| 1 | PVT1, SNCAIP
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| Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
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| Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fčvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD.
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| Nature 488(7409):49-56. doi: 10.1038/nature11327.
2012
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| 2 | PARK25, SNCAIP
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| Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.
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| Keyser RJ, Oppon E, Carr JA, Bardien S.
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| J Neural Transm 118(6):889-97. Epub 2011 Feb 23. 2011
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| 3 | SNCAIP
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| Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.
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| Alvarez-Castelao B, Castańo JG.
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| Cell Mol Life Sci 68(15):2643-54. Epub 2010 Nov 20.
2011
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| 4 | NUB1, SNCAIP
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| Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.
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| Tanji K, Mori F, Kito K, Kakita A, Mimura J, Itoh K, Takahashi H, Kamitani T, Wakabayashi K.
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| J Neuropathol Exp Neurol 70(10):879-89. doi: 10.1097/NEN.0b013e3182303745.
2011
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| 5 | SNCAIP
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| Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
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| Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA.
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| Hum Mol Genet 19(11):2087-98. Epub 2010 Feb 25.
2010
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| 6 | SNCA, SNCAIP
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| Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
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| Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY.
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| FASEB J 24(1):196-205. Epub 2009 Sep 17.
2010
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| 7 | PPHLN1, SNCAIP
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| Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.
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| Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O.
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| Neurogenetics 11(2):203-15.
2010
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| 8 | SNCA, SNCAIP
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| Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.
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| Szargel R, Rott R, Eyal A, Haskin J, Shani V, Balan L, Wolosker H, Engelender S.
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| J Biol Chem 284(17):11706-16. Epub 2009 Feb 17.
2009
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| 9 | SNCAIP
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| Synphilin-1 transgenic mice exhibit mild motor impairments.
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| Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M.
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| Neurosci Lett 445(1):12-7. Epub 2008 Aug 31.
2008
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| 10 | SNCAIP
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| Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.
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| Szargel R, Rott R, Engelender S.
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| Cell Mol Life Sci 65(1):80-8. Review.
2008
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| 11 | PARK25, SNCAIP
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| alpha-Synuclein and Parkinson disease susceptibility.
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| Winkler S, Hagenah J, Lincoln S, Heckman M, Haugarvoll K, Lohmann-Hedrich K, Kostic V, Farrer M, Klein C.
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| Neurology 69(18):1745-50. Epub 2007 Sep 13. 2007
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| 12 | PSMC4,SNCAIP
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| The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease.
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| Marx FP, Soehn AS, Berg D, Melle C, Schiesling C, Lang M, Kautzmann S, Strauss KM, Franck T, Engelender S, Pahnke J, Dawson S, von Eggeling F, Schulz JB, Riess O, Kruger R.
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| FASEB J 21(8):1759-67. Epub 2007 Feb 27. 2007
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| 13 | PARK25, SNCAIP
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| Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.
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| Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Krüger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin MC, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert JC, Lynch T, Mellick GD, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan EK, Van Broeckhoven C; Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.
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| JAMA 296(6):661-70. 2006
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| 14 | SNCAIP
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| Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
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| Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.
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| Proc Natl Acad Sci U S A 103(15):5917-22. Epub 2006 Apr 4. 2006
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| 15 | SNCAIP
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| Interactions of Synphilin-1 with phospholipids and lipid membranes.
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| Takahashi T, Yamashita H, Nagano Y, Nakamura T, Kohriyama T, Matsumoto M.
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| FEBS Lett 580(18):4479-84. Epub 2006 Jul 17. 2006
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| 16 | SNCA,SNCAIP
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| Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
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| Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.
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| Proc Natl Acad Sci U S A 103(15):5917-22. Epub 2006 Apr 4. 2006
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| 17 | PRKN, SNCAIP
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| Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.
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| Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM.
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| J Neurosci 25(8):2002-9. 2005
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| 18 | SNCA, SNCAIP, SIAH1, SIAH2
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| Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.
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| Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.
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| Proc Natl Acad Sci U S A 101(15):5500-5. Epub 2004 Apr 02. 2004
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| 19 | SNCAIP
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| The role of synphilin-1 in synaptic function and protein degradation.
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| Krüger R.
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| Cell Tissue Res 318(1):195-9. Epub 2004 Aug 19. Review.
2004
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| 20 | SNCAIP
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| Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
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| Marx FP, Holzmann C, Strauss KM, Li L, Eberhardt O, Gerhardt E, Cookson MR, Hernandez D, Farrer MJ, Kachergus J, Engelender S, Ross CA, Berger K, Schols L, Schulz JB, Riess O, Kruger R.
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| Hum Mol Genet 12(11):1223-31. 2003
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| 21 | RNF19A, SNCAIP
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| Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.
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| Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G.
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| J Biol Chem 278(31):29106-14. Epub 2003 May 15. 2003
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| 22 | SNCAIP, SNCA
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| Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein.
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| Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S.
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| J Biol Chem 277(26):23927-33. Epub 2002 Apr 15. Erratum in: J Biol Chem 2002 Sep 13;277(37):34651-4. 2002
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| 23 | SNCAIP
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| Synphilin-1 is present in Lewy bodies in Parkinson's disease.
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| Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H.
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| Ann Neurol 47(4):521-3. 2000
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| 24 | SNCAIP
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| Organization of the human synphilin-1 gene, a candidate for Parkinson's disease.
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| Engelender S, Wanner T, Kleiderlein JJ, Wakabayashi K, Tsuji S, Takahashi H, Ashworth R, Margolis RL, Ross CA.
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| Mamm Genome 11(9):763-6. 2000
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| 25 | SNCAIP
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| Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.
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| Engelender S, et al.
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| Nat Genet 22(1):110-4. 1999
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