1 | JAK1, JAK2, SOCS1
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| Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies.
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| Liau NPD, Babon JJ.
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| Methods Mol Biol. 1725:267-280. doi: 10.1007/978-1-4939-7568-6_21 2018
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2 | SOCS1, SOCS5
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| SOCS gene family expression profile in the blood of multiple sclerosis patients.
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| Toghi M, Taheri M, Arsang-Jang S, Ohadi M, Mirfakhraie R, Mazdeh M, Sayad A.
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| J Neurol Sci 375:481-485. doi: 10.1016/j.jns.2017.02.015. Epub 2017 Feb 9.
2017
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3 | APC, GSTP1, SOCS1
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| Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis.
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| Liu M, Cui LH, Li CC, Zhang L.
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| Eur J Cancer Prev 24(6):470-83. doi: 10.1097/CEJ.0000000000000121.
2015
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4 | SOCS1, SOCS3
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| Suppressors of cytokine signaling promote Fas-induced apoptosis through downregulation of NF-κB and mitochondrial Bfl-1 in leukemic T cells.
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| Oh J, Kim SH, Ahn S, Lee CE.
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| J Immunol 189(12):5561-71. doi: 10.4049/jimmunol.1103415. Epub 2012 Nov 14.
2012
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5 | SOCS1, SOCS2, SOCS3
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| Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature.
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| Ocaranza P, Morales F, Román R, Iñiguez G, Fernando C.
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| J Pediatr Endocrinol Metab 25(3-4):273-8.
2012
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6 | LCK, SOCS1, SOCS3
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| Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
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| Venkitachalam S, Chueh FY, Leong KF, Pabich S, Yu CL.
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| Oncol Rep 25(3):677-83. doi: 10.3892/or.2011.1144. Epub 2011 Jan 13. 2011
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7 | SOCS1, ZBTB17
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| IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1
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| Saba I, Kosan C, Vassen L, Möröy T.
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| Blood. Mar 24;117(12):3370-81. doi: 10.1182/blood-2010-09-310680. Epub 2011 Jan 21. 2011
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8 | CCL11, SOCS1, SOCS3
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| Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
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| Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C, Johnston JA.
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| FEBS Lett 584(21):4469-74. doi: 10.1016/j.febslet.2010.10.007. Epub 2010 Oct 8.
2010
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9 | SOCS1, SOCS3, SOCS4, SOCS7
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| Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.
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| Sasi W, Jiang WG, Sharma A, Mokbel K.
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| BMC Cancer 10:178. doi: 10.1186/1471-2407-10-178.
2010
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10 | JAK1, PIAS1, SOCS1, SOCS3, STAT1, STAT3
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| SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
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| Diao Y, Wang X, Wu Z.
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| Mol Cell Biol 29(18):5084-93. Epub 2009 Jul 20.
2009
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11 | CISH, SOCS1, SOCS2, SOCS3, SOCS6, SOCS7
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| Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation.
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| Lee KH, Moon KJ, Kim HS, Yoo BC, Park S, Lee H, Kwon S, Lee ES, Yoon S.
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| FEBS Lett 582(15):2319-24. Epub 2008 Jun 4. 2008
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12 | SOCS1, SOCS3, SOCS6
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| Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells.
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| Liu X, Mameza MG, Lee YS, Eseonu CI, Yu CR, Kang Derwent JJ, Egwuagu CE.
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| Diabetes 57(6):1651-8. Epub 2008 Mar 20.PMID: 18356406 2008
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13 | PINX1, TERT, SOCS1
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| Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.
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| Lin J, Jin R, Zhang B, Yang PX, Chen H, Bai YX, Xie Y, Huang C, Huang J.
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| Biochem Biophys Res Commun 353(4):946-52. Epub 2006 Dec 22. 2007
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14 | SOCS3, SOCS1
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| SOCS proteins, cytokine signalling and immune regulation.
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| Yoshimura A, Naka T, Kubo M.
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| Nat Rev Immunol 7(6):454-65. Epub 2007 May 18. Review. 2007
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15 | NDRG2, SOCS1, STAT3, MAPK14
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| SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells.
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| Park Y, Shon SK, Kim A, Kim KI, Yang Y, Cho DH, Lee MS, Lim JS.
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| Biochem Biophys Res Commun 363(2):361-7. Epub 2007 Sep 14. 2007
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16 | SOCS1
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| SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis.
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| Chung CS, Chen Y, Grutkoski PS, Doughty L, Ayala A.
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| Apoptosis 12(7):1143-53.
2007
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17 | SOCS1, SOCS3
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| Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
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| Ueki K, Kondo T, Kahn CR.
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| Mol Cell Biol 24(12):5434-46. Erratum in: Mol Cell Biol. 2005 Oct;25(19):8762. 2004
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18 | SOCS1, SOCS2, SOCS3, SOCS6, SOCS5, SOCS7, SOCS4
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| SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia.
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| Chen CY, Tsay W, Tang JL, Shen HL, Lin SW, Huang SY, Yao M, Chen YC, Shen MC, Wang CH, Tien HF.
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| Genes Chromosomes Cancer 37(3):300-5. 2003
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19 | GFI1B, SOCS1
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| Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.
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| Jegalian AG, Wu H.
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| J Biol Chem 277(3):2345-52. Epub 2001 Nov 05. 2002
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20 | SOCS1, SOCS2, SOCS3
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| Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor.
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| Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD.
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| J Clin Endocrinol Metab 87(3):1094-7. 2002
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21 | PIM1, PIM2, SOCS1
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| Pim serine/threonine kinases regulate the stability of Socs-1 protein.
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| Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P.
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| Proc Natl Acad Sci U S A 99(4):2175-80. 2002
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22 | SOCS1, IFNG
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| The tumor suppressor activity of SOCS-1.
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| Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P.
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| Oncogene 21(28):4351-62. 2002
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23 | TRIM8, SOCS1
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| TRIM8/GERP RING finger protein interacts with SOCS-1.
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| Toniato E, Chen XP, Losman J, Flati V, Donahue L, Rothman P.
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| J Biol Chem 277(40):37315-22. Epub 2002 Aug 05. 2002
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24 | SOCS1
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| SOCS1/JAB is a negative regulator of LPS-induced macrophage activation.
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| Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A.
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| Immunity 17(5):583-91. 2002
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25 | SOCS1
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| SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.
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| Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC, Herman JG.
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| Nat Genet 28(1):29-35. 2001
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26 | SOCS1
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| SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
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| Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, Zhang JG, Starr R, Hilton DJ, Alexander WS, Ormandy CJ, Visvader J.
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| Genes Dev 15(13):1631-6. 2001
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27 | SOCS1
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| Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
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| Morita Y, Naka T, Kawazoe Y, Fujimoto M, Narazaki M, Nakagawa R, Fukuyama H, Nagata S, Kishimoto T.
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| Proc Natl Acad Sci U S A 97(10):5405-10. 2000
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28 | PTPN11, SOCS1, SOCS3
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| SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
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| Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F.
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| J Biol Chem 275(17):12848-56. 2000
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29 | SOCS1, SOCS2
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| Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.
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| Yandava CN, et al.
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| Genomics 61(1):108-11 1999
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30 | SOCS1, TSG16D
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| Localization of a target region of allelic loss to a 1-cM interval on chromosome 16p.13.13 in hepatocellular carcinoma.
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| Koyama M, Nagai H, Bando K, Ito M, Moriyama Y, Emi M.
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| Jpn J Cancer Res 90(9):951-6 1999
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31 | SOCS1
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| SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
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| Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ.
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| Cell 98(5):597-608. 1999
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32 | SOCS1
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| SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
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| Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN.
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| Cell 98(5):609-16. 1999
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33 | SOCS1
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| Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
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| De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R.
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| EMBO J 18(4):904-15. 1999
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34 | SOCS1
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| A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13.
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| Kramer JA, et al.
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| Somat Cell Mol Genet 24(2):131-3 1998
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35 | SOCS1
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| Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
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| Starr R, Metcalf D, Elefanty AG, Brysha M, Willson TA, Nicola NA, Hilton DJ, Alexander WS.
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| Proc Natl Acad Sci U S A 95(24):14395-9. 1998
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36 | SOCS1, SOCS2
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| A family of cytokine-inducible inhibitors of signalling.
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| Starr R, et al.
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| Nature 387(6636):917-21 1997
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37 | SOCS1
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| Structure and function of a new STAT-induced STAT inhibitor.
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| Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T.
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| Nature 387(6636):924-9. 1997
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38 | SOCS2, SOCS1, SOCS3
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| Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
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| Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T.
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| Biochem Biophys Res Commun 237(1):79-83. 1997
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39 | SOCS1
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| SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.
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| Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H.
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| J Biol Chem 272(43):27178-82. 1997
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40 | CISH, SOCS1
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| A new protein containing an SH2 domain that inhibits JAK kinases.
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| Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A.
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| Nature 387(6636):921-4. 1997
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41 | CISH, SOCS1
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| A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
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| Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A.
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| EMBO J 14(12):2816-26. 1995
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