Citations for
1AIMP2, SNCA
Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion
Ham S, Yun SP, Kim H, Kim D, Seo BA, Kim H, Shin JY, Dar MA, Lee GH, Lee YI, Kim D, Kim S, Kweon HS, Shin JH, Ko HS, Lee Y.
Sci Transl Med. Nov 11;12(569):eaax0091. doi: 10.1126/scitranslmed.aax0091. 2020
2PARK1, SNCA
Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.
McClymont SA, Hook PW, Soto AI, Reed X, Law WD, Kerans SJ, Waite EL, Briceno NJ, Thole JF, Heckman MG, Diehl NN, Wszolek ZK, Moore CD, Zhu H, Akiyama JA, Dickel DE, Visel A, Pennacchio LA, Ross OA, Beer MA, McCallion AS.
Am J Hum Genet 103(6):874-892. doi: 10.1016/j.ajhg.2018.10.018. Epub 2018 Nov 29. 2018
3SNCA, TRIM17, TRIM41, ZSCAN21
The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
Lassot I, Mora S, Lesage S, Zieba BA, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Soulet C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.
Cell Rep. Nov 27;25(9):2484-2496.e9. doi: 10.1016/j.celrep.2018.11.002 2018
4SNCA, TPPP
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J.
Biochim Biophys Acta 1863(1):310-323. doi: 10.1016/j.bbadis.2016.09.017. Epub 2016 Sep 24. 2017
5DNAJB6, HSPA4, SNCA
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C.
Sci Rep 7(1):9039. doi: 10.1038/s41598-017-08324-z. 2017
6RER1, SNCA
The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.
Park HJ, Ryu D, Parmar M, Giasson BI, McFarland NR.
PLoS One 12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017. 2017
7SNCA, TRIM32
Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.
Pavlou MAS, Colombo N, Fuertes-Alvarez S, Nicklas S, Cano LG, Marín MC, Goncalves J, Schwamborn JC.
Mol Neurobiol 54(6):4257-4270. doi: 10.1007/s12035-016-9989-9. Epub 2016 Jun 23. 2017
8ATP13A2, SNCA
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.
Lopes da Fonseca T, Pinho R, Outeiro TF.
Hum Mol Genet 25(14):2959-2971. Epub 2016 Jun 8. 2016
9SNCA
The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy.
Assereto S, Piccirillo R, Baratto S, Scudieri P, Fiorillo C, Massacesi M, Traverso M, Galietta LJ, Bruno C, Minetti C, Zara F, Gazzerro E.
Lab Invest 96(8):862-71. doi: 10.1038/labinvest.2016.63. Epub 2016 Jun 13. 2016
10SNCA, ZSCAN21
Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo.
Dermentzaki G, Paschalidis N, Politis PK, Stefanis L.
J Biol Chem. Apr 15;291(16):8756-72. doi: 10.1074/jbc.M115.704973. Epub 2016 Feb 23 2016
11DYRK1A, MAPT, SNCA
Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A.
Kay LJ, Smulders-Srinivasan TK, Soundararajan M.
Adv Protein Chem Struct Biol. 105:127-71. doi: 10.1016/bs.apcsb.2016.07.001. Epub 2016 Aug 9 2016
12SNCA
Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane.
Pacheco CR, Morales CN, Ramírez AE, Muńoz FJ, Gallegos SS, Caviedes PA, Aguayo LG, Opazo CM.
J Neurochem 132(6):731-41. doi: 10.1111/jnc.13060. Epub 2015 Feb 25. 2015
13PARK1, SNCA
Familial Parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein.
Sahay S, Ghosh D, Dwivedi S, Anoop A, Mohite GM, Kombrabail M, Krishnamoorthy G, Maji SK.
J Biol Chem 290(12):7804-22. doi: 10.1074/jbc.M114.598607. Epub 2015 Jan 29. 2015
14SNCA, TPPP
Targeting the interface of the pathological complex of α-synuclein and TPPP/p25.
Szunyogh S, Oláh J, Szénási T, Szabó A, Ovádi J.
Biochim Biophys Acta 1852(12):2653-61. doi: 10.1016/j.bbadis.2015.09.012. Epub 2015 Sep 25. 2015
15CTSD, SNCA
Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates.
Bae EJ, Yang NY, Lee C, Kim S, Lee HJ, Lee SJ.
Cell Death Dis 6:e1901. doi: 10.1038/cddis.2015.283. 2015
16CPLX1, SNCA
Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology.
Gispert S, Kurz A, Brehm N, Rau K, Walter M, Riess O, Auburger G.
Mol Neurobiol 52(1):57-63. doi: 10.1007/s12035-014-8844-0. Epub 2014 Aug 12. 2015
17EIF4G1, SNCA, VPS35
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD.
Neuron 85(1):76-87. doi: 10.1016/j.neuron.2014.11.027. Epub 2014 Dec 18. Erratum in: Neuron. 2015 Feb 4;85(3):657. 2015
18SNCA
α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.
Bir A, Sen O, Anand S, Khemka VK, Banerjee P, Cappai R, Sahoo A, Chakrabarti S.
J Neurochem 131(6):868-77. doi: 10.1111/jnc.12966. Epub 2014 Nov 18. 2014
19SNCA
Alpha synuclein is transported into and out of the brain by the blood-brain barrier.
Sui YT, Bullock KM, Erickson MA, Zhang J, Banks WA.
Peptides 62:197-202. doi: 10.1016/j.peptides.2014.09.018. Epub 2014 Sep 30. 2014
20SNCA
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Burré J, Sharma M, Südhof TC.
Proc Natl Acad Sci U S A 111(40):E4274-83. doi: 10.1073/pnas.1416598111. Epub 2014 Sep 22. 2014
21HSPA5, SNCA
GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
Bellani S, Mescola A, Ronzitti G, Tsushima H, Tilve S, Canale C, Valtorta F, Chieregatti E.
Cell Death Differ 21(12):1971-83. doi: 10.1038/cdd.2014.111. Epub 2014 Aug 15. 2014
22SNCA
Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.
Ettle B, Reiprich S, Deusser J, Schlachetzki JC, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J.
Mol Cell Neurosci 62:68-78. doi: 10.1016/j.mcn.2014.06.012. Epub 2014 Jul 11. 2014
23SNCA
Differential aggregation properties of alpha-synuclein isoforms.
Bungeroth M, Appenzeller S, Regulin A, Völker W, Lorenzen I, Grötzinger J, Pendziwiat M, Kuhlenbäumer G.
Neurobiol Aging 35(8):1913-9. doi: 10.1016/j.neurobiolaging.2014.02.009. Epub 2014 Feb 19. 2014
24SNCA
α-Synuclein is localized to mitochondria-associated ER membranes.
Guardia-Laguarta C, Area-Gomez E, Rüb C, Liu Y, Magrané J, Becker D, Voos W, Schon EA, Przedborski S.
J Neurosci 34(1):249-59. doi: 10.1523/JNEUROSCI.2507-13.2014. 2014
25FOXO3, SNCA
FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.
Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria JC, Knott GW, Schneider BL.
Hum Mol Genet 23(6):1435-52. doi: 10.1093/hmg/ddt530. Epub 2013 Oct 24. 2014
26RAB8A, SNCA
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.
Neurobiol Dis 70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28. 2014
27CTSB, CTSD, SNCA
Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.
Crabtree D, Dodson M, Ouyang X, Boyer-Guittaut M, Liang Q, Ballestas ME, Fineberg N, Zhang J.
J Neurochem 128(6):950-61. doi: 10.1111/jnc.12497. Epub 2013 Nov 13. 2014
28ENDOG, SNCA
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.
Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F.
EMBO J 32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15. 2013
29PRKN, SNCA
Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.
Lonskaya I, Desforges NM, Hebron ML, Moussa CE.
PLoS One 8(12):e83914. doi: 10.1371/journal.pone.0083914. eCollection 2013. 2013
30SNCA
α-Synuclein as a ferrireductase.
Brown DR.
Biochem Soc Trans 41(6):1513-7. doi: 10.1042/BST20130130. Review. 2013
31SNCA
Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.
Gardai SJ, Mao W, Schüle B, Babcock M, Schoebel S, Lorenzana C, Alexander J, Kim S, Glick H, Hilton K, Fitzgerald JK, Buttini M, Chiou SS, McConlogue L, Anderson JP, Schenk DB, Bard F, Langston JW, Yednock T, Johnston JA.
PLoS One 8(8):e71634. doi: 10.1371/journal.pone.0071634. eCollection 2013. 2013
32SNCA
Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.
Melachroinou K, Xilouri M, Emmanouilidou E, Masgrau R, Papazafiri P, Stefanis L, Vekrellis K.
Neurobiol Aging 34(12):2853-65. doi: 10.1016/j.neurobiolaging.2013.06.006. Epub 2013 Jul 25. 2013
33SNCA
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.
Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ.
Exp Mol Med 45:e22. doi: 10.1038/emm.2013.45. 2013
34SNCA, TOMM40
TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.
Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E.
PLoS One 8(4):e62277. doi: 10.1371/journal.pone.0062277. Print 2013. 2013
35SNCA, TPPP
Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F.
J Biol Chem 288(24):17313-35. doi: 10.1074/jbc.M112.401174. Epub 2013 Apr 29. 2013
36GBA, PSAP, SNCA
Saposin C protects glucocerebrosidase against α-synuclein inhibition.
Yap TL, Gruschus JM, Velayati A, Sidransky E, Lee JC.
Biochemistry 52(41):7161-3. doi: 10.1021/bi401191v. Epub 2013 Oct 1. 2013
37SNCA, SPTBN1
α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.
Lee HJ, Lee K, Im H.
Biochem Biophys Res Commun 424(3):497-502. doi: 10.1016/j.bbrc.2012.06.143. Epub 2012 Jul 4. 2012
38SNCA
Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.
Winner B, Regensburger M, Schreglmann S, Boyer L, Prots I, Rockenstein E, Mante M, Zhao C, Winkler J, Masliah E, Gage FH.
J Neurosci 32(47):16906-16. doi: 10.1523/JNEUROSCI.2723-12.2012. 2012
39PLK2, SNCA
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.
Wang S, Xu B, Liou LC, Ren Q, Huang S, Luo Y, Zhang Z, Witt SN.
Proc Natl Acad Sci U S A 109(40):16119-24. doi: 10.1073/pnas.1206286109. Epub 2012 Sep 17. 2012
40SNCA
Expression pattern and localization of alpha-synuclein in the human enteric nervous system.
Böttner M, Zorenkov D, Hellwig I, Barrenschee M, Harde J, Fricke T, Deuschl G, Egberts JH, Becker T, Fritscher-Ravens A, Arlt A, Wedel T.
Neurobiol Dis 48(3):474-80. doi: 10.1016/j.nbd.2012.07.018. Epub 2012 Jul 28. 2012
41SNCA
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.
Larson ME, Sherman MA, Greimel S, Kuskowski M, Schneider JA, Bennett DA, Lesné SE.
J Neurosci 32(30):10253-66. doi: 10.1523/JNEUROSCI.0581-12.2012. 2012
42PTPN1, SNCA
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
Choi HS, Liew H, Jang A, Kim YM, Lashuel H, Suh YH.
Biochem Biophys Res Commun 424(3):597-603. doi: 10.1016/j.bbrc.2012.06.159. Epub 2012 Jul 7. 2012
43SNCA
α-Synuclein expression is modulated at the translational level by iron.
Febbraro F, Giorgi M, Caldarola S, Loreni F, Romero-Ramos M.
Neuroreport 23(9):576-80. doi: 10.1097/WNR.0b013e328354a1f0. 2012
44SNCA
Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines.
Zhu M, Li W, Lu C.
PLoS One 7(4):e36377. doi: 10.1371/journal.pone.0036377. Epub 2012 Apr 27. 2012
45SNCA
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.
Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK.
J Neurosci 32(10):3306-20. doi: 10.1523/JNEUROSCI.5367-11.2012. 2012
46PLCB1, SNCA
α-Synuclein increases the cellular level of phospholipase Cβ1.
Guo Y, Rosati B, Scarlata S.
Cell Signal 24(5):1109-14. doi: 10.1016/j.cellsig.2012.01.007. Epub 2012 Jan 20. 2012
47NEDD4, SNCA
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.
Tofaris GK, Kim HT, Hourez R, Jung JW, Kim KP, Goldberg AL.
Proc Natl Acad Sci U S A 108(41):17004-9. Epub 2011 Sep 27. 2011
48SNCA, VPS4A
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.
Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A.
PLoS One 6(12):e29460. doi: 10.1371/journal.pone.0029460. Epub 2011 Dec 22. 2011
49RABAC1, SNCA
Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1.
Lee HJ, Kang SJ, Lee K, Im H.
Biochem Biophys Res Commun. Sep 9;412(4):526-31. doi: 10.1016/j.bbrc.2011.07.028. Epub 2011 Jul 21. 2011
50SNCA, TRAF6
TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.
Zucchelli S, Codrich M, Marcuzzi F, Pinto M, Vilotti S, Biagioli M, Ferrer I, Gustincich S.
Hum Mol Genet 19(19):3759-70. Epub 2010 Jul 14. 2010
51SNCA, SNCAIP
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY.
FASEB J 24(1):196-205. Epub 2009 Sep 17. 2010
52BST1, LRRK2, PARK16, PARK4, PARK8, SNCA
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T.
Nat Genet 41(12):1303-7. Epub 2009 Nov 15.PMID: 19915576 2009
53LRRK2, PARK16, PARK4, PARK8, SNCA
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T.
Nat Genet 41(12):1308-12. Epub 2009 Nov 15.PMID: 19915575 2009
54PARK1, PARK4, SNCA
Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.
Ibáńez P, Lesage S, Janin S, Lohmann E, Durif F, Destée A, Bonnet AM, Brefel-Courbon C, Heath S, Zelenika D, Agid Y, Dürr A, Brice A; French Parkinson's Disease Genetics Study Group.
Arch Neurol 66(1):102-8. 2009
55PLK2, SNCA
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP.
J Biol Chem 284(5):2598-602. Epub 2008 Nov 12. 2009
56SNCA, SNCAIP
Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.
Szargel R, Rott R, Eyal A, Haskin J, Shani V, Balan L, Wolosker H, Engelender S.
J Biol Chem 284(17):11706-16. Epub 2009 Feb 17. 2009
57SNCA
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S.
Proc Natl Acad Sci U S A 105(1):145-50. Epub 2007 Dec 27. 2008
58SIAH1, SNCA
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.
Lee JT, Wheeler TC, Li L, Chin LS.
Hum Mol Genet 17(6):906-17. Epub 2007 Dec 7. 2008
59CALB1, FGF20, SNCA
Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.
Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T.
Hum Genet 124(1):89-94. Epub 2008 Jun 22. 2008
60PARK1, SNCA
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.
Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan CF, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A.
Arch Neurol 65(4):514-9.PMID: 18413475 2008
61SNCA
Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.
Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T.
FASEB J 22(5):1327-34. Epub 2007 Dec 27.PMID: 18162487 2008
62SNCA
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL.
Exp Cell Res 314(10):2076-89. Epub 2008 Mar 28.PMID: 18440504 2008
63SNCA
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.
Schneider BL, Seehus CR, Capowski EE, Aebischer P, Zhang SC, Svendsen CN.
Hum Mol Genet 16(6):651-66. Epub 2007 Feb 19. 2007
64SNCA
Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
Periquet M, Fulga T, Myllykangas L, Schlossmacher MG, Feany MB.
J Neurosci 27(12):3338-46. 2007
65SNCA
Oligomeric alpha-synuclein inhibits tubulin polymerization.
Chen L, Jin J, Davis J, Zhou Y, Wang Y, Liu J, Lockhart PJ, Zhang J.
Biochem Biophys Res Commun 356(3):548-53. Epub 2007 Mar 12. 2007
66DYT3, FTDP17, FTDU17, FXTAS, LRRK2, MAPT, PARK1, PARK4, PARK5, PARK6, PARK7, PARK8, PINK1, PRKN, PSRP, SNCA, UCHL1
Genetics of Parkinson disease: paradigm shifts and future prospects.
Farrer MJ.
Nat Rev Genet 7(4):306-18. 2006
67SNCA
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.
Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto M, Hattori N, Murata M, Toda T.
Hum Mol Genet 15(7):1151-8. Epub 2006 Feb 24. 2006
68SNCA, HSPA4
Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates.
Huang C, Cheng H, Hao S, Zhou H, Zhang X, Gao J, Sun QH, Hu H, Wang CC.
J Mol Biol 364(3):323-36. Epub 2006 Aug 26. 2006
69SNCA
Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells.
Fan GH, Zhou HY, Yang H, Chen SD.
FEBS Lett 580(13):3091-8. Epub 2006 Apr 27. 2006
70SNCA,SNCAIP
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.
Proc Natl Acad Sci U S A 103(15):5917-22. Epub 2006 Apr 4. 2006
71SNCA, PARK1
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.
Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N.
Ann Neurol 59(2):298-309. 2006
72PARP1,SNCA
Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.
Chiba-Falek O, Kowalak JA, Smulson ME, Nussbaum RL.
Am J Hum Genet 76(3):478-92. Epub 2005 Jan 25. 2005
73SNCA, PARK1
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.
Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA.
Hum Mol Genet 14(24):3801-11. Epub 2005 Oct 20. 2005
74SNCA
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Chandra S, Gallardo G, Fernandez-Chacon R, Schluter OM, Sudhof TC.
Cell 123(3):383-96. 2005
75PARK1, SNCA
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, Waucquier N, Defebvre L, Amouyel P, Farrer M, Destée A.
Lancet 364(9440):1167-9. 2004
76SNCA, SNCAIP, SIAH1, SIAH2
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.
Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.
Proc Natl Acad Sci U S A 101(15):5500-5. Epub 2004 Apr 02. 2004
77SNCA, PARk1
alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease.
Sidhu A, Wersinger C, Vernier P.
FEBS Lett 565(1-3):1-5. Review. 2004
78SNCA
Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene.
Chiba-Falek O, Touchman JW, Nussbaum RL.
Hum Genet 113(5):426-31. Epub 2003 Aug 16. 2003
79FAM190A, PARK4, SNCA
alpha-Synuclein locus triplication causes Parkinson's disease.
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K.
Science 302(5646):841. 2003
80SNCA
Pathogenesis of parkinson's disease: dopamine, vesicles and alpha-synuclein.
Lotharius J, Brundin P.
Nat Rev Neurosci 3(12):932-942. 2002
81SNCAIP, SNCA
Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein.
Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S.
J Biol Chem 277(26):23927-33. Epub 2002 Apr 15. Erratum in: J Biol Chem 2002 Sep 13;277(37):34651-4. 2002
82SNCA
Structural and functional implications of C-terminal regions of alpha-synuclein.
Kim TD, Paik SR, Yang CH.
Biochemistry 41(46):13782-90. 2002
83PRKN, SNCA
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.
Science 293(5528):263-9. 2001
84SNCA
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA.
Hum Mol Genet 10(9):919-26. 2001
85SNCA
Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system.
Chiba-Falek O, Nussbaum RL.
Hum Mol Genet 10(26):3101-9. 2001
86SNCA
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.
Giasson BI, Murray IV, Trojanowski JQ, Lee VM.
J Biol Chem 276(4):2380-6. 2001
87PARK4, SNCA
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.
Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr.
Proc Natl Acad Sci U S A 97(2):571-6 2000
88SNCA, SNCB, SNCG
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.
Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK.
Cancer 88(9):2154-63. 2000
89SNCA
alpha-synuclein promotes mitochondrial deficit and oxidative stress.
Hsu LJ, Sagara Y, Arroyo A, Rockenstein E, Sisk A, Mallory M, Wong J, Takenouchi T, Hashimoto M, Masliah E.
Am J Pathol 157(2):401-10. 2000
90PARK1, SNCA
Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein.
Athanassiadou A, et al.
Am J Hum Genet 65(2):555-8. No abstract available 1999
91SNCA
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.
Ostrerova N, et al.
J Neurosci 19(14):5782-91 1999
92PARK1, PARK3, SNCA
The genetics of disorders with synuclein pathology and parkinsonism.
Farrer M, Gwinn-Hardy K, Hutton M, Hardy J.
Hum Mol Genet 8(10 REVIEW ISSUE):1901-5 1999
93PARK1, SNCA
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O.
Nat Genet 18(2):106-8. 1998
94PARK1, SNCA
Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations.
Vaughan JR, et al.
Hum Mol Genet 7 : 751-753. 1998
95PARK1, SNCA
Contig map of the Parkinson's disease region on 4q21-q23.
Lavedan C, et al.
DNA Res 5 : 19-23. 1998
96PARK1, SNCA
Alpha-synuclein in filamentous inclusions of lewy bodies from Parkinson's disease and dementia with Lewy bodies.
Spillantini GM, et al.
Proc Natl Acad Sci U S A 95 : 6469-6473. 1998
97PARK1, SNCA
The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease : a study of 230 European cases. European Consortium on genetic susceptibility in Parkinson's disease.
Vaughan J, et al.
Ann Neurol 44 : 270-273. 1998
98SNCA, SNCB
Regulation of phospholipase D2 : selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins.
Jenco JM, et al.
Biochemistry 37 : 4901-4909. 1998
99PARK1, SNCA
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.
Jensen PH, et al.
J Biol Chem 273 : 26292-26294. 1998
100PARK1, SNCA
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.
El-Agnaf OM Jakes R, et al.
FEBS Lett 440 : 67-70. 1998
101PARK1, SNCA
The G209A mutation in the alpha-synuclein gene is not detected in familial cases of Parkinson disease in non-Greek and/or Italian populations.
Wang WW, et al.
Arch Neurol 55 : 1521-1523. 1998
102PARK1, SNCA
Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.
El-Agnaf OM, et al.
Neuroreport 9(17):3925-7. 1998
103SNCA, SNCB, SNCG
The synuclein family.
Lavedan C.
Genome Res 8(9):871-80. Review. 1998
104PARK1, SNCA
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL.
Science 276(5321):2045-7. 1997
105PARK1, SNCA
Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the alpha-synuclein gene in early onset patients.
Munoz E, Oliva R, Obach V, Marti MJ, Pastor P, Ballesta F, Tolosa E.
Neurosci Lett 235(1-2):57-60. 1997
106SNCA
The NACP/synuclein gene : chromosomal assignment and screening for alterations in Alzheimer disease.
Campion D, et al.
Genomics 26 : 254-257. 1995
107SNCA
The human NACP/alpha-synuclein gene : chromosome assignment to 4q21.3-q22 and Taql RFLP analysis.
Chen X, et al.
Genomics 26 : 425-427. 1995
108SNCA, SNCB
Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.
Spillantini MG, et al.
Genomics 27 : 379-381. 1995
109SNCA
High-resolution mapping of SNCA encoding alpha-synuclein, the non-Abeta component of Alzheimer's disease amyloid precursor, to human chromosome 4q21.3-q22 by fluorescence in situ hybridization.
Shibasaki Y, et al.
Cytogenet Cell Genet 71 : 54-55. 1995
110SNCA
Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.
Spillantini MG, Divane A, Goedert M.
Genomics 27(2):379-81. No abstract available. PMID: 7558013 1995
111SNCA, SNCB
Identification of two distinct synucleins from human brain.
Jakes R, et al.
FEBS Lett 345 : 27-32. 1994
112SNCA
Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid.
Ueda K, Saitoh T, Mori H.
Biochem Biophys Res Commun 205(2):1366-72. 1994
113SNCA
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
UŽda K, et al.
Proc Natl Acad Sci U S A 90 : 11282-11286. 1993