| 1 | PCSK5, SPP1
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| Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone.
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| Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD.
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| Bone 107:45-55. doi: 10.1016/j.bone.2017.11.002. Epub 2017 Nov 7.
2018
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| 2 | CCR1, CXCR6, SPP1
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| C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma.
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| Zhu Y, Gao XM, Yang J, Xu D, Zhang Y, Lu M, Zhang Z, Sheng YY, Li JH, Yu XX, Zheng Y, Dong QZ, Qin LX.
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| Cancer Sci 109(3):710-723. doi: 10.1111/cas.13487. Epub 2018 Feb 13.
2018
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| 3 | FN1, SPP1, VTN
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| Osteogenic differentiation of mesenchymal stem cells from dental bud: Role of integrins and cadherins.
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| Di Benedetto A, Brunetti G, Posa F, Ballini A, Grassi FR, Colaianni G, Colucci S, Rossi E, Cavalcanti-Adam EA, Lo Muzio L, Grano M, Mori G.
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| Stem Cell Res 15(3):618-28. doi: 10.1016/j.scr.2015.09.011.
2015
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| 4 | FOXC2, SPP1
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| Inorganic phosphate induces cancer cell mediated angiogenesis dependent on forkhead box protein C2 (FOXC2) regulated osteopontin expression.
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| Lin Y, McKinnon KE, Ha SW, Beck GR Jr.
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| Mol Carcinog ol Carcinog. 2014 Apr 2. doi: 10.1002/mc.22153. [Epub ahead of print]
2014
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| 5 | SPP1, TGM2
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| Identification of transglutaminase reactive residues in human osteopontin and their role in polymerization.
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| Christensen B, Zachariae ED, Scavenius C, Thybo M, Callesen MM, Kløverpris S, Oxvig C, Enghild JJ, Sørensen ES.
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| PLoS One 9(11):e113650. doi: 10.1371/journal.pone.0113650. eCollection 2014.
2014
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| 6 | APLN, EGR1, SPP1
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| Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
|
| Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ.
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| Biochem Biophys Res Commun 439(2):235-40. doi: 10.1016/j.bbrc.2013.08.051. Epub 2013 Aug 22.
2013
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| 7 | SPP1
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| C-terminal modification of osteopontin inhibits interaction with the αVβ3-integrin.
|
| Christensen B, Kläning E, Nielsen MS, Andersen MH, Sørensen ES.
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| J Biol Chem 287(6):3788-97. doi: 10.1074/jbc.M111.277996. Epub 2011 Dec 16.
2012
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| 8 | DNAJB6, GSK3B, SPP1
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| DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.
|
| Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.
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| Oncogene 31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23.
2012
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| 9 | SPP1
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| Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease.
|
| Chu M, Yang P, Hu R, Hou S, Li F, Chen Y, Kijlstra A.
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| Invest Ophthalmol Vis Sci. 52(10):7084-9. 2011
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| 10 | S100A6, SPP1
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| Specific expression of osteopontin and S100A6 in hepatocellular carcinoma.
|
| Hua Z, Chen J, Sun B, Zhao G, Zhang Y, Fong Y, Jia Z, Yao L.
|
| Surgery 149(6):783-91. doi: 10.1016/j.surg.2010.12.007. Epub 2011 Feb 18.
2011
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| 11 | ACP5, SPP1
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| Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase.
|
| Ek-Rylander B, Andersson G.
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| Exp Cell Res 316(3):443-51. Epub 2009 Oct 23.PMID: 19854170 2010
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| 12 | IFNG, IL27, SPP1
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| Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.
|
| Murugaiyan G, Mittal A, Weiner HL.
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| Proc Natl Acad Sci U S A 107(25):11495-500. Epub 2010 Jun 7.PMID: 20534530 2010
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| 13 | SPP1
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| SPP1 promoter polymorphisms and glioma risk in a Chinese Han population.
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| Chen J, Wu Q, Lu Y, Xu T, Huang Y, Ribas J, Ni X, Hu G, Huang F, Zhou L, Lu D.
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| J Hum Genet 55(7):456-61. Epub 2010 May 27.
2010
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| 14 | FBXO15, NANOG, POU5F1, SALL4, SOX15, SPP1
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| Constitutive expression of pluripotency-associated genes in mesodermal progenitor cells (MPCs).
|
| Pacini S, Carnicelli V, Trombi L, Montali M, Fazzi R, Lazzarini E, Giannotti S, Petrini M.
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| PLoS One 5(3):e9861.PMID: 20360837 2010
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| 15 | ING2, SIN3A, SPP1, TMEM71
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| Sumoylation of ING2 regulates the transcription mediated by Sin3A.
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| Ythier D, Larrieu D, Binet R, Binda O, Brambilla C, Gazzeri S, Pedeux R.
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| Oncogene 29(44):5946-56. Epub 2010 Aug 2.
2010
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| 16 | IFITM3, SPP1
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| Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression.
|
| El-Tanani MK, Jin D, Campbell FC, Johnston PG.
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| Oncogene 29(5):752-62. Epub 2009 Nov 9.
2010
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| 17 | SPP1
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| Protective role of osteopontin in endodontic infection.
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| Rittling SR, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H.
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| Immunology. 129(1):105-14 2010
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| 18 | SPP1
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| Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells.
|
| Dai J, Peng L, Fan K, Wang H, Wei R, Ji G, Cai J, Lu B, Li B, Zhang D, Kang Y, Tan M, Qian W, Guo Y.
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| Oncogene 28(38):3412-22. Epub 2009 Jul 13.
2009
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| 19 | SPP1
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| Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblasts.
|
| Kang JA, Zhou Y, Weis TL, Liu H, Ulaszek J, Satgurunathan N, Zhou L, van Besien K, Crispino J, Verma A, Low PS, Wickrema A.
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| J Biol Chem 283(11):6997-7006. Epub 2008 Jan 3. 2008
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| 20 | SPP1
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| Osteopontin regulates development and function of invariant natural killer T cells.
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| Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T.
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| Proc Natl Acad Sci U S A 105(41):15884-9. Epub 2008 Oct 3.
2008
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| 21 | DMP1, DSPP, IBSP, MEPE, SPP1
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| Dentin matrix protein-1 isoforms promote differential cell attachment and migration.
|
| von Marschall Z, Fisher LW.
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| J Biol Chem 283(47):32730-40. Epub 2008 Sep 25.
2008
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| 22 | SDC4, SPP1
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| Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin.
|
| Kon S, Ikesue M, Kimura C, Aoki M, Nakayama Y, Saito Y, Kurotaki D, Diao H, Matsui Y, Segawa T, Maeda M, Kojima T, Uede T.
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| J Exp Med 205(1):25-33. Epub 2007 Dec 24.
2008
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| 23 | SPP1
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| A novel functional motif of osteopontin for human lymphocyte migration and survival.
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| Cao Z, Dai J, Fan K, Wang H, Ji G, Li B, Zhang D, Hou S, Qian W, Zhao J, Wang H, Guo Y.
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| Mol Immunol 45(14):3683-92. Epub 2008 Jul 15.
2008
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| 24 | SPP1
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| PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.
|
| Nakamachi T, Nomiyama T, Gizard F, Heywood EB, Jones KL, Zhao Y, Fuentes L, Takebayashi K, Aso Y, Staels B, Inukai T, Bruemmer D.
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| Diabetes 56(6):1662-70. Epub 2007 Mar 14. 2007
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| 25 | SPP1
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| Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets.
|
| Xanthou G, Alissafi T, Semitekolou M, Simoes DC, Economidou E, Gaga M, Lambrecht BN, Lloyd CM, Panoutsakopoulou V.
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| Nat Med 13(5):570-8. Epub 2007 Apr 15. 2007
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| 26 | BRMS1, SPP1
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| Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation.
|
| Samant RS, Clark DW, Fillmore RA, Cicek M, Metge BJ, Chandramouli KH, Chambers AF, Casey G, Welch DR, Shevde LA.
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| Mol Cancer 6:6.
2007
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| 27 | SPP1
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| Osteopontin promotes pathologic mineralization in articular cartilage.
|
| Rosenthal AK, Gohr CM, Uzuki M, Masuda I.
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| Matrix Biol 26(2):96-105. Epub 2006 Oct 20.
2007
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| 28 | SPP1
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| Osteopontin is required for mechanical stress-dependent signals to bone marrow cells.
|
| Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Ezura Y, Noda M.
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| J Endocrinol 193(2):235-43.
2007
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| 29 | SPP1
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| Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.
|
| Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D.
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| J Clin Invest. 117(10):2877-88. 2007
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| 30 | SPP1
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| Function and regulation of osteopontin in response to mechanical stress.
|
| Fujihara S, Yokozeki M, Oba Y, Higashibata Y, Nomura S, Moriyama K.
|
| J Bone Miner Res 21(6):956-64. 2006
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| 31 | DOCK10, POSTN, SPP1
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| Gene expression in poorly differentiated papillary thyroid carcinomas.
|
| Fluge Ø, Bruland O, Akslen LA, Lillehaug JR, Varhaug JE.
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| Thyroid 16(2):161-75.
2006
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| 32 | SPARC, SPP1, THBS3
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| Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma.
|
| Dalla-Torre CA, Yoshimoto M, Lee CH, Joshua AM, de Toledo SR, Petrilli AS, Andrade JA, Chilton-MacNeill S, Zielenska M, Squire JA.
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| BMC Cancer 6:237. 2006
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| 33 | SPP1
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| Osteopontin, a macrophage-derived matricellular glycoprotein, inhibits axon outgrowth.
|
| Kury P, Zickler P, Stoll G, Hartung HP, Jander S.
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| FASEB J 19(3):398-400. Epub 2004 Dec 29. 2005
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| 34 | MAP4K4, MAPK8, MMP9, SPP1
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| JNK1 differentially regulates osteopontin-induced nuclear factor-inducing kinase/MEKK1-dependent activating protein-1-mediated promatrix metalloproteinase-9 activation.
|
| Rangaswami H, Bulbule A, Kundu GC.
|
| J Biol Chem 280(19):19381-92. Epub 2005 Mar 9. 2005
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| 35 | SPP1
|
| Osteopontin is upregulated by BCR-ABL.
|
| Flamant S, Kortulewski T, Dugray A, Bonnet ML, Guillier M, Guilhot F, Bourhis JH, Vainchenker W, Tronik-Le Roux D, Turhan AG.
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| Biochem Biophys Res Commun 333(4):1378-84. 2005
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| 36 | IFRD1, SPP1, TCF7L2
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| TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent.
|
| Vietor I, Kurzbauer R, Brosch G, Huber LA.
|
| J Biol Chem 280(48):39795-801. Epub 2005 Oct 3. 2005
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| 37 | HNF1A, HNF1B, DPP4, ACE2, SPP1
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| Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line.
|
| Senkel S, Lucas B, Klein-Hitpass L, Ryffel GU.
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| Biochim Biophys Acta 1731(3):179-90. Epub 2005 Nov 2. 2005
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| 38 | SPP1
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| High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation.
|
| Chiocchetti A, Indelicato M, Bensi T, Mesturini R, Giordano M, Sametti S, Castelli L, Bottarel F, Mazzarino MC, Garbarini L, Giacopelli F, Valesini G, Santoro C, Dianzani I, Ramenghi U, Dianzani U.
|
| Blood 103(4):1376-82. Epub 2003 Oct 30. 2004
|
| 39 | ETV4, JUN, SPP1, CTNNB1
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| Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription.
|
| El-Tanani M, Platt-Higgins A, Rudland PS, Campbell FC.
|
| J Biol Chem 279(20):20794-806. Epub 2004 Feb 27. 2004
|
| 40 | SPP1
|
| Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.
|
| Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, Segawa T, Maeda M, Hamuro J, Nakayama T, Taniguchi M, Yagita H, Van Kaer L, Onóe K, Denhardt D, Rittling S, Uede T.
|
| Immunity. 21(4):539-50. 2004
|
| 41 | SPP1, DSPP, DMP1, IBSP
|
| Dentin matrix protein 1 is expressed in human lung cancer.
|
| Chaplet M, De Leval L, Waltregny D, Detry C, Fornaciari G, Bevilacqua G, Fisher LW, Castronovo V, Bellahcene A.
|
| J Bone Miner Res 18(8):1506-12. 2003
|
| 42 | SPP1, AGT
|
| AP-1 is involved in UTP-induced osteopontin expression in arterial smooth muscle cells.
|
| Renault MA, Jalvy S, Belloc I, Pasquet S, Sena S, Olive M, Desgranges C, Gadeau AP.
|
| Circ Res 93(7):674-81. Epub 2003 Sep 11. 2003
|
| 43 | SPP1
|
| Angiogenic activity of osteopontin-derived peptide SVVYGLR.
|
| Hamada Y, Nokihara K, Okazaki M, Fujitani W, Matsumoto T, Matsuo M, Umakoshi Y, Takahashi J, Matsuura N.
|
| Biochem Biophys Res Commun 310(1):153-7. 2003
|
| 44 | SPP1
|
| Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis.
|
| Yamamoto N, Sakai F, Kon S, Morimoto J, Kimura C, Yamazaki H, Okazaki I, Seki N, Fujii T, Uede T.
|
| J Clin Invest. 112(2):181-8. 2003
|
| 45 | SPP1
|
| Identification of the osteopontin gene as a direct target of TP53.
|
| Morimoto I, Sasaki Y, Ishida S, Imai K, Tokino T.
|
| Genes Chromosomes Cancer 33(3):270-8. 2002
|
| 46 | SPP1
|
| An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus.
|
| Forton AC, Petri MA, Goldman D, Sullivan KE.
|
| Hum Mutat 19(4):459. 2002
|
| 47 | SPP1
|
| Overexpression of osteopontin in hepatocellular carcinoma.
|
| Gotoh M, Sakamoto M, Kanetaka K, Chuuma M, Hirohashi S.
|
| Pathol Int 52(1):19-24. 2002
|
| 48 | CD44, DMP1, CFH, SPP1
|
| Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack.
|
| Jain A, Karadag A, Fohr B, Fisher LW, Fedarko NS.
|
| J Biol Chem 277(16):13700-8. 2002
|
| 49 | SPP1
|
| Osteopontin: a novel axon-regulated Schwann cell gene.
|
| Jander S, Bussini S, Neuen-Jacob E, Bosse F, Menge T, Muller HW, Stoll G.
|
| J Neurosci Res 67(2):156-66. 2002
|
| 50 | SPP1
|
| Expression of osteopontin (Eta-1) in Crohn disease of the terminal ileum.
|
| Gassler N, Autschbach F, Gauer S, Bohn J, Sido B, Otto HF, Geiger H, Obermuller N.
|
| Scand J Gastroenterol 37(11):1286-95. 2002
|
| 51 | SPP1
|
| Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation.
|
| Weber GF, Zawaideh S, Hikita S, Kumar VA, Cantor H, Ashkar S.
|
| J Leukoc Biol. 72(4):752-61. 2002
|
| 52 | SPP1
|
| The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
|
| Chabas D, Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L.
|
| Science 294(5547):1731-5. 2001
|
| 53 | IBSP, SPP1
|
| Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin.
|
| Fisher LW, Torchia DA, Fohr B, Young MF, Fedarko NS.
|
| Biochem Biophys Res Commun 280(2):460-5. 2001
|
| 54 | SPP1
|
| Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin.
|
| Bayless KJ, Davis GE.
|
| J Biol Chem 276(16):13483-9. 2001
|
| 55 | SPP1
|
| Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.
|
| Medico E, Gentile A, Lo Celso C, Williams TA, Gambarotta G, Trusolino L, Comoglio PM.
|
| Cancer Res 61(15):5861-8. 2001
|
| 56 | SPP1
|
| Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).
|
| Agnihotri R, Crawford HC, Haro H, Matrisian LM, Havrda MC, Liaw L.
|
| J Biol Chem 276(30):28261-7. 2001
|
| 57 | SPP1
|
| Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth.
|
| Nam TJ, Busby WH Jr, Rees C, Clemmons DR.
|
| Endocrinology. 141(3):1100-6. 2000
|
| 58 | SPP1
|
| Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.
|
| Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR, Denhardt DT, Glimcher MJ, Cantor H.
|
| Science. 287(5454):860-4. 2000
|
| 59 | SPP1
|
| The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.
|
| Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D.
|
| J Biol Chem. 274(51):36328-34. 1999
|
| 60 | SPP1
|
| Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption.
|
| Yoshitake H, Rittling SR, Denhardt DT, Noda M.
|
| Proc Natl Acad Sci U S A. 96(14):8156-60. 1999
|
| 61 | RUNX2, ETS1, SPP1
|
| Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues.
|
| Sato M, et al.
|
| Oncogene 17 : 1517-1525. 1998
|
| 62 | SPP1
|
| Altered wound healing in mice lacking a functional osteopontin gene (spp1).
|
| Liaw L, Birk DE, Ballas CB, Whitsitt JS, Davidson JM, Hogan BL.
|
| J Clin Invest. 101(7):1468-78. 1998
|
| 63 | SPP1
|
| Myocardial osteopontin expression is associated with left ventricular hypertrophy.
|
| Graf K, Do YS, Ashizawa N, Meehan WP, Giachelli CM, Marboe CC, Fleck E, Hsueh WA.
|
| Circulation. 96(9):3063-71. 1997
|
| 64 | IBSP, SPP1
|
| Mapping of the human and mouse bone sialoprotein and osteopontin loci.
|
| Crosby AH, et al.
|
| Mamm Genome 7 : 149-151. 1996
|
| 65 | SPP1, DGI1
|
| Genomic organization of the human osteopontin gene : exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.
|
| Crosby AH, et al.
|
| Genomics 27 : 155-160. 1995
|
| 66 | SPP1
|
| A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5.
|
| Hu DD, Lin EC, Kovach NL, Hoyer JR, Smith JW.
|
| J Biol Chem. 270(44):26232-8. 1995
|
| 67 | SPP1
|
| Structure and expression of the mRNA encoding urinary stone protein (osteopontin).
|
| Kohri K, Nomura S, Kitamura Y, Nagata T, Yoshioka K, Iguchi M, Yamate T, Umekawa T, Suzuki Y, Sinohara H, et al.
|
| J Biol Chem. 268(20):15180-4. 1993
|
| 68 | SPP1
|
| Human bone sialoprotein. Deduced protein sequence and chromosomal localization.
|
| Fisher LW, et al.
|
| J Biol Chem 265 : 2347-2351. 1990
|
| 69 | SPP1
|
| cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN).
|
| Young MF, et al.
|
| Genomics 7 : 491-502. 1990
|