1 | IFI44L, STAT3, TET2
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| Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus. 2022 PMID:
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| Luo S, Wu R, Li Q, Zhang G.
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| J Immunol Res. May 10;2022:4053038. doi: 10.1155/2022/4053038. 2022
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2 | JMJD1C, STAT3
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| Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis.
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| Yin Y, Yang X, Wu S, Ding X, Zhu H, Long X, Wang Y, Zhai S, Chen Y, Che N, Chen J, Wang X.
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| Nat Immunol. Sep;23(9):1342-1354. doi: 10.1038/s41590-022-01287-y. Epub 2022 Aug 22. 2022
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3 | SH3GL3, STAT3
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| SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling
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| Nie Z, Cai S, Wei Z, Li Y, Bian L, Wang C, Wang X, Wang C.
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| Biochem Biophys Res Commun. Mar 12;544:73-80. doi: 10.1016/j.bbrc.2021.01.040. Epub 2021 Jan 29. 2021
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4 | IL6, MARCHF3, STAT3
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| The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis.
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| Lin H, Feng L, Cui KS, Zeng LW, Gao D, Zhang LX, Xu WH, Sun YH, Shu HB, Li S.
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| Cell Mol Immunol. Dec;18(12):2648-2659. doi: 10.1038/s41423-021-00799-1. Epub 2021 Nov 16. 2021
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5 | HNF1A, SOCS3, STAT3
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| HNF1α Controls Liver Lipid Metabolism and Insulin Resistance via Negatively Regulating the SOCS-3-STAT3 Signaling Pathway.
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| Tan J, Xu J, Wei G, Zhang L, Sun L, Wang G, Li F, Jiang F.
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| J Diabetes Res. May 15;2019:5483946. doi: 10.1155/2019/5483946. eCollection 2019 2019
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6 | STAT3, TMUB1
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| Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation.
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| Fu H, Dong R, Zhang Y, Xu J, Liu M, Chen P.
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| Cell Signal. Mar;55:65-72. doi: 10.1016/j.cellsig.2018.12.013. Epub 2019 Jan 2 2019
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7 | STAT3, ZDHHC19
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| Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.
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| Niu J, Sun Y, Chen B, Zheng B, Jarugumilli GK, Walker SR, Hata AN, Mino-Kenudson M, Frank DA, Wu X.
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| Nature. Sep;573(7772):139-143. doi: 10.1038/s41586-019-1511-x. Epub 2019 Aug 28. 2019
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8 | NFATC1, STAT3
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| STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription
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| Yang Y, Chung MR, Zhou S, Gong X, Xu H, Hong Y, Jin A, Huang X, Zou W, Dai Q, Jiang L.
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| J Biol Chem. Oct 18;294(42):15395-15407. doi: 10.1074/jbc.RA119.010139. Epub 2019 Aug 28. 2019
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9 | METTL8, STAT3
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| The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway.
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| Gu H, Do DV, Liu X, Xu L, Su Y, Nah JM, Wong Y, Li Y, Sheng N, Tilaye GA, Yang H, Guo H, Yan J, Fu XY.
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| Stem Cell Reports 10(6):1807-1820. doi: 10.1016/j.stemcr.2018.03.022. Epub 2018 Apr 26.
2018
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10 | GFAP, OSMR, SMARCA4, STAT3
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| Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes.
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| Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa T.
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| Mol Biol Cell 29(2):209-219. doi: 10.1091/mbc.E17-05-0271. Epub 2017 Nov 15.
2018
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11 | ALDH1A2, STAT3
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| ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3.
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| Wang Y, Shao F, Chen L.
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| Onco Targets Ther. Jan 31;11:599-608. doi: 10.2147/OTT.S145864. 2018
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12 | BCL6, IKZF1, IKZF3, STAT3
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| Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells.
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| Read KA, Powell MD, Baker CE, Sreekumar BK, Ringel-Scaia VM, Bachus H, Martin RE, Cooley ID, Allen IC, Ballesteros-Tato A, Oestreich KJ.
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| J Immunol 199(7):2377-2387. doi: 10.4049/jimmunol.1700106. Epub 2017 Aug 28.
2017
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13 | LEPR, STAT3
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| STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.
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| Thiagarajan PS, Zheng Q, Bhagrath M, Mulkearns-Hubert EE, Myers MG, Lathia JD, Reizes O.
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| Endocr Relat Cancer 24(8):415-426. doi: 10.1530/ERC-16-0349.
2017
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14 | IFNA1, STAT3
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| A novel anti-viral role for STAT3 in IFN-α signalling responses.
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| Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ.
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| Cell Mol Life Sci 74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17.
2017
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15 | CXCL1, IL8, STAT3
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| Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.
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| Tang AC, Saferali A, He G, Sandford AJ, Strug LJ, Turvey SE.
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| J Infect Dis 215(2):293-302. doi: 10.1093/infdis/jiw516.
2017
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16 | LOXL3, STAT3
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| Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation
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| Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE.
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| Mol Cell. Jan 19;65(2):296-309. doi: 10.1016/j.molcel.2016.12.002. Epub 2017 Jan 5. 2017
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17 | FOXL2, STAT3
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| Cloning of the promoter region of a human gene, FOXL2, and its regulation by STAT3.
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| Han Y, Wang T, Sun S, Zhai Z, Tang S.
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| Mol Med Rep. Sep;16(3):2856-2862. doi: 10.3892/mmr.2017.6914. Epub 2017 Jul 4. 2017
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18 | MAPK14, STAT3, TNFSF18
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| GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.
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| Tang X, Tian J, Ma J, Wang J, Qi C, Rui K, Wang Y, Xu H, Lu L, Wang S.
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| Oncotarget 7(8):8590-600. doi: 10.18632/oncotarget.6535.
2016
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19 | BTG2, STAT3
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| B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.
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| Kim S, Hong JW, Park KW.
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| Mol Cell Biochem 413(1-2):145-53. doi: 10.1007/s11010-015-2648-z.
2016
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20 | SH2D4A, SORBS3, STAT3
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| Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.
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| Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S.
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| Hepatology 64(3):828-42. doi: 10.1002/hep.28684.
2016
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21 | DOCK8, HIES2, STAT3
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| Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.
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| Keles S, Charbonnier LM, Kabaleeswaran V, Reisli I, Genel F, Gulez N, Al-Herz W, Ramesh N, Perez-Atayde A, Karaca NE, Kutukculer N, Wu H, Geha RS, Chatila TA.
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| J Allergy Clin Immunol 138(5):1384-1394.e2. doi: 10.1016/j.jaci.2016.04.023. Epub 2016 May 24.
2016
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22 | SENP3, STAT3
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| SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.
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| Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J.
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| Oncogene 35(45):5826-5838. doi: 10.1038/onc.2016.124. Epub 2016 May 16.
2016
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23 | ARL3, STAT3
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| A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.
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| Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, Matsumoto N, Kon S, Sekine Y, Oritani K, Matsuda T.
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| J Biol Chem 291(21):11161-71. doi: 10.1074/jbc.M116.724849. Epub 2016 Apr 5.
2016
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24 | EFNB1, STAT3
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| Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury.
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| Nikolakopoulou AM, Koeppen J, Garcia M, Leish J, Obenaus A, Ethell IM.
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| ASN Neuro 8(1):1-18. doi: 10.1177/1759091416630220. Print 2016 Jan-Feb.
2016
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25 | NFKB1, STAT3, UACA
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| Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3.
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| Dang HV, Sakai T, Pham TA, Tran DH, Yorita K, Shishido Y, Fukui K.
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| J Biol Chem 290(40):24626-35. doi: 10.1074/jbc.M115.673848.
2015
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26 | MYOCD, STAT3
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| STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin.
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| Liao XH, Wang N, Zhao DW, Zheng DL, Zheng L, Xing WJ, Ma WJ, Bao LY, Dong J, Zhang TC.
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| J Biol Chem 290(32):19641-52. doi: 10.1074/jbc.M114.630111. Epub 2015 Jun 22.
2015
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27 | IL22, STAT3, TYK2
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| Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
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| Hainzl E, Stockinger S, Rauch I, Heider S, Berry D, Lassnig C, Schwab C, Rosebrock F, Milinovich G, Schlederer M, Wagner M, Schleper C, Loy A, Urich T, Kenner L, Han X, Decker T, Strobl B, Müller M.
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| J Immunol 195(10):5011-24. doi: 10.4049/jimmunol.1402565. Epub 2015 Oct 2.
2015
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28 | IL21, STAT1, STAT3
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| Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.
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| Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ.
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| Proc Natl Acad Sci U S A 112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13.
2015
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29 | PTPRT, STAT3
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| PTPRT regulates high-fat diet-induced obesity and insulin resistance.
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| Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z.
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| PLoS One 9(6):e100783. doi: 10.1371/journal.pone.0100783. eCollection 2014.
2014
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30 | KLF4, NANOG, STAT3
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| NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.
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| Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S, Nichols J, Silva JC.
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| Curr Biol 24(3):340-6. doi: 10.1016/j.cub.2013.12.040. Epub 2014 Jan 23.
2014
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31 | MAF, RORC, SOX5, STAT3
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| Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
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| Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H.
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| J Exp Med 211(9):1857-74. doi: 10.1084/jem.20130791. Epub 2014 Jul 29.
2014
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32 | PTPN2, STAT3, UBL4A
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| GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.
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| Wang Y, Ning H, Ren F, Zhang Y, Rong Y, Wang Y, Su F, Cai C, Jin Z, Li Z, Gong X, Zhai Y, Wang D, Jia B, Qiu Y, Tomita Y, Sung JJ, Yu J, Irwin DM, Yang X, Fu X, Chin YE, Chang Z.
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| Mol Cell 53(5):752-65. doi: 10.1016/j.molcel.2014.01.020. Epub 2014 Feb 13.
2014
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33 | STAT3, UBD
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| NFκB and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53.
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| Choi Y, Kim JK, Yoo JY.
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| Mol Oncol 8(3):642-55. doi: 10.1016/j.molonc.2014.01.007. Epub 2014 Jan 24.
2014
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34 | NHLH2, STAT3
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| Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).
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| Al Rayyan N, Zhang J, Burnside AS, Good DJ.
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| Mol Cell Endocrinol. Mar 25;384(1-2):134-42. doi: 10.1016/j.mce.2014.01.017. Epub 2014 Jan 29. 2014
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35 | GLI1, STAT3
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| Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
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| Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME.
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| J Biol Chem 288(17):11786-94. doi: 10.1074/jbc.M112.438846. Epub 2013 Mar 12.
2013
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36 | STAT3, WASF3
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| Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility.
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| Teng Y, Ghoshal P, Ngoka L, Mei Y, Cowell JK.
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| Carcinogenesis 34(9):1994-9. doi: 10.1093/carcin/bgt167. Epub 2013 May 14.
2013
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37 | NDUFA13, STAT3
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| Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.
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| Nallar SC, Kalakonda S, Lindner DJ, Lorenz RR, Lamarre E, Weihua X, Kalvakolanu DV.
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| J Biol Chem 288(11):7930-41. doi: 10.1074/jbc.M112.440610. Epub 2013 Feb 5.
2013
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38 | NDUFA13, STAT3
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| Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas.
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| Zhou T, Chao L, Rong G, Wang C, Ma R, Wang X.
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| Hum Pathol 44(9):1773-9. doi: 10.1016/j.humpath.2012.12.018. Epub 2013 Apr 22.
2013
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39 | NDUFA13, STAT3
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| The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain.
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| Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB.
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| J Biol Chem 288(7):4723-32. doi: 10.1074/jbc.M112.378984. Epub 2012 Dec 27.
2013
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40 | EGFR, IL6, SOCS3, STAT3
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| STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.
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| Wang Y, van Boxel-Dezaire AH, Cheon H, Yang J, Stark GR.
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| Proc Natl Acad Sci U S A 110(42):16975-80. doi: 10.1073/pnas.1315862110. Epub 2013 Sep 30.
2013
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41 | HIC1, STAT3
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| HIC1 interacts with and modulates the activity of STAT3.
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| Lin YM, Wang CM, Jeng JC, Leprince D, Shih HM.
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| Cell Cycle 12(14):2266-76. doi: 10.4161/cc.25365.
2013
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42 | FOXP3, STAT3
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| FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
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| Hossain DM, Panda AK, Manna A, Mohanty S, Bhattacharjee P, Bhattacharyya S, Saha T, Chakraborty S, Kar RK, Das T, Chatterjee S, Sa G.
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| Immunity 39(6):1057-69. doi: 10.1016/j.immuni.2013.11.005. Epub 2013 Dec 5.
2013
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43 | BCL6, STAT3, STAT5B
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| STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.
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| Walker SR, Nelson EA, Yeh JE, Pinello L, Yuan GC, Frank DA.
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| Mol Cell Biol 33(15):2879-90. doi: 10.1128/MCB.01620-12. Epub 2013 May 28.
2013
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44 | EGFR, PTPN2, STAT3
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| TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
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| Shields BJ, Wiede F, Gurzov EN, Wee K, Hauser C, Zhu HJ, Molloy TJ, O'Toole SA, Daly RJ, Sutherland RL, Mitchell CA, McLean CA, Tiganis T.
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| Mol Cell Biol 33(3):557-70. doi: 10.1128/MCB.01016-12. Epub 2012 Nov 19.
2013
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45 | EIF2AK2, EIF2S1, STAT3
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| Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy.
|
| Niso-Santano M, Shen S, Adjemian S, Malik SA, Mariño G, Lachkar S, Senovilla L, Kepp O, Galluzzi L, Maiuri MC, Kroemer G.
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| Autophagy 9(3):415-7. doi: 10.4161/auto.22910. Epub 2012 Dec 7.
2013
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46 | BTG2, IL6, sTAT3
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| TIS21(/BTG2/PC3) inhibits interleukin-6 expression via downregulation of STAT3 pathway.
|
| Quy LN, Choi YW, Kim YH, Chwae YJ, Park TJ, Lim IK.
|
| Cell Signal 25(12):2391-9. doi: 10.1016/j.cellsig.2013.07.024.
2013
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47 | AR, CCL4, STAT3
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| Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling.
|
| Fang LY, Izumi K, Lai KP, Liang L, Li L, Miyamoto H, Lin WJ, Chang C.
|
| Cancer Res 73(18):5633-46. doi: 10.1158/0008-5472.CAN-12-3228. Epub 2013 Jul 22.
2013
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48 | NME1, STAT3
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| Metastasis suppressor Nm23-H1 inhibits STAT3 signaling via a negative feedback mechanism
|
| Gong L, Wu Z, Guo L, Li L, Zhao R, Zhu D, Zhou Q.
|
| Biochem Biophys Res Commun. May 10;434(3):541-6. doi: 10.1016/j.bbrc.2013.03.110. Epub 2013 Apr 10 2013
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49 | GCG, GCGR, STAT3
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| Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation.
|
| Shiraishi D, Fujiwara Y, Komohara Y, Mizuta H, Takeya M.
|
| Biochem Biophys Res Commun 425(2):304-8. doi: 10.1016/j.bbrc.2012.07.086. Epub 2012 Jul 25.
2012
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50 | HIES, STAT3
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| Frequent and Widespread Vascular Abnormalities in Human Signal Transducer and Activator of Transcription 3 Deficiency.
|
| Chandesris MO, Azarine A, Ong KT, Taleb S, Boutouyrie P, Mousseaux E, Romain M, Bozec E, Laurent S, Boddaert N, Thumerelle C, Tillie-Leblond I, Hoarau C, Lebranchu Y, Aladjidi N, Tron F, Barlogis V, Body G, Munzer M, Jaussaud R, Suarez F, Clément O, Hermine O, Tedgui A, Lortholary O, Picard C, Mallat Z, Fischer A.
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| Circ Cardiovasc Genet 5(1):25-34. Epub 2011 Nov 14.
2012
|
51 | HIES, STAT3
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| Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome: Molecular, Cellular, and Clinical Features From a French National Survey.
|
| Chandesris MO, Melki I, Natividad A, Puel A, Fieschi C, Yun L, Thumerelle C, Oksenhendler E, Boutboul D, Thomas C, Hoarau C, Lebranchu Y, Stephan JL, Cazorla C, Aladjidi N, Micheau M, Tron F, Baruchel A, Barlogis V, Palenzuela G, Mathey C, Dominique S, Body G, Munzer M, Fouyssac F, Jaussaud R, Bader-Meunier B, Mahlaoui N, Blanche S, Debré M, Le Bourgeois M, Gandemer V, Lambert N, Grandin V, Ndaga S, Jacques C, Harre C, Forveille M, Alyanakian MA, Durandy A, Bodemer C, Suarez F, Hermine O, Lortholary O, Casanova JL, Fischer A, Picard C.
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| Medicine (Baltimore) 91(4):e1-e19.
2012
|
52 | CDH1, STAT3, ZEB1
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| Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.
|
| Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su WY, Wang JL, Cui Y, Wang ZH, Fang JY.
|
| J Biol Chem 287(8):5819-32. doi: 10.1074/jbc.M111.295964. Epub 2011 Dec 28.
2012
|
53 | CCNB1, SPARC, STAT3
|
| SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.
|
| Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS.
|
| Biochem Biophys Res Commun 417(2):874-9. doi: 10.1016/j.bbrc.2011.12.065. Epub 2011 Dec 20.
2012
|
54 | STAT3, TRAF6
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| The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination.
|
| Wei J, Yuan Y, Jin C, Chen H, Leng L, He F, Wang J.
|
| PLoS One 7(11):e49567. doi: 10.1371/journal.pone.0049567. Epub 2012 Nov 19.
2012
|
55 | GREB1, IL6, STAT3
|
| GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer.
|
| Liu M, Wang G, Gomez-Fernandez CR, Guo S.
|
| PLoS One 7(10):e46410. doi: 10.1371/journal.pone.0046410. Epub 2012 Oct 3. 2012
|
56 | IGSF3, SIN3A, STAT3
|
| The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
|
| Icardi L, Mori R, Gesellchen V, Eyckerman S, De Cauwer L, Verhelst J, Vercauteren K, Saelens X, Meuleman P, Leroux-Roels G, De Bosscher K, Boutros M, Tavernier J.
|
| Proc Natl Acad Sci U S A 109(30):12058-63. doi: 10.1073/pnas.1206458109. Epub 2012 Jul 10.
2012
|
57 | IL6, NFKB1, STAT3
|
| NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells.
|
| Yoon S, Woo SU, Kang JH, Kim K, Shin HJ, Gwak HS, Park S, Chwae YJ.
|
| Oncogene ncogene. 2012 2012
|
58 | STAT3
|
| Oncostatin M inhibits TGF-β1-induced CTGF expression via STAT3 in human proximal tubular cells.
|
| Sarközi R, Flucher K, Haller VM, Pirklbauer M, Mayer G, Schramek H.
|
| Biochem Biophys Res Commun 424(4):801-6. doi: 10.1016/j.bbrc.2012.07.042. Epub 2012 Jul 16.
2012
|
59 | CTGF, OSM, STAT3
|
| Oncostatin M inhibits TGF-β1-induced CTGF expression via STAT3 in human proximal tubular cells.
|
| Sarközi R, Flucher K, Haller VM, Pirklbauer M, Mayer G, Schramek H.
|
| Biochem Biophys Res Commun 424(4):801-6. doi: 10.1016/j.bbrc.2012.07.042. Epub 2012 Jul 16.
2012
|
60 | EIF2AK2, STAT3
|
| Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.
|
| Shen S, Niso-Santano M, Adjemian S, Takehara T, Malik SA, Minoux H, Souquere S, Mariño G, Lachkar S, Senovilla L, Galluzzi L, Kepp O, Pierron G, Maiuri MC, Hikita H, Kroemer R, Kroemer G.
|
| Mol Cell 48(5):667-80. doi: 10.1016/j.molcel.2012.09.013. Epub 2012 Oct 17.
2012
|
61 | AGER, STAT3
|
| The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
|
| Kang R, Loux T, Tang D, Schapiro NE, Vernon P, Livesey KM, Krasinskas A, Lotze MT, Zeh HJ 3rd.
|
| Proc Natl Acad Sci U S A 109(18):7031-6. doi: 10.1073/pnas.1113865109. Epub 2012 Apr 16.
2012
|
62 | STAT3, YWHAZ
|
| 14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.
|
| Zhang J, Chen F, Li W, Xiong Q, Yang M, Zheng P, Li C, Pei J, Ge F.
|
| PLoS One 7(1):e29554. doi: 10.1371/journal.pone.0029554. Epub 2012 Jan 18.
2012
|
63 | HIF1A, OSM, STAT1, STAT3
|
| Opposing roles of STAT-1 and STAT-3 in regulating vascular endothelial growth factor expression in vascular smooth muscle cells.
|
| Albasanz-Puig A, Murray J, Namekata M, Wijelath ES.
|
| Biochem Biophys Res Commun 428(1):179-84. doi: 10.1016/j.bbrc.2012.10.037. Epub 2012 Oct 12.
2012
|
64 | STAT3
|
| In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.
|
| Bareyre FM, Garzorz N, Lang C, Misgeld T, Büning H, Kerschensteiner M.
|
| Proc Natl Acad Sci U S A 108(15):6282-7. Epub 2011 Mar 29.
2011
|
65 | SOX6, STAT3
|
| Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene.
|
| Snyder M, Huang XY, Zhang JJ.
|
| FEBS Lett 585(1):148-52. Epub 2010 Nov 19.
2011
|
66 | PKD1, STAT3
|
| Polycystin-1 regulates STAT activity by a dual mechanism.
|
| Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.
|
| Proc Natl Acad Sci U S A 108(19):7985-90. Epub 2011 Apr 25.
2011
|
67 | STAT3
|
| STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.
|
| Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA, Bardeesy N.
|
| Cancer Res 71(14):5020-9. Epub 2011 May 17.
2011
|
68 | STAT3
|
| STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.
|
| Oh HM, Yu CR, Golestaneh N, Amadi-Obi A, Lee YS, Eseonu A, Mahdi RM, Egwuagu CE.
|
| J Biol Chem 286(35):30888-97. Epub 2011 Jul 5.
2011
|
69 | STAT3
|
| Antitumorigenic potential of STAT3 alternative splicing modulation.
|
| Zammarchi F, de Stanchina E, Bournazou E, Supakorndej T, Martires K, Riedel E, Corben AD, Bromberg JF, Cartegni L.
|
| Proc Natl Acad Sci U S A 108(43):17779-84. Epub 2011 Oct 17.
2011
|
70 | PKD1, STAT3
|
| Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
|
| Takakura A, Nelson EA, Haque N, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J.
|
| Hum Mol Genet. 20(21):4143-54. 2011
|
71 | STAT3
|
| Absolute requirement for STAT3 function in small-intestine crypt stem cell survival.
|
| Matthews JR, Sansom OJ, Clarke AR.
|
| Cell Death Differ 18(12):1934-43. doi: 10.1038/cdd.2011.77. Epub 2011 Jun 3.
2011
|
72 | STAT3
|
| Absolute requirement for STAT3 function in small-intestine crypt stem cell survival.
|
| Matthews JR, Sansom OJ, Clarke AR.
|
| Cell Death Differ 18(12):1934-43. doi: 10.1038/cdd.2011.77. Epub 2011 Jun 3.
2011
|
73 | MMP7, STAT3
|
| Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
|
| Fukuda A, Wang SC, Morris JP 4th, Folias AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M.
|
| Cancer Cell 19(4):441-55. doi: 10.1016/j.ccr.2011.03.002.
2011
|
74 | PTK6, STAP2, STAT3
|
| Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
|
| Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.
|
| Cancer Sci 102(4):756-61. doi: 10.1111/j.1349-7006.2010.01842.x. Epub 2011 Jan 23.
2011
|
75 | STAT3, STMN3
|
| SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.
|
| Ng DC, Lim CP, Lin BH, Zhang T, Cao X.
|
| Biochemical Journal 425 2010
|
76 | ROR1, STAT3
|
| Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.
|
| Li P, Harris D, Liu Z, Liu J, Keating M, Estrov Z.
|
| PLoS One 5(7):e11859.
2010
|
77 | S1PR1, STAT3
|
| STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.
|
| Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, Kortylewski M, Horne D, Somlo G, Forman S, Jove R, Yu H.
|
| Nat Med 16(12):1421-8. Epub 2010 Nov 21.
2010
|
78 | PTK6, STAP2, STAT3
|
| Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
|
| Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.
|
| J Biol Chem 285(49):38093-103. doi: 10.1074/jbc.M110.162388. Epub 2010 Oct 7.
2010
|
79 | CTF2P, LIFR, STAT3
|
| Neuropoietin activates STAT3 independent of LIFR activation in adipocytes.
|
| White UA, Stephens JM.
|
| Biochem Biophys Res Commun. Apr 23;395(1):48-50. doi: 10.1016/j.bbrc.2010.03.132. Epub 2010 Mar 28. 2010
|
80 | HIES, HIES3, STAT3
|
| Clinical Manifestations, Etiology, and Pathogenesis of the Hyper IgE Syndromes.
|
| Freeman AF, Holland SM.
|
| Pediatr Res ediatr Res. 2009 Jan 28. [Epub ahead of print] 2009
|
81 | STAT3
|
| Function of mitochondrial Stat3 in cellular respiration.
|
| Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC.
|
| Science 323(5915):793-7. Epub 2009 Jan 8.
2009
|
82 | JAK1, PIAS1, SOCS1, SOCS3, STAT1, STAT3
|
| SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
|
| Diao Y, Wang X, Wu Z.
|
| Mol Cell Biol 29(18):5084-93. Epub 2009 Jul 20.
2009
|
83 | SOCS3, STAT3
|
| Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.
|
| Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z.
|
| J Exp Med 206(10):2067-77. Epub 2009 Sep 8.PMID: 19737863 2009
|
84 | PTPN11, STAT3
|
| Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
|
| Zhang W, Chan RJ, Chen H, Yang Z, He Y, Zhang X, Luo Y, Yin F, Moh A, Miller LC, Payne RM, Zhang ZY, Fu XY, Shou W.
|
| J Biol Chem 284(33):22353-63. Epub 2009 Jun 9.PMID: 19509418 2009
|
85 | MUC1, STAT3
|
| MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion.
|
| Gao J, McConnell MJ, Yu B, Li J, Balko JM, Black EP, Johnson JO, Lloyd MC, Altiok S, Haura EB.
|
| Int J Oncol 35(2):337-45.
2009
|
86 | STAT3
|
| A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas.
|
| Lee TL, Yeh J, Friedman J, Yan B, Yang X, Yeh NT, Van Waes C, Chen Z.
|
| Int J Cancer 122(9):1987-98. 2008
|
87 | CSF3, MXD1, STAT3
|
| Regulation of the MAD1 promoter by G-CSF.
|
| Jiang K, Hein N, Eckert K, LŸscher-Firzlaff J, LŸscher B.
|
| Nucleic Acids Res 36(5):1517-31. Epub 2008 Jan 18. 2008
|
88 | GADD45GIP1, STAT3
|
| Crif1 is a novel transcriptional coactivator of STAT3.
|
| Kwon MC, Koo BK, Moon JS, Kim YY, Park KC, Kim NS, Kwon MY, Kong MP, Yoon KJ, Im SK, Ghim J, Han YM, Jang SK, Shong M, Kong YY.
|
| EMBO J 27(4):642-53. Epub 2008 Jan 17.
2008
|
89 | JAK2, STAT2, STAT3
|
| JAK2/STAT2/STAT3 are required for myogenic differentiation.
|
| Wang K, Wang C, Xiao F, Wang H, Wu Z.
|
| J Biol Chem 283(49):34029-36. Epub 2008 Oct 2.
2008
|
90 | CD274, STAT3
|
| Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
|
| Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, Wang HY, Wysocka M, Cheng M, Ruggeri BA, Wasik MA.
|
| Proc Natl Acad Sci U S A 105(52):20852-7. Epub 2008 Dec 16.PMID: 19088198 2008
|
91 | ARL2Bp, STAT3
|
| BART is essential for nuclear retention of STAT3.
|
| Muromoto R, Sekine Y, Imoto S, Ikeda O, Okayama T, Sato N, Matsuda T.
|
| Int Immunol 20(3):395-403. Epub 2008 Jan 29.PMID: 18234692 2008
|
92 | STAT3, TRIM28
|
| Physical and functional interactions between STAT3 and KAP1.
|
| Tsuruma R, Ohbayashi N, Kamitani S, Ikeda O, Sato N, Muromoto R, Sekine Y, Oritani K, Matsuda T.
|
| Oncogene 27(21):3054-9. Epub 2007 Nov 26.PMID: 18037959 2008
|
93 | STAT3
|
| Physical and functional interactions between STAT3 and KAP1.
|
| Tsuruma R, Ohbayashi N, Kamitani S, Ikeda O, Sato N, Muromoto R, Sekine Y, Oritani K, Matsuda T.
|
| Oncogene. 27(21):3054-9. 2008
|
94 | STAT3, CTSD, PRL
|
| A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy.
|
| Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H.
|
| Cell 128(3):589-600. 2007
|
95 | SOX6,STAT3
|
| The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels.
|
| Hwang MN, Min CH, Kim HS, Lee H, Yoon KA, Park SY, Lee ES, Yoon S.
|
| Biochem Biophys Res Commun 360(2):333-8. Epub 2007 Jun 19. 2007
|
96 | CDK5,STAT3
|
| Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells.
|
| Lin H, Chen MC, Chiu CY, Song YM, Lin SY.
|
| J Biol Chem 282(5):2776-84. Epub 2006 Dec 4. 2007
|
97 | STAT3, MASP2
|
| Stat3 is involved in control of MASP2 gene expression.
|
| Unterberger C, Hanson S, Klingenhoff A, Oesterle D, Frankenberger M, Endo Y, Matsushita M, Fujita T, Schwaeble W, Weiss EH, Ziegler-Heitbrock L, Stover C.
|
| Biochem Biophys Res Commun 364(4):1022-5. Epub 2007 Oct 29. 2007
|
98 | NDRG2, SOCS1, STAT3, MAPK14
|
| SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells.
|
| Park Y, Shon SK, Kim A, Kim KI, Yang Y, Cho DH, Lee MS, Lim JS.
|
| Biochem Biophys Res Commun 363(2):361-7. Epub 2007 Sep 14. 2007
|
99 | HIES, STAT3
|
| STAT3 mutations in the hyper-IgE syndrome.
|
| Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, SchŠffer AA, Puck JM, Grimbacher B.
|
| N Engl J Med 357(16):1608-19. Epub 2007 Sep 19. 2007
|
100 | HIES, HIES3, STAT3, TYK2
|
| Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
|
| Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
|
| Nature 448(7157):1058-62. Epub 2007 Aug 5. 2007
|
101 | HIES, STAT3
|
| Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
|
| Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
|
| Nature 448(7157):1058-62. Epub 2007 Aug 5.
2007
|
102 | MAP3K14, STAT3
|
| LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
|
| Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC.
|
| Biochem Biophys Res Commun 359(2):379-84. Epub 2007 May 25.
2007
|
103 | STAT3, TRPS1
|
| Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.
|
| Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.
|
| Dev Biol 312(2):572-81. Epub 2007 Oct 10.PMID: 17997399 2007
|
104 | PTPRT, STAT3
|
| Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
|
| Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD, Kinzler KW, Vogelstein B, Velculescu VE, Wang ZJ.
|
| Proc Natl Acad Sci U S A 104(10):4060-4. Epub 2007 Feb 21.
2007
|
105 | IL10, STAT3, BTK
|
| Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.
|
| Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Kawakami Y, Xiao W, Nagai H, Croft M, Kawakami T.
|
| Proc Natl Acad Sci U S A 103(1):153-8. Epub 2005 Dec 21. 2006
|
106 | SOCS3, STAT3
|
| Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.
|
| Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G.
|
| J Biol Chem 281(48):36683-90. Epub 2006 Oct 6.
2006
|
107 | STAT3
|
| Physical and functional interactions between Daxx and STAT3.
|
| Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K, Matsuda T.
|
| Oncogene. 25(14):2131-6. 2006
|
108 | STAT3
|
| Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
|
| Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H.
|
| Nat Med. 12(7):829-34. 2006
|
109 | STAT3, NLK, MAP3K7
|
| STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.
|
| Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K.
|
| Proc Natl Acad Sci U S A 102(12):4524-9. Epub 2005 Mar 11. 2005
|
110 | HDAC1, STAT3, PTPN6, DNMT1
|
| STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
|
| Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA.
|
| Proc Natl Acad Sci U S A 102(19):6948-53. Epub 2005 May 3. 2005
|
111 | STAT3, ALK, NPM1
|
| Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.
|
| Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, Karras JG, Levy DE, Inghirami G.
|
| Nat Med 11(6):623-629. Epub 2005 May 15. 2005
|
112 | STAT3, HGF, SOCS3
|
| SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration.
|
| Tokumaru S, Sayama K, Yamasaki K, Shirakata Y, Hanakawa Y, Yahata Y, Dai X, Tohyama M, Yang L, Yoshimura A, Hashimoto K.
|
| Biochem Biophys Res Commun 327(1):100-5. 2005
|
113 | CXCR4, JAK2, STAT3
|
| Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.
|
| Ahr B, Denizot M, Robert-Hebmann V, Brelot A, Biard-Piechaczyk M.
|
| J Biol Chem 280(8):6692-700. Epub 2004 Dec 22. 2005
|
114 | STAT3
|
| Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
|
| Sato N, Tsuruma R, Imoto S, Sekine Y, Muromoto R, Sugiyama K, Matsuda T.
|
| Biochem Biophys Res Commun 336(2):617-24. 2005
|
115 | AKT1,STAT3
|
| Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
|
| Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ.
|
| J Biol Chem 280(47):38932-41. Epub 2005 Sep 20. 2005
|
116 | STAT3
|
| Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
|
| Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC.
|
| Cancer Cell. 7(6):575-89. 2005
|
117 | STAT3
|
| HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
|
| Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE.
|
| Oncogene. 24(19):3110-20. 2005
|
118 | STAT3
|
| Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
|
| Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M.
|
| Nat Med 10(2):168-74. Epub 2004 Jan 11. 2004
|
119 | STAT3
|
| Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.
|
| Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY.
|
| Proc Natl Acad Sci U S A 101(13):4661-6. Epub 2004 Mar 22. 2004
|
120 | IRAK1, STAT3
|
| IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.
|
| Huang Y, Li T, Sane DC, Li L.
|
| J Biol Chem 279(49):51697-703. Epub 2004 Oct 1. 2004
|
121 | SMARCA4, STAT3
|
| Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene.
|
| Giraud S, Hurlstone A, Avril S, Coqueret O.
|
| Oncogene. 23(44):7391-8. 2004
|
122 | STAT3
|
| STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets.
|
| Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI.
|
| J Mol Biol. 340(4):641-53. 2004
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123 | STAT3
|
| Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex.
|
| Yang CH, Murti A, Baker SJ, Frangou-Lazaridis M, Vartapetian AB, Murti KG, Pfeffer LM.
|
| Exp Cell Res. 298(1):197-206. 2004
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124 | STAT3
|
| Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
|
| Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS.
|
| Oncogene. 23(15):2617-29. 2004
|
125 | STAT3
|
| The STAT3 isoforms alpha and beta have unique and specific functions.
|
| Maritano D, Sugrue ML, Tininini S, Dewilde S, Strobl B, Fu X, Murray-Tait V, Chiarle R, Poli V.
|
| Nat Immunol. 5(4):401-9. 2004
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126 | STAT3
|
| Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
|
| Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J.
|
| J Clin Invest. 114(5):720-8. 2004
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127 | STAT3
|
| STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity
|
| Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY.
|
| Proc Natl Acad Sci U S A 100(4):1879-84. 2003
|
128 | STAT3
|
| Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.
|
| Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY.
|
| Proc Natl Acad Sci U S A 100(22):12929-34. Epub 2003 Oct 17. No abstract available. 2003
|
129 | STAT3
|
| Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor.
|
| Yamamoto T, Sato N, Sekine Y, Yumioka T, Imoto S, Junicho A, Fuse H, Matsuda T.
|
| Biochem Biophys Res Commun. 306(2):610-5. 2003
|
130 | STAT3
|
| Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
|
| Sato N, Yamamoto T, Sekine Y, Yumioka T, Junicho A, Fuse H, Matsuda T.
|
| Biochem Biophys Res Commun. 300(4):847-52. 2003
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131 | STAT3
|
| Tip60 is a co-repressor for STAT3.
|
| Xiao H, Chung J, Kao HY, Yang YC.
|
| J Biol Chem. 278(13):11197-204. 2003
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132 | STAT3
|
| GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.
|
| Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong CT, Cao X
|
| EMBO J. 22(6):1325-35. 2003
|
133 | STAT3
|
| STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
|
| Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY.
|
| Proc Natl Acad Sci U S A. 100(4):1879-84. 2003
|
134 | STAT3
|
| Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation.
|
| Hevehan DL, Miller WM, Papoutsakis ET.
|
| Blood 99(5):1627-37. 2002
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135 | EP300, NCOA1, STAT3
|
| Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
|
| Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O.
|
| J Biol Chem 277(10):8004-11. 2002
|
136 | STAT1, STAT2, STAT3
|
| Cytokine signaling: STATS in plasma membrane rafts.
|
| Sehgal PB, Guo GG, Shah M, Kumar V, Patel K.
|
| J Biol Chem 277(14):12067-74. 2002
|
137 | EPOR, STAT1, STAT3, STAT5A
|
| Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.
|
| Kirito K, Nakajima K, Watanabe T, Uchida M, Tanaka M, Ozawa K, Komatsu N.
|
| Blood 99(1):102-10. 2002
|
138 | STAT3
|
| STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
|
| Lee CK, Raz R, Gimeno R, Gertner R, Wistinghausen B, Takeshita K, DePinho RA, Levy DE.
|
| Immunity 17(1):63-72. 2002
|
139 | STAT3, ZNF467
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| A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.
|
| Nakayama K, Kim KW, Miyajima A.
|
| EMBO J 21(22):6174-84. 2002
|
140 | JAK2, STAT3
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| ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
|
| Ren Z, Schaefer TS.
|
| J Biol Chem. 277(41):38486-93. 2002
|
141 | STAT3
|
| Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function.
|
| Waris G, Siddiqui A.
|
| J Virol. 76(6):2721-9. 2002
|
142 | STAT3
|
| STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.
|
| Velichko S, Wagner TC, Turkson J, Jove R, Croze E.
|
| J Biol Chem. 277(38):35635-41. 2002
|
143 | STAT3
|
| Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB.
|
| Yu Z, Zhang W, Kone BC.
|
| Biochem J. 367(Pt 1):97-105. 2002
|
144 | STAT3
|
| Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes.
|
| Guo GG, Patel K, Kumar V, Shah M, Fried VA, Etlinger JD, Sehgal PB.
|
| J Interferon Cytokine Res. 22(5):555-63. 2002
|
145 | STAT3
|
| Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock.
|
| Yoo JY, Huso DL, Nathans D, Desiderio S.
|
| Cell. 108(3):331-44. 2002
|
146 | BRCA1, JAK2, STAT3
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| Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.
|
| Gao B, Shen X, Kunos G, Meng Q, Goldberg ID, Rosen EM, Fan S.
|
| FEBS Lett. 488(3):179-84. 2001
|
147 | STAT3
|
| Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.
|
| Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR.
|
| EMBO J. 20(10):2487-96. 2001
|
148 | STAT3
|
| Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3.
|
| Wang LH, Yang XY, Mihalic K, Xiao W, Li D, Farrar WL.
|
| J Biol Chem. 276(34):31839-44. 2001
|
149 | STAT3
|
| Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse.
|
| Miyoshi K, Cui Y, Riedlinger G, Robinson P, Lehoczky J, Zon L, Oka T, Dewar K, Hennighausen L.
|
| Genomics. 71(2):150-5. 2001
|
150 | STAT3
|
| Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
|
| Kunisada K, Negoro S, Tone E, Funamoto M, Osugi T, Yamada S, Okabe M, Kishimoto T, Yamauchi-Takihara K.
|
| Proc Natl Acad Sci U S A 97(1):315-9 2000
|
151 | GHTF, JAK2, STAT3
|
| Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway.
|
| Park ES, Kim H, Suh JM, Park SJ, You SH, Chung HK, Lee KW, Kwon OY, Cho BY, Kim YK, Ro HK, Chung J, Shong M.
|
| Mol Endocrinol 14(5):662-70. 2000
|
152 | PIAS3, STAT3
|
| Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells.
|
| Kato K, Nomoto M, Izumi H, Ise T, Nakano S, Niho Y, Kohno K.
|
| Biochim Biophys Acta 1493(1-2):91-100. 2000
|
153 | FER, STAT3
|
| FER kinase activation of Stat3 is determined by the N-terminal sequence.
|
| Priel-Halachmi S, Ben-Dor I, Shpungin S, Tennenbaum T, Molavani H, Bachrach M, Salzberg S, Nir U.
|
| J Biol Chem 275(37):28902-10. 2000
|
154 | STAT3
|
| Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.
|
| Coqueret O, Gascan H.
|
| J Biol Chem. 275(25):18794-800. 2000
|
155 | STAT3
|
| Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
|
| Delespine-Carmagnat M, Bouvier G, Bertoglio J.
|
| Eur J Immunol. 30(1):59-68. 2000
|
156 | STAT3
|
| Regulation of STAT3 by direct binding to the Rac1 GTPase.
|
| Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL.
|
| Science. 290(5489):144-7. 2000
|
157 | STAT3
|
| Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity.
|
| Kim J, Kim D, Chung J.
|
| Cell Biol Int. 24(7):467-73. 2000
|
158 | STAT3
|
| Essential role of STAT3 for embryonic stem cell pluripotency.
|
| Raz R, et al.
|
| Proc Natl Acad Sci U S A 96(6):2846-2851. 1999
|
159 | STAT3
|
| Stat3 as an oncogene.
|
| Bromberg JF, et al.
|
| Cell 98(3):295-303. 1999
|
160 | STAT3
|
| Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.
|
| Woetmann A, et al.
|
| Proc Natl Acad Sci U S A 96(19):10620-5 1999
|
161 | BMP2, EP300, LIF, SMAD1, STAT3
|
| Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
|
| Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T.
|
| Science 284(5413):479-82. 1999
|
162 | JUN, STAT3
|
| Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
|
| Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE Jr.
|
| Mol Cell Biol. 19(10):7138-46. 1999
|
163 | STAT3
|
| Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
|
| Jain N, Zhang T, Kee WH, Li W, Cao X.
|
| J Biol Chem. 274(34):24392-400. 1999
|
164 | IL6ST, STAT3
|
| STAT3 orchestrates contradictory signals in cytokine-induced G 1 to S cell-cycle transition.
|
| Fukada T, et al.
|
| EMBO J 17 : 6670-6677. 1998
|
165 | STAT3
|
| STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities.
|
| Yang CH, Murti A, Pfeffer LM.
|
| Proc Natl Acad Sci U S A 95(10):5568-72 1998
|
166 | IL6ST, STAT3
|
| Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.
|
| Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S.
|
| J Immunol 161(9):4652-60 1998
|
167 | STAT3
|
| STAT3 forms stable homodimers in the presence of divalent cations prior to activation.
|
| Novak U, Ji H, Kanagasundaram V, Simpson R, Paradiso L.
|
| Biochem Biophys Res Commun. 247(3):558-63. 1998
|
168 | STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B
|
| STATs and gene regulation.
|
| Darnell JE Jr.
|
| Science 277(5332):1630-5. Review. 1997
|
169 | STAT3
|
| STAT3 acts as a co-activator of glucocorticoid receptor signaling.
|
| Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM.
|
| J Biol Chem. 272(49):30607-10. 1997
|
170 | STAT3
|
| Assignment of the acute phase response factor (APRF) gene to 17q21 by microdissection clone sequencing and fluorescence in situ hybridization of a P1 clone.
|
| Choi JY, et al.
|
| Genomics 37 : 264-265. 1996
|
171 | STAT3
|
| Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor.
|
| Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM.
|
| J Biol Chem. 271(14):8057-61. 1996
|
172 | STAT3
|
| Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
|
| Akira S, et al.
|
| Cell 77 : 63-71. 1994
|