Citations for
1ERBB2, PERP, SPRY2
ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells.
Khan IA, Yoo BH, Masson O, Baron S, Corkery D, Dellaire G, Attardi LD, Rosen KV.
Oncogene 35(44):5759-5769. doi: 10.1038/onc.2016.109. Epub 2016 Apr 25. 2016
2ERRFI1, SPRY2
Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cells.
Walsh AM, Lazzara MJ.
J Cell Sci 126(Pt 19):4339-48. doi: 10.1242/jcs.123208. Epub 2013 Jul 18. 2013
3SPRY2
Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling.
Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S.
Biochem Biophys Res Commun 404(4):1076-82. Epub 2010 Dec 30. 2011
4SPRY1, SPRY2, SPRY4
Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.
Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA.
Development 138(14):2957-68. 2011
5SPRY1, SPRY2
Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.
Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V.
Invest Ophthalmol Vis Sci 52(9):6887-97. Print 2011 Aug. 2011
6SPRY1, SPRY2, SPRY3, SPRY4
Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway.
Zaremba A, Schmuecker U, Esche H.
Virol J 8:192. 2011
7CRKL, SPRY1, SPRY2
CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling.
Satoh T, Torii S, Nakayama K, Nishida E.
Genes Cells enes Cells. 2010 Feb 3. [Epub ahead of print]PMID: 20136656 2010
8SPRY2, ZEB1
SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity.
Barbáchano A, Ordóñez-Morán P, García JM, Sánchez A, Pereira F, Larriba MJ, Martínez N, Hernández J, Landolfi S, Bonilla F, Pálmer HG, Rojas JM, Muñoz A.
Oncogene 29(34):4800-13. Epub 2010 Jun 14. 2010
9NEDD4, SPRY1, SPRY2
HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.
Edwin F, Anderson K, Patel TB.
J Biol Chem 285(1):255-64. Epub 2009 Oct 28. 2010
10DEL13Q32, EFNB2, GPC5, SPRY2, ZIC2
Twelve new patients with 13q deletion syndrome: genotype-phenotype analyses in progress.
Quélin C, Bendavid C, Dubourg C, de la Rochebrochard C, Lucas J, Henry C, Jaillard S, Loget P, Loeuillet L, Lacombe D, Rival JM, David V, Odent S, Pasquier L.
Eur J Med Genet 52(1):41-6. Epub 2008 Oct 31. 2009
11AKT1, MDM2, RAC1, SPRY2
Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts.
Lito P, Mets BD, Appledorn DM, Maher VM, McCormick JJ.
J Biol Chem 284(2):848-54. Epub 2008 Nov 13. 2009
12SPRY2
Evidence That Sprouty 2 Is Necessary for Sarcoma Formation by H-Ras Oncogene-transformed Human Fibroblasts.
Lito P, Mets BD, Kleff S, O'Reilly S, Maher VM, McCormick JJ.
J Biol Chem 283(4):2002-9. Epub 2007 Nov 28. 2008
13SPRY2
A novel role of Sprouty 2 in regulating cellular apoptosis.
Edwin F, Patel TB.
J Biol Chem 283(6):3181-90. Epub 2007 Dec 10. 2008
14EGLN3, SIAH2, SPRY2
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways.
Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z.
Proc Natl Acad Sci U S A 105(43):16713-8. Epub 2008 Oct 22. 2008
15DYRK1A, SPRY2
Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.
Aranda S, Alvarez M, Turró S, Laguna A, de la Luna S.
Mol Cell Biol 28(19):5899-911. Epub 2008 Aug 4. 2008
16SPRY2, TESK1
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Chandramouli S, Yu CY, Yusoff P, Lao DH, Leong HF, Mizuno K, Guy GR.
J Biol Chem 283(3):1679-91. Epub 2007 Nov 1. 2008
17BDNF, SPRY2
Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.
Gross I, Armant O, Benosman S, de Aguilar JL, Freund JN, Kedinger M, Licht JD, Gaiddon C, Loeffler JP.
Cell Death Differ 14(10):1802-12. Epub 2007 Jun 29. 2007
18FGF10, SPRY2
FGF 10 and Sprouty 2 modulate trophoblast invasion and branching morphogenesis.
Natanson-Yaron S, Anteby EY, Greenfield C, Goldman-Wohl D, Hamani Y, Hochner-Celnikier D, Yagel S.
Mol Hum Reprod 13(7):511-9. Epub 2007 May 12. 2007
19SPRY2, SPRY4
Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.
Taniguchi K, Ayada T, Ichiyama K, Kohno R, Yonemitsu Y, Minami Y, Kikuchi A, Maehara Y, Yoshimura A.
Biochem Biophys Res Commun 352(4):896-902. Epub 2006 Dec 1. 2007
20FGF6, SPRY2
Sprouty gene expression is regulated by nerve and FGF6 during regeneration of mouse muscles.
Laziz I, Armand AS, Pariset C, Lecolle S, Della Gaspera B, Charbonnier F, Chanoine C.
Growth Factors 25(3):151-9. 2007
21PTEN, SPRY2
The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.
Edwin F, Singh R, Endersby R, Baker SJ, Patel TB.
J Biol Chem 281(8):4816-22. Epub 2005 Dec 21. 2006
22SPRY2
Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma.
Fong CW, Chua MS, McKie AB, Ling SH, Mason V, Li R, Yusoff P, Lo TL, Leung HY, So SK, Guy GR.
Cancer Res 66(4):2048-58. 2006
23MKNK1, SPRY2
Regulation of sprouty stability by Mnk1-dependent phosphorylation.
DaSilva J, Xu L, Kim HJ, Miller WT, Bar-Sagi D.
Mol Cell Biol 26(5):1898-907. 2006
24FGF9, SPRY2
Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis.
Chi L, ItŠranta P, Zhang S, Vainio S.
Endocrinology 147(8):3777-88. Epub 2006 May 4. 2006
25SPRY1, SPRY2, SPRY3, SPRY4, CAV1
A functional interaction between sprouty proteins and caveolin-1.
Cabrita MA, JŠggi F, Widjaja SP, Christofori G.
J Biol Chem 281(39):29201-12. Epub 2006 Jul 28. 2006
26SPRY2
Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer.
McKie AB, Douglas DA, Olijslagers S, Graham J, Omar MM, Heer R, Gnanapragasam VJ, Robson CN, Leung HY.
Oncogene 24(13):2166-74. 2005
27SPRY2
Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2.
Zhang C, Chaturvedi D, Jaggar L, Magnuson D, Lee JM, Patel TB.
Arterioscler Thromb Vasc Biol 25(3):533-8. Epub 2005 Jan 13. 2005
28SPRY2
Expression and regulation of Sprouty-2 in the granulosa-lutein cells of the corpus luteum.
Haimov-Kochman R, Ravhon A, Prus D, Greenfield C, Finci-Yeheskel Z, S Goldman-Wohl D, Natanson-Yaron S, Reich R, Yagel S, Hurwitz A.
Mol Hum Reprod 11(8):537-42. Epub 2005 Aug 26. 2005
29FGF8, SPRY1, SPRY2
Regulation and function of FGF8 in patterning of midbrain and anterior hindbrain.
Mason I, Chambers D, Shamim H, Walshe J, Irving C.
Biochem Cell Biol 78(5):577-84. 2000
30SPRY1, SPRY2, SPRY3, SPRY3Y
sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.
Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA.
Cell 92(2):253-63. 1998