| 1 | ACTR2, CEBPB, MMD, SPRED2
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| Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis.
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| Wang NN, Zhang Y, Jiang F, Zhu DL, Di CX, Hu SY, Chen XF, Zhi LQ, Rong Y, Ke X, Duan YY, Dong SS, Yang TL, Yang Z, Guo Y.
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| Am J Hum Genet. Apr 6;110(4):625-637. doi: 10.1016/j.ajhg.2023.02.012. Epub 2023 Mar 15. 2023
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| 2 | NNL4, SPRED2
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| SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype
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| Motta M, Fasano G, Gredy S, Brinkmann J, Bonnard AA, Simsek-Kiper PO, Gulec EY, Essaddam L, Utine GE, Guarnetti Prandi I, Venditti M, Pantaleoni F, Radio FC, Ciolfi A, Petrini S, Consoli F, Vignal C, Hepbasli D, Ullrich M, de Boer E, Vissers LELM, Gritli S, Rossi C, De Luca A, Ben Becher S, Gelb BD, Dallapiccola B, Lauri A, Chillemi G, Schuh K, Cavé H, Zenker M, Tartaglia M.
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| Am J Hum Genet. Nov 4;108(11):2112-2129. doi: 10.1016/j.ajhg.2021.09.007. Epub 2021 Oct 8. 2021
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| 3 | SPRED1, SPRED2
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| The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis.
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| Wazin F, Lovicu FJ.
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| Exp Eye Res. Feb;191:107917. doi: 10.1016/j.exer.2020.107917. Epub 2020 Jan 7. 2020
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| 4 | SPRED1, SPRED2
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| Spred negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation.
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| Susanto A, Zhao G, Wazin F, Feng Y, Rasko JEJ, Bailey CG, Lovicu FJ.
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| Exp Eye Res 178:160-175. doi: 10.1016/j.exer.2018.09.019. Epub 2018 Oct 2.
2019
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| 5 | SPRED2
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| SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy
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| Ullrich M, Aßmus B, Augustin AM, Häbich H, Abeßer M, Martin Machado J, Werner F, Erkens R, Arias-Loza AP, Umbenhauer S, Wagner H, Benz PM, Unger A, Linke WA, Frantz S, Baba HA, Kuhn M, Schuh K.
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| J Mol Cell Cardiol. Apr;129:13-26. doi: 10.1016/j.yjmcc.2019.01.023. Epub 2019 Feb 13. 2019
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| 6 | SPRED2
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| A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation.
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| Takahashi S, Yoshimura T, Ohkura T, Fujisawa M, Fushimi S, Ito T, Itakura J, Hiraoka S, Okada H, Yamamoto K, Matsukawa A.
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| Sci Rep. Nov 21;6:37531. doi: 10.1038/srep37531. 2016
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| 7 | SPRED2
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| Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice
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| Xu Y, Ito T, Fushimi S, Takahashi S, Itakura J, Kimura R, Sato M, Mino M, Yoshimura A, Matsukawa A.
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| PLoS One. Oct 2;9(9):e108914. doi: 10.1371/journal.pone.0108914. 2014
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| 8 | SPRED2
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| Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.
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| Ullrich M, Bundschu K, Benz PM, Abesser M, Freudinger R, Fischer T, Ullrich J, Renné T, Walter U, Schuh K.
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| J Biol Chem 286(11):9477-88. Epub 2011 Jan 3.
2011
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| 9 | DYRK1A, SPRED1, SPRED2
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| Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.
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| Li D, Jackson RA, Yusoff P, Guy GR.
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| J Biol Chem 285(46):35374-85. Epub 2010 Aug 24. 2010
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| 10 | SPRED2
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| Spred2 expression during mouse development.
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| Tuduce IL, Schuh K, Bundschu K.
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| Dev Dyn 239(11):3072-85.
2010
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| 11 | NBR1, SPRED2
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| Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
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| Mardakheh FK, Yekezare M, Machesky LM, Heath JK.
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| J Cell Biol 187(2):265-77. Epub 2009 Oct 12.PMID: 19822672 2009
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| 12 | SPRED2
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| Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.
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| Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS.
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| Biochem Biophys Res Commun 351(4):1018-23. Epub 2006 Nov 3.
2006
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| 13 | SPRED2
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| Tissue-specific Spred-2 promoter activity characterized by a gene trap approach.
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| Bundschu K, Gattenlöhner S, Knobeloch KP, Walter U, Schuh K.
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| Gene Expr Patterns 6(3):247-55. Epub 2005 Dec 27.
2006
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| 14 | SPRED1, SPRED2, SPRED3
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| Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.
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| Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS.
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| Biochem Biophys Res Commun 351(4):1018-23. Epub 2006 Nov 3.
2006
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| 15 | SPRED1, SPRED2
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| Distinct requirements for the Sprouty domain for functional activity of Spred proteins.
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| King JA, Straffon AF, D'Abaco GM, Poon CL, I ST, Smith CM, Buchert M, Corcoran NM, Hall NE, Callus BA, Sarcevic B, Martin D, Lock P, Hovens CM.
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| Biochem J 388(Pt 2):445-54. 2005
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| 16 | SPRED2
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| Gene disruption of Spred-2 causes dwarfism.
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| Bundschu K, Knobeloch KP, Ullrich M, Schinke T, Amling M, Engelhardt CM, Renne T, Walter U, Schuh K.
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| J Biol Chem 280(31):28572-80. Epub 2005 Jun 9. 2005
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| 17 | SPRED1, SPRED2
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| The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.
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| Miyoshi K, Wakioka T, Nishinakamura H, Kamio M, Yang L, Inoue M, Hasegawa M, Yonemitsu Y, Komiya S, Yoshimura A.
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| Oncogene 23(33):5567-76.
2004
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| 18 | SPRED1, SPRED2
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| Spred is a Sprouty-related suppressor of Ras signalling.
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| Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A.
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| Nature 412(6847):647-51. 2001
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| 19 | ABCB6, ADCK2, ANAPC7, ANKRD46, ASPHD1, AVPI1, AZIN1, BRINP2, C12orf24, C14orf79, C17orf90, C17orf91, C5orf15, C9orf127, C9orf25, C9orf82, CNIH3, COG3, COG7, CREB3L1, CSRNP2, DHX29, DHX57, DLAT, EIF2B2, ERI3, FAM13C1, FAM35A, FAM54B, FLAD1, GHITM, GRIP2, GRPEL1, HMGCLL1, IP6K2, IP6K2, ITGB1BP1, KCMF1, KIFC2, LRP10, MDM1, MFN1, NAPG, NCALD, NECAB2, NIPAL4, NPTN, NTNG2, PASK, PCDHB10, PDIA6, PHPT1, PI4K2A, PNPLA2, POGK, PTOV1, RNF13, RNF41, SAC3D1, SDCBP2, SELT, SLC38A6, SLC39A3, SMURF1, SPRED2, SUCLG2, TMCO1, TMEM183A, TP53I11, TRPC4AP, TSC22D3, TUBB, TXNDC12, UTP18, WDR40A, WDR77, WSB2, ZMIZ1
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| Large-scale concatenation cDNA sequencing.
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| Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY,Wentland MA, Lennon G, Gibbs RA.
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| Genome Res 7(4):353-8. 1997
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| 20 | ADCK2, ANAPC7, ARHGAP22, AVPI1, AZIN1, C12orf24, C14orf79, C5orf15, C9orf25, CNIH3, COG3, COG7, CREB3L1, DHX29, DHX57, DLAT, DLGAP3, EIF2B2, EXOC3, FAM13C1, FAM152B, FAM35A, FAM54B, FAM89B, FLAD1, GHITM, GRPEL1, HMGCLL1, IP6K2, IPO4, ITGB1BP1, KCMF1, KIFC2, LRP10, MDM1, MFN1, NAPG, NCALD, NECAB2, NPTN, NTNG2, PASK, PCDHB10, PHPT1, PI4K2A, PNPLA2, POGK, PTOV1, RNF41, SAC3D1, SDCBP2, SELT, SEMA6C, SLC38A6, SLC39A3, SMURF1, SPRED2, STX12, SUCLG2, TAX1BP3, TMEM183A, TP53I11, TRAPPC3, TRPC4AP, TSC22D3, TUBB, TXNDC12, UTP18, WDFY3, WDR40A, WDR77, WSB2, ZMIZ1, ZNF410, ZXDC
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| A double adaptor method for improved shotgun library construction.
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| Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA.
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| Anal Biochem 236(1):107-13. 1996
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