| 1 | ERBB2, FUT4, SMYD2
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| SMYD2 facilitates cancer cell malignancy and xenograft tumor development through ERBB2-mediated FUT4 expression in colon cancer.
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| Lai Y, Yang Y.
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| Mol Cell Biochem. Apr 27. doi: 10.1007/s11010-020-03738-2. Online ahead of print 2020
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| 2 | SMYD2
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| SMYD2 glutathionylation contributes to degradation of sarcomeric proteins.
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| Munkanatta Godage DNP, VanHecke GC, Samarasinghe KTG, Feng HZ, Hiske M, Holcomb J, Yang Z, Jin JP, Chung CS, Ahn YH.
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| Nat Commun 9(1):4341. doi: 10.1038/s41467-018-06786-x.
2018
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| 3 | ESR1, HSP90AA1, PTGES3, SMYD2
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| A motif in HSP90 and P23 that links molecular chaperones to efficient estrogen receptor α methylation by the lysine methyltransferase SMYD2.
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| Obermann WMJ.
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| J Biol Chem 293(42):16479-16487. doi: 10.1074/jbc.RA118.003578. Epub 2018 Sep 6.
2018
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| 4 | SMYD2
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| SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells.
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| Toghill BJ, Saratzis A, Freeman PJ, Sylvius N; UKAGS collaborators, Bown MJ.
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| Clin Epigenetics 10:29. doi: 10.1186/s13148-018-0460-9. eCollection 2018.
2018
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| 5 | SMYD2
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| Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.
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| Li LX, Zhou JX, Calvet JP, Godwin AK, Jensen RA, Li X.
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| Cell Death Dis 9(3):326. doi: 10.1038/s41419-018-0347-x.
2018
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| 6 | SMYD2
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| Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling.
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| Deng X, Hamamoto R, Vougiouklakis T, Wang R, Yoshioka Y, Suzuki T, Dohmae N, Matsuo Y, Park JH, Nakamura Y.
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| Oncotarget 8(34):55837-55847. doi: 10.18632/oncotarget.19646. eCollection 2017 Aug 22.
2017
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| 7 | SMYD2
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| Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
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| Li LX, Fan LX, Zhou JX, Grantham JJ, Calvet JP, Sage J, Li X.
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| J Clin Invest 127(7):2751-2764. doi: 10.1172/JCI90921. Epub 2017 Jun 12.
2017
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| 8 | BMPR2, SMYD2
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| The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.
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| Gao S, Wang Z, Wang W, Hu X, Chen P, Li J, Feng X, Wong J, Du JX.
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| J Biol Chem 292(30):12702-12712. doi: 10.1074/jbc.M117.776278. Epub 2017 Jun 6.
2017
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| 9 | SMYD2
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| Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
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| Bagislar S, Sabò A, Kress TR, Doni M, Nicoli P, Campaner S, Amati B.
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| Oncotarget 7(41):66398-66415. doi: 10.18632/oncotarget.12012.
2016
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| 10 | SMYD2
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| Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.
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| Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut P, Kaznowska EB, Arrowsmith CH, Khatri P, Stresemann C, Gozani O, Sage J.
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| Genes Dev 30(7):772-85. doi: 10.1101/gad.275529.115. Epub 2016 Mar 17.
2016
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| 11 | SMYD2
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| The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) production.
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| Xu G, Liu G, Xiong S, Liu H, Chen X, Zheng B.
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| J Biol Chem 290(9):5414-23. doi: 10.1074/jbc.M114.610345. Epub 2015 Jan 12.
2015
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| 12 | HSP90AB1, SMYD2
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| SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.
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| Hamamoto R, Toyokawa G, Nakakido M, Ueda K, Nakamura Y.
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| Cancer Lett 351(1):126-33. doi: 10.1016/j.canlet.2014.05.014. Epub 2014 May 28.
2014
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| 13 | SMYD2
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| Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation.
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| Jiang Y, Trescott L, Holcomb J, Zhang X, Brunzelle J, Sirinupong N, Shi X, Yang Z.
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| J Mol Biol 426(20):3413-25. doi: 10.1016/j.jmb.2014.02.019. Epub 2014 Mar 1.
2014
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| 14 | EP300, ESR1, KDM1A, SMYD2
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| Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.
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| Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X.
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| Proc Natl Acad Sci U S A 110(43):17284-9. doi: 10.1073/pnas.1307959110. Epub 2013 Oct 7.
2013
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| 15 | SMYD2
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| SMYD2 is induced during cell differentiation and participates in early development.
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| Sesé B, Barrero MJ, Fabregat MC, Sander V, Izpisua Belmonte JC.
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| Int J Dev Biol 57(5):357-64. doi: 10.1387/ijdb.130051ji.
2013
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| 16 | HSP90AA1, SMYD2
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| Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.
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| Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, Kruger M, Jacobs EY, Unger A, Zieseniss A, Dobenecker MW, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, Tarakhovsky A, Linke WA.
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| Genes Dev 26(2):114-9. Epub 2012 Jan 12.
2012
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| 17 | RB1, SMYD2
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| RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation.
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| Cho HS, Hayami S, Toyokawa G, Maejima K, Yamane Y, Suzuki T, Dohmae N, Kogure M, Kang D, Neal DE, Ponder BA, Yamaue H, Nakamura Y, Hamamoto R.
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| Neoplasia 14(6):476-86.
2012
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| 18 | SMYD2
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| Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2.
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| Abu-Farha M, Lanouette S, Elisma F, Tremblay V, Butson J, Figeys D, Couture JF.
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| J Mol Cell Biol 3(5):301-8. doi: 10.1093/jmcb/mjr025.
2011
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| 19 | SMYD2
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| Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
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| Wang L, Li L, Zhang H, Luo X, Dai J, Zhou S, Gu J, Zhu J, Atadja P, Lu C, Li E, Zhao K.
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| J Biol Chem 286(44):38725-37. Epub 2011 Aug 31.
2011
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| 20 | SMYD2
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| Structural basis of substrate methylation and inhibition of SMYD2.
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| Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N.
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| Structure 19(9):1262-73. Epub 2011 Jul 21.
2011
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| 21 | SMYD2
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| Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase.
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| Wu J, Cheung T, Grande C, Ferguson AD, Zhu X, Theriault K, Code E, Birr C, Keen N, Chen H.
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| Biochemistry 50(29):6488-97. Epub 2011 Jun 29.
2011
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| 22 | L3MBTL1, RB1, SMYD2
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| Methylation of the retinoblastoma tumor suppressor by SMYD2.
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| Saddic LA, West LE, Aslanian A, Yates JR 3rd, Rubin SM, Gozani O, Sage J.
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| J Biol Chem 285(48):37733-40. Epub 2010 Sep 24. 2010
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| 23 | HELZ, SMYD2, SMYD3
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| Cardiac deletion of Smyd2 is dispensable for mouse heart development.
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| Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Böttger T, Harvey RP, Tucker PW, Engel FB.
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| PLoS One 5(3):e9748. doi: 10.1371/journal.pone.0009748.
2010
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| 24 | SMYD2
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| Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma.
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| Komatsu S, Imoto I, Tsuda H, Kozaki KI, Muramatsu T, Shimada Y, Aiko S, Yoshizumi Y, Ichikawa D, Otsuji E, Inazawa J.
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| Carcinogenesis 30(7):1139-46. Epub 2009 May 7.
2009
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| 25 | SMYD2, TACC2
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| The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase.
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| Abu-Farha M, Lambert JP, Al-Madhoun AS, Elisma F, Skerjanc IS, Figeys D.
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| Mol Cell Proteomics 7(3):560-72. Epub 2007 Dec 7. 2008
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| 26 | SMYD1, SMYD2, SMYD3, SMYD4, SMYD5
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| A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development.
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| Thompson EC, Travers AA.
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| PLoS ONE 3(8):e3008.
2008
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| 27 | TP53, SMYD2
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| Repression of p53 activity by Smyd2-mediated methylation.
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| Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL.
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| Nature 444(7119):629-32. Epub 2006 Nov 15. 2006
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| 28 | AADACL3, AADACL4, ADCK3, AGBL1, AGBL4, ANKRD13C, ANKRD45, ATP13A2, B3GALT2, B3GALT4, B3GALT6, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT6, BLZF1, BSDC1, C1orf100, C1orf101, C1orf103, C1orf104, C1orf110, C1orf115, C1orf120, C1orf122, C1orf123, C1orf126, C1orf130, C1orf31, C1orf35, C1orf49, C1orf51, C1orf53, C1orf54, C1orf65, C1orf74, C1orf95, C1orf97, CCDC76, CCDC76, CCT3, COL16A1, DDX59, DENND2D, DNALI1, DPM3, FAM131C, FAM167B, FAM176B, FAM76A, FAM78B, FHAD1, FMO4, GJC2, GLUL, GNPAT, GPR157, GPR161, GPR89A, GPR89B, GPR89C, HMGN2, HSPB7, IBA57, ITGB3BP, KIAA1107, KLHL20, MAN1A2, MAP1LC3C, METTL11B, MLK4, MRTO4, NFYC, OR2M3, OR2M7, OR2T12, OR2T33, OR2T34, OR4F16, PEX10, PLA2G2D, PRAMEF12, PRAMEF13, PRAMEF14, PRAMEF15, PRAMEF16, PRAMEF17, PRAMEF18, PRAMEF19, PRAMEF20, PRAMEF21, PTCH2, RC3H1, RGS18, RIMKLA, SEP15, SLC35D1, SMYD2, SRARP, STX6, TBX15, TRIM62, TTLL7, VASH2, WLS, ZBTB18, ZMYM1, ZNF436, ZNF642
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| The DNA sequence and biological annotation of human chromosome 1.
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| Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E.
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| Nature 441(7091):315-21. 2006
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| 29 | SMYD2
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| Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
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| Brown MA, Sims RJ 3rd, Gottlieb PD, Tucker PW.
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| Mol Cancer 5:26.
2006
|