Citations for
1LZTR1, NS10, NS9, SOS2
Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.
Capri Y, Flex E, Krumbach OHF, Carpentieri G, Cecchetti S, Lißewski C, Rezaei Adariani S, Schanze D, Brinkmann J, Piard J, Pantaleoni F, Lepri FR, Goh ES, Chong K, Stieglitz E, Meyer J, Kuechler A, Bramswig NC, Sacharow S, Strullu M, Vial Y, Vignal C, Kensah G, Cuturilo G, Kazemein Jasemi NS, Dvorsky R, Monaghan KG, Vincent LM, Cavé H, Verloes A, Ahmadian MR, Tartaglia M, Zenker M.
Am J Hum Genet 104(6):1223-1232. doi: 10.1016/j.ajhg.2019.04.013. Epub 2019 May 23. 2019
2KRAS, SOS2
Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.
Sheffels E, Sealover NE, Wang C, Kim DH, Vazirani IA, Lee E, M Terrell E, Morrison DK, Luo J, Kortum RL.
Sci Signal 11(546). pii: eaar8371. doi: 10.1126/scisignal.aar8371. 2018
3SOS1, SOS2
Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.
Liceras-Boillos P, Jimeno D, García-Navas R, Lorenzo-Martín LF, Menacho-Marquez M, Segrelles C, Gómez C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Baltanás FC, Santos E.
Mol Cell Biol 38(16). pii: e00049-18. doi: 10.1128/MCB.00049-18. Print 2018 Aug 15. 2018
4NS9, SOS2
Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.
Cordeddu V, Yin JC, Gunnarsson C, Virtanen C, Drunat S, Lepri F, De Luca A, Rossi C, Ciolfi A, Pugh TJ, Bruselles A, Priest JR, Pennacchio LA, Lu Z, Danesh A, Quevedo R, Hamid A, Martinelli S, Pantaleoni F, Gnazzo M, Daniele P, Lissewski C, Bocchinfuso G, Stella L, Odent S, Philip N, Faivre L, Vlckova M, Seemanova E, Digilio C, Zenker M, Zampino G, Verloes A, Dallapiccola B, Roberts AE, Cavé H, Gelb BD, Neel BG, Tartaglia M.
Hum Mutat 36(11):1080-7. doi: 10.1002/humu.22834. Epub 2015 Aug 3. 2015
5SOS1, SOS2
Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.
Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE.
Eur J Immunol 45(8):2389-95. doi: 10.1002/eji.201445226. Epub 2015 Jun 5. 2015
6SOS1, SOS2
Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.
Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E.
Mol Cell Biol 33(22):4562-78. doi: 10.1128/MCB.01026-13. Epub 2013 Sep 16. 2013
7SOS2
Sos2 is dispensable for NMDA-induced Erk activation and LTP induction.
Arai JA, Li S, Feig LA.
Neurosci Lett 455(1):22-5. doi: 10.1016/j.neulet.2009.03.047. Epub 2009 Mar 18. 2009
8SOS2
Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1.
Scholler JK, Perez-Villar JJ, O'Day K, Kanner SB.
Eur J Immunol 30(8):2378-87. 2000
9SOS2
The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties.
Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E.
EMBO J 19(4):642-54. 2000
10SOS2
Differential interactions of human Sos1 and Sos2 with Grb2.
Yang SS, Van Aelst L, Bar-Sagi D.
J Biol Chem 270(31):18212-5. 1995
11SOS1, SOS2
Chromosomal localization of two genes encoding human ras exchange factors : SOS1, maps to the 2p22-p16 region and SOS2 to the 14q21-q22 region of the human genome.
Chardin P, et al.
Cytogenet Cell Genet 66 : 68-69. 1994
12SOS2, SOS1
Identification of two human homologues to Drosophila SOS (Son of Sevenless) localized on two different chromosomes.
Fath I, et al.
Nucleic Acids Res 21 : 4398. 1993
13SOS1, SOS2
Mammalian homologues of the Drosophila son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively.
Webb GC, et al.
Genomics 18 : 14-19. 1993