| 1 | NQO1, SREBF1
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| The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability.
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| Wang X, Liu Y, Han A, Tang C, Xu R, Feng L, Yang Y, Chen L, Lin Z.
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| Oncogene. Nov;41(47):5107-5120. doi: 10.1038/s41388-022-02477-6. Epub 2022 Oct 17. 2022
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| 2 | IFAP2, MBTPS2, SREBF1, SREBF2
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| Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome.
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| Wang H, Humbatova A, Liu Y, Qin W, Lee M, Cesarato N, Kortüm F, Kumar S, Romano MT, Dai S, Mo R, Sivalingam S, Motameny S, Wu Y, Wang X, Niu X, Geng S, Bornholdt D, Kroisel PM, Tadini G, Walter SD, Hauck F, Girisha KM, Calza AM, Bottani A, Altmüller J, Buness A, Yang S, Sun X, Ma L, Kutsche K, Grzeschik KH, Betz RC, Lin Z.
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| Am J Hum Genet. Jul 2;107(1):34-45. doi: 10.1016/j.ajhg.2020.05.006. Epub 2020 Jun 3 2020
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| 3 | FOXA2, SREBF1
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| Srebf1 Controls Midbrain Dopaminergic Neurogenesis.
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| Toledo EM, Yang S, Gyllborg D, van Wijk KE, Sinha I, Varas-Godoy M, Grigsby CL, Lönnerberg P, Islam S, Steffensen KR, Linnarsson S, Arenas E.
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| Cell Rep. May 5;31(5):107601. doi: 10.1016/j.celrep.2020.107601 2020
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| 4 | KRT80, SREBF1
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| SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
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| Perone Y, Farrugia AJ, Rodríguez-Meira A, Győrffy B, Ion C, Uggetti A, Chronopoulos A, Marrazzo P, Faronato M, Shousha S, Davies C, Steel JH, Patel N, Del Rio Hernandez A, Coombes C, Pruneri G, Lim A, Calvo F, Magnani L.
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| Nat Commun. May 9;10(1):2115. doi: 10.1038/s41467-019-09676-y. Erratum in: Nat Commun. 2019 Aug 19;10(1):3791. 2019
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| 5 | SREBF1
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| Association analysis of SNP rs11868035 in SREBF1 with sporadic Parkinson's disease, sporadic amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.
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| Yuan X, Cao B, Wu Y, Chen Y, Wei Q, Ou R, Yang J, Chen X, Zhao B, Song W, Shang H.
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| Neurosci Lett. Jan 18;664:128-132. doi: 10.1016/j.neulet.2017.11.015. Epub 2017 Nov 8 2018
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| 6 | ATF4, SREBF1, USP7
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| ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation.
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| Chen H, Yuan R, Zhang Y, Zhang X, Chen L, Zhou X, Yuan Z, Nie Y, Li M, Mo D, Chen Y.
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| Biochim Biophys Acta 1859(11):1459-1469. doi: 10.1016/j.bbagrm.2016.07.010. Epub 2016 Jul 21.
2016
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| 7 | MIOX, SREBF1
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| Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
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| Tominaga T, Dutta RK, Joladarashi D, Doi T, Reddy JK, Kanwar YS.
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| J Biol Chem 291(3):1348-67. doi: 10.1074/jbc.M115.698191. Epub 2015 Nov 17.
2016
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| 8 | CD274, SREBF1
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| PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma.
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| Wang Y, Wang H, Zhao Q, Xia Y, Hu X, Guo J.
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| Med Oncol 32(8):212. doi: 10.1007/s12032-015-0655-2. Epub 2015 Jul 4.
2015
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| 9 | RXRA, RXRG, SREBF1
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| Regulation of retinoid X receptor gamma expression by fed state in mouse liver.
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| Park S, Lee YJ, Ko EH, Kim JW.
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| Biochem Biophys Res Commun 458(1):134-9. doi: 10.1016/j.bbrc.2015.01.082. Epub 2015 Jan 28.
2015
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| 10 | SFRP2, SREBF1
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| Sfrp2 is a transcriptional target of SREBP-1 in mouse chondrogenic cells.
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| Kim MJ, Kim JE, Lee W, Park SY.
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| Mol Cell Biochem. Aug;406(1-2):163-71. doi: 10.1007/s11010-015-2434-y. Epub 2015 May 14 2015
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| 11 | ELOVL5, SREBF1
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| Identification of human ELOVL5 enhancer regions controlled by SREBP. .
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| Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N
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| Biochem Biophys Res Commun. Oct 2;465(4):857-63. doi: 10.1016/j.bbrc.2015.08.101. Epub 2015 Aug 28. 2015
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| 12 | RNF20, SREBF1
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| Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
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| Lee JH, Lee GY, Jang H, Choe SS, Koo SH, Kim JB.
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| Hepatology 60(3):844-57. doi: 10.1002/hep.27011. Epub 2014 Jul 28.
2014
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| 13 | SCAP, SREBF1, SREBF2
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| Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).
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| Shao W, Espenshade PJ.
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| J Biol Chem 289(11):7547-57. doi: 10.1074/jbc.M113.545699. Epub 2014 Jan 29.
2014
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| 14 | MLXIPL, SREBF1
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| Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.
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| Xu X, So JS, Park JG, Lee AH.
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| Semin Liver Dis 33(4):301-11. doi: 10.1055/s-0033-1358523. Epub 2013 Nov 12. Review.
2013
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| 15 | CEBPA, DDIT3, PPARA, SREBF1
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| C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.
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| Chikka MR, McCabe DD, Tyra HM, Rutkowski DT.
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| J Biol Chem 288(6):4405-15. doi: 10.1074/jbc.M112.432344. Epub 2012 Dec 31.
2013
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| 16 | ERLIN1, ERLIN2, SCAP, SREBF1, SREBF2
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| Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
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| Huber MD, Vesely PW, Datta K, Gerace L.
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| J Cell Biol 203(3):427-36. doi: 10.1083/jcb.201305076.
2013
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| 17 | CLU, SREBF1
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| Clusterin decreases hepatic SREBP-1c expression and lipid accumulation.
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| Seo HY, Kim MK, Jung YA, Jang BK, Yoo EK, Park KG, Lee IK.
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| Endocrinology 154(5):1722-30. doi: 10.1210/en.2012-2009. Epub 2013 Mar 20. Erratum in: Endocrinology. 2013 Jun;154(6):2254.
2013
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| 18 | FGFR3, SCD, SREBF1
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| FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth.
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| Du X, Wang QR, Chan E, Merchant M, Liu J, French D, Ashkenazi A, Qing J.
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| Cancer Res 72(22):5843-55. doi: 10.1158/0008-5472.CAN-12-1329. Epub 2012 Sep 26.
2012
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| 19 | FASN, SREBF1
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| Reduced expression of FASN through SREBP-1 down-regulation is responsible for hypoxic cell death in HepG2 cells.
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| Jung SY, Jeon HK, Choi JS, Kim YJ.
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| J Cell Biochem 113(12):3730-9. doi: 10.1002/jcb.24247.
2012
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| 20 | SCAP, SREBF1, SREBF2
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| The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
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| Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD.
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| Cell Metab 15(2):240-6. doi: 10.1016/j.cmet.2011.12.017.
2012
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| 21 | PPARA, SREBF1
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| Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha).
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| Fernández-Alvarez A, Alvarez MS, Gonzalez R, Cucarella C, Muntané J, Casado M.
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| J Biol Chem 286(24):21466-77. Epub 2011 May 2.
2011
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| 22 | RPS6KB1, SREBF1
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| Role of S6K1 in regulation of SREBP1c expression in the liver.
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| Li S, Ogawa W, Emi A, Hayashi K, Senga Y, Nomura K, Hara K, Yu D, Kasuga M.
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| Biochem Biophys Res Commun 412(2):197-202. Epub 2011 Jul 22.
2011
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| 23 | INSIG1, SREBF1
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| Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.
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| Taghibiglou C, Lu J, Mackenzie IR, Wang YT, Cashman NR.
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| Biochem Biophys Res Commun 413(2):159-63. Epub 2011 Aug 19.
2011
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| 24 | INSIG1, SREBF1
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| Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
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| Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH.
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| J Biomed Sci 18:57.
2011
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| 25 | SREBF1
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| Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.
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| Duband-Goulet I, Woerner S, Gasparini S, Attanda W, Kondé E, Tellier-Lebčgue C, Craescu CT, Gombault A, Roussel P, Vadrot N, Vicart P, Ostlund C, Worman HJ, Zinn-Justin S, Buendia B.
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| Exp Cell Res 317(20):2800-13. doi: 10.1016/j.yexcr.2011.09.012. Epub 2011 Oct 4.
2011
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| 26 | SREBF1
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| FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells.
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| Liu X, Qiao A, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, Fang F.
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| FEBS Lett 584(20):4330-4. Epub 2010 Sep 23.
2010
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| 27 | SIRT1, SREBF1
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| SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
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| Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, Wu SY, Chiang CM, Veenstra TD, Kemper JK.
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| J Biol Chem 285(44):33959-70. Epub 2010 Sep 3.
2010
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| 28 | SREBF1
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| A phosphorylation cascade controls the degradation of active SREBP1.
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| Bengoechea-Alonso MT, Ericsson J.
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| J Biol Chem 284(9):5885-95. Epub 2009 Jan 5.
2009
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| 29 | ADIPOQ, ADIPOR1, SREBF1
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| Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.
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| Awazawa M, Ueki K, Inabe K, Yamauchi T, Kaneko K, Okazaki Y, Bardeesy N, Ohnishi S, Nagai R, Kadowaki T.
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| Biochem Biophys Res Commun 382(1):51-6. Epub 2009 Feb 28.
2009
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| 30 | ACACA, FASN, SIK1, SREBF1
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| Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation.
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| Yoon YS, Seo WY, Lee MW, Kim ST, Koo SH.
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| J Biol Chem 284(16):10446-52. Epub 2009 Feb 25.PMID: 1924423 2009
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| 31 | SREBF1
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| Regulation of SREBP1c expression by mTOR signaling in hepatocytes.
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| Takashima M, Ogawa W, Emi A, Kasuga M.
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| Kobe J Med Sci 55(2):E45-52.
2009
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| 32 | SREBF1
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| Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors.
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| Fern‡ndez-Alvarez A, Tur G, L—pez-Rodas G, Casado M.
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| FEBS Lett 582(2):177-84. Epub 2007 Dec 7. 2008
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| 33 | SREBF1, SREBF2
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| Alternative splicing produces a constitutively active form of human SREBP-1.
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| Harada N, Yonemoto H, Yoshida M, Yamamoto H, Yin Y, Miyamoto A, Hattori A, Wu Q, Nakagawa T, Nakano M, Teshigawara K, Mawatari K, Hosaka T, Takahashi A, Nakaya Y.
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| Biochem Biophys Res Commun 368(3):820-6. Epub 2008 Feb 11. 2008
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| 34 | PTEN, SREBF1
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| Regulation of the PTEN promoter by statins and SREBP.
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| Teresi RE, Planchon SM, Waite KA, Eng C.
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| Hum Mol Genet 17(7):919-28. Epub 2007 Dec 7. 2008
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| 35 | MTOR, SREBF1
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| SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.
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| Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A.
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| Cell Metab 8(3):224-36.
2008
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| 36 | RXRG, SREBF1
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| Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.
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| Kamei Y, Miura S, Suganami T, Akaike F, Kanai S, Sugita S, Katsumata A, Aburatani H, Unterman TG, Ezaki O, Ogawa Y.
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| Endocrinology 149(5):2293-305. doi: 10.1210/en.2007-1461. Epub 2008 Jan 17.
2008
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| 37 | SREBF1
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| Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.
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| RisŽ P, Ghezzi S, Carissimi R, Mastromauro F, Petroni A, Galli C.
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| Eur J Pharmacol 571(2-3):97-105. Epub 2007 Jun 27. 2007
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| 38 | SREBF1
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| Involvement of glomerular SREBP-1c in diabetic nephropathy.
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| Ishigaki N, Yamamoto T, Shimizu Y, Kobayashi K, Yatoh S, Sone H, Takahashi A, Suzuki H, Yamagata K, Yamada N, Shimano H.
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| Biochem Biophys Res Commun 364(3):502-8. Epub 2007 Oct 16. 2007
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| 39 | SREBF1, TFE3
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| SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling.
|
| Shimano H.
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| J Mol Med 85(5):437-44. Epub 2007 Feb 6. Review.
2007
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| 40 | SREBF1
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| SREBP inhibits VEGF expression in human smooth muscle cells.
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| Motoyama K, Fukumoto S, Koyama H, Emoto M, Shimano H, Maemura K, Nishizawa Y.
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| Biochem Biophys Res Commun 342(1):354-60. Epub 2006 Feb 3. 2006
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| 41 | SLC2A4, SREBF1
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| Regulation of GLUT4 gene expression by SREBP-1c in adipocytes.
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| Im SS, Kwon SK, Kang SY, Kim TH, Kim HI, Hur MW, Kim KS, Ahn YH.
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| Biochem J 399(1):131-9. 2006
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| 42 | SREBF1, SYTL4
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| Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
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| Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N.
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| Cell Metab 4(2):143-54.
2006
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| 43 | SREBF1
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| Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers.
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| Datta S, Osborne TF.
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| J Biol Chem 280(5):3338-45. Epub 2004 Nov 17. 2005
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| 44 | LMNA, SREBF1
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| Altered pre-lamin A processing is a common mechanism leading to lipodystrophy.
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| Capanni C, Mattioli E, Columbaro M, Lucarelli E, Parnaik VK, Novelli G, Wehnert M, Cenni V, Maraldi NM, Squarzoni S, Lattanzi G.
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| Hum Mol Genet 14(11):1489-502. Epub 2005 Apr 20. 2005
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| 45 | SREBF1
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| Hyperphosphorylation regulates the activity of SREBP1 during mitosis.
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| Bengoechea-Alonso MT, Punga T, Ericsson J.
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| Proc Natl Acad Sci U S A 102(33):11681-6. Epub 2005 Aug 4. 2005
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| 46 | SREBF1, HNF4A, PPARGC1B
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| SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
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| Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, Toyoshima H, Sato R, Yamada N.
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| J Biol Chem 279(13):12027-35. Epub 2004 Jan 13. 2004
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| 47 | SREBF1
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| SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts.
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| Eberle D, Clement K, Meyre D, Sahbatou M, Vaxillaire M, Le Gall A, Ferre P, Basdevant A, Froguel P, Foufelle F.
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| Diabetes 53(8):2153-7. 2004
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| 48 | CEBPA, ADD1, SREBF1, RETN
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| Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha.
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| Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, Park SD, Kim JB.
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| Mol Endocrinol 17(8):1522-33. Epub 2003 May 1. 2003
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| 49 | FPLD2, LMNA, SREBF1
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| A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies.
|
| Lloyd DJ, Trembath RC, Shackleton S.
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| Hum Mol Genet 11(7):769-77. 2002
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| 50 | NR1H2, NR1H3, SREBF1
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| Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
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| Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N.
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| Mol Cell Biol 21(9):2991-3000. 2001
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| 51 | SCAP, SREBF1, SREBF2
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| Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes.
|
| Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ.
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| Cell 102(3):315-23. 2000
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| 52 | MBTPS1, SREBF1, SREBF2
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| Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins.
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| Cheng D, Espenshade PJ, Slaughter CA, Jaen JC, Brown MS, Goldstein JL.
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| J Biol Chem 274(32):22805-12. 1999
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| 53 | MBTPS1, SREBF1, SREBF2
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| Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.
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| DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ.
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| Cell 99(7):703-12. 1999
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| 54 | MBTPS1, SREBF1, SREBF2
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| Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.
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| Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS.
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| Mol Cell 2(4):505-14. 1998
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| 55 | SREBF1, SREBF2
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| Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).
|
| Miserez AR, et al.
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| Genomics 40 : 31-40. 1997
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| 56 | SREBF1, SREBF2
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| The SREBP pathway : regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.
|
| Brown MS, et al.
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| Cell 89 : 331-340. 1997
|
| 57 | SREBF1, SREBF2
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| Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
|
| Hua X, Sakai J, Brown MS, Goldstein JL.
|
| J Biol Chem 271(17):10379-84.
1996
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| 58 | SREBF1, SREBF2
|
| Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.
|
| Hua X, et al.
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| Genomics 25 : 667-673. 1995
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| 59 | SREBF1
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| SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
|
| Wang X, et al.
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| Cell 77 : 53-62. 1994
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| 60 | SREBF1
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| SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
|
| Yokoyama C, et al.
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| Cell 75 : 187-197. 1993
|