Citations for
1CES1, SORT1
Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T.
J Biol Chem 292(1):146-160. doi: 10.1074/jbc.M116.762005. Epub 2016 Nov 23. 2017
2AP1S2, DLK1, SORT1
σ1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.
Baltes J, Larsen JV, Radhakrishnan K, Geumann C, Kratzke M, Petersen CM, Schu P.
J Cell Sci 127(Pt 16):3477-87. doi: 10.1242/jcs.146886. Epub 2014 Jun 13. 2014
3BACE1, SORT1
BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.
Finan GM, Okada H, Kim TW.
J Biol Chem 286(14):12602-16. Epub 2011 Jan 18. 2011
4SORT1
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.
Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ.
Nature 466(7307):714-9.PMID: 20686566 2010
5SORT1
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, Petersen RC, Graff-Radford NR, Younkin SG, Rademakers R.
Am J Hum Genet 87(6):890-7. Epub 2010 Nov 18.PMID: 21087763 2010
6CNTF, IL6ST, SORT1
Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.
Larsen JV, Hansen M, Møller B, Madsen P, Scheller J, Nielsen M, Petersen CM.
Mol Cell Biol 30(17):4175-87. Epub 2010 Jun 28. 2010
7SORT1
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.
Quistgaard EM, Madsen P, Grøftehauge MK, Nissen P, Petersen CM, Thirup SS.
Nat Struct Mol Biol 16(1):96-8. Epub 2009 Jan 4. 2009
8APP, IGF2R, PACS1, SORCS1, SORCS2, SORCS3, SORL1, SORT1
VPS10P-domain receptors - regulators of neuronal viability and function.
Willnow TE, Petersen CM, Nykjaer A.
Nat Rev Neurosci. 9(12):899-909. 2009
9CTSD, CTSH, SORT1
Sortilin mediates the lysosomal targeting of cathepsins D and H.
Canuel M, Korkidakis A, Konnyu K, Morales CR.
Biochem Biophys Res Commun 373(2):292-7. Epub 2008 Jun 16. 2008
10SORT1
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, Wahlstrand B, Hedner T, Corella D, Tai ES, Ordovas JM, Berglund G, Vartiainen E, Jousilahti P, Hedblad B, Taskinen MR, Newton-Cheh C, Salomaa V, Peltonen L, Groop L, Altshuler DM, Orho-Melander M.
Nature Genet. 40(2):189-97. 2008
11sort1
Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes.
Ariga M, Nedachi T, Katagiri H, Kanzaki M.
J Biol Chem. 283(15):10208-20. 2008
12SORT1
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A.
Nat Neurosci 10(11):1449-57. Epub 2007 Oct 14. 2007
13SORT1
The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles.
Shi J, Kandror KV.
J Biol Chem 282(12):9008-16. Epub 2007 Jan 12. 2007
14SORT1
Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development.
Nakamura K, Namekata K, Harada C, Harada T.
Cell Death Differ. 14(8):1552-4. 2007
15SORT1
Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes.
Shi J, Kandror KV.
Dev Cell. 9(1):99-108. 2005
16CALM1, CDK5R1, CFHR1, FGF13, GABRB3, HBB, MAP1B, MAP2, MAP2K4, RAB6A, RAP2A, SCN2B, SORT1, SYN2, VAMP1, YWHAZ, ZBTB18
Gene regulation and DNA damage in the ageing human brain.
Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA.
Nature 429(6994):883-91. Epub 2004 Jun 09. 2004
17NGFR, SORT1
Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM.
Nature. 427(6977):798-9. 2004
18SORCS1, SORCS2, SORCS3, SORL1, SORT1
The genes for the human VPS10 domain-containing receptors are large and contain many small exons.
Hampe W, Rezgaoui M, Hermans-Borgmeyer I, Schaller HC.
Hum Genet 108(6):529-36. 2001
19GGA1, GGA2, GGA3, SORT1
Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.
Takatsu H, Katoh Y, Shiba Y, Nakayama K.
J Biol Chem 276(30):28541-5. 2001
20SORT1
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM.
EMBO J. 20(9):2180-90. 2001
21SORT1
Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.
Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J, Petersen CM.
J Biol Chem. 274(13):8832-6. 1999
22SORT1
The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor.
Mazella J, Zsurger N, Navarro V, Chabry J, Kaghad M, Caput D, Ferrara P, Vita N, Gully D, Maffrand JP, Vincent JP.
J Biol Chem 273(41):26273-6. 1998
23SORT1
Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes.
Morris NJ, Ross SA, Lane WS, Moestrup SK, Petersen CM, Keller SR, Lienhard GE.
J Biol Chem 273(6):3582-7. 1998
24SORT1
Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.
Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, Roigaard H, Gliemann J, Madsen P, Moestrup SK.
J Biol Chem 272(6):3599-605. 1997