Citations for
1FTDALS3, NADGP, SQSTM1
Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy.
Haack TB, Ignatius E, Calvo-Garrido J, Iuso A, Isohanni P, Maffezzini C, L÷nnqvist T, Suomalainen A, Gorza M, Kremer LS, Graf E, Hartig M, Berutti R, Paucar M, Svenningsson P, Stranneheim H, Brandberg G, Wedell A, Kurian MA, Hayflick SA, Venco P, Tiranti V, Strom TM, Dichgans M, Horvath R, Holinski-Feder E, Freyer C, Meitinger T, Prokisch H, Senderek J, Wredenberg A, Carroll CJ, Klopstock T.
Am J Hum Genet 99(3):735-43. doi: 10.1016/j.ajhg.2016.06.026. Epub 2016 Aug 18. 2016
2CUL2, DCUN1D1, SQSTM1
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α.
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, Yu G, Xiao W, Xu H, Ye Z.
J Cell Sci. Feb 15;129(4):817-30. doi: 10.1242/jcs.178756. Epub 2016 Jan 7 2016
3CD40, SQSTM1, TRAF6
p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6.
Seibold K, Ehrenschwender M.
Biochem Biophys Res Commun 464(1):330-5. doi: 10.1016/j.bbrc.2015.06.153. Epub 2015 Jun 29. 2015
4HACE1, OPTN, SQSTM1
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R.
Cancer Cell 26(1):106-20. doi: 10.1016/j.ccr.2014.05.015. 2014
5AMBRA1, MAP1LC3A, SQSTM1
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.
Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M, Cecconi F.
Cell Death Differ ell Death Differ. 2014 Sep 12. doi: 10.1038/cdd.2014.139. [Epub ahead of print] 2014
6CHDH, SQSTM1
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Park S, Choi SG, Yoo SM, Son JH, Jung YK.
Autophagy 10(11). [Epub ahead of print] 2014
7BIK, SQSTM1
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S.
Mol Cell Biol 34(18):3435-49. doi: 10.1128/MCB.01383-13. Epub 2014 Jul 7. 2014
8SQSTM1
p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.
Wei H, Wang C, Croce CM, Guan JL.
Genes Dev 28(11):1204-16. doi: 10.1101/gad.237354.113. 2014
9SQSTM1
p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium.
Wang L, Cano M, Handa JT.
Biochim Biophys Acta 1843(7):1248-58. doi: 10.1016/j.bbamcr.2014.03.016. Epub 2014 Mar 22. 2014
10MAP1LC3B, SQSTM1
Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels.
Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI.
Exp Cell Res 327(2):340-52. doi: 10.1016/j.yexcr.2014.08.001. Epub 2014 Aug 14. 2014
11SESN2, SQSTM1, ULK1
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
Ro SH, Semple IA, Park H, Park H, Park HW, Kim M, Kim JS, Lee JH.
FEBS J 281(17):3816-27. doi: 10.1111/febs.12905. Epub 2014 Jul 28. 2014
12SQSTM1, TWIST1
Regulation of cell proliferation and migration by p62 through stabilization of Twist1.
Qiang L, Zhao B, Ming M, Wang N, He TC, Hwang S, Thorburn A, He YY.
Proc Natl Acad Sci U S A 111(25):9241-6. doi: 10.1073/pnas.1322913111. Epub 2014 Jun 9. 2014
13ELAVL1, SQSTM1
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.
Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K.
PLoS One 8(7):e69563. doi: 10.1371/journal.pone.0069563. Print 2013. 2013
14SQSTM1
SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity.
Yan J, Seibenhener ML, Calderilla-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, Wooten MW, Wooten MC.
PLoS One 8(9):e76016. doi: 10.1371/journal.pone.0076016. eCollection 2013. 2013
15BCL2, BECN1, SQSTM1
Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro.
Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH.
Acta Pharmacol Sin 34(5):651-6. doi: 10.1038/aps.2013.12. Epub 2013 Apr 8. 2013
16EGLN3, SQSTM1
p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation.
Rantanen K, Pursiheimo JP, H÷gel H, Miikkulainen P, Sundstr÷m J, Jaakkola PM.
J Cell Sci 126(Pt 5):1144-54. doi: 10.1242/jcs.115667. Epub 2013 Jan 23. 2013
17SQSTM1
Mutations in the gene encoding p62 in Japanese patients with amyotrophic lateral sclerosis.
Hirano M, Nakamura Y, Saigoh K, Sakamoto H, Ueno S, Isono C, Miyamoto K, Akamatsu M, Mitsui Y, Kusunoki S.
Neurology 80(5):458-63. doi: 10.1212/WNL.0b013e31827f0fe5. Epub 2013 Jan 9. 2013
18SQSTM1
p62 links β-adrenergic input to mitochondrial function and thermogenesis.
MŘller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, KŘchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tsch÷p MH.
J Clin Invest 123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21. 2013
19KEAP1, NFE2L2, SQSTM1
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.
Mol Cell 51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5. 2013
20AMER1, KEAP1, NFE2L2, SQSTM1
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4. 2013
21DRAM1, SQSTM1
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.
Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C, Salomoni P.
Oncogene 32(6):699-712. doi: 10.1038/onc.2012.111. Epub 2012 Apr 23. 2013
22FTDALS3, SQSTM1
Mutations in the gene encoding p62 in Japanese patients with amyotrophic lateral sclerosis.
Hirano M, Nakamura Y, Saigoh K, Sakamoto H, Ueno S, Isono C, Miyamoto K, Akamatsu M, Mitsui Y, Kusunoki S.
Neurology 80(5):458-63. doi: 10.1212/WNL.0b013e31827f0fe5. Epub 2013 Jan 9. 2013
23FTDALS3, SQSTM1
SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis.
Le Ber I, Camuzat A, Guerreiro R, Bouya-Ahmed K, Bras J, Nicolas G, Gabelle A, Didic M, De Septenville A, Millecamps S, Lenglet T, Latouche M, Kabashi E, Campion D, Hannequin D, Hardy J, Brice A; French Clinical and Genetic Research Network on FTD/FTD-ALS.
JAMA Neurol 70(11):1403-10. doi: 10.1001/jamaneurol.2013.3849. 2013
24SQSTM1
SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Rubino E, Rainero I, Chi˛ A, Rogaeva E, Galimberti D, Fenoglio P, Grinberg Y, Isaia G, Calvo A, Gentile S, Bruni AC, St George-Hyslop PH, Scarpini E, Gallone S, Pinessi L; TODEM Study Group.
Neurology 79(15):1556-62. doi: 10.1212/WNL.0b013e31826e25df. Epub 2012 Sep 12. 2012
25IRS1, SQSTM1
Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein.
Geetha T, Zheng C, Vishwaprakash N, Broderick TL, Babu JR.
J Biol Chem 287(35):29672-8. doi: 10.1074/jbc.M111.322404. Epub 2012 Jul 3. 2012
26NFE2L2, NQO1, SQSTM1
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J.
EMBO Rep 13(2):150-6. doi: 10.1038/embor.2011.246. 2012
27SQSTM1, TRIM13, ZFYVE1
TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.
Tomar D, Singh R, Singh AK, Pandya CD, Singh R.
Biochim Biophys Acta 1823(2):316-26. doi: 10.1016/j.bbamcr.2011.11.015. Epub 2011 Dec 8. 2012
28FTDALS3, SQSTM1
SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Rubino E, Rainero I, Chi˛ A, Rogaeva E, Galimberti D, Fenoglio P, Grinberg Y, Isaia G, Calvo A, Gentile S, Bruni AC, St George-Hyslop PH, Scarpini E, Gallone S, Pinessi L; TODEM Study Group.
Neurology 79(15):1556-62. doi: 10.1212/WNL.0b013e31826e25df. Epub 2012 Sep 12. 2012
29SQSTM1, USP36
The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
Taillebourg E, Gregoire I, Viargues P, Jacomin AC, Thevenon D, Faure M, Fauvarque MO.
Autophagy 8(5):767-79. doi: 10.4161/auto.19381. Epub 2012 May 1. 2012
30PDB3, SQSTM1
A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.
Daroszewska A, van 't Hof RJ, Rojas JA, Layfield R, Landao-Basonga E, Rose L, Rose K, Ralston SH.
Hum Mol Genet 20(14):2734-44. Epub 2011 Apr 21. 2011
31SQSTM1
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.
Fecto F, Yan J, Vemula SP, Liu E, Yang Y, Chen W, Zheng JG, Shi Y, Siddique N, Arrat H, Donkervoort S, Ajroud-Driss S, Sufit RL, Heller SL, Deng HX, Siddique T.
Arch Neurol 68(11):1440-6. doi: 10.1001/archneurol.2011.250. 2011
32MTOR, RPTOR, SQSTM1
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT.
Mol Cell 44(1):134-46. doi: 10.1016/j.molcel.2011.06.038. 2011
33FTDALS3, SQSTM1
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.
Fecto F, Yan J, Vemula SP, Liu E, Yang Y, Chen W, Zheng JG, Shi Y, Siddique N, Arrat H, Donkervoort S, Ajroud-Driss S, Sufit RL, Heller SL, Deng HX, Siddique T.
Arch Neurol 68(11):1440-6. doi: 10.1001/archneurol.2011.250. 2011
34CALCOCO2, SQSTM1
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.
Cemma M, Kim PK, Brumell JH.
Autophagy 7(3):341-5. 2011
35MAP3K3, SQSTM1
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.
Nakamura K, Kimple AJ, Siderovski DP, Johnson GL.
J Biol Chem 285(3):2077-89. Epub 2009 Nov 10.PMID: 19903815 2010
36SQSTM1
Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.
Pankiv S, Lamark T, Bruun JA, ěvervatn A, Bj°rk°y G, Johansen T.
J Biol Chem 285(8):5941-53. Epub 2009 Dec 15. 2010
37BNIP3L, CALR, CLTC, GABARAP, NBR1, SQSTM1
Atg8-family interacting motif crucial for selective autophagy.
Noda NN, Ohsumi Y, Inagaki F.
FEBS Lett 584(7):1379-85. Epub 2010 Jan 17. Review.PMID: 20083108 2010
38NBR1, SQSTM1
Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, Jovanovic JV, Xavier GM, Kashima TG, Cobourne MT, Richards GO, Sharpe PT, Skerry TM, Grigoriadis AE, Solomon E.
Proc Natl Acad Sci U S A 107(29):12913-8. Epub 2010 Jun 29.PMID: 20616007 2010
39SQSTM1, WDFY3
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, ěvervatn A, Stenmark H, Bj°rk°y G, Simonsen A, Johansen T.
Autophagy 6(3):330-44. Epub 2010 Apr 11. 2010
40PDB3, SQSTM1, WDFY3
Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts.
Hocking LJ, Mellis DJ, McCabe PS, Helfrich MH, Rogers MJ.
Biochem Biophys Res Commun 402(3):543-8. Epub 2010 Oct 29. 2010
41NBR1, SQSTM1
NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.
Kirkin V, Lamark T, Johansen T, Dikic I.
Autophagy 5(5):732-3. Epub 2009 Jul 30. 2009
42SQSTM1
Conformation and dynamics of the three-helix bundle UBA domain of p62 from experiment and simulation.
Evans CL, Long JE, Gallagher TR, Hirst JD, Searle MS.
Proteins 71(1):227-40. 2008
43PDB3, SQSTM1
A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment.
Hiruma Y, Kurihara N, Subler MA, Zhou H, Boykin CS, Zhang H, Ishizuka S, Dempster DW, Roodman GD, Windle JJ.
Hum Mol Genet 17(23):3708-19. Epub 2008 Sep 2. 2008
44SQSTM1
Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1.
Kawai K, Saito A, Sudo T, Osada H.
J Biochem 143(6):765-72. Epub 2008 Feb 22.PMID: 18296712 2008
45PDB3, SQSTM1
Paget's disease of bone in the French population: novel SQSTM1 mutations, functional analysis, and genotype-phenotype correlations.
Collet C, Michou L, Audran M, Chasseigneaux S, Hilliquin P, Bardin T, Lemaire I, CornÚlis F, Launay JM, Orcel P, Laplanche JL.
J Bone Miner Res 22(2):310-7. 2007
46PDB3, SQSTM1
Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.
Kurihara N, Hiruma Y, Zhou H, Subler MA, Dempster DW, Singer FR, Reddy SV, Gruber HE, Windle JJ, Roodman GD.
J Clin Invest 117(1):133-42. Epub 2006 Dec 21. 2007
47SQSTM1, PDB3
A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.
Rea SL, Walsh JP, Ward L, Yip K, Ward BK, Kent GN, Steer JH, Xu J, Ratajczak T.
J Bone Miner Res 21(7):1136-45. 2006
48PDB3, SQSTM1
Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget's disease of bone.
Morissette J, Laurin N, Brown JP.
J Bone Miner Res 21 Suppl 2:P38-44. 2006
49PDB3, SQSTM1
Clinical and cellular phenotypes associated with sequestosome 1 (SQSTM1) mutations.
Leach RJ, Singer FR, Ench Y, Wisdom JH, Pina DS, Johnson-Pais TL.
J Bone Miner Res 21 Suppl 2:P45-50. 2006
50MPRM, NBR1, SQSTM1, TTN
The kinase domain of titin controls muscle gene expression and protein turnover.
Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edstrom L, Ehler E, Udd B, Gautel M.
Science 308(5728):1599-603. Epub 2005 Mar 31. 2005
51SQSTM1, PDB3
Ubiquitin-associated domain mutations of SQSTM1 in Paget's disease of bone: evidence for a founder effect in patients of British descent.
Lucas GJ, Hocking LJ, Daroszewska A, Cundy T, Nicholson GC, Walsh JP, Fraser WD, Meier C, Hooper MJ, Ralston SH.
J Bone Miner Res 20(2):227-31. Epub 2004 Nov 16. 2005
52SQSTM1, PDB3
Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.
Hocking LJ, Lucas GJ, Daroszewska A, Cundy T, Nicholson GC, Donath J, Walsh JP, Finlayson C, Cavey JR, Ciani B, Sheppard PW, Searle MS, Layfield R, Ralston SH.
J Bone Miner Res 19(7):1122-7. Epub 2004 Mar 22. 2004
53SQSTM1, PDB3
Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB).
Falchetti A, Di Stefano M, Marini F, Del Monte F, Mavilia C, Strigoli D, De Feo ML, Isaia G, Masi L, Amedei A, Cioppi F, Ghinoi V, Bongi SM, Di Fede G, Sferrazza C, Rini GB, Melchiorre D, Matucci-Cerinic M, Brandi ML.
J Bone Miner Res 19(6):1013-7. Epub 2004 Feb 2. 2004
54SQSTM1, TNFRSF11A, TNFRSF11B
Genetic regulation of osteoclast development and function.
Teitelbaum SL, Ross FP.
Nat Rev Genet 4(8):638-49. Review. 2003
55PDB3, SQSTM1
Three novel mutations in SQSTM1 identified in familial Paget's disease of bone.
Johnson-Pais TL, Wisdom JH, Weldon KS, Cody JD, Hansen MF, Singer FR, Leach RJ.
J Bone Miner Res 18(10):1748-53. 2003
56MAPK9, PDB3, SQSTM1
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.
Laurin N, Brown JP, Morissette J, Raymond V.
Am J Hum Genet 70(6):1582-8. 2002
57SQSTM1
Mallory body--a disease-associated type of sequestosome.
Stumptner C, Fuchsbichler A, Heid H, Zatloukal K, Denk H.
Hepatology 35(5):1053-62. 2002
58PDB3, SQSTM1
Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease.
Hocking LJ, Lucas GJ, Daroszewska A, Mangion J, Olavesen M, Cundy T, Nicholson GC, Ward L, Bennett ST, Wuyts W, Van Hul W, Ralston SH.
Hum Mol Genet 11(22):2735-9. 2002
59SQSTM1
Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein.
Vadlamudi RK, Shin J.
FEBS Lett 435(2-3):138-42. 1998
60EBI3, SQSTM1
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.
Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M.
J Virol 70(2):1143-53. 1996
61SQSTM1
Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain.
Joung I, Strominger JL, Shin J.
Proc Natl Acad Sci U S A 93(12):5991-5. 1996
62SQSTM1
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.
Vadlamudi RK, Joung I, Strominger JL, Shin J.
J Biol Chem 271(34):20235-7. 1996