| 1 | OSBPL2, SQLE
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| OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
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| Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X.
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| Exp Cell Res 383(2):111512. doi: 10.1016/j.yexcr.2019.111512. Epub 2019 Jul 26.
2019
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| 2 | MARCHF6, SQLE
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| Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.
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| Chua NK, Hart-Smith G, Brown AJ.
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| J Biol Chem 294(20):8134-8147. doi: 10.1074/jbc.RA119.007798. Epub 2019 Apr 2.
2019
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| 3 | SQLE
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| The shape of human squalene epoxidase expands the arsenal against cancer.
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| Brown AJ, Chua NK, Yan N.
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| Nat Commun 10(1):888. doi: 10.1038/s41467-019-08866-y. Review.
2019
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| 4 | SQLE
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| Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling.
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| Ge H, Zhao Y, Shi X, Tan Z, Chi X, He M, Jiang G, Ji L, Li H.
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| Thorac Cancer 10(3):428-436. doi: 10.1111/1759-7714.12944. Epub 2019 Feb 7.
2019
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| 5 | SQLE
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| Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
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| Padyana AK, Gross S, Jin L, Cianchetta G, Narayanaswamy R, Wang F, Wang R, Fang C, Lv X, Biller SA, Dang L, Mahoney CE, Nagaraja N, Pirman D, Sui Z, Popovici-Muller J, Smolen GA.
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| Nat Commun 10(1):97. doi: 10.1038/s41467-018-07928-x.
2019
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| 6 | SQLE
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| A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.
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| Chua NK, Howe V, Jatana N, Thukral L, Brown AJ.
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| J Biol Chem 292(49):19959-19973. doi: 10.1074/jbc.M117.794230. Epub 2017 Sep 27.
2017
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| 7 | HMGCR, SQLE
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| New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.
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| Howe V, Sharpe LJ, Prabhu AV, Brown AJ.
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| Biochim Biophys Acta Mol Cell Biol Lipids 1862(7):647-657. doi: 10.1016/j.bbalip.2017.03.009. Epub 2017 Mar 23.
2017
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| 8 | SQLE
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| The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.
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| Howe V, Chua NK, Stevenson J, Brown AJ.
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| J Biol Chem 290(46):27533-44. doi: 10.1074/jbc.M115.675181. Epub 2015 Oct 3.
2015
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| 9 | HMGCR, MARCHF6, SQLE
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| The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
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| Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook EC, Phan L, Stevenson J, Brown AJ.
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| Mol Cell Biol 34(7):1262-70. doi: 10.1128/MCB.01140-13. Epub 2014 Jan 21.
2014
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| 10 | SQLE
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| Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.
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| Stevenson J, Luu W, Kristiana I, Brown AJ.
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| Biochem J 461(3):435-42. doi: 10.1042/BJ20131404.
2014
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| 11 | SQLE
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| Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.
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| Helms MW, Kemming D, Pospisil H, Vogt U, Buerger H, Korsching E, Liedtke C, Schlotter CM, Wang A, Chan SY, Brandt BH.
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| Br J Cancer 99(5):774-80. Epub 2008 Aug 12.
2008
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| 12 | SQLE
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| Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.
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| Li L, Porter TD.
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| Arch Biochem Biophys 461(1):76-84. Epub 2007 Mar 2.
2007
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| 13 | SQLE
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| Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y.
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| Murphy C, Ledmyr H, Ehrenborg E, Gåfvels M.
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| Biochim Biophys Acta 1761(10):1213-27. Epub 2006 Sep 1.
2006
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| 14 | SEC14L2, SQLE
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| Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase.
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| Singh DK, Mokashi V, Elmore CL, Porter TD.
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| J Biol Chem 278(8):5646-51. Epub 2002 Nov 25.
2003
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| 15 | SQLE
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| SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase.
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| Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T.
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| Biochem Biophys Res Commun 295(1):74-80. 2002
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| 16 | SQLE
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| Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.
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| Laden BP, Tang Y, Porter TD.
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| Arch Biochem Biophys 374(2):381-8. 2000
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| 17 | SQLE
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| Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1.
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| Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T.
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| Genomics 44(1):141-3. 1997
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