Citations for
1LHX9, SMURF1
Smad ubiquitylation regulatory factor 1 promotes LIM-homeobox gene 9 degradation and represses testosterone production in Leydig cells.
Hu F, Zhu Q, Sun B, Cui C, Li C, Zhang L.
FASEB J 32(9):4627-4640. doi: 10.1096/fj.201701480R. Epub 2018 Mar 22. 2018
2PKHD1, RHOA, SMURF1, SMURF2
NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology
Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG
Sci Rep. Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4. 2017
3SMURF1, USP5
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5
Qian G, Ren Y, Zuo Y, Yuan Y, Zhao P, Wang X, Cheng Q, Liu J, Zhang L, Guo T, Liu C, Zheng H.
Biochem Biophys Res Commun. Jun 3;474(3):491-496. doi: 10.1016/j.bbrc.2016.04.135. Epub 2016 Apr 29. 2016
4FBXO3, SMURF1
F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.
Li D, Xie P, Zhao F, Shu J, Li L, Zhan Y, Zhang L.
Biochem Biophys Res Commun 458(4):941-5. doi: 10.1016/j.bbrc.2015.02.089. Epub 2015 Feb 24. 2015
5RUNX2, SMURF1
A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells.
Yang F, Xu N, Li D, Guan L, He Y, Zhang Y, Lu Q, Zhang X.
J Endod 40(10):1579-86. doi: 10.1016/j.joen.2014.04.010. Epub 2014 Jun 11. 2014
6RUNX2, SMURF1
A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells.
Yang F, Xu N, Li D, Guan L, He Y, Zhang Y, Lu Q, Zhang X.
J Endod 40(10):1579-86. doi: 10.1016/j.joen.2014.04.010. Epub 2014 Jun 11. 2014
7RHOB, SMURF1
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Wang M, Guo L, Wu Q, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, Ren L, Zhang S, Pei Y, Yin Z, Ding F, Wang HR.
Nat Commun 5:4901. doi: 10.1038/ncomms5901. 2014
8NEDD8, SMURF1
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F, Zhang L.
Nat Commun 5:3733. doi: 10.1038/ncomms4733. 2014
9SMURF1
Smurf1-mediated axin ubiquitination requires Smurf1 C2 domain and is cell cycle-dependent.
Fei C, He X, Xie S, Miao H, Zhou Z, Li L.
J Biol Chem 289(20):14170-7. doi: 10.1074/jbc.M113.536714. Epub 2014 Apr 3. 2014
10PLEKHO1, SMURF1
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Nie J, Liu L, Xing G, Zhang M, Wei R, Guo M, Li X, Xie P, Li L, He F, Han W, Zhang L.
Oncogene 33(28):3677-87. doi: 10.1038/onc.2013.340. Epub 2013 Sep 2. 2014
11BMPR1A, FGFR3, SMURF1
FGFR3 induces degradation of BMP type I receptor to regulate skeletal development.
Qi H, Jin M, Duan Y, Du X, Zhang Y, Ren F, Wang Y, Tian Q, Wang X, Wang Q, Zhu Y, Xie Y, Liu C, Cao X, Mishina Y, Chen D, Deng CX, Chang Z, Chen L.
Biochim Biophys Acta 1843(7):1237-47. doi: 10.1016/j.bbamcr.2014.03.011. Epub 2014 Mar 20. 2014
12BTRC, RFWD2, SMURF1, TRIB2
TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells.
Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, Liu W, Wang J, Sun F.
FEBS Lett 588(23):4334-41. doi: 10.1016/j.febslet.2014.09.042. Epub 2014 Oct 13. 2014
13NAE1, NEDD8, SMURF1, UBE2M
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F, Zhang L.
Nat Commun. May 13;5:3733. doi: 10.1038/ncomms4733. 2014
14SMURF1, USP9X
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.
Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.
J Biol Chem 288(5):2976-85. doi: 10.1074/jbc.M112.430066. Epub 2012 Nov 26. 2013
15EFNB1, SMURF1, SMURF2
The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.
Hwang YS, Lee HS, Kamata T, Mood K, Cho HJ, Winterbottom E, Ji YJ, Singh A, Daar IO.
Genes Dev 27(5):491-503. doi: 10.1101/gad.208355.112. 2013
16PLEKHO1, PSMC5, SMURF1
CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation.
Wang Y, Nie J, Wang Y, Zhang L, Lu K, Xing G, Xie P, He F, Zhang L.
EMBO Rep 13(11):1004-11. doi: 10.1038/embor.2012.144. Epub 2012 Oct 2. 2012
17SMURF1, STAT1
Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation.
Yuan C, Qi J, Zhao X, Gao C.
J Biol Chem 287(21):17006-15. doi: 10.1074/jbc.M112.341198. Epub 2012 Apr 2. Erratum in: J Biol Chem. 2014 Oct 24;289(43):30189. 2012
18CDH1, RHOA, SMURF1
The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth.
Kannan M, Lee SJ, Schwedhelm-Domeyer N, Stegmüller J.
Development 139(19):3600-12. doi: 10.1242/dev.081786. 2012
19SMURF1, WFS1
The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum.
Guo X, Shen S, Song S, He S, Cui Y, Xing G, Wang J, Yin Y, Fan L, He F, Zhang L.
J Biol Chem 286(20):18037-47. Epub 2011 Mar 28. 2011
20KLF2, SELL, SMURF1
Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.
Xie P, Tang Y, Shen S, Wang Y, Xing G, Yin Y, He F, Zhang L.
Biochem Biophys Res Commun 407(1):254-9. Epub 2011 Mar 5. 2011
21FBXL15, SMURF1
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L.
EMBO J 30(13):2675-89. doi: 10.1038/emboj.2011.155. Erratum in: EMBO J. 2011;30(13):2748. 2011
22RHOA, SMURF1
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.
Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR.
FEBS Lett 585(14):2199-204. Epub 2011 Jun 23. 2011
23CDH1, SMURF1
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W.
Mol Cell 44(5):721-33. doi: 10.1016/j.molcel.2011.09.024. 2011
24ING2, SMURF1
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.
Nie J, Liu L, Wu M, Xing G, He S, Yin Y, Tian C, He F, Zhang L.
FEBS Lett 584(14):3005-12. Epub 2010 Jun 1. 2010
25MDM2, MDM4, SMURF1, SMURF2
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.
J Biol Chem 285(30):22818-30. Epub 2010 May 18. 2010
26CDK5, SMURF1
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH.
Nat Cell Biol 11(5):624-30. Epub 2009 Apr 12. 2009
27SMURF1
Smurf1 zaps the talin head.
Critchley DR.
Nat Cell Biol 11(5):538-40. 2009
28SMURF1, SMURF2
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.
J Biol Chem 283(51):35660-7. Epub 2008 Oct 16. 2008
29ARHGEF9, SMURF1
Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway.
Yamaguchi K, Ohara O, Ando A, Nagase T.
Biol Chem 389(4):405-13.PMID: 18208356 2008
30SMURF1
Modeling and analysis of molecularinteraction between Smurf1-WW2 domain and various isoforms of LIM mineralization protein.
Sangadala S, Boden SD, Metpally RP, Reddy BV.
Proteins 68(3):690-701. 2007
31SMURF1
Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S.
Cancer Sci 98(3):392-400. Epub 2007 Jan 12. 2007
32FKBP1A, SMURF1, SMAD7
FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.
Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H.
J Mol Endocrinol 36(3):569-79. 2006
33RUNX2, SMAD6, SMURF1
Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.
Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D.
J Biol Chem 281(6):3569-76. Epub 2005 Nov 18. 2006
34PDLIM7, SMURF1
LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads.
Sangadala S, Boden SD, Viggeswarapu M, Liu Y, Titus L.
J Biol Chem 281(25):17212-9. Epub 2006 Apr 11. 2006
35SMURF1, RUNX2
Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo.
Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D.
J Biol Chem 279(13):12854-9. Epub 2003 Dec 29. 2004
36ANKRD36B, BCOR, BEND3, CACHD1, CHD8, CNNM4, DDX55, DHTKD1, EIF2C4, EPB41L5, EPG5, FAM160B1, GBA2, GPAM, GPR107, HERC4, KIAA1586, KIAA1609, KIF16B, MAGEE1, MAGI3, MED12L, MED12L, METTL14, MIER1, MOV10, NCKAP5L, NCOA5, PCDHB16, RNF213, SEMA4G, SFMBT2, SMURF1, TNRC6C, TRPM3, USP37, VAT1L, WDFY4, WDR19, WNK3, ZBTB26, ZNF532, ZPR1 ZNF319, ZSWIM5, ZSWIM6
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O.
DNA Res 7(4):273-81. 2000
37SMURF1
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH.
Nature 400(6745):687-93. 1999
38ABCB6, ADCK2, ANAPC7, ANKRD46, ASPHD1, AVPI1, AZIN1, BRINP2, C12orf24, C14orf79, C17orf90, C17orf91, C5orf15, C9orf127, C9orf25, C9orf82, CNIH3, COG3, COG7, CREB3L1, CSRNP2, DHX29, DHX57, DLAT, EIF2B2, ERI3, FAM13C1, FAM35A, FAM54B, FLAD1, GHITM, GRIP2, GRPEL1, HMGCLL1, IP6K2, IP6K2, ITGB1BP1, KCMF1, KIFC2, LRP10, MDM1, MFN1, NAPG, NCALD, NECAB2, NIPAL4, NPTN, NTNG2, PASK, PCDHB10, PDIA6, PHPT1, PI4K2A, PNPLA2, POGK, PTOV1, RNF13, RNF41, SAC3D1, SDCBP2, SELT, SLC38A6, SLC39A3, SMURF1, SPRED2, SUCLG2, TMCO1, TMEM183A, TP53I11, TRPC4AP, TSC22D3, TUBB, TXNDC12, UTP18, WDR40A, WDR77, WSB2, ZMIZ1
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY,Wentland MA, Lennon G, Gibbs RA.
Genome Res 7(4):353-8. 1997
39ADCK2, ANAPC7, ARHGAP22, AVPI1, AZIN1, C12orf24, C14orf79, C5orf15, C9orf25, CNIH3, COG3, COG7, CREB3L1, DHX29, DHX57, DLAT, DLGAP3, EIF2B2, EXOC3, FAM13C1, FAM152B, FAM35A, FAM54B, FAM89B, FLAD1, GHITM, GRPEL1, HMGCLL1, IP6K2, IPO4, ITGB1BP1, KCMF1, KIFC2, LRP10, MDM1, MFN1, NAPG, NCALD, NECAB2, NPTN, NTNG2, PASK, PCDHB10, PHPT1, PI4K2A, PNPLA2, POGK, PTOV1, RNF41, SAC3D1, SDCBP2, SELT, SEMA6C, SLC38A6, SLC39A3, SMURF1, SPRED2, STX12, SUCLG2, TAX1BP3, TMEM183A, TP53I11, TRAPPC3, TRPC4AP, TSC22D3, TUBB, TXNDC12, UTP18, WDFY3, WDR40A, WDR77, WSB2, ZMIZ1, ZNF410, ZXDC
A double adaptor method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA.
Anal Biochem 236(1):107-13. 1996