1 | ADORA2B, SPHK1
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| Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.
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| Sun K, Zhang Y, Bogdanov MV, Wu H, Song A, Li J, Dowhan W, Idowu M, Juneja HS, Molina JG, Blackburn MR, Kellems RE, Xia Y.
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| Blood 125(10):1643-52. doi: 10.1182/blood-2014-08-595751. Epub 2015 Jan 13.
2015
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2 | ANKH, MYBBP1A, SPHK1
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| The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes.
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| Minashima T, Campbell KA, Hadley SR, Zhang Y, Kirsch T.
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| Osteoarthritis Cartilage 22(6):852-61. doi: 10.1016/j.joca.2014.04.008. Epub 2014 Apr 18.
2014
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3 | SPHK1, TFRC
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| Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.
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| Pham DH, Powell JA, Gliddon BL, Moretti PA, Tsykin A, Van der Hoek M, Kenyon R, Goodall GJ, Pitson SM.
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| Oncogene 33(48):5559-68. doi: 10.1038/onc.2013.502. Epub 2013 Nov 25.
2014
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4 | EP300, SPHK1
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| Acetylation of sphingosine kinase 1 regulates cell growth and cell-cycle progression.
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| Yu H, Shao Y, Gao L, Zhang L, Guo K, Wu C, Hu X, Duan H.
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| Biochem Biophys Res Commun 417(4):1242-7. doi: 10.1016/j.bbrc.2011.12.117. Epub 2011 Dec 29.
2012
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5 | SPHK1
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| Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner.
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| Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM.
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| J Biol Chem 287(38):31794-803. doi: 10.1074/jbc.M112.385765. Epub 2012 Jul 24.
2012
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6 | SPHK1
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| Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
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| Grin'kina NM, Karnabi EE, Damania D, Wadgaonkar S, Muslimov IA, Wadgaonkar R.
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| PLoS One 7(5):e36475. doi: 10.1371/journal.pone.0036475. Epub 2012 May 17.
2012
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7 | SPHK1
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| Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
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| Sun WY, Abeynaike LD, Escarbe S, Smith CD, Pitson SM, Hickey MJ, Bonder CS.
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| Am J Pathol 180(4):1740-50. doi: 10.1016/j.ajpath.2011.12.024. Epub 2012 Feb 7.
2012
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8 | SPHK1
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| Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
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| Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, Yamada A, Zhao R, Milstien S, Zhou H, Spiegel S, Takabe K.
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| Cancer Res 72(3):726-35. doi: 10.1158/0008-5472.CAN-11-2167.
2012
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9 | S1PR4, SPHK1
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| Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
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| Ohotski J, Long JS, Orange C, Elsberger B, Mallon E, Doughty J, Pyne S, Pyne NJ, Edwards J.
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| Br J Cancer 106(8):1453-9. doi: 10.1038/bjc.2012.98. Epub 2012 Mar 29. Erratum in: Br J Cancer. 2012 Aug 7;107(4):756.
2012
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10 | EEF1A1, SPHK1
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| Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
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| Leclercq TM, Moretti PA, Pitson SM.
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| Oncogene 30(3):372-8. Epub 2010 Sep 13.
2011
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11 | SPHK1
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| Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia.
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| Meng H, Yuan Y, Lee VM.
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| PLoS One 6(11):e27150. doi: 10.1371/journal.pone.0027150. Epub 2011 Nov 9.
2011
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12 | SPHK1
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| Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.
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| Lan T, Liu W, Xie X, Xu S, Huang K, Peng J, Shen X, Liu P, Wang L, Xia P, Huang H.
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| Mol Endocrinol 25(12):2094-105. doi: 10.1210/me.2011-0095. Epub 2011 Oct 13.
2011
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13 | SPHK1
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| Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer.
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| Guan H, Liu L, Cai J, Liu J, Ye C, Li M, Li Y.
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| Mol Endocrinol 25(11):1858-66. doi: 10.1210/me.2011-1048. Epub 2011 Sep 22.
2011
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14 | SPHK1
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| Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells.
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| Barrett JM, Parham KA, Pippal JB, Cockshell MP, Moretti PA, Brice SL, Pitson SM, Bonder CS.
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| Microcirculation 18(7):583-97. doi: 10.1111/j.1549-8719.2011.00119.x.
2011
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15 | SPHK1
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| Sphingosine kinase localization in the control of sphingolipid metabolism.
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| Siow DL, Anderson CD, Berdyshev EV, Skobeleva A, Natarajan V, Pitson SM, Wattenberg BW.
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| Adv Enzyme Regul 51(1):229-44. doi: 10.1016/j.advenzreg.2010.09.004. Epub 2010 Nov 12.
2011
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16 | GAP43, GDNF, SPHK1
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| Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.
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| Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T.
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| J Cell Biochem 112(11):3449-58. doi: 10.1002/jcb.23275.
2011
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17 | RIPK1, SGPP1, SPHK1, TRAF2
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| Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
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| Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.
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| Nature 465(7301):1084-8.PMID: 20577214 2010
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18 | DEFB4A, SPHK1
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| Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes.
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| Benakanakere MR, Zhao J, Galicia JC, Martin M, Kinane DF.
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| PLoS One 5(7):e11512.
2010
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19 | SERK, SPHK1, SPHK2
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| A lipid binding domain in sphingosine kinase 2.
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| Don AS, Rosen H.
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| Biochem Biophys Res Commun 380(1):87-92. Epub 2009 Jan 23.
2009
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20 | SPHK1
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| Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells.
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| Schwalm S, Dšll F, Ršmer I, Bubnova S, Pfeilschifter J, Huwiler A.
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| Biochem Biophys Res Commun 368(4):1020-5. Epub 2008 Feb 7. 2008
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21 | EEF1A1, SPHK1, SPHK2
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| Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.
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| Leclercq TM, Moretti PA, Vadas MA, Pitson SM.
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| J Biol Chem 283(15):9606-14. Epub 2008 Feb 8. 2008
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22 | PPP2CA, SPHK1
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| Deactivation of sphingosine kinase 1 by protein phosphatase 2A.
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| Barr RK, Lynn HE, Moretti PA, Khew-Goodall Y, Pitson SM.
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| J Biol Chem 283(50):34994-5002. Epub 2008 Oct 13.PMID: 18852266 2008
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23 | AKT2, MTOR, RIPK1, SPHK1, TRAF2
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| Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells.
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| Francy JM, Nag A, Conroy EJ, Hengst JA, Yun JK.
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| Biochim Biophys Acta 1769(4):253-65. Epub 2007 Apr 3. 2007
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24 | SPHK1
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| Essential role for sphingosine kinases in neural and vascular development.
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| Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL.
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| Mol Cell Biol 25(24):11113-21. 2005
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25 | SPHK1, TIMP1
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| Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
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| Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M.
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| J Biol Chem 279(52):53994-4001. Epub 2004 Oct 12. 2004
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26 | SPHK1
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| Identification of functional nuclear export sequences in human sphingosine kinase 1.
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| Inagaki Y, Li PY, Wada A, Mitsutake S, Igarashi Y.
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| Biochem Biophys Res Commun 311(1):168-73. 2003
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27 | SPHK1
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| Functional characterization of human sphingosine kinase-1.
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| Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S.
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| FEBS Lett 473(1):81-4. 2000
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28 | SPHK1
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| Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.
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| Pitson SM, D'andrea RJ, Vandeleur L, Moretti PA, Xia P, Gamble JR, Vadas MA, Wattenberg BW.
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| Biochem J 350 Pt 2:429-41. 2000
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29 | SPHK1
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| Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.
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| Melendez AJ, Carlos-Dias E, Gosink M, Allen JM, Takacs L.
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| Gene 251(1):19-26. 2000
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30 | SPHK1
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| Molecular cloning and functional characterization of murine sphingosine kinase.
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| Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S.
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| J Biol Chem 273(37):23722-8. 1998
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