Citations for
1NEDMACE, NEDMIDF, SPOP
De Novo Variants in SPOP Cause Two Clinically Distinct Neurodevelopmental Disorders
Nabais Sá MJ, El Tekle G, de Brouwer APM, Sawyer SL, Del Gaudio D, Parker MJ, Kanani F, van den Boogaard MH, van Gassen K, Van Allen MI, Wierenga K, Purcarin G, Elias ER, Begtrup A, Keller-Ramey J, Bernasocchi T, van de Wiel L, Gilissen C, Venselaar H, Pfundt R, Vissers LELM, Theurillat JP, de Vries BBA.
Am J Hum Genet. Mar 5;106(3):405-411. doi: 10.1016/j.ajhg.2020.02.001. Epub 2020 Feb 27 2020
2INF2, SPOP
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
Jin X, Wang J, Gao K, Zhang P, Yao L, Tang Y, Tang L, Ma J, Xiao J, Zhang E, Zhu J, Zhang B, Zhao SM, Li Y, Ren S, Huang H, Yu L, Wang C.
PLoS Genet 13(4):e1006748. doi: 10.1371/journal.pgen.1006748. [Epub ahead of print] 2017
3MYC, SPOP
SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.
Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N.
Oncogene ncogene. 2017 Apr 17. doi: 10.1038/onc.2017.80. [Epub ahead of print] 2017
4EGLN2, SPOP
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J.
Cancer Lett 390:11-20. doi: 10.1016/j.canlet.2017.01.003. Epub 2017 Jan 13. 2017
5SIRT2, SPOP
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
Luo J, Bao YC, Ji XX, Chen B, Deng QF, Zhou SW.
Biochem Biophys Res Commun 483(2):880-884. doi: 10.1016/j.bbrc.2017.01.027. Epub 2017 Jan 7. 2017
6GLI2, GLI3, SPOP
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.
Cai H, Liu A.
Proc Natl Acad Sci U S A 113(51):14751-14756. doi: 10.1073/pnas.1612520114. Epub 2016 Dec 5. 2016
7SPOP
SPOP promotes tumor progression via activation of β-catenin/TCF4 complex in clear cell renal cell carcinoma.
Zhao W, Zhou J, Deng Z, Gao Y, Cheng Y.
Int J Oncol 49(3):1001-8. doi: 10.3892/ijo.2016.3609. Epub 2016 Jul 6. 2016
8SENP7, SPOP
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase.
Zhu H, Ren S, Bitler BG, Aird KM, Tu Z, Skordalakes E, Zhu Y, Yan J, Sun Y, Zhang R.
Cell Rep 13(6):1183-93. doi: 10.1016/j.celrep.2015.09.083. Epub 2015 Oct 29. 2015
9ERG, SPOP
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W.
Mol Cell 59(6):917-30. doi: 10.1016/j.molcel.2015.07.026. Epub 2015 Sep 3. 2015
10SPOP
Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer.
Zuhlke KA, Johnson AM, Tomlins SA, Palanisamy N, Carpten JD, Lange EM, Isaacs WB, Cooney KA.
Prostate 74(9):983-90. doi: 10.1002/pros.22818. Epub 2014 May 6. 2014
11SPOP
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP.
Cancer Cell 25(4):455-68. doi: 10.1016/j.ccr.2014.02.007. Epub 2014 Mar 20. 2014
12SPOP
Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP.
van Geersdaele LK, Stead MA, Harrison CM, Carr SB, Close HJ, Rosbrook GO, Connell SD, Wright SC.
Acta Crystallogr D Biol Crystallogr 69(Pt 9):1677-84. doi: 10.1107/S0907444913012687. Epub 2013 Aug 15. 2013
13DZIP1, SPOP
Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling.
Schwend T, Jin Z, Jiang K, Mitchell BJ, Jia J, Yang J.
J Biol Chem 288(45):32809-20. doi: 10.1074/jbc.M113.512962. Epub 2013 Sep 26. 2013
14SPOP, SPOPL
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
Errington WJ, Khan MQ, Bueler SA, Rubinstein JL, Chakrabartty A, Privé GG.
Structure 20(7):1141-53. doi: 10.1016/j.str.2012.04.009. Epub 2012 May 24. 2012
15FOXA1, MED12, SPOP
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA.
Nat Genet 44(6):685-9. doi: 10.1038/ng.2279. 2012
16NCOA3, SPOP
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.
Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O'Malley BW.
Oncogene 30(42):4350-64. doi: 10.1038/onc.2011.151. Epub 2011 May 16. 2011
17BRMS1, CUL3, SPOP
Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex.
Kim B, Nam HJ, Pyo KE, Jang MJ, Kim IS, Kim D, Boo K, Lee SH, Yoon JB, Baek SH, Kim JH.
Biochem Biophys Res Commun 415(4):720-6. doi: 10.1016/j.bbrc.2011.10.154. Epub 2011 Nov 9. 2011
18PDX1, SPOP
Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice.
Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA.
J Clin Invest Clin Invest. 2010 Sep 1. pii: 40440. doi: 10.1172/JCI40440. [Epub ahead of print]PMID: 20811152 2010
19SPOP, SPOPL
Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.
Choo KB, Chuang TJ, Lin WY, Chang CM, Tsai YH, Huang CJ.
Gene 460(1-2):39-47. Epub 2010 Apr 22.PMID: 20399258 2010
20CUL3, SPOP
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Zhuang M, Calabrese MF, Liu J, Waddell MB, Nourse A, Hammel M, Miller DJ, Walden H, Duda DM, Seyedin SN, Hoggard T, Harper JW, White KP, Schulman BA.
Mol Cell 36(1):39-50.PMID: 19818708 2009
21GLI1, GLI2, GLI3, SPOP, SUFU
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.
Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT.
Genes Dev 23(16):1910-28. 2009
22SPOP
Repression of transcriptional activity of estrogen receptor alpha by a Cullin3/SPOP ubiquitin E3 ligase complex.
Byun B, Jung Y.
Mol Cells 25(2):289-93. Epub 2008 Mar 31.PMID: 18414007 2008
23SPOP
BTB/POZ domain of speckle-type POZ protein (SPOP) confers proapoptotic function in HeLa cells.
Byun B, Tak H, Joe CO.
Biofactors 31(3-4):165-9.PMID: 18997279 2007
24CUL3, SPOP
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
Kwon JE, La M, Oh KH, Oh YM, Kim GR, Seol JH, Baek SH, Chiba T, Tanaka K, Bang OS, Joe CO, Chung CH.
J Biol Chem 281(18):12664-72. Epub 2006 Mar 8.PMID: 16524876 2006
25SPOP
Identification of a novel nuclear speckle-type protein, SPOP.
Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T,Hagiwara M.
FEBS Lett 418(1-2):23-6. 1997