1 | LHX9, SMURF1
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| Smad ubiquitylation regulatory factor 1 promotes LIM-homeobox gene 9 degradation and represses testosterone production in Leydig cells.
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| Hu F, Zhu Q, Sun B, Cui C, Li C, Zhang L.
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| FASEB J 32(9):4627-4640. doi: 10.1096/fj.201701480R. Epub 2018 Mar 22.
2018
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2 | PKHD1, RHOA, SMURF1, SMURF2
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| NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology
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| Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG
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| Sci Rep. Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4. 2017
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3 | SMURF1, USP5
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| Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5
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| Qian G, Ren Y, Zuo Y, Yuan Y, Zhao P, Wang X, Cheng Q, Liu J, Zhang L, Guo T, Liu C, Zheng H.
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| Biochem Biophys Res Commun. Jun 3;474(3):491-496. doi: 10.1016/j.bbrc.2016.04.135. Epub 2016 Apr 29. 2016
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4 | FBXO3, SMURF1
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| F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.
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| Li D, Xie P, Zhao F, Shu J, Li L, Zhan Y, Zhang L.
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| Biochem Biophys Res Commun 458(4):941-5. doi: 10.1016/j.bbrc.2015.02.089. Epub 2015 Feb 24.
2015
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5 | RUNX2, SMURF1
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| A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells.
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| Yang F, Xu N, Li D, Guan L, He Y, Zhang Y, Lu Q, Zhang X.
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| J Endod 40(10):1579-86. doi: 10.1016/j.joen.2014.04.010. Epub 2014 Jun 11.
2014
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6 | RUNX2, SMURF1
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| A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells.
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| Yang F, Xu N, Li D, Guan L, He Y, Zhang Y, Lu Q, Zhang X.
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| J Endod 40(10):1579-86. doi: 10.1016/j.joen.2014.04.010. Epub 2014 Jun 11.
2014
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7 | RHOB, SMURF1
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| ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
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| Wang M, Guo L, Wu Q, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, Ren L, Zhang S, Pei Y, Yin Z, Ding F, Wang HR.
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| Nat Commun 5:4901. doi: 10.1038/ncomms5901.
2014
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8 | NEDD8, SMURF1
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| The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
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| Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F, Zhang L.
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| Nat Commun 5:3733. doi: 10.1038/ncomms4733.
2014
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9 | SMURF1
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| Smurf1-mediated axin ubiquitination requires Smurf1 C2 domain and is cell cycle-dependent.
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| Fei C, He X, Xie S, Miao H, Zhou Z, Li L.
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| J Biol Chem 289(20):14170-7. doi: 10.1074/jbc.M113.536714. Epub 2014 Apr 3.
2014
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10 | PLEKHO1, SMURF1
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| CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
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| Nie J, Liu L, Xing G, Zhang M, Wei R, Guo M, Li X, Xie P, Li L, He F, Han W, Zhang L.
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| Oncogene 33(28):3677-87. doi: 10.1038/onc.2013.340. Epub 2013 Sep 2.
2014
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11 | BMPR1A, FGFR3, SMURF1
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| FGFR3 induces degradation of BMP type I receptor to regulate skeletal development.
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| Qi H, Jin M, Duan Y, Du X, Zhang Y, Ren F, Wang Y, Tian Q, Wang X, Wang Q, Zhu Y, Xie Y, Liu C, Cao X, Mishina Y, Chen D, Deng CX, Chang Z, Chen L.
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| Biochim Biophys Acta 1843(7):1237-47. doi: 10.1016/j.bbamcr.2014.03.011. Epub 2014 Mar 20.
2014
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12 | BTRC, RFWD2, SMURF1, TRIB2
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| TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells.
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| Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, Liu W, Wang J, Sun F.
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| FEBS Lett 588(23):4334-41. doi: 10.1016/j.febslet.2014.09.042. Epub 2014 Oct 13.
2014
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13 | NAE1, NEDD8, SMURF1, UBE2M
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| The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
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| Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F, Zhang L.
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| Nat Commun. May 13;5:3733. doi: 10.1038/ncomms4733. 2014
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14 | SMURF1, USP9X
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| Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.
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| Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.
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| J Biol Chem 288(5):2976-85. doi: 10.1074/jbc.M112.430066. Epub 2012 Nov 26.
2013
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15 | EFNB1, SMURF1, SMURF2
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| The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.
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| Hwang YS, Lee HS, Kamata T, Mood K, Cho HJ, Winterbottom E, Ji YJ, Singh A, Daar IO.
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| Genes Dev 27(5):491-503. doi: 10.1101/gad.208355.112.
2013
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16 | PLEKHO1, PSMC5, SMURF1
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| CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation.
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| Wang Y, Nie J, Wang Y, Zhang L, Lu K, Xing G, Xie P, He F, Zhang L.
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| EMBO Rep 13(11):1004-11. doi: 10.1038/embor.2012.144. Epub 2012 Oct 2.
2012
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17 | SMURF1, STAT1
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| Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation.
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| Yuan C, Qi J, Zhao X, Gao C.
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| J Biol Chem 287(21):17006-15. doi: 10.1074/jbc.M112.341198. Epub 2012 Apr 2. Erratum in: J Biol Chem. 2014 Oct 24;289(43):30189.
2012
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18 | CDH1, RHOA, SMURF1
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| The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth.
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| Kannan M, Lee SJ, Schwedhelm-Domeyer N, Stegmüller J.
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| Development 139(19):3600-12. doi: 10.1242/dev.081786.
2012
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19 | SMURF1, WFS1
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| The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum.
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| Guo X, Shen S, Song S, He S, Cui Y, Xing G, Wang J, Yin Y, Fan L, He F, Zhang L.
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| J Biol Chem 286(20):18037-47. Epub 2011 Mar 28.
2011
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20 | KLF2, SELL, SMURF1
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| Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.
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| Xie P, Tang Y, Shen S, Wang Y, Xing G, Yin Y, He F, Zhang L.
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| Biochem Biophys Res Commun 407(1):254-9. Epub 2011 Mar 5.
2011
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21 | FBXL15, SMURF1
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| SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
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| Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L.
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| EMBO J 30(13):2675-89. doi: 10.1038/emboj.2011.155. Erratum in: EMBO J. 2011;30(13):2748.
2011
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22 | RHOA, SMURF1
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| Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.
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| Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR.
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| FEBS Lett 585(14):2199-204. Epub 2011 Jun 23.
2011
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23 | CDH1, SMURF1
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| Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
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| Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W.
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| Mol Cell 44(5):721-33. doi: 10.1016/j.molcel.2011.09.024.
2011
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24 | ING2, SMURF1
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| HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.
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| Nie J, Liu L, Wu M, Xing G, He S, Yin Y, Tian C, He F, Zhang L.
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| FEBS Lett 584(14):3005-12. Epub 2010 Jun 1.
2010
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25 | MDM2, MDM4, SMURF1, SMURF2
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| Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
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| Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.
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| J Biol Chem 285(30):22818-30. Epub 2010 May 18.
2010
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26 | CDK5, SMURF1
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| Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
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| Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH.
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| Nat Cell Biol 11(5):624-30. Epub 2009 Apr 12.
2009
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27 | SMURF1
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| Smurf1 zaps the talin head.
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| Critchley DR.
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| Nat Cell Biol 11(5):538-40.
2009
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28 | SMURF1, SMURF2
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| Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
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| Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.
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| J Biol Chem 283(51):35660-7. Epub 2008 Oct 16.
2008
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29 | ARHGEF9, SMURF1
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| Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway.
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| Yamaguchi K, Ohara O, Ando A, Nagase T.
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| Biol Chem 389(4):405-13.PMID: 18208356 2008
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30 | SMURF1
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| Modeling and analysis of molecularinteraction between Smurf1-WW2 domain and various isoforms of LIM mineralization protein.
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| Sangadala S, Boden SD, Metpally RP, Reddy BV.
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| Proteins 68(3):690-701. 2007
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31 | SMURF1
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| Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
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| Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S.
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| Cancer Sci 98(3):392-400. Epub 2007 Jan 12.
2007
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32 | FKBP1A, SMURF1, SMAD7
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| FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.
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| Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H.
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| J Mol Endocrinol 36(3):569-79. 2006
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33 | RUNX2, SMAD6, SMURF1
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| Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.
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| Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D.
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| J Biol Chem 281(6):3569-76. Epub 2005 Nov 18.
2006
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34 | PDLIM7, SMURF1
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| LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads.
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| Sangadala S, Boden SD, Viggeswarapu M, Liu Y, Titus L.
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| J Biol Chem 281(25):17212-9. Epub 2006 Apr 11.
2006
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35 | SMURF1, RUNX2
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| Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo.
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| Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D.
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| J Biol Chem 279(13):12854-9. Epub 2003 Dec 29. 2004
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36 | ANKRD36B, BCOR, BEND3, CACHD1, CHD8, CNNM4, DDX55, DHTKD1, EIF2C4, EPB41L5, EPG5, FAM160B1, GBA2, GPAM, GPR107, HERC4, KIAA1586, KIAA1609, KIF16B, MAGEE1, MAGI3, MED12L, MED12L, METTL14, MIER1, MOV10, NCKAP5L, NCOA5, PCDHB16, RNF213, SEMA4G, SFMBT2, SMURF1, TNRC6C, TRPM3, USP37, VAT1L, WDFY4, WDR19, WNK3, ZBTB26, ZNF532, ZPR1 ZNF319, ZSWIM5, ZSWIM6
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| Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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| Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O.
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| DNA Res 7(4):273-81. 2000
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37 | SMURF1
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| A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
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| Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH.
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| Nature 400(6745):687-93. 1999
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38 | ABCB6, ADCK2, ANAPC7, ANKRD46, ASPHD1, AVPI1, AZIN1, BRINP2, C12orf24, C14orf79, C17orf90, C17orf91, C5orf15, C9orf127, C9orf25, C9orf82, CNIH3, COG3, COG7, CREB3L1, CSRNP2, DHX29, DHX57, DLAT, EIF2B2, ERI3, FAM13C1, FAM35A, FAM54B, FLAD1, GHITM, GRIP2, GRPEL1, HMGCLL1, IP6K2, IP6K2, ITGB1BP1, KCMF1, KIFC2, LRP10, MDM1, MFN1, NAPG, NCALD, NECAB2, NIPAL4, NPTN, NTNG2, PASK, PCDHB10, PDIA6, PHPT1, PI4K2A, PNPLA2, POGK, PTOV1, RNF13, RNF41, SAC3D1, SDCBP2, SELT, SLC38A6, SLC39A3, SMURF1, SPRED2, SUCLG2, TMCO1, TMEM183A, TP53I11, TRPC4AP, TSC22D3, TUBB, TXNDC12, UTP18, WDR40A, WDR77, WSB2, ZMIZ1
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| Large-scale concatenation cDNA sequencing.
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| Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY,Wentland MA, Lennon G, Gibbs RA.
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| Genome Res 7(4):353-8. 1997
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39 | ADCK2, ANAPC7, ARHGAP22, AVPI1, AZIN1, C12orf24, C14orf79, C5orf15, C9orf25, CNIH3, COG3, COG7, CREB3L1, DHX29, DHX57, DLAT, DLGAP3, EIF2B2, EXOC3, FAM13C1, FAM152B, FAM35A, FAM54B, FAM89B, FLAD1, GHITM, GRPEL1, HMGCLL1, IP6K2, IPO4, ITGB1BP1, KCMF1, KIFC2, LRP10, MDM1, MFN1, NAPG, NCALD, NECAB2, NPTN, NTNG2, PASK, PCDHB10, PHPT1, PI4K2A, PNPLA2, POGK, PTOV1, RNF41, SAC3D1, SDCBP2, SELT, SEMA6C, SLC38A6, SLC39A3, SMURF1, SPRED2, STX12, SUCLG2, TAX1BP3, TMEM183A, TP53I11, TRAPPC3, TRPC4AP, TSC22D3, TUBB, TXNDC12, UTP18, WDFY3, WDR40A, WDR77, WSB2, ZMIZ1, ZNF410, ZXDC
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| A double adaptor method for improved shotgun library construction.
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| Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA.
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| Anal Biochem 236(1):107-13. 1996
|