Citations for
1ELOB, SPAG16, SRSF2
Elongin B is a binding partner of the male germ cell nuclear speckle protein sperm-associated antigen 16S (SPAG16S) and is regulated post-transcriptionally in the testis.
Zhang Z, Huang Q, Wang Z, Zou J, Yu Z, Strauss Iii JF, Zhang Z.
Reprod Fertil Dev. Apr;31(5):962-971. doi: 10.1071/RD18303 2019
2IDH2, INTS3, SRSF2
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.
Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O.
Nature Oct;574(7777):273-277. doi: 10.1038/s41586-019-1618-0. Epub 2019 Oct 2 2019
3SRSF2
Activation of Cryptic 3' Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping.
Moon H, Jang HN, Liu Y, Choi N, Oh J, Ha J, Zheng X, Shen H.
Cell Jul 10;8(7):696. doi: 10.3390/cells8070696. 2019
4SRSF2
SRSF2 mutations in myelodysplasia/myeloproliferative neoplasms.
Aujla A, Linder K, Iragavarapu C, Karass M, Liu D.
Biomark Res. Sep 26;6:29. doi: 10.1186/s40364-018-0142-y. eCollection 2018 2018
5SRSF2
Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis.
Arbab Jafari P, Ayatollahi H, Sadeghi R, Sheikhi M, Asghari A.
Hematology Dec;23(10):778-784. doi: 10.1080/10245332.2018.1471794. Epub 2018 May 14 2018
6SRSF2
SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.
Liang Y, Tebaldi T, Rejeski K, Joshi P, Stefani G, Taylor A, Song Y, Vasic R, Maziarz J, Balasubramanian K, Ardasheva A, Ding A, Quattrone A, Halene S.
Leukemia Dec;32(12):2659-2671. doi: 10.1038/s41375-018-0152-7. Epub 2018 Jun 1 2018
7SRSF2, U2AF1
Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells.
Bapat A, Keita N, Martelly W, Kang P, Seet C, Jacobsen JR, Stoilov P, Hu C, Crooks GM, Sharma S.
Stem Cells. Nov;36(11):1663-1675. doi: 10.1002/stem.2885. Epub 2018 Jul 27 2018
8SRSF2
SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development.
Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z, Wu W, Feng Y.
Cancer Res. Mar 1;77(5):1168-1178. doi: 10.1158/0008-5472.CAN-16-1919. Epub 2017 Jan 12 2017
9SRSF2
SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion.
Moon H, Cho S, Loh TJ, Jang HN, Liu Y, Choi N, Oh J, Ha J, Zhou J, Cho S, Kim DE, Ye MB, Zheng X, Shen H.
BMB Rep. Aug;50(8):423-428. doi: 10.5483/bmbrep.2017.50.8.103 2017
10SRSF2
Decreased Expression of SRSF2 Splicing Factor Inhibits Apoptotic Pathways in Renal Cancer.
Kędzierska H, Popławski P, Hoser G, Rybicka B, Rodzik K, Sokół E, Bogusławska J, Tański Z, Fogtman A, Koblowska M, Piekiełko-Witkowska A.
Int J Mol Sci. Sep 28;17(10):1598. doi: 10.3390/ijms17101598 2016
11SRSF1, SRSF2
Characterization of RNA-Protein Interactions: Lessons from Two RNA-Binding Proteins, SRSF1 and SRSF2.
Skrdlant L, Lin RJ.
Methods Mol Biol. 1421:1-13. doi: 10.1007/978-1-4939-3591-8_1 2016
12SRSF2
Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice.
Cheng Y, Luo C, Wu W, Xie Z, Fu X, Feng Y.
Mol Cell Biol. May 16;36(11):1628-38. doi: 10.1128/MCB.01071-15. Print 2016 Jun 1 2016
13SRSF2
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.
Zhang J, Lieu YK, Ali AM, Penson A, Reggio KS, Rabadan R, Raza A, Mukherjee S, Manley JL.
Proc Natl Acad Sci U S A. Aug 25;112(34):E4726-34. doi: 10.1073/pnas.1514105112. Epub 2015 2015
14SRSF2
SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.
Komeno Y, Huang YJ, Qiu J, Lin L, Xu Y, Zhou Y, Chen L, Monterroza DD, Li H, DeKelver RC, Yan M, Fu XD, Zhang DE.
Mol Cell Biol. Sep 1;35(17):3071-82. doi: 10.1128/MCB.00202-15. Epub 2015 Jun 29 2015
15MST1R, SRSF2
SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene.
Moon H, Cho S, Loh TJ, Oh HK, Jang HN, Zhou J, Kwon YS, Liao DJ, Jun Y, Eom S, Ghigna C, Biamonti G, Green MR, Zheng X, Shen H.
Biochim Biophys Acta. Nov;1839(11):1132-40. doi: 10.1016/j.bbagrm.2014.09.003. Epub 2014 Sep 8. 2014
16SRSF2, TRA2B
Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation.
Bruch J, Xu H, De Andrade A, Höglinger G.
PLoS One. Nov 17;9(11):e113070. doi: 10.1371/journal.pone.0113070. eCollection 2014 2014
17E2F1, SRSF2
A new function of the splicing factor SRSF2 in the control of E2F1-mediated cell cycle progression in neuroendocrine lung tumors.
Edmond V, Merdzhanova G, Gout S, Brambilla E, Gazzeri S, Eymin B.
Cell Cycle Apr 15;12(8):1267-78. doi: 10.4161/cc.24363. Epub 2013 Mar 21 2013
18SRSF2, U2AF1
Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation.
Mo S, Ji X, Fu XD.
Transcription Sep-Dec;4(5):251-9. doi: 10.4161/trns.26932 2013
19SRSF2, U2AF1, ZRSR2
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.
Thol F, Kade S, Schlarmann C, Löffeld P, Morgan M, Krauter J, Wlodarski MW, Kölking B, Wichmann M, Görlich K, Göhring G, Bug G, Ottmann O, Niemeyer CM, Hofmann WK, Schlegelberger B, Ganser A, Heuser M.
Blood 119(15):3578-84. Epub 2012 Mar 2. 2012
20SRSF2
Splicing factor SC35 promotes tau expression through stabilization of its mRNA.
Qian W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F.
FEBS Lett 585(6):875-80. Epub 2011 Feb 17. 2011
21KAT5, SRSF2
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.
Edmond V, Moysan E, Khochbin S, Matthias P, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
EMBO J 30(3):510-23. Epub 2010 Dec 14. 2011
22CDKN1A, SRSF2
SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines.
Edmond V, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
Cell Cycle 10(12):1968-77. Epub 2011 Jun 15. 2011
23SF3B1, SRSF1, SRSF2, U2AF1, U2AF2, ZRSR2
Frequent pathway mutations of splicing machinery in myelodysplasia.
Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S.
Nature 478(7367):64-9. doi: 10.1038/nature10496. 2011
24PNN, SRSF2
Pnn and SR family proteins are differentially expressed in mouse central nervous system.
Hsu SY, Chen YJ, Ouyang P.
Histochem Cell Biol 135(4):361-73. doi: 10.1007/s00418-011-0795-1. Epub 2011 Mar 10. 2011
25SRSF2
Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway.
Chen KL, Yuan RY, Hu CJ, Hsu CY.
Neurobiol Dis 40(2):378-85. Epub 2010 Jul 6. 2010
26HOS1, SRSF2, TBX5
Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35.
Fan C, Chen Q, Wang QK.
J Biol Chem 284(38):25653-63. Epub 2009 Jul 31.PMID: 19648116 2009
27SRSF2
Caffeine regulates alternative splicing in a subset of cancer-associated genes: a role for SC35.
Shi J, Hu Z, Pabon K, Scotto KW.
Mol Cell Biol 28(2):883-95. Epub 2007 Nov 19. 2008
28ELF5, GH1, IGHD2, SRSF1, SRSF2
Growth hormone deficiency and splicing fidelity: two serine/arginine-rich proteins, ASF/SF2 and SC35, act antagonistically.
Solis AS, Peng R, Crawford JB, Phillips JA 3rd, Patton JG.
J Biol Chem 283(35):23619-26. Epub 2008 Jun 27. 2008
29E2F1, SRSF2
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35.
Merdzhanova G, Edmond V, De Seranno S, Van den Broeck A, Corcos L, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
Cell Death Differ 15(12):1815-23. Epub 2008 Sep 19. 2008
30HNRNPA1, SRSF2
A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms.
Donev R, Newall A, Thome J, Sheer D.
Mol Psychiatry 12(7):681-90. Epub 2007 Mar 13. 2007
31SRSF2
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis.
Xiao R, Sun Y, Ding JH, Lin S, Rose DW, Rosenfeld MG, Fu XD, Li X.
Mol Cell Biol 27(15):5393-402. Epub 2007 May 25. 2007
32PNN, SRRM2, SRSF2, SRSF5, SRSF6
Loss of Pnn expression attenuates expression levels of SR family splicing factors and modulates alternative pre-mRNA splicing in vivo.
Chiu Y, Ouyang P.
Biochem Biophys Res Commun 341(2):663-71. Epub 2006 Jan 17. 2006
33CIR1, RP9, SRSF2, U2AF1
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing.
Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM.
Exp Cell Res 303(2):375-87. Epub 2004 Nov 18. 2005
34SFRS11, SFRS9, SRSF1, SRSF2, SRSF4, SRSF5, SRSF6, SRSF7, TRA2B
Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing.
Hertel KJ, et al.
Proc Natl Acad Sci U S A 96(6):2651-5. 1999
35ATF4B, ATF4C, D17S1534, D17S802, D17S929, D17S939, EBJPAB, GRB2, HNA, ITGB4, LGALS3BP, NPTX1, SRSF2, ST6GALNAC2
A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes.
Kuhlenbaumer G, Schirmacher A, Meuleman J, Tissir F, Del-Favero J, Stogbauer F, Young P, Ringelstein B, Van Broeckhoven C, Timmerman V.
Genomics 62(2):242-50. 1999
36HNA, MYBET, SRSF2
Mutation analysis of a putative sialyltransferase gene, the SFRS2 splicing factor gene and the c-myb ET-locus in two families with hereditary neuralgic amyotrophy (HNA).
Kuhlenbaeumer G, et al.
Ann Hum Genet 62 : 397-400. 1998
37FUS, SFRS13A, SRSF2
Oncoptotein TLS interacts with serine-arginine ptoteins involved in RNA xplicing. involved in RNA splicing.
Yang L, Embree LJ, Tsai S, Hickstein DD.
J Biol Chem 273(43):27761-4. 1998
38NCBP1, PTBP1, SFPQ, SFRS11, SFRS8, SFRS9, SRPK1, SRPK2, SRSF1, SRSF2, SRSF3, SRSF4, SRSF5, SRSF6, SRSF7, TRA2B, U2AF1
The structure and function of proteins involved in mammalian pre-mRNA splicing.
Kramer A.
Annu Rev Biochem 65:367-409. Review. 1996
39SRSF1, SRSF2
Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2).
Bermingham JR, et al.
Genomics 29 : 70-79. 1995
40SFRS9, SRSF2, SRSF5, SRSF6, SRSF7
Identification and characterisation of three members of the SR family of pre-mRNA splicing factors.
Screaton GR, et al.
EMBO J 14 : 4336-4349. 1995
41SRSF2
A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.
Vellard M, et al.
Proc Natl Acad Sci U S A 89 : 2511-2515. 1992
42SRSF2
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35.
Fu XD, Maniatis T.
Science 256(5056):535-8. 1992