1 | SPACA1, SPGF74
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| Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome-acroplaxome complex
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| Chen P, Saiyin H, Shi R, Liu B, Han X, Gao Y, Ye X, Zhang X, Sun Y.
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| Hum Reprod. 18;36(9):2587-2596. doi: 10.1093/humrep/deab144. 2021
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2 | IZUMO1, SPACA1
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| Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa†.
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| Yamatoya K, Kousaka M, Ito C, Nakata K, Hatano M, Araki Y, Toshimori K.
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| Biol Reprod. Mar 13;102(3):750-757. doi: 10.1093/biolre/ioz223. 2020
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3 | DPY19L2, SPACA1
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| Proteomic Analysis of Dpy19l2-Deficient Human Globozoospermia Reveals Multiple Molecular Defects
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| Guo Y, Jiang J, Zhang H, Wen Y, Zhang H, Cui Y, Tian J, Jiang M, Liu X, Wang G, Li Y, Hu Z, Zhou Z, Sha J, Chen D, Yang X, Guo X.
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| Proteomics Clin Appl. Nov;13(6):e1900007. doi: 10.1002/prca.201900007. Epub 2019 Sep 4. 2019
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4 | CCDC136, SPACA1
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| A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice
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| Geng Q, Ni L, Ouyang B, Hu Y, Zhao Y, Guo J.
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| Reprod Sci. Oct;23(10):1387-96. doi: 10.1177/1933719116641762. Epub 2016 Apr 12. 2016
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5 | SPACA1
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| SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia
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| Fujihara Y, Satouh Y, Inoue N, Isotani A, Ikawa M, Okabe M.
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| Development. 2 Oct;139(19):3583-9. doi: 10.1242/dev.081778. 2012
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6 | SPACA1
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| SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associatedprotein.
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| Hao Z, Wolkowicz MJ, Shetty J, Klotz K, Bolling L, Sen B, Westbrook VA,Coonrod S, Flickinger CJ, Herr JC.
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| Biol Reprod 66(3):735-44. 2002
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