophys Res Commun 424(4):801-6. doi: 10.1016/j.bbrc.2012.07.042. Epub 2012 Jul 16. 2012
60EIF2AK2, STAT3
Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.
Shen S, Niso-Santano M, Adjemian S, Takehara T, Malik SA, Minoux H, Souquere S, Mariño G, Lachkar S, Senovilla L, Galluzzi L, Kepp O, Pierron G, Maiuri MC, Hikita H, Kroemer R, Kroemer G.
Mol Cell 48(5):667-80. doi: 10.1016/j.molcel.2012.09.013. Epub 2012 Oct 17. 2012
61AGER, STAT3
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
Kang R, Loux T, Tang D, Schapiro NE, Vernon P, Livesey KM, Krasinskas A, Lotze MT, Zeh HJ 3rd.
Proc Natl Acad Sci U S A 109(18):7031-6. doi: 10.1073/pnas.1113865109. Epub 2012 Apr 16. 2012
62STAT3, YWHAZ
14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.
Zhang J, Chen F, Li W, Xiong Q, Yang M, Zheng P, Li C, Pei J, Ge F.
PLoS One 7(1):e29554. doi: 10.1371/journal.pone.0029554. Epub 2012 Jan 18. 2012
63HIF1A, OSM, STAT1, STAT3
Opposing roles of STAT-1 and STAT-3 in regulating vascular endothelial growth factor expression in vascular smooth muscle cells.
Albasanz-Puig A, Murray J, Namekata M, Wijelath ES.
Biochem Biophys Res Commun 428(1):179-84. doi: 10.1016/j.bbrc.2012.10.037. Epub 2012 Oct 12. 2012
64STAT3
In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.
Bareyre FM, Garzorz N, Lang C, Misgeld T, Büning H, Kerschensteiner M.
Proc Natl Acad Sci U S A 108(15):6282-7. Epub 2011 Mar 29. 2011
65SOX6, STAT3
Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene.
Snyder M, Huang XY, Zhang JJ.
FEBS Lett 585(1):148-52. Epub 2010 Nov 19. 2011
66PKD1, STAT3
Polycystin-1 regulates STAT activity by a dual mechanism.
Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.
Proc Natl Acad Sci U S A 108(19):7985-90. Epub 2011 Apr 25. 2011
67STAT3
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.
Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA, Bardeesy N.
Cancer Res 71(14):5020-9. Epub 2011 May 17. 2011
68STAT3
STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.
Oh HM, Yu CR, Golestaneh N, Amadi-Obi A, Lee YS, Eseonu A, Mahdi RM, Egwuagu CE.
J Biol Chem 286(35):30888-97. Epub 2011 Jul 5. 2011
69STAT3
Antitumorigenic potential of STAT3 alternative splicing modulation.
Zammarchi F, de Stanchina E, Bournazou E, Supakorndej T, Martires K, Riedel E, Corben AD, Bromberg JF, Cartegni L.
Proc Natl Acad Sci U S A 108(43):17779-84. Epub 2011 Oct 17. 2011
70PKD1, STAT3
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
Takakura A, Nelson EA, Haque N, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J.
Hum Mol Genet. 20(21):4143-54. 2011
71STAT3
Absolute requirement for STAT3 function in small-intestine crypt stem cell survival.
Matthews JR, Sansom OJ, Clarke AR.
Cell Death Differ 18(12):1934-43. doi: 10.1038/cdd.2011.77. Epub 2011 Jun 3. 2011
72STAT3
Absolute requirement for STAT3 function in small-intestine crypt stem cell survival.
Matthews JR, Sansom OJ, Clarke AR.
Cell Death Differ 18(12):1934-43. doi: 10.1038/cdd.2011.77. Epub 2011 Jun 3. 2011
73MMP7, STAT3
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Fukuda A, Wang SC, Morris JP 4th, Folias AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M.
Cancer Cell 19(4):441-55. doi: 10.1016/j.ccr.2011.03.002. 2011
74PTK6, STAP2, STAT3
Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.
Cancer Sci 102(4):756-61. doi: 10.1111/j.1349-7006.2010.01842.x. Epub 2011 Jan 23. 2011
75STAT3, STMN3
SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.
Ng DC, Lim CP, Lin BH, Zhang T, Cao X.
Biochemical Journal 425 2010
76ROR1, STAT3
Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.
Li P, Harris D, Liu Z, Liu J, Keating M, Estrov Z.
PLoS One 5(7):e11859. 2010
77S1PR1, STAT3
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.
Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, Kortylewski M, Horne D, Somlo G, Forman S, Jove R, Yu H.
Nat Med 16(12):1421-8. Epub 2010 Nov 21. 2010
78PTK6, STAP2, STAT3
Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.
J Biol Chem 285(49):38093-103. doi: 10.1074/jbc.M110.162388. Epub 2010 Oct 7. 2010
79CTF2P, LIFR, STAT3
Neuropoietin activates STAT3 independent of LIFR activation in adipocytes.
White UA, Stephens JM.
Biochem Biophys Res Commun. Apr 23;395(1):48-50. doi: 10.1016/j.bbrc.2010.03.132. Epub 2010 Mar 28. 2010
80HIES, HIES3, STAT3
Clinical Manifestations, Etiology, and Pathogenesis of the Hyper IgE Syndromes.
Freeman AF, Holland SM.
Pediatr Res ediatr Res. 2009 Jan 28. [Epub ahead of print] 2009
81STAT3
Function of mitochondrial Stat3 in cellular respiration.
Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC.
Science 323(5915):793-7. Epub 2009 Jan 8. 2009
82JAK1, PIAS1, SOCS1, SOCS3, STAT1, STAT3
SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Diao Y, Wang X, Wu Z.
Mol Cell Biol 29(18):5084-93. Epub 2009 Jul 20. 2009
83SOCS3, STAT3
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.
Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z.
J Exp Med 206(10):2067-77. Epub 2009 Sep 8.PMID: 19737863 2009
84PTPN11, STAT3
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
Zhang W, Chan RJ, Chen H, Yang Z, He Y, Zhang X, Luo Y, Yin F, Moh A, Miller LC, Payne RM, Zhang ZY, Fu XY, Shou W.
J Biol Chem 284(33):22353-63. Epub 2009 Jun 9.PMID: 19509418 2009
85MUC1, STAT3
MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion.
Gao J, McConnell MJ, Yu B, Li J, Balko JM, Black EP, Johnson JO, Lloyd MC, Altiok S, Haura EB.
Int J Oncol 35(2):337-45. 2009
86STAT3
A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas.
Lee TL, Yeh J, Friedman J, Yan B, Yang X, Yeh NT, Van Waes C, Chen Z.
Int J Cancer 122(9):1987-98. 2008
87CSF3, MXD1, STAT3
Regulation of the MAD1 promoter by G-CSF.
Jiang K, Hein N, Eckert K, LŸscher-Firzlaff J, LŸscher B.
Nucleic Acids Res 36(5):1517-31. Epub 2008 Jan 18. 2008
88GADD45GIP1, STAT3
Crif1 is a novel transcriptional coactivator of STAT3.
Kwon MC, Koo BK, Moon JS, Kim YY, Park KC, Kim NS, Kwon MY, Kong MP, Yoon KJ, Im SK, Ghim J, Han YM, Jang SK, Shong M, Kong YY.
EMBO J 27(4):642-53. Epub 2008 Jan 17. 2008
89JAK2, STAT2, STAT3
JAK2/STAT2/STAT3 are required for myogenic differentiation.
Wang K, Wang C, Xiao F, Wang H, Wu Z.
J Biol Chem 283(49):34029-36. Epub 2008 Oct 2. 2008
90CD274, STAT3
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, Wang HY, Wysocka M, Cheng M, Ruggeri BA, Wasik MA.
Proc Natl Acad Sci U S A 105(52):20852-7. Epub 2008 Dec 16.PMID: 19088198 2008
91ARL2Bp, STAT3
BART is essential for nuclear retention of STAT3.
Muromoto R, Sekine Y, Imoto S, Ikeda O, Okayama T, Sato N, Matsuda T.
Int Immunol 20(3):395-403. Epub 2008 Jan 29.PMID: 18234692 2008
92STAT3, TRIM28
Physical and functional interactions between STAT3 and KAP1.
Tsuruma R, Ohbayashi N, Kamitani S, Ikeda O, Sato N, Muromoto R, Sekine Y, Oritani K, Matsuda T.
Oncogene 27(21):3054-9. Epub 2007 Nov 26.PMID: 18037959 2008
93STAT3
Physical and functional interactions between STAT3 and KAP1.
Tsuruma R, Ohbayashi N, Kamitani S, Ikeda O, Sato N, Muromoto R, Sekine Y, Oritani K, Matsuda T.
Oncogene. 27(21):3054-9. 2008
94STAT3, CTSD, PRL
A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy.
Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H.
Cell 128(3):589-600. 2007
95SOX6,STAT3
The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels.
Hwang MN, Min CH, Kim HS, Lee H, Yoon KA, Park SY, Lee ES, Yoon S.
Biochem Biophys Res Commun 360(2):333-8. Epub 2007 Jun 19. 2007
96CDK5,STAT3
Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells.
Lin H, Chen MC, Chiu CY, Song YM, Lin SY.
J Biol Chem 282(5):2776-84. Epub 2006 Dec 4. 2007
97STAT3, MASP2
Stat3 is involved in control of MASP2 gene expression.
Unterberger C, Hanson S, Klingenhoff A, Oesterle D, Frankenberger M, Endo Y, Matsushita M, Fujita T, Schwaeble W, Weiss EH, Ziegler-Heitbrock L, Stover C.
Biochem Biophys Res Commun 364(4):1022-5. Epub 2007 Oct 29. 2007
98NDRG2, SOCS1, STAT3, MAPK14
SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells.
Park Y, Shon SK, Kim A, Kim KI, Yang Y, Cho DH, Lee MS, Lim JS.
Biochem Biophys Res Commun 363(2):361-7. Epub 2007 Sep 14. 2007
99HIES, STAT3
STAT3 mutations in the hyper-IgE syndrome.
Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, SchŠffer AA, Puck JM, Grimbacher B.
N Engl J Med 357(16):1608-19. Epub 2007 Sep 19. 2007
100HIES, HIES3, STAT3, TYK2
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
Nature 448(7157):1058-62. Epub 2007 Aug 5. 2007
101HIES, STAT3
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
Nature 448(7157):1058-62. Epub 2007 Aug 5. 2007
102MAP3K14, STAT3
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC.
Biochem Biophys Res Commun 359(2):379-84. Epub 2007 May 25. 2007
103STAT3, TRPS1
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.
Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.
Dev Biol 312(2):572-81. Epub 2007 Oct 10.PMID: 17997399 2007
104PTPRT, STAT3
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD, Kinzler KW, Vogelstein B, Velculescu VE, Wang ZJ.
Proc Natl Acad Sci U S A 104(10):4060-4. Epub 2007 Feb 21. 2007
105IL10, STAT3, BTK
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.
Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Kawakami Y, Xiao W, Nagai H, Croft M, Kawakami T.
Proc Natl Acad Sci U S A 103(1):153-8. Epub 2005 Dec 21. 2006
106SOCS3, STAT3
Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.
Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G.
J Biol Chem 281(48):36683-90. Epub 2006 Oct 6. 2006
107STAT3
Physical and functional interactions between Daxx and STAT3.
Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K, Matsuda T.
Oncogene. 25(14):2131-6. 2006
108STAT3
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H.
Nat Med. 12(7):829-34. 2006
109STAT3, NLK, MAP3K7
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.
Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K.
Proc Natl Acad Sci U S A 102(12):4524-9. Epub 2005 Mar 11. 2005
110HDAC1, STAT3, PTPN6, DNMT1
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA.
Proc Natl Acad Sci U S A 102(19):6948-53. Epub 2005 May 3. 2005
111STAT3, ALK, NPM1
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.
Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, Karras JG, Levy DE, Inghirami G.
Nat Med 11(6):623-629. Epub 2005 May 15. 2005
112STAT3, HGF, SOCS3
SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration.
Tokumaru S, Sayama K, Yamasaki K, Shirakata Y, Hanakawa Y, Yahata Y, Dai X, Tohyama M, Yang L, Yoshimura A, Hashimoto K.
Biochem Biophys Res Commun 327(1):100-5. 2005
113CXCR4, JAK2, STAT3
Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.
Ahr B, Denizot M, Robert-Hebmann V, Brelot A, Biard-Piechaczyk M.
J Biol Chem 280(8):6692-700. Epub 2004 Dec 22. 2005
114STAT3
Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
Sato N, Tsuruma R, Imoto S, Sekine Y, Muromoto R, Sugiyama K, Matsuda T.
Biochem Biophys Res Commun 336(2):617-24. 2005
115AKT1,STAT3
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ.
J Biol Chem 280(47):38932-41. Epub 2005 Sep 20. 2005
116STAT3
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC.
Cancer Cell. 7(6):575-89. 2005
117STAT3
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE.
Oncogene. 24(19):3110-20. 2005
118STAT3
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M.
Nat Med 10(2):168-74. Epub 2004 Jan 11. 2004
119STAT3
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.
Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY.
Proc Natl Acad Sci U S A 101(13):4661-6. Epub 2004 Mar 22. 2004
120IRAK1, STAT3
IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.
Huang Y, Li T, Sane DC, Li L.
J Biol Chem 279(49):51697-703. Epub 2004 Oct 1. 2004
121SMARCA4, STAT3
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene.
Giraud S, Hurlstone A, Avril S, Coqueret O.
Oncogene. 23(44):7391-8. 2004
122STAT3
STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets.
Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI.
J Mol Biol. 340(4):641-53. 2004
123STAT3
Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex.
Yang CH, Murti A, Baker SJ, Frangou-Lazaridis M, Vartapetian AB, Murti KG, Pfeffer LM.
Exp Cell Res. 298(1):197-206. 2004
124STAT3
Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS.
Oncogene. 23(15):2617-29. 2004
125STAT3
The STAT3 isoforms alpha and beta have unique and specific functions.
Maritano D, Sugrue ML, Tininini S, Dewilde S, Strobl B, Fu X, Murray-Tait V, Chiarle R, Poli V.
Nat Immunol. 5(4):401-9. 2004
126STAT3
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J.
J Clin Invest. 114(5):720-8. 2004
127STAT3
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity
Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY.
Proc Natl Acad Sci U S A 100(4):1879-84. 2003
128STAT3
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.
Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY.
Proc Natl Acad Sci U S A 100(22):12929-34. Epub 2003 Oct 17. No abstract available. 2003
129STAT3
Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor.
Yamamoto T, Sato N, Sekine Y, Yumioka T, Imoto S, Junicho A, Fuse H, Matsuda T.
Biochem Biophys Res Commun. 306(2):610-5. 2003
130STAT3
Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
Sato N, Yamamoto T, Sekine Y, Yumioka T, Junicho A, Fuse H, Matsuda T.
Biochem Biophys Res Commun. 300(4):847-52. 2003
131STAT3
Tip60 is a co-repressor for STAT3.
Xiao H, Chung J, Kao HY, Yang YC.
J Biol Chem. 278(13):11197-204. 2003
132STAT3
GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.
Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong CT, Cao X
EMBO J. 22(6):1325-35. 2003
133STAT3
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY.
Proc Natl Acad Sci U S A. 100(4):1879-84. 2003
134STAT3
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation.
Hevehan DL, Miller WM, Papoutsakis ET.
Blood 99(5):1627-37. 2002
135EP300, NCOA1, STAT3
Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O.
J Biol Chem 277(10):8004-11. 2002
136STAT1, STAT2, STAT3
Cytokine signaling: STATS in plasma membrane rafts.
Sehgal PB, Guo GG, Shah M, Kumar V, Patel K.
J Biol Chem 277(14):12067-74. 2002
137EPOR, STAT1, STAT3, STAT5A
Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.
Kirito K, Nakajima K, Watanabe T, Uchida M, Tanaka M, Ozawa K, Komatsu N.
Blood 99(1):102-10. 2002
138STAT3
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
Lee CK, Raz R, Gimeno R, Gertner R, Wistinghausen B, Takeshita K, DePinho RA, Levy DE.
Immunity 17(1):63-72. 2002
139STAT3, ZNF467
A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.
Nakayama K, Kim KW, Miyajima A.
EMBO J 21(22):6174-84. 2002
140JAK2, STAT3
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
Ren Z, Schaefer TS.
J Biol Chem. 277(41):38486-93. 2002
141STAT3
Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function.
Waris G, Siddiqui A.
J Virol. 76(6):2721-9. 2002
142STAT3
STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.
Velichko S, Wagner TC, Turkson J, Jove R, Croze E.
J Biol Chem. 277(38):35635-41. 2002
143STAT3
Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB.
Yu Z, Zhang W, Kone BC.
Biochem J. 367(Pt 1):97-105. 2002
144STAT3
Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes.
Guo GG, Patel K, Kumar V, Shah M, Fried VA, Etlinger JD, Sehgal PB.
J Interferon Cytokine Res. 22(5):555-63. 2002
145STAT3
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock.
Yoo JY, Huso DL, Nathans D, Desiderio S.
Cell. 108(3):331-44. 2002
146BRCA1, JAK2, STAT3
Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.
Gao B, Shen X, Kunos G, Meng Q, Goldberg ID, Rosen EM, Fan S.
FEBS Lett. 488(3):179-84. 2001
147STAT3
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.
Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR.
EMBO J. 20(10):2487-96. 2001
148STAT3
Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3.
Wang LH, Yang XY, Mihalic K, Xiao W, Li D, Farrar WL.
J Biol Chem. 276(34):31839-44. 2001
149STAT3
Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse.
Miyoshi K, Cui Y, Riedlinger G, Robinson P, Lehoczky J, Zon L, Oka T, Dewar K, Hennighausen L.
Genomics. 71(2):150-5. 2001
150STAT3
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
Kunisada K, Negoro S, Tone E, Funamoto M, Osugi T, Yamada S, Okabe M, Kishimoto T, Yamauchi-Takihara K.
Proc Natl Acad Sci U S A 97(1):315-9 2000
151GHTF, JAK2, STAT3
Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway.
Park ES, Kim H, Suh JM, Park SJ, You SH, Chung HK, Lee KW, Kwon OY, Cho BY, Kim YK, Ro HK, Chung J, Shong M.
Mol Endocrinol 14(5):662-70. 2000
152PIAS3, STAT3
Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells.
Kato K, Nomoto M, Izumi H, Ise T, Nakano S, Niho Y, Kohno K.
Biochim Biophys Acta 1493(1-2):91-100. 2000
153FER, STAT3
FER kinase activation of Stat3 is determined by the N-terminal sequence.
Priel-Halachmi S, Ben-Dor I, Shpungin S, Tennenbaum T, Molavani H, Bachrach M, Salzberg S, Nir U.
J Biol Chem 275(37):28902-10. 2000
154STAT3
Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.
Coqueret O, Gascan H.
J Biol Chem. 275(25):18794-800. 2000
155STAT3
Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
Delespine-Carmagnat M, Bouvier G, Bertoglio J.
Eur J Immunol. 30(1):59-68. 2000
156STAT3
Regulation of STAT3 by direct binding to the Rac1 GTPase.
Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL.
Science. 290(5489):144-7. 2000
157STAT3
Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity.
Kim J, Kim D, Chung J.
Cell Biol Int. 24(7):467-73. 2000
158STAT3
Essential role of STAT3 for embryonic stem cell pluripotency.
Raz R, et al.
Proc Natl Acad Sci U S A 96(6):2846-2851. 1999
159STAT3
Stat3 as an oncogene.
Bromberg JF, et al.
Cell 98(3):295-303. 1999
160STAT3
Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.
Woetmann A, et al.
Proc Natl Acad Sci U S A 96(19):10620-5 1999
161BMP2, EP300, LIF, SMAD1, STAT3
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T.
Science 284(5413):479-82. 1999
162JUN, STAT3
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE Jr.
Mol Cell Biol. 19(10):7138-46. 1999
163STAT3
Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
Jain N, Zhang T, Kee WH, Li W, Cao X.
J Biol Chem. 274(34):24392-400. 1999
164IL6ST, STAT3
STAT3 orchestrates contradictory signals in cytokine-induced G 1 to S cell-cycle transition.
Fukada T, et al.
EMBO J 17 : 6670-6677. 1998
165STAT3
STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities.
Yang CH, Murti A, Pfeffer LM.
Proc Natl Acad Sci U S A 95(10):5568-72 1998
166IL6ST, STAT3
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.
Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S.
J Immunol 161(9):4652-60 1998
167STAT3
STAT3 forms stable homodimers in the presence of divalent cations prior to activation.
Novak U, Ji H, Kanagasundaram V, Simpson R, Paradiso L.
Biochem Biophys Res Commun. 247(3):558-63. 1998
168STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B
STATs and gene regulation.
Darnell JE Jr.
Science 277(5332):1630-5. Review. 1997
169STAT3
STAT3 acts as a co-activator of glucocorticoid receptor signaling.
Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM.
J Biol Chem. 272(49):30607-10. 1997
170STAT3
Assignment of the acute phase response factor (APRF) gene to 17q21 by microdissection clone sequencing and fluorescence in situ hybridization of a P1 clone.
Choi JY, et al.
Genomics 37 : 264-265. 1996
171STAT3
Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor.
Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM.
J Biol Chem. 271(14):8057-61. 1996
172STAT3
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Akira S, et al.
Cell 77 : 63-71. 1994