| 1 | SMPD3
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| Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.
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| Stoffel W, Hammels I, Jenke B, Schmidt-Soltau I, Niehoff A.
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| Am J Pathol 189(9):1831-1845. doi: 10.1016/j.ajpath.2019.05.008. Epub 2019 Jun 12.
2019
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| 2 | SMPD3
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| Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression.
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| Manickam G, Moffatt P, Murshed M.
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| Mol Cell Biol 39(4). pii: e00370-18. doi: 10.1128/MCB.00370-18. Print 2019 Feb 15.
2019
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| 3 | SMPD3
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| SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment.
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| Stoffel W, Jenke B, Schmidt-Soltau I, Binczek E, Brodesser S, Hammels I.
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| Cell Death Dis 9(5):507. doi: 10.1038/s41419-018-0560-7.
2018
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| 4 | SMPD3
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| Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice.
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| Zhong L, Kong JN, Dinkins MB, Leanhart S, Zhu Z, Spassieva SD, Qin H, Lin HP, Elsherbini A, Wang R, Jiang X, Nikolova-Karakashian M, Wang G, Bieberich E.
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| J Lipid Res 59(5):795-804. doi: 10.1194/jlr.M080879. Epub 2018 Mar 22.
2018
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| 5 | SMPD3
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| Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination.
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| Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY.
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| Mol Neurobiol 55(7):5741-5756. doi: 10.1007/s12035-017-0784-z. Epub 2017 Oct 17.
2018
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| 6 | SMPD3
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| Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.
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| Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA.
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| Proc Natl Acad Sci U S A 114(28):E5549-E5558. doi: 10.1073/pnas.1705134114. Epub 2017 Jun 26.
2017
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| 7 | SMPD3
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| Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition.
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| Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Schauss A, Etich J, Heilig J, Zaucke F.
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| Cell Death Dis 7(11):e2488. doi: 10.1038/cddis.2016.385.
2016
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| 8 | SMPD3
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| Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development.
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| Li J, Manickam G, Ray S, Oh CD, Yasuda H, Moffatt P, Murshed M.
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| Mol Cell Biol 36(17):2282-99. doi: 10.1128/MCB.01077-15. Print 2016 Sep 1.
2016
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| 9 | SMPD3
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| Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation.
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| Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA.
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| Am J Physiol Lung Cell Mol Physiol 309(6):L614-24. doi: 10.1152/ajplung.00141.2015. Epub 2015 Jul 2.
2015
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| 10 | SMPD3
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| Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
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| Shamseddine AA, Airola MV, Hannun YA.
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| Adv Biol Regul 57:24-41. doi: 10.1016/j.jbior.2014.10.002. Epub 2014 Oct 27. Review.
2015
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| 11 | SMPD3
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| Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state.
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| Dotson PP 2nd, Karakashian AA, Nikolova-Karakashian MN.
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| Biochem J 465(3):371-82. doi: 10.1042/BJ20140665.
2015
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| 12 | SMPD3
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| Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
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| He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong JN, Spassieva SD, Bieberich E.
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| Mol Biol Cell 25(11):1715-29. doi: 10.1091/mbc.E13-12-0730. Epub 2014 Apr 2.
2014
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| 13 | SMPD3
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| Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.
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| Khavandgar Z, Alebrahim S, Eimar H, Tamimi F, McKee MD, Murshed M.
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| J Dent Res 92(4):358-64. doi: 10.1177/0022034513478429. Epub 2013 Feb 21.
2013
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| 14 | FOXO1, IL1B, SMPD3
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| Interleukin 1β regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism.
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| Dobierzewska A, Shi L, Karakashian AA, Nikolova-Karakashian MN.
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| J Biol Chem 287(53):44749-60. doi: 10.1074/jbc.M112.378836. Epub 2012 Oct 26.
2012
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| 15 | SMPD3
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| Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration.
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| Zhu D, Sreekumar PG, Hinton DR, Kannan R.
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| Vision Res 50(7):643-51. Epub 2009 Sep 16.PMID: 19765607 2010
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| 16 | EED, NSMAF, SMPD2, SMPD3, TNFRSF1A
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| The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
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| Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D.
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| Proc Natl Acad Sci U S A 107(3):1112-7. Epub 2009 Dec 28.PMID: 20080539 2010
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| 17 | SMPD3
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| Upregulation of smpd3 via BMP2 stimulation and Runx2.
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| Chae YM, Heo SH, Kim JY, Lee JM, Ryoo HM, Cho JY.
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| BMB Rep 42(2):86-90.PMID: 19250608 2009
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| 18 | SMPD2, SMPD3, SMPD4
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| Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.
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| Ito H, Murakami M, Furuhata A, Gao S, Yoshida K, Sobue S, Hagiwara K, Takagi A, Kojima T, Suzuki M, Banno Y, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Nozawa Y, Murate T.
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| Biochim Biophys Acta 1789(11-12):681-90. Epub 2009 Aug 19.PMID: 19698806 2009
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| 19 | NSMAF, SMPD3
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| Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
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| Clarke CJ, Guthrie JM, Hannun YA.
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| Mol Pharmacol 74(4):1022-32. Epub 2008 Jul 24.PMID: 18653803 2008
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| 20 | SMPD3
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| Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
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| Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.
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| Blood 111(9):4716-22. Epub 2008 Feb 25.PMID: 18299447 2008
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| 21 | SMPD3
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| nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis.
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| Levy M, Castillo SS, Goldkorn T.
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| Biochem Biophys Res Commun 344(3):900-5. Epub 2006 Apr 19.PMID: 16631623 2006
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| 22 | SMPD2, SMPD3
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| Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.
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| Marchesini N, Luberto C, Hannun YA.
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| J Biol Chem 278(16):13775-83. Epub 2003 Feb 3.PMID: 12566438 2003
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| 23 | SMPD3
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| Cloning and characterization of the mammalian brain-specific, Mg2+-dependentneutral sphingomyelinase.
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| Hofmann K, Tomiuk S, Wolff G, Stoffel W.
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| Proc Natl Acad Sci U S A 97(11):5895-900. 2000
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