1 | SPINT1, SPINT2
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| The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.
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| Friis S, Sales KU, Schafer JM, Vogel LK, Kataoka H, Bugge TH.
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| J Biol Chem 289(32):22319-32. doi: 10.1074/jbc.M114.574400. Epub 2014 Jun 24.
2014
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2 | SERPINA1, SPINT1, SPINT2, TMPRSS11B
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| HATL5: a cell surface serine protease differentially expressed in epithelial cancers.
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| Miller GS, Zoratti GL, Murray AS, Bergum C, Tanabe LM, List K.
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| PLoS One 9(2):e87675. doi: 10.1371/journal.pone.0087675. eCollection 2014. 2014
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3 | SPINT1
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| Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis.
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| Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H.
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| Cancer Res 73(8):2659-70. doi: 10.1158/0008-5472.CAN-12-3337. Epub 2013 Feb 27.
2013
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4 | SPINT1, SPINT2
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| Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
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| Koivuniemi R, Mäkelä J, Hokkanen ME, Bruelle C, Ho TH, Ola R, Korhonen L, Schröder J, Kataoka H, Lindholm D.
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| PLoS One 8(2):e56117. doi: 10.1371/journal.pone.0056117. Epub 2013 Feb 7.
2013
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5 | SPINT1
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| Expression of Hepatocyte growth factor activator inhibitor type-1 (HAI-1) in prostate cancer.
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| Yasuda K, Komiya A, Watanabe A, Morii A, Oya T, Nagakawa O, Fujiuchi Y, Fuse H.
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| Anticancer Res 33(2):575-81.
2013
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6 | PRSS8, SPINT1, ST14
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| Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.
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| Kohama K, Kawaguchi M, Fukushima T, Lin CY, Kataoka H.
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| Hum Cell 25(4):100-10. doi: 10.1007/s13577-012-0055-2. Epub 2012 Dec 18.
2012
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7 | SPINT1, ST14
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| Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.
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| Domoto T, Takino T, Guo L, Sato H.
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| Cancer Sci 103(3):448-54. doi: 10.1111/j.1349-7006.2011.02162.x. Epub 2011 Dec 28.
2012
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8 | SPINT1, ST14
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| Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1.
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| Xu H, Xu Z, Tseng IC, Chou FP, Chen YW, Wang JK, Johnson MD, Kataoka H, Lin CY.
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| Am J Physiol Cell Physiol 302(2):C453-62. doi: 10.1152/ajpcell.00344.2011. Epub 2011 Oct 26.
2012
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9 | PRSS8, SPINT1, SPINT2, ST14
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| Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.
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| Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH.
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| PLoS Genet 8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30.
2012
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10 | SPINT1, SPINT2
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| Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.
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| Huang HP, Chang MH, Chen YT, Hsu HY, Chiang CL, Cheng TS, Wu YM, Wu MZ, Hsu YC, Shen CC, Lee CN, Chuang YH, Hong CL, Jeng YM, Chen PH, Chen HL, Lee MS.
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| Hepatology 55(1):161-72. doi: 10.1002/hep.24657. Epub 2011 Nov 16.
2012
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11 | SPINT1
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| Membrane-bound serine protease inhibitor HAI-1 is required for maintenance of intestinal epithelial integrity.
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| Kawaguchi M, Takeda N, Hoshiko S, Yorita K, Baba T, Sawaguchi A, Nezu Y, Yoshikawa T, Fukushima T, Kataoka H.
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| Am J Pathol 179(4):1815-26. doi: 10.1016/j.ajpath.2011.06.038. Epub 2011 Aug 12.
2011
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12 | SPINT1, SPINT2
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| The role of hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 in endometrial cancer.
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| Nakamura K, Hongo A, Kodama J, Hiramatsu Y.
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| Int J Cancer 128(11):2613-24. doi: 10.1002/ijc.25606. Epub 2010 Oct 4.
2011
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13 | SPINT1, TMPRSS13
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| TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.
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| Hashimoto T, Kato M, Shimomura T, Kitamura N.
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| FEBS J 277(23):4888-900. doi: 10.1111/j.1742-4658.2010.07894.x. Epub 2010 Oct 26.
2010
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14 | SPINT1
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| The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer.
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| Nakamura K, Abarzua F, Hongo A, Kodama J, Nasu Y, Kumon H, Hiramatsu Y.
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| Int J Oncol 35(2):239-48.
2009
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15 | SPINT1, ST14
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| Role of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I.
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| Kojima K, Tsuzuki S, Fushiki T, Inouye K.
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| J Biochem 145(6):783-90. doi: 10.1093/jb/mvp036. Epub 2009 Mar 10.
2009
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16 | SPINT1
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| Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.
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| Nagaike K, Kawaguchi M, Takeda N, Fukushima T, Sawaguchi A, Kohama K, Setoyama M, Kataoka H.
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| Am J Pathol 173(5):1464-75. doi: 10.2353/ajpath.2008.071142. Epub 2008 Oct 2.
2008
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17 | SPINT1
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| Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses.
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| Komaki W, Fukushima T, Tanaka H, Itoh H, Chosa E, Kataoka H.
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| Virchows Arch 453(4):347-57. doi: 10.1007/s00428-008-0662-1. Epub 2008 Sep 4.
2008
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18 | PRSS8, SPINT1, ST14
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| Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary.
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| Godiksen S, Selzer-Plon J, Pedersen ED, Abell K, Rasmussen HB, Szabo R, Bugge TH, Vogel LK.
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| Biochem J 413(2):251-9. doi: 10.1042/BJ20071496.
2008
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19 | SPINT1
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| Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase.
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| Kojima K, Tsuzuki S, Fushiki T, Inouye K.
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| J Biol Chem 283(5):2478-87. Epub 2007 Nov 29.
2008
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20 | SPINT1
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| Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.
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| Fan B, Brennan J, Grant D, Peale F, Rangell L, Kirchhofer D.
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| Dev Biol 303(1):222-30. Epub 2006 Nov 10.
2007
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21 | SPINT1, PRSS8
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| Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin.
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| Fan B, Wu TD, Li W, Kirchhofer D.
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| J Biol Chem 280(41):34513-20. Epub 2005 Aug 15. 2005
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22 | SPINT1
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| Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.
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| Zeng L, Cao J, Zhang X.
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| World J Gastroenterol 11(39):6202-7. 2005
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23 | SPINT1
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| Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta.
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| Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T, Miyazawa K, Kitamura N, Yamada G, Kataoka H.
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| Mol Cell Biol 25(13):5687-98. 2005
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24 | SPINT1, SPINT2
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| Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes.
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| Itoh H, Yamauchi M, Kataoka H, Hamasuna R, Kitamura N, Koono M.
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| Eur J Biochem 267(11):3351-9. 2000
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25 | SPINT1
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| Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.
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| Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.
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| J Biol Chem 272(10):6370-6. 1997
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