1 | CBL, SMAD7
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| Smad7 modulates EGFR turnover through sequestration of c-Cbl.
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| Ha Thi HT, Kim HY, Choi SW, Kang JM, Kim SJ, Hong S.
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| Mol Cell Biol ol Cell Biol. 2015 Jun 8. pii: MCB.00274-15. [Epub ahead of print]
2015
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2 | SMAD7
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| Genetic disruption of Smad7 impairs skeletal muscle growth and regeneration.
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| Cohen TV, Kollias HD, Liu N, Ward CW, Wagner KR.
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| J Physiol 593(11):2479-97. doi: 10.1113/JP270201. Epub 2015 May 15.
2015
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3 | ITCH, SMAD7
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| Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination.
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| Park SH, Jung EH, Kim GY, Kim BC, Lim JH, Woo CH.
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| Mol Cells 38(1):20-5. doi: 10.14348/molcells.2015.2120. Epub 2014 Dec 16.
2015
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4 | SMAD7
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| Smad7 maintains epithelial phenotype of ovarian cancer stem-like cells and supports tumor colonization by mesenchymal-epithelial transition.
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| Li Y, Gong W, Ma X, Sun X, Jiang H, Chen T.
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| Mol Med Rep 11(1):309-16. doi: 10.3892/mmr.2014.2714. Epub 2014 Oct 21.
2015
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5 | SMAD7
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| Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair.
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| Park S, Kang JM, Kim SJ, Kim H, Hong S, Lee YJ, Kim SJ.
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| Cell Mol Life Sci 72(3):583-96. doi: 10.1007/s00018-014-1687-z. Epub 2014 Jul 26.
2015
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6 | SMAD7
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| M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.
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| Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK.
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| Proc Natl Acad Sci U S A 111(13):E1211-20. doi: 10.1073/pnas.1321347111. Epub 2014 Mar 17.
2014
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7 | SMAD7
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| A functional role for Smad7 in sustaining colon cancer cell growth and survival.
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| Stolfi C, De Simone V, Colantoni A, Franzè E, Ribichini E, Fantini MC, Caruso R, Monteleone I, Sica GS, Sileri P, MacDonald TT, Pallone F, Monteleone G.
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| Cell Death Dis 5:e1073. doi: 10.1038/cddis.2014.49.
2014
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8 | CASP8, IRF1, SMAD7
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| Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
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| Hong S, Kim HY, Kim J, Ha HT, Kim YM, Bae E, Kim TH, Lee KC, Kim SJ.
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| J Biol Chem 288(5):3560-70. doi: 10.1074/jbc.M112.400408. Epub 2012 Dec 19. 2013
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9 | SMAD7
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| Smad7 regulates terminal maturation of chondrocytes in the growth plate.
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| Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM.
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| Dev Biol 382(2):375-84. doi: 10.1016/j.ydbio.2013.08.021. Epub 2013 Aug 29.
2013
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10 | CBLB, SMAD7
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| Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
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| Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A, Pfeifhofer-Obermair C, Baier G.
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| J Mol Cell Biol 5(6):358-68. doi: 10.1093/jmcb/mjt017. Epub 2013 May 24.
2013
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11 | SMAD2, SMAD3, SMAD7
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| Smad signaling pathways regulate pancreatic endocrine development.
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| El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G.
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| Dev Biol 378(2):83-93. doi: 10.1016/j.ydbio.2013.04.003. Epub 2013 Apr 17.
2013
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12 | SMAD7
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| SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.
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| Ozair MZ, Noggle S, Warmflash A, Krzyspiak JE, Brivanlou AH.
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| Stem Cells 31(1):35-47. doi: 10.1002/stem.1246.
2013
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13 | SMAD7, TBX1
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| Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.
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| Papangeli I, Scambler PJ.
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| Circ Res 112(1):90-102. doi: 10.1161/CIRCRESAHA.112.270223. Epub 2012 Sep 25.
2013
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14 | SMAD7
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| Smad7-deficient mice show growth retardation with reduced viability.
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| Tojo M, Takebe A, Takahashi S, Tanaka K, Imamura T, Miyazono K, Chiba T.
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| J Biochem 151(6):621-31. doi: 10.1093/jb/mvs022. Epub 2012 Feb 29.
2012
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15 | APC, SMAD7, TGFBR1
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| APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.
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| Ekman M, Mu Y, Lee SY, Edlund S, Kozakai T, Thakur N, Tran H, Qian J, Groeden J, Heldin CH, Landström M.
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| Mol Biol Cell 23(11):2109-21. doi: 10.1091/mbc.E10-12-1000. Epub 2012 Apr 11.
2012
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16 | SMAD7, TGFBR1, TOLLIP
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| Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathway.
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| Zhu L, Wang L, Luo X, Zhang Y, Ding Q, Jiang X, Wang X, Pan Y, Chen Y.
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| J Biol Chem 287(47):39653-63. doi: 10.1074/jbc.M112.388009. Epub 2012 Oct 1.
2012
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17 | SMAD7
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| Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.
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| Yan X, Chen YG.
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| Biochem J 434(1):1-10. Review.
2011
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18 | SMAD7, TSC22D1
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| TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.
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| Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG.
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| Mol Cell Biol 31(18):3700-9. doi: 10.1128/MCB.05448-11. Epub 2011 Jul 26.
2011
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19 | IL1B, SMAD7
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| IL1B induced Smad 7 negatively regulates gastrin expression.
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| Datta De D, Bhattacharjya S, Maitra M, Datta A, Choudhury A, Dhali GK, Roychoudhury S.
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| PLoS One 6(3):e14775. doi: 10.1371/journal.pone.0014775.
2011
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20 | SMAD7, ZEB1
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| Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.
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| Nakahata S, Yamazaki S, Nakauchi H, Morishita K.
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| Oncogene 29(29):4157-69. Epub 2010 May 31. 2010
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21 | SMAD7
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| Roles of Smad3 and Smad7 in rat pancreatic stellate cells activated by transforming growth factor-beta 1.
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| Qian ZY, Peng Q, Zhang ZW, Zhou LA, Miao Y.
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| Hepatobiliary Pancreat Dis Int 9(5):531-6.
2010
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22 | SMAD7
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| Smad7 is required for the development and function of the heart.
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| Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, Chen Y.
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| J Biol Chem 284(1):292-300. Epub 2008 Oct 24.
2009
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23 | SMAD7
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| The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.
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| Pittman AM, Naranjo S, Webb E, Broderick P, Lips EH, van Wezel T, Morreau H, Sullivan K, Fielding S, Twiss P, Vijayakrishnan J, Casares F, Qureshi M, Gómez-Skarmeta JL, Houlston RS.
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| Genome Res 19(6):987-93. Epub 2009 Apr 24.
2009
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24 | BAMBI, SMAD7
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| Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
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| Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG.
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| J Biol Chem 284(44):30097-104. Epub 2009 Sep 15.PMID: 19758997 2009
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25 | SMAD7
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| Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.
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| Tang Y, Liu Z, Zhao L, Clemens TL, Cao X.
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| J Biol Chem 283(35):23956-63. Epub 2008 Jun 30.
2008
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26 | MAPK14, SMAD7
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| Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways.
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| Iwai T, Murai J, Yoshikawa H, Tsumaki N.
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| J Biol Chem 283(40):27154-64. Epub 2008 Jul 21. 2008
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27 | SMAD7, TGFB1I1
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| Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55.
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| Wang H, Song K, Krebs TL, Yang J, Danielpour D.
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| Oncogene 27(54):6791-805. Epub 2008 Sep 1.
2008
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28 | SMAD1, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9
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| SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.
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| Itman C, Loveland KL.
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| Dev Dyn 237(1):97-111.PMID: 18069690 2008
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29 | SMAD7
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| Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes.
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| Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, Kanzler S, Heuchel R, Ueberham U, Gebhardt R, Breitkopf K, Dooley S.
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| Hepatology 46(4):1257-70. 2007
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30 | SMAD7
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| A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
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| Broderick P, Carvajal-Carmona L, Pittman AM, Webb E, Howarth K, Rowan A, Lubbe S, Spain S, Sullivan K, Fielding S, Jaeger E, Vijayakrishnan J, Kemp Z, Gorman M, Chandler I, Papaemmanuil E, Penegar S, Wood W, Sellick G, Qureshi M, Teixeira A, Domingo E, Barclay E, Martin L, Sieber O; CORGI Consortium, Kerr D, Gray R, Peto J, Cazier JB, Tomlinson I, Houlston RS.
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| Nat Genet 39(11):1315-7. Epub 2007 Oct 14. 2007
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31 | YAP1, SMAD7
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| Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma.
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| Guo J, Kleeff J, Zhao Y, Li J, Giese T, Esposito I, BŸchler MW, Korc M, Friess H.
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| Int J Mol Med 17(5):761-7. 2006
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32 | FKBP1A, SMURF1, SMAD7
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| FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.
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| Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H.
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| J Mol Endocrinol 36(3):569-79. 2006
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33 | MYOD1, SMAD7
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| Smad7 promotes and enhances skeletal muscle differentiation.
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| Kollias HD, Perry RL, Miyake T, Aziz A, McDermott JC.
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| Mol Cell Biol 26(16):6248-60. 2006
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34 | SMAD7
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| Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling.
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| Mochizuki T, Miyazaki H, Hara T, Furuya T, Imamura T, Watabe T, Miyazono K.
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| J Biol Chem 279(30):31568-74. Epub 2004 May 17. 2004
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35 | SMAD6, SMAD7
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| SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke.
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| Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A.
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| Biol Chem 385(7):649-53. 2004
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36 | RNF111, SMAD7
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| Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.
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| Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K.
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| EMBO J 22(24):6458-70. 2003
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37 | SMAD7, TGFB1
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| Deficient Smad7 expression: a putative molecular defect in scleroderma.
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| Dong C, Zhu S, Wang T, Yoon W, Li Z, Alvarez RJ, ten Dijke P, White B, Wigley FM, Goldschmidt-Clermont PJ.
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| Proc Natl Acad Sci U S A 99(6):3908-13. 2002
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38 | SMAD7
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| Smad7: a new key player in TGF-beta-associated disease.
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| Nakao A, Okumura K, Ogawa H.
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| Trends Mol Med 8(8):361-3. 2002
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39 | SMAD7, RPLP0
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| Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7.
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| Boulay JL, Mild G, Reuter J, Lagrange M, Terracciano L, Lowy A, Laffer U, Orth B, Metzger U, Stamm B, Martinoli S, Herrmann R, Rochlitz C.
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| Genes Chromosomes Cancer 31(3):240-7. 2001
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40 | SMAD3, SMAD4, SMAD7
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| Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta.
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| von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Bottinger EP.
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| J Biol Chem 275(15):11320-6. 2000
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41 | SMAD4, SMAD7
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| Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer.
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| Jonson T, et al.
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| Genes Chromosomes Cancer 24 : 62-71. 1999
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42 | SMAD7
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| Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization.
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| Roijer E, Moren A, ten Dijke P, Stenman G.
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| Cytogenet Cell Genet 81(3-4):189-90. 1998
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43 | SMAD7, TSG18C
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| Cytogenetic and FISH analyses of pancreatic carcinoma reveal breaks in 18q11 with consistent loss of 18q12-qter and frequent gain of 18p.
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| Hoglund M, et al.
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| Br J Cancer 77(11):1893-9. 1998
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44 | SMAD6, SMAD7, SMAD9
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| Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.
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| Topper JN, Cai J, Qiu Y, Anderson KR, Xu YY, Deeds JD, Feeley R, Gimeno CJ, Woolf EA, Tayber O, Mays GG, Sampson BA, Schoen FJ, Gimbrone MA Jr, Falb D.
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| Proc Natl Acad Sci U S A 94(17):9314-9. 1997
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45 | SMAD7
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| Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
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| Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P.
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| Nature 389(6651):631-5. 1997
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