Citations for
1NANOG, SOX2, ZBTB38
Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression
Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y, Matsuda E.
Cell Prolif. Apr;55(4):e13215. doi: 10.1111/cpr.13215. Epub 2022 Mar 17 2022
2SLC7A11, SOX2
Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Wang X, Chen Y, Wang X, Tian H, Wang Y, Jin J, Shan Z, Liu Y, Cai Z, Tong X, Luan Y, Tan X, Luan B, Ge X, Ji H, Jiang X, Wang P.
Cancer Res. Oct 15;81(20):5217-5229. doi: 10.1158/0008-5472.CAN-21-0567. Epub 2021 Aug 12. 2021
3AKT1, FSCN1, HBEGF, SOX2
SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF
Xiao W, Zheng S, Xie X, Li X, Zhang L, Yang A, Wang J, Tang H, Xie X.
Mol Ther Oncolytics. Mar 13;17:118-129. doi: 10.1016/j.omto.2020.03.001. 2020
4MELK, SOX2
MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells.
Ren L, Deng B, Saloura V, Park JH, Nakamura Y.
Oncol Rep 41(4):2540-2548. doi: 10.3892/or.2019.6988. Epub 2019 Jan 30. 2019
5SOX1, SOX2
Expression of a SOX1 overlapping transcript in neural differentiation and cancer models
Ahmad A, Strohbuecker S, Tufarelli C, Sottile V.
Cell Mol Life Sci. Nov;74(22):4245-4258. doi: 10.1007/s00018-017-2580-3. Epub 2017 Jul 3. 2017
6SOX2, SOX3
Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes.
Adikusuma F, Pederick D, McAninch D, Hughes J, Thomas P.
Genetics. Jul;206(3):1495-1503. doi: 10.1534/genetics.117.202549. Epub 2017 May 17. 2017
7LEF1, PITX2, SOX2
Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.
Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA.
Development 143(22):4115-4126. 2016
8NACC1, POU5F1, SOX2, TCF3
Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation.
Malleshaiah M, Padi M, Rué P, Quackenbush J, Martinez-Arias A, Gunawardena J.
Cell Rep 14(5):1181-94. doi: 10.1016/j.celrep.2015.12.101. 2016
9DDX17, SOX2
DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer.
Alqahtani H, Gopal K, Gupta N, Jung K, Alshareef A, Ye X, Wu F, Li L, Lai R.
Cell Signal 28(2):42-50. doi: 10.1016/j.cellsig.2015.11.004. Epub 2015 Nov 10. 2016
10NOS1, SOX2
nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription.
Zhang D, Wang H, Liu H, Tao T, Wang N, Shen A.
Mol Neurobiol 53(9):6444-6458. doi: 10.1007/s12035-015-9545-z. Epub 2015 Nov 25. 2016
11LIN28A, NANOG, PCGF6, POU5F1, SOX2
Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity
Yang CS, Chang KY, Dang J, Rana TM.
Sci Rep. Jun 1;6:26899. doi: 10.1038/srep26899. 2016
12ACTL6A, NANOG, SOX2
Actl6a protects embryonic stem cells from differentiating into primitive endoderm.
Lu W, Fang L, Ouyang B, Zhang X, Zhan S, Feng X, Bai Y, Han X, Kim H, He Q, Wan M, Shi FT, Feng XH, Liu D, Huang J, Songyang Z.
Stem Cells 33(6):1782-93. doi: 10.1002/stem.2000. 2015
13MSX2, NODAL, SOX2
MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling.
Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Feng S, Han M, Xu Y, Wang F, Zhou J.
Cell Res 25(12):1314-32. doi: 10.1038/cr.2015.118. 2015
14IL6, SOX2
Interleukin-6 induces the lineage commitment of bone marrow-derived mesenchymal multipotent cells through down-regulation of Sox2 by osteogenic transcription factors.
Yoon DS, Kim YH, Lee S, Lee KM, Park KH, Jang Y, Lee JW.
FASEB J 28(7):3273-86. doi: 10.1096/fj.13-248567. Epub 2014 Apr 9. 2014
15SOX2, SOX3, SOXB1
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes
Hoffmann SA, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S.
Development. Jan;141(1):39-50. doi: 10.1242/dev.098418. Epub 2013 Nov 20. 2014
16POU5F1, SOX17, SOX2
Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.
Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR, Stanton LW.
EMBO J 32(7):938-53. doi: 10.1038/emboj.2013.31. Epub 2013 Mar 8. 2013
17CDX2, SOX2
Disturbed balance between SOX2 and CDX2 in human vitelline duct anomalies and intestinal duplications.
Raghoebir L, Biermann K, Buscop-van Kempen M, Wijnen RM, Tibboel D, Smits R, Rottier RJ.
Virchows Arch 462(5):515-22. doi: 10.1007/s00428-013-1405-5. Epub 2013 Apr 9. 2013
18ANOP3, SOX2
SOX2 anophthalmia syndrome in adulthood - a neurodegenerative picture?
Ragge NK, Quaghebeur G, Stewart H.
Clin Genet 83(5):482-4. doi: 10.1111/j.1399-0004.2012.01922.x. Epub 2012 Jul 27. No abstract available. 2013
19FN1, SOX2
SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention.
Lou X, Han X, Jin C, Tian W, Yu W, Ding D, Cheng L, Huang B, Jiang H, Lin B.
OMICS 17(10):510-8. doi: 10.1089/omi.2013.0058. Epub 2013 Jul 29. 2013
20NANOG, SOX2
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.
Gagliardi A, Mullin NP, Ying Tan Z, Colby D, Kousa AI, Halbritter F, Weiss JT, Felker A, Bezstarosti K, Favaro R, Demmers J, Nicolis SK, Tomlinson SR, Poot RA, Chambers I.
EMBO J 32(16):2231-47. doi: 10.1038/emboj.2013.161. Epub 2013 Jul 26. 2013
21PQBP1, SOX2
Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.
Li C, Ito H, Fujita K, Shiwaku H, Qi Y, Tagawa K, Tamura T, Okazawa H.
PLoS One 8(7):e68627. doi: 10.1371/journal.pone.0068627. Print 2013. 2013
22SIX3, SOX2
Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.
Lee B, Song H, Rizzoti K, Son Y, Yoon J, Baek K, Jeong Y.
Dev Biol 381(2):491-501. doi: 10.1016/j.ydbio.2013.06.016. Epub 2013 Jun 19. 2013
23BIRC5, SOX2
Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression.
Feng R, Zhou S, Liu Y, Song D, Luan Z, Dai X, Li Y, Tang N, Wen J, Li L.
Biochem J 450(3):459-68. doi: 10.1042/BJ20120924. 2013
24NANOG, OCT4, SOX2
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells.
Wang Z, Oron E, Nelson B, Razis S, Ivanova N.
Cell Stem Cell 10(4):440-54. doi: 10.1016/j.stem.2012.02.016. 2012
25PARP1, SOX2
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency.
Lai YS, Chang CW, Pawlik KM, Zhou D, Renfrow MB, Townes TM.
Proc Natl Acad Sci U S A 109(10):3772-7. doi: 10.1073/pnas.1108595109. Epub 2012 Feb 23. 2012
26NTRK3, SOX2
Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells.
Fong H, Wong RC, Donovan PJ.
Stem Cell Res 8(2):206-14. doi: 10.1016/j.scr.2011.10.003. Epub 2011 Oct 26. 2012
27FGF8, OTX2, SOX2
Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
Nishihara D, Yajima I, Tabata H, Nakai M, Tsukiji N, Katahira T, Takeda K, Shibahara S, Nakamura H, Yamamoto H.
PLoS One 7(11):e48879. doi: 10.1371/journal.pone.0048879. Epub 2012 Nov 8. 2012
28SOX2
Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas.
Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA, Orkin SH, Mansukhani A, Basilico C.
Oncogene 31(18):2270-82. doi: 10.1038/onc.2011.405. Epub 2011 Sep 19. 2012
29ASXL1, SOX2
Positive regulation of additional sex comb-like 1 gene expression by the pluripotency factor SOX2.
Kang M, Lee SW, Kim EJ, Um SJ.
Biochem Biophys Res Commun 421(3):621-6. doi: 10.1016/j.bbrc.2012.04.072. 2012
30SOX2
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S.
Nat Genet 44(10):1111-6. doi: 10.1038/ng.2405. Epub 2012 Sep 2. 2012
31ANOP3, SOX2
Isolated hypogonadotropic hypogonadism with SOX2 mutation and anophthalmia/microphthalmia in offspring.
Stark Z, Storen R, Bennetts B, Savarirayan R, Jamieson RV.
Eur J Hum Genet 19(7):753-6. doi: 10.1038/ejhg.2011.11. Epub 2011 Feb 16. 2011
32SOX2
SOX2 is required for adult human muller stem cell survival and maintenance of progenicity in vitro.
Bhatia B, Singhal S, Tadman DN, Khaw PT, Limb GA.
Invest Ophthalmol Vis Sci. 52(1):136-45. 2011
33SOX2
The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.
Iwafuchi-Doi M, Yoshida Y, Onichtchouk D, Leichsenring M, Driever W, Takemoto T, Uchikawa M, Kamachi Y, Kondoh H.
Dev Biol 352(2):354-66. Epub 2010 Dec 23. 2011
34SOX2
SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon.
Hutton SR, Pevny LH.
Dev Biol 352(1):40-7. Epub 2011 Jan 21. 2011
35MET, SOX2
Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation.
Cai YR, Zhang HQ, Qu Y, Mu J, Zhao D, Zhou LJ, Yan H, Ye JW, Liu Y.
Oncol Rep 26(4):877-85. doi: 10.3892/or.2011.1349. Epub 2011 Jun 15. 2011
36CHD7, SOX2
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.
Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van Ijcken W, Dekkers DH, Demmers J, Rijkers EJ, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA.
Nat Genet 43(6):607-11. Epub 2011 May 1. 2011
37CHD7, SOX2
SOX2 and CHD7 cooperatively regulate human disease genes.
Puc J, Rosenfeld MG.
Nat Genet 43(6):505-6. No abstract available. 2011
38NANOG, POU5F1, SOX2
A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.
Fong YW, Inouye C, Yamaguchi T, Cattoglio C, Grubisic I, Tjian R.
Cell 147(1):120-31. 2011
39BMI1, SOX2
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.
Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A.
Mol Cell Biol 31(22):4593-608. doi: 10.1128/MCB.05798-11. Epub 2011 Sep 19. 2011
40SOX2
SOX2 modulates alternative splicing in transitional cell carcinoma.
Tung CL, Hou PH, Kao YL, Huang YW, Shen CC, Cheng YH, Wu SF, Lee MS, Li C.
Biochem Biophys Res Commun 393(3):420-5. Epub 2010 Feb 6.PMID: 20138825 2010
41SOX2
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells.
Riggi N, Suvà ML, De Vito C, Provero P, Stehle JC, Baumer K, Cironi L, Janiszewska M, Petricevic T, Suvà D, Tercier S, Joseph JM, Guillou L, Stamenkovic I.
Genes Dev 24(9):916-32. Epub 2010 Apr 9. 2010
42SOX2
Sox2 regulatory region 2 sequence works as a DNA nuclear targeting sequence enhancing the efficiency of an exogenous gene expression in ES cells.
Funabashi H, Takatsu M, Saito M, Matsuoka H.
Biochem Biophys Res Commun 400(4):554-8. Epub 2010 Aug 31. 2010
43ANOP3, SOX2
Supernumerary impacted teeth in a patient with SOX2 anophthalmia syndrome.
Numakura C, Kitanaka S, Kato M, Ishikawa S, Hamamoto Y, Katsushima Y, Kimura T, Hayasaka K.
Am J Med Genet A 152A(9):2355-9. 2010
44SOX2
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.
Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M.
Nat Genet 41(11):1238-42. Epub 2009 Oct 4.PMID: 19801978 2009
45ANOP3, SOX2
Novel SOX2 partner-factor domain mutation in a four-generation family.
Mihelec M, Abraham P, Gibson K, Krowka R, Susman R, Storen R, Chen Y, Donald J, Tam PP, Grigg JR, Flaherty M, Gole GA, Jamieson RV.
Eur J Hum Genet 17(11):1417-22. Epub 2009 May 27.PMID: 19471311 2009
46ANOP3, SOX2
Novel SOX2 mutations and genotype-phenotype correlation in anophthalmia and microphthalmia.
Schneider A, Bardakjian T, Reis LM, Tyler RC, Semina EV.
Am J Med Genet A 149A(12):2706-15.PMID: 19921648 2009
47SOX2
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS.
Cell. 137(4):647-58. 2009
48SOX1, SOX2, SOX9
Expression of Sox1, Sox2 and Sox9 is maintained in adult human cerebellar cortex.
Alcock J, Lowe J, England T, Bath P, Sottile V.
Neurosci Lett. Jan 30;450(2):114-6. doi: 10.1016/j.neulet.2008.11.047. Epub 2008 Nov 27. 2009
49OTX2, SOX2, RAX
Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression.
Danno H, Michiue T, Hitachi K, Yukita A, Ishiura S, Asashima M.
Proc Natl Acad Sci U S A 105(14):5408-13. Epub 2008 Apr 2. 2008
50CPHD3, LHX3, SOX2
Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.
Rajab A, Kelberman D, de Castro SC, Biebermann H, Shaikh H, Pearce K, Hall CM, Shaikh G, Gerrelli D, Grueters A, Krude H, Dattani MT.
Hum Mol Genet 17(14):2150-9. Epub 2008 Apr 10. 2008
51ANOP3, SOX2
Familial recurrence of SOX2 anophthalmia syndrome: phenotypically normal mother with two affected daughters.
Schneider A, Bardakjian TM, Zhou J, Hughes N, Keep R, Dorsainville D, Kherani F, Katowitz J, Schimmenti LA, Hummel M, Fitzpatrick DR, Young TL.
Am J Med Genet A 146A(21):2794-8. 2008
52SOX2
Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells.
Fong H, Hohenstein KA, Donovan PJ.
Stem Cells 26(8):1931-8. Epub 2008 Apr 3. 2008
53ATOH1, SOX2
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.
Dabdoub A, Puligilla C, Jones JM, Fritzsch B, Cheah KS, Pevny LH, Kelley MW.
Proc Natl Acad Sci U S A 105(47):18396-401. Epub 2008 Nov 14. 2008
54EYA1, SOX2
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear.
Zou D, Erickson C, Kim EH, Jin D, Fritzsch B, Xu PX.
Hum Mol Genet 17(21):3340-56. Epub 2008 Aug 4. 2008
55ANOP3, SOX2
Novel SOX2 mutation associated with ocular coloboma in a Chinese family.
Wang P, Liang X, Yi J, Zhang Q.
Arch Ophthalmol 126(5):709-13.PMID: 18474784 2008
56SOX2
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.
Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R.
Dev Biol 317(1):296-309. Epub 2008 Feb 29.PMID: 18374910 2008
57SOX2
Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions.
Park ET, Gum JR, Kakar S, Kwon SW, Deng G, Kim YS.
Int J Cancer. 122(6):1253-60. 2008
58SOX2
SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis.
Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y.
Br J Cancer. 98(4):824-31. 2008
59SOX2
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.
Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y, Archer TK.
Mol Cell Biol. 28(20):6426-38. 2008
60SOX2
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer.
Chen Y, Shi L, Zhang L, Li R, Liang J, Yu W, Sun L, Yang X, Wang Y, Zhang Y, Shang Y.
J Biol Chem. 283(26):17969-78 2008
61NANOG, POU5F1, SOX2, ZNF281
The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes.
Wang ZX, Teh CH, Chan CM, Chu C, Rossbach M, Kunarso G, Allapitchay TB, Wong KY, Stanton LW.
Stem Cells 26(11):2791-9. doi: 10.1634/stemcells.2008-0443. Epub 2008 Aug 28. 2008
62SOX2, ANOP3
Germinal mosaicism and familial recurrence of a SOX2 mutation with highly variable phenotypic expression extending from AEG syndrome to absence of ocular involvement.
Chassaing N, Gilbert-Dussardier B, Nicot F, Fermeaux V, Encha-Razavi F, Fiorenza M, Toutain A, Calvas P.
Am J Med Genet A 143(3):289-91. No abstract available. 2007
63NANOG, POU5F1, SOX2, ZIC3
Zic3 is required for maintenance of pluripotency in embryonic stem cells.
Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW.
Mol Biol Cell 18(4):1348-58. Epub 2007 Jan 31. 2007
64SOX2, ANOP3
Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome.
Williamson KA, Hever AM, Rainger J, Rogers RC, Magee A, Fiedler Z, Keng WT, Sharkey FH, McGill N, Hill CJ, Schneider A, Messina M, Turnpenny PD, Fantes JA, van Heyningen V, FitzPatrick DR.
Hum Mol Genet 15(9):1413-22. Epub 2006 Mar 16. 2006
65PAX6, SOX2, OTX2
Developmental malformations of the eye: the role of PAX6, SOX2 and OTX2.
Hever AM, Williamson KA, van Heyningen V.
Clin Genet 69(6):459-70. 2006
66SOX2, ANOP3
Anophthalmia-esophageal atresia syndrome caused by an SOX2 gene deletion in monozygotic twin brothers with markedly discordant phenotypes.
Zenteno JC, Perez-Cano HJ, Aguinaga M.
Am J Med Genet A 140(18):1899-903. 2006
67SOX2
SOX2 is a dose-dependent regulator of retinal neural progenitor competence.
Taranova OV, Magness ST, Fagan BM, Wu Y, Surzenko N, Hutton SR, Pevny LH.
Genes Dev 20(9):1187-202. 2006
68SOX2, ANOP3
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans.
Kelberman D, Rizzoti K, Avilion A, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK, Kirk JM, Achermann JC, Ross R, Carmignac D, Lovell-Badge R, Robinson IC, Dattani MT.
J Clin Invest 116(9):2442-55. Epub 2006 Aug 24. 2006
69SOX2, ANOP3
SOX2 anophthalmia syndrome.
Ragge NK, Lorenz B, Schneider A, Bushby K, de Sanctis L, de Sanctis U, Salt A, Collin JR, Vivian AJ, Free SL, Thompson P, Williamson KA, Sisodiya SM, van Heyningen V, Fitzpatrick DR.
Am J Med Genet A 135(1):1-7; discussion 8. 2005
70SOX2, ANOP3
SOX2 mutation causes anophthalmia, hearing loss, and brain anomalies.
Hagstrom SA, Pauer GJ, Reid J, Simpson E, Crowe S, Maumenee IH, Traboulsi EI.
Am J Med Genet A 138(2):95-8. 2005
71SOX2, ANOP3
Bilateral anophthalmia and brain malformations caused by a 20-bp deletion in the SOX2 gene.
Zenteno JC, Gascon-Guzman G, Tovilla-Canales JL.
Clin Genet 68(6):564-6. No abstract available. 2005
72SOX2
Sox2 is required for sensory organ development in the mammalian inner ear.
Kiernan AE, Pelling AL, Leung KK, Tang AS, Bell DM, Tease C, Lovell-Badge R, Steel KP, Cheah KS.
Nature. 434(7036):1031-5. 2005
73SOX2
Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex.
Williams DC Jr, Cai M, Clore GM.
J Biol Chem. 279(2):1449-57. 2004
74SOX2
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.
Ferri AL, Cavallaro M, Braida D, Di Cristofano A, Canta A, Vezzani A, Ottolenghi S, Pandolfi PP, Sala M, DeBiasi S, Nicolis SK.
Development. 131(15):3805-19. 2004
75ANOP3, SOX2, SOX2OT
Mutations in SOX2 cause anophthalmia.
Fantes J, Ragge NK, Lynch SA, McGill NI, Collin JR, Howard-Peebles PN,Hayward C, Vivian AJ, Williamson K, van Heyningen V, FitzPatrick DR.
Nat Genet 33(4):461-3. Epub 2003 Mar 03. 2003
76SOX2, SOX3
Modulation of SOX2 and SOX3 gene expression during differentiation of human neuronal precursor cell line NTERA2.
Stevanovic M.
Mol Biol Rep 30(2):127-32. 2003
77SOX2, SOX11
Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity.
Wiebe MS, Nowling TK, Rizzino A.
J Biol Chem 278(20):17901-11. Epub 2003 Mar 10. 2003
78SOX1, SOX10, SOX11, SOX13, SOX14, SOX2, SOX15, SOX21, SOX12, SOX3, SOX30, SOX4, SOX5, SOX9, SRY
Members of the SRY family regulate the human LINE retrotransposons.
Tchenio T, Casella JF, Heidmann T.
Nucleic Acids Res 28(2):411-5 2000
79SOX1, SOX10, SOX11, SOX14, SOX2, SOX15, SOX12, SOX2L, SOX3, SOX4, SOX5, SOX5P, SOX9
From head to toes: the multiple facets of Sox proteins.
Wegner M.
Nucleic Acids Res 27(6):1409-1420. 1999
80CDLS,CHRD,DUP3QD,GSC,SOX2
Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes.
Smith M, et al.
Hum Genet 105(1-2):104-11. 1999
81SOX2
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
Yuan H, Corbi N, Basilico C, Dailey L.
Genes Dev 9(21):2635-45. 1995
82SOX2, SOX2L
The cDNA sequence and chromosomal location of the human SOX2 gene.
Stevanovic M, et al.
Mamm Genome 5 : 640-642. 1994