1 | KHSRP, SPRY4
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| K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer.
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| Bikkavilli RK, Zerayesus SA, Van Scoyk M, Wilson L, Wu PY, Baskaran A, Tang K, Raheem S, Samuelson BA, Reddy NM, Reddy SP, Cool CD, Kosmider B, Avasarala S, Winn RA.
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| J Biol Chem 292(18):7423-7434. doi: 10.1074/jbc.M116.757906. Epub 2017 Mar 8.
2017
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2 | DUSP6, FGF17, FLRT3, HH20, HH21, IL17RD, SPRY4
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| Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism.
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| Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N.
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| Am J Hum Genet 92(5):725-43. doi: 10.1016/j.ajhg.2013.04.008. 2013
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3 | ATF7IP, BAK1, DMRT1, KITLG, SPRY4, TERT
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| Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.
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| Karlsson R, Andreassen KE, Kristiansen W, Aschim EL, Bremnes RM, Dahl O, Fossĺ SD, Klepp O, Langberg CW, Solberg A, Tretli S, Magnusson PK, Adami HO, Haugen TB, Grotmol T, Wiklund F.
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| Hum Mol Genet 22(16):3373-80. doi: 10.1093/hmg/ddt188. Epub 2013 May 2.
2013
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4 | ITGB3, SPRY4
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| Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.
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| Gong Y, Yang X, He Q, Gower L, Prudovsky I, Vary CP, Brooks PC, Friesel RE.
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| Angiogenesis 16(4):861-75. doi: 10.1007/s10456-013-9361-x. Epub 2013 Aug 17.
2013
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5 | SPRY1, SPRY2, SPRY4
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| Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.
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| Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA.
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| Development 138(14):2957-68.
2011
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6 | SPRY1, SPRY2, SPRY3, SPRY4
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| Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway.
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| Zaremba A, Schmuecker U, Esche H.
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| Virol J 8:192.
2011
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7 | SPRY4
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| Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
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| Labalette C, Bouchoucha YX, Wassef MA, Gongal PA, Le Men J, Becker T, Gilardi-Hebenstreit P, Charnay P.
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| Development 138(2):317-26.
2011
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8 | SPRY4
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| Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
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| Tennis MA, Van Scoyk MM, Freeman SV, Vandervest KM, Nemenoff RA, Winn RA.
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| Mol Cancer Res 8(6):833-43. Epub 2010 May 25.
2010
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9 | SPRY4
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| Sprouty4 levels are increased under hypoxic conditions by enhanced mRNA stability and transcription.
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| Haigl B, Mayer CE, Siegwart G, Sutterlüty H.
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| Biol Chem 391(7):813-21.
2010
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10 | SPRY4
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| Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis.
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| Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A.
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| Oncogene 28(8):1076-88. Epub 2009 Jan 12.
2009
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11 | KITLG, SPRY4
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| Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
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| Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn DJ, Letrero R, Ciosek SL, Doody DR, Smith LM, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Reilly MP, Hakonarson H, Schwartz SM, Nathanson KL.
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| Nat Genet 41(7):811-5. Epub 2009 May 31.
2009
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12 | FGFR3, SPRY4
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| Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum.
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| Lievens PM, Zanolli E, Garofalo S, Liboi E.
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| FEBS Lett 583(19):3254-8. Epub 2009 Sep 15.PMID: 19761767 2009
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13 | SPRY4
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| Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum.
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| Lievens PM, Zanolli E, Garofalo S, Liboi E.
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| FEBS Lett 583(19):3254-8. Epub 2009 Sep 15.
2009
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14 | SPRY4
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| Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.
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| Taniguchi K, Ishizaki T, Ayada T, Sugiyama Y, Wakabayashi Y, Sekiya T, Nakagawa R, Yoshimura A.
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| Cancer Sci 100(9):1648-54. Epub 2009 May 12.
2009
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15 | SPRY2, SPRY4
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| Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.
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| Taniguchi K, Ayada T, Ichiyama K, Kohno R, Yonemitsu Y, Minami Y, Kikuchi A, Maehara Y, Yoshimura A.
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| Biochem Biophys Res Commun 352(4):896-902. Epub 2006 Dec 1.
2007
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16 | SPRY4
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| FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells.
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| Katoh Y, Katoh M.
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| Int J Mol Med 17(3):529-32. 2006
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17 | SPRY4
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| Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.
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| Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B.
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| Prostate 66(6):613-24. 2006
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18 | SPRY1, SPRY2, SPRY3, SPRY4, CAV1
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| A functional interaction between sprouty proteins and caveolin-1.
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| Cabrita MA, Jggi F, Widjaja SP, Christofori G.
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| J Biol Chem 281(39):29201-12. Epub 2006 Jul 28. 2006
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19 | TESK1, SPRY4
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| Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.
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| Tsumura Y, Toshima J, Leeksma OC, Ohashi K, Mizuno K.
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| Biochem J 387(Pt 3):627-37. 2005
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20 | SPRY4
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| Assignment of human sprouty 4 gene to chromosome segment 5q32 approximately 33 and analysis of its pattern of expression.
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| Liu H, Chen JZ, Gu SH, Dai JL, Zhao EP, Huang L, Xu WX, Xie Y, Mao YM.
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| J Genet 82(1-2):23-6. 2003
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21 | SPRY4
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| Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.
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| Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ.
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| Eur J Biochem 269(10):2546-56. 2002
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