Citations for
1KHSRP, SPRY4
K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer.
Bikkavilli RK, Zerayesus SA, Van Scoyk M, Wilson L, Wu PY, Baskaran A, Tang K, Raheem S, Samuelson BA, Reddy NM, Reddy SP, Cool CD, Kosmider B, Avasarala S, Winn RA.
J Biol Chem 292(18):7423-7434. doi: 10.1074/jbc.M116.757906. Epub 2017 Mar 8. 2017
2DUSP6, FGF17, FLRT3, IL17RD, SPRY4
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism.
Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N.
Am J Hum Genet 92(5):725-43. doi: 10.1016/j.ajhg.2013.04.008. 2013
3ATF7IP, BAK1, DMRT1, KITLG, SPRY4, TERT
Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.
Karlsson R, Andreassen KE, Kristiansen W, Aschim EL, Bremnes RM, Dahl O, Fossĺ SD, Klepp O, Langberg CW, Solberg A, Tretli S, Magnusson PK, Adami HO, Haugen TB, Grotmol T, Wiklund F.
Hum Mol Genet 22(16):3373-80. doi: 10.1093/hmg/ddt188. Epub 2013 May 2. 2013
4ITGB3, SPRY4
Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.
Gong Y, Yang X, He Q, Gower L, Prudovsky I, Vary CP, Brooks PC, Friesel RE.
Angiogenesis 16(4):861-75. doi: 10.1007/s10456-013-9361-x. Epub 2013 Aug 17. 2013
5SPRY1, SPRY2, SPRY4
Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.
Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA.
Development 138(14):2957-68. 2011
6SPRY1, SPRY2, SPRY3, SPRY4
Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway.
Zaremba A, Schmuecker U, Esche H.
Virol J 8:192. 2011
7SPRY4
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Labalette C, Bouchoucha YX, Wassef MA, Gongal PA, Le Men J, Becker T, Gilardi-Hebenstreit P, Charnay P.
Development 138(2):317-26. 2011
8SPRY4
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
Tennis MA, Van Scoyk MM, Freeman SV, Vandervest KM, Nemenoff RA, Winn RA.
Mol Cancer Res 8(6):833-43. Epub 2010 May 25. 2010
9SPRY4
Sprouty4 levels are increased under hypoxic conditions by enhanced mRNA stability and transcription.
Haigl B, Mayer CE, Siegwart G, Sutterlüty H.
Biol Chem 391(7):813-21. 2010
10SPRY4
Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis.
Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A.
Oncogene 28(8):1076-88. Epub 2009 Jan 12. 2009
11KITLG, SPRY4
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn DJ, Letrero R, Ciosek SL, Doody DR, Smith LM, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Reilly MP, Hakonarson H, Schwartz SM, Nathanson KL.
Nat Genet 41(7):811-5. Epub 2009 May 31. 2009
12FGFR3, SPRY4
Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum.
Lievens PM, Zanolli E, Garofalo S, Liboi E.
FEBS Lett 583(19):3254-8. Epub 2009 Sep 15.PMID: 19761767 2009
13SPRY4
Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum.
Lievens PM, Zanolli E, Garofalo S, Liboi E.
FEBS Lett 583(19):3254-8. Epub 2009 Sep 15. 2009
14SPRY4
Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.
Taniguchi K, Ishizaki T, Ayada T, Sugiyama Y, Wakabayashi Y, Sekiya T, Nakagawa R, Yoshimura A.
Cancer Sci 100(9):1648-54. Epub 2009 May 12. 2009
15SPRY2, SPRY4
Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.
Taniguchi K, Ayada T, Ichiyama K, Kohno R, Yonemitsu Y, Minami Y, Kikuchi A, Maehara Y, Yoshimura A.
Biochem Biophys Res Commun 352(4):896-902. Epub 2006 Dec 1. 2007
16SPRY4
FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells.
Katoh Y, Katoh M.
Int J Mol Med 17(3):529-32. 2006
17SPRY4
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.
Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B.
Prostate 66(6):613-24. 2006
18SPRY1, SPRY2, SPRY3, SPRY4, CAV1
A functional interaction between sprouty proteins and caveolin-1.
Cabrita MA, JŠggi F, Widjaja SP, Christofori G.
J Biol Chem 281(39):29201-12. Epub 2006 Jul 28. 2006
19TESK1, SPRY4
Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.
Tsumura Y, Toshima J, Leeksma OC, Ohashi K, Mizuno K.
Biochem J 387(Pt 3):627-37. 2005
20SPRY4
Assignment of human sprouty 4 gene to chromosome segment 5q32 approximately 33 and analysis of its pattern of expression.
Liu H, Chen JZ, Gu SH, Dai JL, Zhao EP, Huang L, Xu WX, Xie Y, Mao YM.
J Genet 82(1-2):23-6. 2003
21SPRY4
Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.
Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ.
Eur J Biochem 269(10):2546-56. 2002