Citations for
1SPINT1, SPINT2
The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.
Friis S, Sales KU, Schafer JM, Vogel LK, Kataoka H, Bugge TH.
J Biol Chem 289(32):22319-32. doi: 10.1074/jbc.M114.574400. Epub 2014 Jun 24. 2014
2SERPINA1, SPINT1, SPINT2, TMPRSS11B
HATL5: a cell surface serine protease differentially expressed in epithelial cancers.
Miller GS, Zoratti GL, Murray AS, Bergum C, Tanabe LM, List K.
PLoS One 9(2):e87675. doi: 10.1371/journal.pone.0087675. eCollection 2014. 2014
3SPINT1
Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis.
Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H.
Cancer Res 73(8):2659-70. doi: 10.1158/0008-5472.CAN-12-3337. Epub 2013 Feb 27. 2013
4SPINT1, SPINT2
Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
Koivuniemi R, Mäkelä J, Hokkanen ME, Bruelle C, Ho TH, Ola R, Korhonen L, Schröder J, Kataoka H, Lindholm D.
PLoS One 8(2):e56117. doi: 10.1371/journal.pone.0056117. Epub 2013 Feb 7. 2013
5SPINT1
Expression of Hepatocyte growth factor activator inhibitor type-1 (HAI-1) in prostate cancer.
Yasuda K, Komiya A, Watanabe A, Morii A, Oya T, Nagakawa O, Fujiuchi Y, Fuse H.
Anticancer Res 33(2):575-81. 2013
6PRSS8, SPINT1, ST14
Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.
Kohama K, Kawaguchi M, Fukushima T, Lin CY, Kataoka H.
Hum Cell 25(4):100-10. doi: 10.1007/s13577-012-0055-2. Epub 2012 Dec 18. 2012
7SPINT1, ST14
Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.
Domoto T, Takino T, Guo L, Sato H.
Cancer Sci 103(3):448-54. doi: 10.1111/j.1349-7006.2011.02162.x. Epub 2011 Dec 28. 2012
8SPINT1, ST14
Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1.
Xu H, Xu Z, Tseng IC, Chou FP, Chen YW, Wang JK, Johnson MD, Kataoka H, Lin CY.
Am J Physiol Cell Physiol 302(2):C453-62. doi: 10.1152/ajpcell.00344.2011. Epub 2011 Oct 26. 2012
9PRSS8, SPINT1, SPINT2, ST14
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.
Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH.
PLoS Genet 8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30. 2012
10SPINT1, SPINT2
Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.
Huang HP, Chang MH, Chen YT, Hsu HY, Chiang CL, Cheng TS, Wu YM, Wu MZ, Hsu YC, Shen CC, Lee CN, Chuang YH, Hong CL, Jeng YM, Chen PH, Chen HL, Lee MS.
Hepatology 55(1):161-72. doi: 10.1002/hep.24657. Epub 2011 Nov 16. 2012
11SPINT1
Membrane-bound serine protease inhibitor HAI-1 is required for maintenance of intestinal epithelial integrity.
Kawaguchi M, Takeda N, Hoshiko S, Yorita K, Baba T, Sawaguchi A, Nezu Y, Yoshikawa T, Fukushima T, Kataoka H.
Am J Pathol 179(4):1815-26. doi: 10.1016/j.ajpath.2011.06.038. Epub 2011 Aug 12. 2011
12SPINT1, SPINT2
The role of hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 in endometrial cancer.
Nakamura K, Hongo A, Kodama J, Hiramatsu Y.
Int J Cancer 128(11):2613-24. doi: 10.1002/ijc.25606. Epub 2010 Oct 4. 2011
13SPINT1, TMPRSS13
TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.
Hashimoto T, Kato M, Shimomura T, Kitamura N.
FEBS J 277(23):4888-900. doi: 10.1111/j.1742-4658.2010.07894.x. Epub 2010 Oct 26. 2010
14SPINT1
The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer.
Nakamura K, Abarzua F, Hongo A, Kodama J, Nasu Y, Kumon H, Hiramatsu Y.
Int J Oncol 35(2):239-48. 2009
15SPINT1, ST14
Role of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I.
Kojima K, Tsuzuki S, Fushiki T, Inouye K.
J Biochem 145(6):783-90. doi: 10.1093/jb/mvp036. Epub 2009 Mar 10. 2009
16SPINT1
Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.
Nagaike K, Kawaguchi M, Takeda N, Fukushima T, Sawaguchi A, Kohama K, Setoyama M, Kataoka H.
Am J Pathol 173(5):1464-75. doi: 10.2353/ajpath.2008.071142. Epub 2008 Oct 2. 2008
17SPINT1
Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses.
Komaki W, Fukushima T, Tanaka H, Itoh H, Chosa E, Kataoka H.
Virchows Arch 453(4):347-57. doi: 10.1007/s00428-008-0662-1. Epub 2008 Sep 4. 2008
18PRSS8, SPINT1, ST14
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary.
Godiksen S, Selzer-Plon J, Pedersen ED, Abell K, Rasmussen HB, Szabo R, Bugge TH, Vogel LK.
Biochem J 413(2):251-9. doi: 10.1042/BJ20071496. 2008
19SPINT1
Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase.
Kojima K, Tsuzuki S, Fushiki T, Inouye K.
J Biol Chem 283(5):2478-87. Epub 2007 Nov 29. 2008
20SPINT1
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.
Fan B, Brennan J, Grant D, Peale F, Rangell L, Kirchhofer D.
Dev Biol 303(1):222-30. Epub 2006 Nov 10. 2007
21SPINT1, PRSS8
Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin.
Fan B, Wu TD, Li W, Kirchhofer D.
J Biol Chem 280(41):34513-20. Epub 2005 Aug 15. 2005
22SPINT1
Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.
Zeng L, Cao J, Zhang X.
World J Gastroenterol 11(39):6202-7. 2005
23SPINT1
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta.
Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T, Miyazawa K, Kitamura N, Yamada G, Kataoka H.
Mol Cell Biol 25(13):5687-98. 2005
24SPINT1, SPINT2
Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes.
Itoh H, Yamauchi M, Kataoka H, Hamasuna R, Kitamura N, Koono M.
Eur J Biochem 267(11):3351-9. 2000
25SPINT1
Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.
Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.
J Biol Chem 272(10):6370-6. 1997