| 1 | DDX10, SNCA
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| DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
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| Popova B, Wang D, Pätz C, Akkermann D, Lázaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Möbius W, Bohnsack KE, Outeiro TF, Braus GH.
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| PLoS Genet. Mar 3;17(3):e1009407. doi: 10.1371/journal.pgen.1009407 2021
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| 2 | HIP1, MOBP, SNCA
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| MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
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| Bettencourt C, Miki Y, Piras IS, de Silva R, Foti SC, Talboom JS, Revesz T, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL.
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| Neuropathol Appl Neurobiol. Aug;47(5):640-652. doi: 10.1111/nan.12688. Epub 2021 Jan 19. 2021
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| 3 | AIMP2, SNCA
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| Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion
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| Ham S, Yun SP, Kim H, Kim D, Seo BA, Kim H, Shin JY, Dar MA, Lee GH, Lee YI, Kim D, Kim S, Kweon HS, Shin JH, Ko HS, Lee Y.
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| Sci Transl Med. Nov 11;12(569):eaax0091. doi: 10.1126/scitranslmed.aax0091. 2020
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| 4 | PARK1, SNCA
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| Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.
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| McClymont SA, Hook PW, Soto AI, Reed X, Law WD, Kerans SJ, Waite EL, Briceno NJ, Thole JF, Heckman MG, Diehl NN, Wszolek ZK, Moore CD, Zhu H, Akiyama JA, Dickel DE, Visel A, Pennacchio LA, Ross OA, Beer MA, McCallion AS.
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| Am J Hum Genet 103(6):874-892. doi: 10.1016/j.ajhg.2018.10.018. Epub 2018 Nov 29.
2018
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| 5 | SNCA, TRIM17, TRIM41, ZSCAN21
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| The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
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| Lassot I, Mora S, Lesage S, Zieba BA, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Soulet C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.
|
| Cell Rep. Nov 27;25(9):2484-2496.e9. doi: 10.1016/j.celrep.2018.11.002 2018
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| 6 | SNCA, TPPP
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| Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
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| Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J.
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| Biochim Biophys Acta 1863(1):310-323. doi: 10.1016/j.bbadis.2016.09.017. Epub 2016 Sep 24.
2017
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| 7 | DNAJB6, HSPA4, SNCA
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| The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
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| Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C.
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| Sci Rep 7(1):9039. doi: 10.1038/s41598-017-08324-z.
2017
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| 8 | RER1, SNCA
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| The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.
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| Park HJ, Ryu D, Parmar M, Giasson BI, McFarland NR.
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| PLoS One 12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017.
2017
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| 9 | SNCA, TRIM32
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| Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.
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| Pavlou MAS, Colombo N, Fuertes-Alvarez S, Nicklas S, Cano LG, Marín MC, Goncalves J, Schwamborn JC.
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| Mol Neurobiol 54(6):4257-4270. doi: 10.1007/s12035-016-9989-9. Epub 2016 Jun 23.
2017
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| 10 | ATP13A2, SNCA
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| A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.
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| Lopes da Fonseca T, Pinho R, Outeiro TF.
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| Hum Mol Genet 25(14):2959-2971. Epub 2016 Jun 8.
2016
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| 11 | SNCA
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| The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy.
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| Assereto S, Piccirillo R, Baratto S, Scudieri P, Fiorillo C, Massacesi M, Traverso M, Galietta LJ, Bruno C, Minetti C, Zara F, Gazzerro E.
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| Lab Invest 96(8):862-71. doi: 10.1038/labinvest.2016.63. Epub 2016 Jun 13.
2016
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| 12 | SNCA, ZSCAN21
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| Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo.
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| Dermentzaki G, Paschalidis N, Politis PK, Stefanis L.
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| J Biol Chem. Apr 15;291(16):8756-72. doi: 10.1074/jbc.M115.704973. Epub 2016 Feb 23 2016
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| 13 | DYRK1A, MAPT, SNCA
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| Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A.
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| Kay LJ, Smulders-Srinivasan TK, Soundararajan M.
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| Adv Protein Chem Struct Biol. 105:127-71. doi: 10.1016/bs.apcsb.2016.07.001. Epub 2016 Aug 9 2016
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| 14 | SNCA
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| Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane.
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| Pacheco CR, Morales CN, Ramírez AE, Muńoz FJ, Gallegos SS, Caviedes PA, Aguayo LG, Opazo CM.
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| J Neurochem 132(6):731-41. doi: 10.1111/jnc.13060. Epub 2015 Feb 25.
2015
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| 15 | PARK1, SNCA
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| Familial Parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein.
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| Sahay S, Ghosh D, Dwivedi S, Anoop A, Mohite GM, Kombrabail M, Krishnamoorthy G, Maji SK.
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| J Biol Chem 290(12):7804-22. doi: 10.1074/jbc.M114.598607. Epub 2015 Jan 29.
2015
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| 16 | SNCA, TPPP
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| Targeting the interface of the pathological complex of α-synuclein and TPPP/p25.
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| Szunyogh S, Oláh J, Szénási T, Szabó A, Ovádi J.
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| Biochim Biophys Acta 1852(12):2653-61. doi: 10.1016/j.bbadis.2015.09.012. Epub 2015 Sep 25.
2015
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| 17 | CTSD, SNCA
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| Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates.
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| Bae EJ, Yang NY, Lee C, Kim S, Lee HJ, Lee SJ.
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| Cell Death Dis 6:e1901. doi: 10.1038/cddis.2015.283.
2015
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| 18 | CPLX1, SNCA
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| Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology.
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| Gispert S, Kurz A, Brehm N, Rau K, Walter M, Riess O, Auburger G.
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| Mol Neurobiol 52(1):57-63. doi: 10.1007/s12035-014-8844-0. Epub 2014 Aug 12.
2015
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| 19 | EIF4G1, SNCA, VPS35
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| Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
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| Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD.
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| Neuron 85(1):76-87. doi: 10.1016/j.neuron.2014.11.027. Epub 2014 Dec 18. Erratum in: Neuron. 2015 Feb 4;85(3):657.
2015
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| 20 | SNCA
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| α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.
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| Bir A, Sen O, Anand S, Khemka VK, Banerjee P, Cappai R, Sahoo A, Chakrabarti S.
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| J Neurochem 131(6):868-77. doi: 10.1111/jnc.12966. Epub 2014 Nov 18.
2014
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| 21 | SNCA
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| Alpha synuclein is transported into and out of the brain by the blood-brain barrier.
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| Sui YT, Bullock KM, Erickson MA, Zhang J, Banks WA.
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| Peptides 62:197-202. doi: 10.1016/j.peptides.2014.09.018. Epub 2014 Sep 30.
2014
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| 22 | SNCA
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| α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
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| Burré J, Sharma M, Südhof TC.
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| Proc Natl Acad Sci U S A 111(40):E4274-83. doi: 10.1073/pnas.1416598111. Epub 2014 Sep 22.
2014
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| 23 | HSPA5, SNCA
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| GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
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| Bellani S, Mescola A, Ronzitti G, Tsushima H, Tilve S, Canale C, Valtorta F, Chieregatti E.
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| Cell Death Differ 21(12):1971-83. doi: 10.1038/cdd.2014.111. Epub 2014 Aug 15.
2014
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| 24 | SNCA
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| Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.
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| Ettle B, Reiprich S, Deusser J, Schlachetzki JC, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J.
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| Mol Cell Neurosci 62:68-78. doi: 10.1016/j.mcn.2014.06.012. Epub 2014 Jul 11.
2014
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| 25 | SNCA
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| Differential aggregation properties of alpha-synuclein isoforms.
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| Bungeroth M, Appenzeller S, Regulin A, Völker W, Lorenzen I, Grötzinger J, Pendziwiat M, Kuhlenbäumer G.
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| Neurobiol Aging 35(8):1913-9. doi: 10.1016/j.neurobiolaging.2014.02.009. Epub 2014 Feb 19.
2014
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| 26 | SNCA
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| α-Synuclein is localized to mitochondria-associated ER membranes.
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| Guardia-Laguarta C, Area-Gomez E, Rüb C, Liu Y, Magrané J, Becker D, Voos W, Schon EA, Przedborski S.
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| J Neurosci 34(1):249-59. doi: 10.1523/JNEUROSCI.2507-13.2014.
2014
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| 27 | FOXO3, SNCA
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| FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.
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| Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria JC, Knott GW, Schneider BL.
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| Hum Mol Genet 23(6):1435-52. doi: 10.1093/hmg/ddt530. Epub 2013 Oct 24.
2014
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| 28 | RAB8A, SNCA
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| α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
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| Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.
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| Neurobiol Dis 70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28.
2014
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| 29 | CTSB, CTSD, SNCA
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| Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.
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| Crabtree D, Dodson M, Ouyang X, Boyer-Guittaut M, Liang Q, Ballestas ME, Fineberg N, Zhang J.
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| J Neurochem 128(6):950-61. doi: 10.1111/jnc.12497. Epub 2013 Nov 13.
2014
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| 30 | ENDOG, SNCA
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| Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.
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| Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F.
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| EMBO J 32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15.
2013
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| 31 | PRKN, SNCA
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| Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.
|
| Lonskaya I, Desforges NM, Hebron ML, Moussa CE.
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| PLoS One 8(12):e83914. doi: 10.1371/journal.pone.0083914. eCollection 2013. 2013
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| 32 | SNCA
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| α-Synuclein as a ferrireductase.
|
| Brown DR.
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| Biochem Soc Trans 41(6):1513-7. doi: 10.1042/BST20130130. Review.
2013
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| 33 | SNCA
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| Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.
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| Gardai SJ, Mao W, Schüle B, Babcock M, Schoebel S, Lorenzana C, Alexander J, Kim S, Glick H, Hilton K, Fitzgerald JK, Buttini M, Chiou SS, McConlogue L, Anderson JP, Schenk DB, Bard F, Langston JW, Yednock T, Johnston JA.
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| PLoS One 8(8):e71634. doi: 10.1371/journal.pone.0071634. eCollection 2013.
2013
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| 34 | SNCA
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| Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.
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| Melachroinou K, Xilouri M, Emmanouilidou E, Masgrau R, Papazafiri P, Stefanis L, Vekrellis K.
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| Neurobiol Aging 34(12):2853-65. doi: 10.1016/j.neurobiolaging.2013.06.006. Epub 2013 Jul 25.
2013
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| 35 | SNCA
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| Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.
|
| Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ.
|
| Exp Mol Med 45:e22. doi: 10.1038/emm.2013.45.
2013
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| 36 | SNCA, TOMM40
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| TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.
|
| Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E.
|
| PLoS One 8(4):e62277. doi: 10.1371/journal.pone.0062277. Print 2013.
2013
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| 37 | SNCA, TPPP
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| Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
|
| Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F.
|
| J Biol Chem 288(24):17313-35. doi: 10.1074/jbc.M112.401174. Epub 2013 Apr 29.
2013
|
| 38 | GBA, PSAP, SNCA
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| Saposin C protects glucocerebrosidase against α-synuclein inhibition.
|
| Yap TL, Gruschus JM, Velayati A, Sidransky E, Lee JC.
|
| Biochemistry 52(41):7161-3. doi: 10.1021/bi401191v. Epub 2013 Oct 1.
2013
|
| 39 | SNCA, SPTBN1
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| α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.
|
| Lee HJ, Lee K, Im H.
|
| Biochem Biophys Res Commun 424(3):497-502. doi: 10.1016/j.bbrc.2012.06.143. Epub 2012 Jul 4.
2012
|
| 40 | SNCA
|
| Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.
|
| Winner B, Regensburger M, Schreglmann S, Boyer L, Prots I, Rockenstein E, Mante M, Zhao C, Winkler J, Masliah E, Gage FH.
|
| J Neurosci 32(47):16906-16. doi: 10.1523/JNEUROSCI.2723-12.2012.
2012
|
| 41 | PLK2, SNCA
|
| α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.
|
| Wang S, Xu B, Liou LC, Ren Q, Huang S, Luo Y, Zhang Z, Witt SN.
|
| Proc Natl Acad Sci U S A 109(40):16119-24. doi: 10.1073/pnas.1206286109. Epub 2012 Sep 17.
2012
|
| 42 | SNCA
|
| Expression pattern and localization of alpha-synuclein in the human enteric nervous system.
|
| Böttner M, Zorenkov D, Hellwig I, Barrenschee M, Harde J, Fricke T, Deuschl G, Egberts JH, Becker T, Fritscher-Ravens A, Arlt A, Wedel T.
|
| Neurobiol Dis 48(3):474-80. doi: 10.1016/j.nbd.2012.07.018. Epub 2012 Jul 28.
2012
|
| 43 | SNCA
|
| Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.
|
| Larson ME, Sherman MA, Greimel S, Kuskowski M, Schneider JA, Bennett DA, Lesné SE.
|
| J Neurosci 32(30):10253-66. doi: 10.1523/JNEUROSCI.0581-12.2012.
2012
|
| 44 | PTPN1, SNCA
|
| Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
|
| Choi HS, Liew H, Jang A, Kim YM, Lashuel H, Suh YH.
|
| Biochem Biophys Res Commun 424(3):597-603. doi: 10.1016/j.bbrc.2012.06.159. Epub 2012 Jul 7.
2012
|
| 45 | SNCA
|
| α-Synuclein expression is modulated at the translational level by iron.
|
| Febbraro F, Giorgi M, Caldarola S, Loreni F, Romero-Ramos M.
|
| Neuroreport 23(9):576-80. doi: 10.1097/WNR.0b013e328354a1f0.
2012
|
| 46 | SNCA
|
| Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines.
|
| Zhu M, Li W, Lu C.
|
| PLoS One 7(4):e36377. doi: 10.1371/journal.pone.0036377. Epub 2012 Apr 27.
2012
|
| 47 | SNCA
|
| Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.
|
| Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK.
|
| J Neurosci 32(10):3306-20. doi: 10.1523/JNEUROSCI.5367-11.2012.
2012
|
| 48 | PLCB1, SNCA
|
| α-Synuclein increases the cellular level of phospholipase Cβ1.
|
| Guo Y, Rosati B, Scarlata S.
|
| Cell Signal 24(5):1109-14. doi: 10.1016/j.cellsig.2012.01.007. Epub 2012 Jan 20.
2012
|
| 49 | NEDD4, SNCA
|
| Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.
|
| Tofaris GK, Kim HT, Hourez R, Jung JW, Kim KP, Goldberg AL.
|
| Proc Natl Acad Sci U S A 108(41):17004-9. Epub 2011 Sep 27.
2011
|
| 50 | SNCA, VPS4A
|
| The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.
|
| Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A.
|
| PLoS One 6(12):e29460. doi: 10.1371/journal.pone.0029460. Epub 2011 Dec 22.
2011
|
| 51 | RABAC1, SNCA
|
| Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1.
|
| Lee HJ, Kang SJ, Lee K, Im H.
|
| Biochem Biophys Res Commun. Sep 9;412(4):526-31. doi: 10.1016/j.bbrc.2011.07.028. Epub 2011 Jul 21. 2011
|
| 52 | SNCA, TRAF6
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| TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.
|
| Zucchelli S, Codrich M, Marcuzzi F, Pinto M, Vilotti S, Biagioli M, Ferrer I, Gustincich S.
|
| Hum Mol Genet 19(19):3759-70. Epub 2010 Jul 14.
2010
|
| 53 | SNCA, SNCAIP
|
| Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
|
| Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY.
|
| FASEB J 24(1):196-205. Epub 2009 Sep 17.
2010
|
| 54 | BST1, LRRK2, PARK16, PARK4, PARK8, SNCA
|
| Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
| Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T.
|
| Nat Genet 41(12):1303-7. Epub 2009 Nov 15.PMID: 19915576 2009
|
| 55 | LRRK2, PARK16, PARK4, PARK8, SNCA
|
| Genome-wide association study reveals genetic risk underlying Parkinson's disease.
|
| Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T.
|
| Nat Genet 41(12):1308-12. Epub 2009 Nov 15.PMID: 19915575 2009
|
| 56 | PARK1, PARK4, SNCA
|
| Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.
|
| Ibáńez P, Lesage S, Janin S, Lohmann E, Durif F, Destée A, Bonnet AM, Brefel-Courbon C, Heath S, Zelenika D, Agid Y, Dürr A, Brice A; French Parkinson's Disease Genetics Study Group.
|
| Arch Neurol 66(1):102-8.
2009
|
| 57 | PLK2, SNCA
|
| Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
|
| Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP.
|
| J Biol Chem 284(5):2598-602. Epub 2008 Nov 12. 2009
|
| 58 | SNCA, SNCAIP
|
| Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.
|
| Szargel R, Rott R, Eyal A, Haskin J, Shani V, Balan L, Wolosker H, Engelender S.
|
| J Biol Chem 284(17):11706-16. Epub 2009 Feb 17.
2009
|
| 59 | SNCA
|
| The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
|
| Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S.
|
| Proc Natl Acad Sci U S A 105(1):145-50. Epub 2007 Dec 27. 2008
|
| 60 | SIAH1, SNCA
|
| Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.
|
| Lee JT, Wheeler TC, Li L, Chin LS.
|
| Hum Mol Genet 17(6):906-17. Epub 2007 Dec 7. 2008
|
| 61 | CALB1, FGF20, SNCA
|
| Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.
|
| Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T.
|
| Hum Genet 124(1):89-94. Epub 2008 Jun 22.
2008
|
| 62 | PARK1, SNCA
|
| Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.
|
| Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan CF, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A.
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| Arch Neurol 65(4):514-9.PMID: 18413475 2008
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| 63 | SNCA
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| Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.
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| Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T.
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| FASEB J 22(5):1327-34. Epub 2007 Dec 27.PMID: 18162487 2008
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| 64 | SNCA
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| Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
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| Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL.
|
| Exp Cell Res 314(10):2076-89. Epub 2008 Mar 28.PMID: 18440504 2008
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| 65 | SNCA
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| Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.
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| Schneider BL, Seehus CR, Capowski EE, Aebischer P, Zhang SC, Svendsen CN.
|
| Hum Mol Genet 16(6):651-66. Epub 2007 Feb 19. 2007
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| 66 | SNCA
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| Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
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| Periquet M, Fulga T, Myllykangas L, Schlossmacher MG, Feany MB.
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| J Neurosci 27(12):3338-46. 2007
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| 67 | SNCA
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| Oligomeric alpha-synuclein inhibits tubulin polymerization.
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| Chen L, Jin J, Davis J, Zhou Y, Wang Y, Liu J, Lockhart PJ, Zhang J.
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| Biochem Biophys Res Commun 356(3):548-53. Epub 2007 Mar 12. 2007
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| 68 | DYT3, FTDP17, FTDU17, FXTAS, LRRK2, MAPT, PARK1, PARK4, PARK5, PARK6, PARK7, PARK8, PINK1, PRKN, PSRP, SNCA, UCHL1
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| Genetics of Parkinson disease: paradigm shifts and future prospects.
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| Farrer MJ.
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| Nat Rev Genet 7(4):306-18. 2006
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| 69 | SNCA
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| Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.
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| Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto M, Hattori N, Murata M, Toda T.
|
| Hum Mol Genet 15(7):1151-8. Epub 2006 Feb 24. 2006
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| 70 | SNCA, HSPA4
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| Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates.
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| Huang C, Cheng H, Hao S, Zhou H, Zhang X, Gao J, Sun QH, Hu H, Wang CC.
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| J Mol Biol 364(3):323-36. Epub 2006 Aug 26. 2006
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| 71 | SNCA
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| Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells.
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| Fan GH, Zhou HY, Yang H, Chen SD.
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| FEBS Lett 580(13):3091-8. Epub 2006 Apr 27. 2006
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| 72 | SNCA,SNCAIP
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| Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
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| Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.
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| Proc Natl Acad Sci U S A 103(15):5917-22. Epub 2006 Apr 4. 2006
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| 73 | SNCA, PARK1
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| Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.
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| Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N.
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| Ann Neurol 59(2):298-309. 2006
|
| 74 | PARP1,SNCA
|
| Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.
|
| Chiba-Falek O, Kowalak JA, Smulson ME, Nussbaum RL.
|
| Am J Hum Genet 76(3):478-92. Epub 2005 Jan 25. 2005
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| 75 | SNCA, PARK1
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| Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.
|
| Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA.
|
| Hum Mol Genet 14(24):3801-11. Epub 2005 Oct 20. 2005
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| 76 | SNCA
|
| Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
|
| Chandra S, Gallardo G, Fernandez-Chacon R, Schluter OM, Sudhof TC.
|
| Cell 123(3):383-96. 2005
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| 77 | PARK1, SNCA
|
| Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
|
| Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, Waucquier N, Defebvre L, Amouyel P, Farrer M, Destée A.
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| Lancet 364(9440):1167-9.
2004
|
| 78 | SNCA, SNCAIP, SIAH1, SIAH2
|
| Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.
|
| Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.
|
| Proc Natl Acad Sci U S A 101(15):5500-5. Epub 2004 Apr 02. 2004
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| 79 | SNCA, PARk1
|
| alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease.
|
| Sidhu A, Wersinger C, Vernier P.
|
| FEBS Lett 565(1-3):1-5. Review. 2004
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| 80 | SNCA
|
| Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene.
|
| Chiba-Falek O, Touchman JW, Nussbaum RL.
|
| Hum Genet 113(5):426-31. Epub 2003 Aug 16. 2003
|
| 81 | FAM190A, PARK4, SNCA
|
| alpha-Synuclein locus triplication causes Parkinson's disease.
|
| Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K.
|
| Science 302(5646):841. 2003
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| 82 | SNCA
|
| Pathogenesis of parkinson's disease: dopamine, vesicles and alpha-synuclein.
|
| Lotharius J, Brundin P.
|
| Nat Rev Neurosci 3(12):932-942. 2002
|
| 83 | SNCAIP, SNCA
|
| Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein.
|
| Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S.
|
| J Biol Chem 277(26):23927-33. Epub 2002 Apr 15. Erratum in: J Biol Chem 2002 Sep 13;277(37):34651-4. 2002
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| 84 | SNCA
|
| Structural and functional implications of C-terminal regions of alpha-synuclein.
|
| Kim TD, Paik SR, Yang CH.
|
| Biochemistry 41(46):13782-90. 2002
|
| 85 | PRKN, SNCA
|
| Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
|
| Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.
|
| Science 293(5528):263-9. 2001
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| 86 | SNCA
|
| Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
|
| Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA.
|
| Hum Mol Genet 10(9):919-26. 2001
|
| 87 | SNCA
|
| Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system.
|
| Chiba-Falek O, Nussbaum RL.
|
| Hum Mol Genet 10(26):3101-9. 2001
|
| 88 | SNCA
|
| A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.
|
| Giasson BI, Murray IV, Trojanowski JQ, Lee VM.
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| J Biol Chem 276(4):2380-6. 2001
|
| 89 | PARK4, SNCA
|
| Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.
|
| Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr.
|
| Proc Natl Acad Sci U S A 97(2):571-6 2000
|
| 90 | SNCA, SNCB, SNCG
|
| Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.
|
| Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK.
|
| Cancer 88(9):2154-63. 2000
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| 91 | SNCA
|
| alpha-synuclein promotes mitochondrial deficit and oxidative stress.
|
| Hsu LJ, Sagara Y, Arroyo A, Rockenstein E, Sisk A, Mallory M, Wong J, Takenouchi T, Hashimoto M, Masliah E.
|
| Am J Pathol 157(2):401-10. 2000
|
| 92 | PARK1, SNCA
|
| Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein.
|
| Athanassiadou A, et al.
|
| Am J Hum Genet 65(2):555-8. No abstract available 1999
|
| 93 | SNCA
|
| alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.
|
| Ostrerova N, et al.
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| J Neurosci 19(14):5782-91 1999
|
| 94 | PARK1, PARK3, SNCA
|
| The genetics of disorders with synuclein pathology and parkinsonism.
|
| Farrer M, Gwinn-Hardy K, Hutton M, Hardy J.
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| Hum Mol Genet 8(10 REVIEW ISSUE):1901-5 1999
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| 95 | PARK1, SNCA
|
| Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
|
| Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O.
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| Nat Genet 18(2):106-8. 1998
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| 96 | PARK1, SNCA
|
| Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations.
|
| Vaughan JR, et al.
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| Hum Mol Genet 7 : 751-753. 1998
|
| 97 | PARK1, SNCA
|
| Contig map of the Parkinson's disease region on 4q21-q23.
|
| Lavedan C, et al.
|
| DNA Res 5 : 19-23. 1998
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| 98 | PARK1, SNCA
|
| Alpha-synuclein in filamentous inclusions of lewy bodies from Parkinson's disease and dementia with Lewy bodies.
|
| Spillantini GM, et al.
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| Proc Natl Acad Sci U S A 95 : 6469-6473. 1998
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| 99 | PARK1, SNCA
|
| The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease : a study of 230 European cases. European Consortium on genetic susceptibility in Parkinson's disease.
|
| Vaughan J, et al.
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| Ann Neurol 44 : 270-273. 1998
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| 100 | SNCA, SNCB
|
| Regulation of phospholipase D2 : selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins.
|
| Jenco JM, et al.
|
| Biochemistry 37 : 4901-4909. 1998
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| 101 | PARK1, SNCA
|
| Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.
|
| Jensen PH, et al.
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| J Biol Chem 273 : 26292-26294. 1998
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| 102 | PARK1, SNCA
|
| Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.
|
| El-Agnaf OM Jakes R, et al.
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| FEBS Lett 440 : 67-70. 1998
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| 103 | PARK1, SNCA
|
| The G209A mutation in the alpha-synuclein gene is not detected in familial cases of Parkinson disease in non-Greek and/or Italian populations.
|
| Wang WW, et al.
|
| Arch Neurol 55 : 1521-1523. 1998
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| 104 | PARK1, SNCA
|
| Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.
|
| El-Agnaf OM, et al.
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| Neuroreport 9(17):3925-7. 1998
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| 105 | SNCA, SNCB, SNCG
|
| The synuclein family.
|
| Lavedan C.
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| Genome Res 8(9):871-80. Review. 1998
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| 106 | PARK1, SNCA
|
| Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
|
| Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL.
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| Science 276(5321):2045-7. 1997
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| 107 | PARK1, SNCA
|
| Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the alpha-synuclein gene in early onset patients.
|
| Munoz E, Oliva R, Obach V, Marti MJ, Pastor P, Ballesta F, Tolosa E.
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| Neurosci Lett 235(1-2):57-60. 1997
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| 108 | SNCA
|
| The NACP/synuclein gene : chromosomal assignment and screening for alterations in Alzheimer disease.
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| Campion D, et al.
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| Genomics 26 : 254-257. 1995
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| 109 | SNCA
|
| The human NACP/alpha-synuclein gene : chromosome assignment to 4q21.3-q22 and Taql RFLP analysis.
|
| Chen X, et al.
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| Genomics 26 : 425-427. 1995
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| 110 | SNCA, SNCB
|
| Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.
|
| Spillantini MG, et al.
|
| Genomics 27 : 379-381. 1995
|
| 111 | SNCA
|
| High-resolution mapping of SNCA encoding alpha-synuclein, the non-Abeta component of Alzheimer's disease amyloid precursor, to human chromosome 4q21.3-q22 by fluorescence in situ hybridization.
|
| Shibasaki Y, et al.
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| Cytogenet Cell Genet 71 : 54-55. 1995
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| 112 | SNCA
|
| Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.
|
| Spillantini MG, Divane A, Goedert M.
|
| Genomics 27(2):379-81. No abstract available. PMID: 7558013 1995
|
| 113 | SNCA, SNCB
|
| Identification of two distinct synucleins from human brain.
|
| Jakes R, et al.
|
| FEBS Lett 345 : 27-32. 1994
|
| 114 | SNCA
|
| Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid.
|
| Ueda K, Saitoh T, Mori H.
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| Biochem Biophys Res Commun 205(2):1366-72. 1994
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| 115 | SNCA
|
| Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
|
| Uda K, et al.
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| Proc Natl Acad Sci U S A 90 : 11282-11286. 1993
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