Citations for
1ADORA2B, SPHK1
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.
Sun K, Zhang Y, Bogdanov MV, Wu H, Song A, Li J, Dowhan W, Idowu M, Juneja HS, Molina JG, Blackburn MR, Kellems RE, Xia Y.
Blood 125(10):1643-52. doi: 10.1182/blood-2014-08-595751. Epub 2015 Jan 13. 2015
2ANKH, MYBBP1A, SPHK1
The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes.
Minashima T, Campbell KA, Hadley SR, Zhang Y, Kirsch T.
Osteoarthritis Cartilage 22(6):852-61. doi: 10.1016/j.joca.2014.04.008. Epub 2014 Apr 18. 2014
3SPHK1, TFRC
Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.
Pham DH, Powell JA, Gliddon BL, Moretti PA, Tsykin A, Van der Hoek M, Kenyon R, Goodall GJ, Pitson SM.
Oncogene 33(48):5559-68. doi: 10.1038/onc.2013.502. Epub 2013 Nov 25. 2014
4EP300, SPHK1
Acetylation of sphingosine kinase 1 regulates cell growth and cell-cycle progression.
Yu H, Shao Y, Gao L, Zhang L, Guo K, Wu C, Hu X, Duan H.
Biochem Biophys Res Commun 417(4):1242-7. doi: 10.1016/j.bbrc.2011.12.117. Epub 2011 Dec 29. 2012
5SPHK1
Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner.
Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM.
J Biol Chem 287(38):31794-803. doi: 10.1074/jbc.M112.385765. Epub 2012 Jul 24. 2012
6SPHK1
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Grin'kina NM, Karnabi EE, Damania D, Wadgaonkar S, Muslimov IA, Wadgaonkar R.
PLoS One 7(5):e36475. doi: 10.1371/journal.pone.0036475. Epub 2012 May 17. 2012
7SPHK1
Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
Sun WY, Abeynaike LD, Escarbe S, Smith CD, Pitson SM, Hickey MJ, Bonder CS.
Am J Pathol 180(4):1740-50. doi: 10.1016/j.ajpath.2011.12.024. Epub 2012 Feb 7. 2012
8SPHK1
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, Yamada A, Zhao R, Milstien S, Zhou H, Spiegel S, Takabe K.
Cancer Res 72(3):726-35. doi: 10.1158/0008-5472.CAN-11-2167. 2012
9S1PR4, SPHK1
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
Ohotski J, Long JS, Orange C, Elsberger B, Mallon E, Doughty J, Pyne S, Pyne NJ, Edwards J.
Br J Cancer 106(8):1453-9. doi: 10.1038/bjc.2012.98. Epub 2012 Mar 29. Erratum in: Br J Cancer. 2012 Aug 7;107(4):756. 2012
10EEF1A1, SPHK1
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
Leclercq TM, Moretti PA, Pitson SM.
Oncogene 30(3):372-8. Epub 2010 Sep 13. 2011
11SPHK1
Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia.
Meng H, Yuan Y, Lee VM.
PLoS One 6(11):e27150. doi: 10.1371/journal.pone.0027150. Epub 2011 Nov 9. 2011
12SPHK1
Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.
Lan T, Liu W, Xie X, Xu S, Huang K, Peng J, Shen X, Liu P, Wang L, Xia P, Huang H.
Mol Endocrinol 25(12):2094-105. doi: 10.1210/me.2011-0095. Epub 2011 Oct 13. 2011
13SPHK1
Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer.
Guan H, Liu L, Cai J, Liu J, Ye C, Li M, Li Y.
Mol Endocrinol 25(11):1858-66. doi: 10.1210/me.2011-1048. Epub 2011 Sep 22. 2011
14SPHK1
Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells.
Barrett JM, Parham KA, Pippal JB, Cockshell MP, Moretti PA, Brice SL, Pitson SM, Bonder CS.
Microcirculation 18(7):583-97. doi: 10.1111/j.1549-8719.2011.00119.x. 2011
15SPHK1
Sphingosine kinase localization in the control of sphingolipid metabolism.
Siow DL, Anderson CD, Berdyshev EV, Skobeleva A, Natarajan V, Pitson SM, Wattenberg BW.
Adv Enzyme Regul 51(1):229-44. doi: 10.1016/j.advenzreg.2010.09.004. Epub 2010 Nov 12. 2011
16GAP43, GDNF, SPHK1
Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.
Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T.
J Cell Biochem 112(11):3449-58. doi: 10.1002/jcb.23275. 2011
17RIPK1, SGPP1, SPHK1, TRAF2
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.
Nature 465(7301):1084-8.PMID: 20577214 2010
18DEFB4A, SPHK1
Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes.
Benakanakere MR, Zhao J, Galicia JC, Martin M, Kinane DF.
PLoS One 5(7):e11512. 2010
19SERK, SPHK1, SPHK2
A lipid binding domain in sphingosine kinase 2.
Don AS, Rosen H.
Biochem Biophys Res Commun 380(1):87-92. Epub 2009 Jan 23. 2009
20SPHK1
Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells.
Schwalm S, Dšll F, Ršmer I, Bubnova S, Pfeilschifter J, Huwiler A.
Biochem Biophys Res Commun 368(4):1020-5. Epub 2008 Feb 7. 2008
21EEF1A1, SPHK1, SPHK2
Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.
Leclercq TM, Moretti PA, Vadas MA, Pitson SM.
J Biol Chem 283(15):9606-14. Epub 2008 Feb 8. 2008
22PPP2CA, SPHK1
Deactivation of sphingosine kinase 1 by protein phosphatase 2A.
Barr RK, Lynn HE, Moretti PA, Khew-Goodall Y, Pitson SM.
J Biol Chem 283(50):34994-5002. Epub 2008 Oct 13.PMID: 18852266 2008
23AKT2, MTOR, RIPK1, SPHK1, TRAF2
Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells.
Francy JM, Nag A, Conroy EJ, Hengst JA, Yun JK.
Biochim Biophys Acta 1769(4):253-65. Epub 2007 Apr 3. 2007
24SPHK1
Essential role for sphingosine kinases in neural and vascular development.
Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL.
Mol Cell Biol 25(24):11113-21. 2005
25SPHK1, TIMP1
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M.
J Biol Chem 279(52):53994-4001. Epub 2004 Oct 12. 2004
26SPHK1
Identification of functional nuclear export sequences in human sphingosine kinase 1.
Inagaki Y, Li PY, Wada A, Mitsutake S, Igarashi Y.
Biochem Biophys Res Commun 311(1):168-73. 2003
27SPHK1
Functional characterization of human sphingosine kinase-1.
Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S.
FEBS Lett 473(1):81-4. 2000
28SPHK1
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.
Pitson SM, D'andrea RJ, Vandeleur L, Moretti PA, Xia P, Gamble JR, Vadas MA, Wattenberg BW.
Biochem J 350 Pt 2:429-41. 2000
29SPHK1
Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.
Melendez AJ, Carlos-Dias E, Gosink M, Allen JM, Takacs L.
Gene 251(1):19-26. 2000
30SPHK1
Molecular cloning and functional characterization of murine sphingosine kinase.
Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S.
J Biol Chem 273(37):23722-8. 1998