Citations for
1JAK1, JAK2, SOCS1
Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies.
Liau NPD, Babon JJ.
Methods Mol Biol. 1725:267-280. doi: 10.1007/978-1-4939-7568-6_21 2018
2SOCS1, SOCS5
SOCS gene family expression profile in the blood of multiple sclerosis patients.
Toghi M, Taheri M, Arsang-Jang S, Ohadi M, Mirfakhraie R, Mazdeh M, Sayad A.
J Neurol Sci 375:481-485. doi: 10.1016/j.jns.2017.02.015. Epub 2017 Feb 9. 2017
3APC, GSTP1, SOCS1
Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis.
Liu M, Cui LH, Li CC, Zhang L.
Eur J Cancer Prev 24(6):470-83. doi: 10.1097/CEJ.0000000000000121. 2015
4SOCS1, SOCS3
Suppressors of cytokine signaling promote Fas-induced apoptosis through downregulation of NF-κB and mitochondrial Bfl-1 in leukemic T cells.
Oh J, Kim SH, Ahn S, Lee CE.
J Immunol 189(12):5561-71. doi: 10.4049/jimmunol.1103415. Epub 2012 Nov 14. 2012
5SOCS1, SOCS2, SOCS3
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature.
Ocaranza P, Morales F, Román R, Iñiguez G, Fernando C.
J Pediatr Endocrinol Metab 25(3-4):273-8. 2012
6LCK, SOCS1, SOCS3
Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
Venkitachalam S, Chueh FY, Leong KF, Pabich S, Yu CL.
Oncol Rep 25(3):677-83. doi: 10.3892/or.2011.1144. Epub 2011 Jan 13. 2011
7SOCS1, ZBTB17
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1
Saba I, Kosan C, Vassen L, Möröy T.
Blood. Mar 24;117(12):3370-81. doi: 10.1182/blood-2010-09-310680. Epub 2011 Jan 21. 2011
8CCL11, SOCS1, SOCS3
Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C, Johnston JA.
FEBS Lett 584(21):4469-74. doi: 10.1016/j.febslet.2010.10.007. Epub 2010 Oct 8. 2010
9SOCS1, SOCS3, SOCS4, SOCS7
Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.
Sasi W, Jiang WG, Sharma A, Mokbel K.
BMC Cancer 10:178. doi: 10.1186/1471-2407-10-178. 2010
10JAK1, PIAS1, SOCS1, SOCS3, STAT1, STAT3
SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Diao Y, Wang X, Wu Z.
Mol Cell Biol 29(18):5084-93. Epub 2009 Jul 20. 2009
11CISH, SOCS1, SOCS2, SOCS3, SOCS6, SOCS7
Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation.
Lee KH, Moon KJ, Kim HS, Yoo BC, Park S, Lee H, Kwon S, Lee ES, Yoon S.
FEBS Lett 582(15):2319-24. Epub 2008 Jun 4. 2008
12SOCS1, SOCS3, SOCS6
Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells.
Liu X, Mameza MG, Lee YS, Eseonu CI, Yu CR, Kang Derwent JJ, Egwuagu CE.
Diabetes 57(6):1651-8. Epub 2008 Mar 20.PMID: 18356406 2008
13PINX1, TERT, SOCS1
Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.
Lin J, Jin R, Zhang B, Yang PX, Chen H, Bai YX, Xie Y, Huang C, Huang J.
Biochem Biophys Res Commun 353(4):946-52. Epub 2006 Dec 22. 2007
14SOCS3, SOCS1
SOCS proteins, cytokine signalling and immune regulation.
Yoshimura A, Naka T, Kubo M.
Nat Rev Immunol 7(6):454-65. Epub 2007 May 18. Review. 2007
15NDRG2, SOCS1, STAT3, MAPK14
SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells.
Park Y, Shon SK, Kim A, Kim KI, Yang Y, Cho DH, Lee MS, Lim JS.
Biochem Biophys Res Commun 363(2):361-7. Epub 2007 Sep 14. 2007
16SOCS1
SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis.
Chung CS, Chen Y, Grutkoski PS, Doughty L, Ayala A.
Apoptosis 12(7):1143-53. 2007
17SOCS1, SOCS3
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Ueki K, Kondo T, Kahn CR.
Mol Cell Biol 24(12):5434-46. Erratum in: Mol Cell Biol. 2005 Oct;25(19):8762. 2004
18SOCS1, SOCS2, SOCS3, SOCS6, SOCS5, SOCS7, SOCS4
SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia.
Chen CY, Tsay W, Tang JL, Shen HL, Lin SW, Huang SY, Yao M, Chen YC, Shen MC, Wang CH, Tien HF.
Genes Chromosomes Cancer 37(3):300-5. 2003
19GFI1B, SOCS1
Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.
Jegalian AG, Wu H.
J Biol Chem 277(3):2345-52. Epub 2001 Nov 05. 2002
20SOCS1, SOCS2, SOCS3
Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor.
Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD.
J Clin Endocrinol Metab 87(3):1094-7. 2002
21PIM1, PIM2, SOCS1
Pim serine/threonine kinases regulate the stability of Socs-1 protein.
Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P.
Proc Natl Acad Sci U S A 99(4):2175-80. 2002
22SOCS1, IFNG
The tumor suppressor activity of SOCS-1.
Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P.
Oncogene 21(28):4351-62. 2002
23TRIM8, SOCS1
TRIM8/GERP RING finger protein interacts with SOCS-1.
Toniato E, Chen XP, Losman J, Flati V, Donahue L, Rothman P.
J Biol Chem 277(40):37315-22. Epub 2002 Aug 05. 2002
24SOCS1
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation.
Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A.
Immunity 17(5):583-91. 2002
25SOCS1
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.
Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC, Herman JG.
Nat Genet 28(1):29-35. 2001
26SOCS1
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, Zhang JG, Starr R, Hilton DJ, Alexander WS, Ormandy CJ, Visvader J.
Genes Dev 15(13):1631-6. 2001
27SOCS1
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
Morita Y, Naka T, Kawazoe Y, Fujimoto M, Narazaki M, Nakagawa R, Fukuyama H, Nagata S, Kishimoto T.
Proc Natl Acad Sci U S A 97(10):5405-10. 2000
28PTPN11, SOCS1, SOCS3
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F.
J Biol Chem 275(17):12848-56. 2000
29SOCS1, SOCS2
Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.
Yandava CN, et al.
Genomics 61(1):108-11 1999
30SOCS1, TSG16D
Localization of a target region of allelic loss to a 1-cM interval on chromosome 16p.13.13 in hepatocellular carcinoma.
Koyama M, Nagai H, Bando K, Ito M, Moriyama Y, Emi M.
Jpn J Cancer Res 90(9):951-6 1999
31SOCS1
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ.
Cell 98(5):597-608. 1999
32SOCS1
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN.
Cell 98(5):609-16. 1999
33SOCS1
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R.
EMBO J 18(4):904-15. 1999
34SOCS1
A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13.
Kramer JA, et al.
Somat Cell Mol Genet 24(2):131-3 1998
35SOCS1
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
Starr R, Metcalf D, Elefanty AG, Brysha M, Willson TA, Nicola NA, Hilton DJ, Alexander WS.
Proc Natl Acad Sci U S A 95(24):14395-9. 1998
36SOCS1, SOCS2
A family of cytokine-inducible inhibitors of signalling.
Starr R, et al.
Nature 387(6636):917-21 1997
37SOCS1
Structure and function of a new STAT-induced STAT inhibitor.
Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T.
Nature 387(6636):924-9. 1997
38SOCS2, SOCS1, SOCS3
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T.
Biochem Biophys Res Commun 237(1):79-83. 1997
39SOCS1
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.
Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H.
J Biol Chem 272(43):27178-82. 1997
40CISH, SOCS1
A new protein containing an SH2 domain that inhibits JAK kinases.
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A.
Nature 387(6636):921-4. 1997
41CISH, SOCS1
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A.
EMBO J 14(12):2816-26. 1995