Citations for
1SMAD3, SMAD4, TRIM27, ZNF165, ZNF446
The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
Gibbs ZA, Reza LC, Cheng CC, Westcott JM, McGlynn K, Whitehurst AW.
Elife Jun 9;9:e57679. doi: 10.7554/eLife.57679. 2020
2SMAD2, SMAD4, TGFB1, TGIF1
TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.
Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ.
Nucleic Acids Res 46(17):9220-9235. doi: 10.1093/nar/gky680. 2018
3SMAD2, SMAD3, SMAD4, ZFYVE16, ZFYVE9
Zfyve16 regulates the proliferation of B-lymphoid cells.
Zhao X, Li D, Qiu Q, Jiao B, Zhang R, Liu P, Ren R.
Front Med 12(5):559-565. doi: 10.1007/s11684-017-0562-3. Epub 2017 Dec 16. 2018
4SMAD4, TPM2
Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2.
Hsu WL, Ma YL, Liu YC, Lee EHY.
BMC Biol 15(1):112. doi: 10.1186/s12915-017-0452-9. 2017
5SKIL, SMAD3, SMAD4
SnoN Stabilizes the SMAD3/SMAD4 Protein Complex.
Walldén K, Nyman T, Hällberg BM.
Sci Rep 7:46370. doi: 10.1038/srep46370. 2017
6CDH2, EXOC4, SMAD3, SMAD4
Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.
Tanaka T, Goto K, Iino M.
Cell Signal 29:115-126. doi: 10.1016/j.cellsig.2016.10.007. Epub 2016 Oct 18. 2017
7BSG, SMAD4
CD147-induced cell proliferation is associated with Smad4 signal inhibition.
Qin H, Rasul A, Li X, Masood M, Yang G, Wang N, Wei W, He X, Watanabe N, Li J, Li X.
Exp Cell Res 358(2):279-289. doi: 10.1016/j.yexcr.2017.07.003. Epub 2017 Jul 3. 2017
8SMAD4, STRA8
Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming
Wu Q, Fukuda K, Kato Y, Zhou Z, Deng CX, Saga Y.
PLoS Biol. Sep 8;14(9):e1002553. doi: 10.1371/journal.pbio.1002553. 2016
9SMAD4, rHOT1
Role of RHOT1 on migration and proliferation of pancreatic cancer.
Li Q, Yao L, Wei Y, Geng S, He C, Jiang H.
Am J Cancer Res 5(4):1460-70. eCollection 2015. 2015
10SMAD4, ZBTB7A
Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses.
Yang Y, Cui J, Xue F, Zhang C, Mei Z, Wang Y, Bi M, Shan D, Meredith A, Li H, Xu ZQ.
Biochim Biophys Acta 1849(3):270-81. doi: 10.1016/j.bbagrm.2014.12.008. Epub 2014 Dec 13. 2015
11SMAD4
Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesis.
Yan J, Zhang L, Xu J, Sultana N, Hu J, Cai X, Li J, Xu PX, Cai CL.
PLoS One 9(8):e104503. doi: 10.1371/journal.pone.0104503. eCollection 2014. 2014
12FHL1, SMAD4, VEGFA
FHL1 and Smad4 synergistically inhibit vascular endothelial growth factor expression.
Zhou Z, Lu J, Dou J, Lv Z, Qin X, Lin J.
Mol Med Rep 7(2):649-53. doi: 10.3892/mmr.2012.1202. Epub 2012 Nov 26. 2013
13NR2F2, SMAD4, TGFB1
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.
Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY.
Nature 493(7431):236-40. doi: 10.1038/nature11674. Epub 2012 Nov 28. 2013
14SMAD4, TRIM33
Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition.
Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R.
Development 140(1):167-75. doi: 10.1242/dev.085068. Epub 2012 Nov 15. 2013
15SMAD4, TRIM33
Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition.
Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R.
Development 140(1):167-75. doi: 10.1242/dev.085068. Epub 2012 Nov 15. 2013
16MYHRS, SMAD4
A Restricted Spectrum of Mutations in the SMAD4 Tumor-Suppressor Gene Underlies Myhre Syndrome.
Caputo V, Cianetti L, Niceta M, Carta C, Ciolfi A, Bocchinfuso G, Carrani E, Dentici ML, Biamino E, Belligni E, Garavelli L, Boccone L, Melis D, Andria G, Gelb BD, Stella L, Silengo M, Dallapiccola B, Tartaglia M.
Am J Hum Genet 90(1):161-9. 2012
17SMAD4
Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds.
Bénazet JD, Pignatti E, Nugent A, Unal E, Laurent F, Zeller R.
Development 139(22):4250-60. doi: 10.1242/dev.084822. Epub 2012 Oct 3. 2012
18SMAD4
Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo.
Rörby E, Nifelt Hägerström M, Blank U, Karlsson G, Karlsson S.
Blood lood. 2012 Sep 27. [Epub ahead of print] 2012
19MYHRS, SMAD4
Mutations of SMAD4 account for both LAPS and Myhre syndromes.
Lindor NM, Gunawardena SR, Thibodeau SN.
Am J Med Genet A 158A(6):1520-1. doi: 10.1002/ajmg.a.35374. Epub 2012 May 14. No abstract available. 2012
20FGF6, SMAD4, TGFB1
A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development.
Han D, Zhao H, Parada C, Hacia JG, Bringas P Jr, Chai Y.
Development 139(9):1640-50. doi: 10.1242/dev.076653. Epub 2012 Mar 21. 2012
21RHOT1, SMAD4
RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
Jiang H, He C, Geng S, Sheng H, Shen X, Zhang X, Li H, Zhu S, Chen X, Yang C, Gao H.
PLoS One 7(7):e42234. doi: 10.1371/journal.pone.0042234. Epub 2012 Jul 31. 2012
22SMAD4
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA.
Nature 470(7333):269-73. Epub 2011 Feb 2. 2011
23ASD2, GATA4, ID2, SMAD4
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE.
Proc Natl Acad Sci U S A 108(10):4006-11. Epub 2011 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5921. 2011
24SMAD4
SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis.
Li J, Huang X, Xu X, Mayo J, Bringas P Jr, Jiang R, Wang S, Chai Y.
Development 138(10):1977-89. Epub 2011 Apr 13. 2011
25SMAD4
Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients.
Calva D, Dahdaleh FS, Woodfield G, Weigel RJ, Carr JC, Chinnathambi S, Howe JR.
Nucleic Acids Res 39(13):5369-78. Epub 2011 Mar 17. 2011
26MYHRS, SMAD4
Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome.
Le Goff C, Mahaut C, Abhyankar A, Le Goff W, Serre V, Afenjar A, Destrée A, di Rocco M, Héron D, Jacquemont S, Marlin S, Simon M, Tolmie J, Verloes A, Casanova JL, Munnich A, Cormier-Daire V.
Nat Genet 44(1):85-8. doi: 10.1038/ng.1016. 2011
27SMAD4
Inactivation of Smad4 leads to impaired ocular development and cataract formation.
Liu Y, Kawai K, Khashabi S, Deng C, Liu YH, Yiu S.
Biochem Biophys Res Commun 400(4):476-82. Epub 2010 Aug 22. 2010
28PARP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6
PARP-1 attenuates Smad-mediated transcription.
Lönn P, van der Heide LP, Dahl M, Hellman U, Heldin CH, Moustakas A.
Mol Cell 40(4):521-32. 2010
29NLK, SMAD4
Human SMAD4 is phosphorylated at Thr9 and Ser138 by interacting with NLK.
Shi Y, Ye K, Wu H, Sun Y, Shi H, Huo K.
Mol Cell Biochem 333(1-2):293-8. Epub 2009 Aug 19. 2010
30SMAD2, SMAD4, SMAD6, TGFBR1
Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin.
Yu H, Mrowietz U, Seifert O.
Acta Derm Venereol 89(4):351-6. 2009
31BMPR1A, JPS, JPS3, SMAD4
The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis.
Calva-Cerqueira D, Chinnathambi S, Pechman B, Bair J, Larsen-Haidle J, Howe JR.
Clin Genet 75(1):79-85. Epub 2008 Sep 24. 2009
32SMAD4, TRIM33, USP9X
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.
Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S.
Cell 136(1):123-35. 2009
33SMAD4
The role of SMAD4 in early onset colorectal cancer.
Royce SG, Alsop K, Haydon A, Mead L, Smith LD, Tesoriero AA, Giles GG, Jenkins MA, Hopper JL, Southey MC.
Colorectal Dis olorectal Dis. 2009 Jan 27. [Epub ahead of print] 2009
34SMAD3, SMAD4, SNAI1
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J.
Nat Cell Biol 11(8):943-50. Epub 2009 Jul 13. 2009
35EIF4EBP1, SMAD4
4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.
Azar R, Alard A, Susini C, Bousquet C, Pyronnet S.
EMBO J 28(22):3514-22. Epub 2009 Oct 15.PMID: 19834456 2009
36BMPR1A, ENG, JPS, JPS2, JPS3, JPS4, PTEN, SMAD4
Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
van Hattem WA, Brosens LA, de Leng WW, Morsink FH, Lens S, Carvalho R, Giardiello FM, Offerhaus GJ.
Gut 57(5):623-7. Epub 2008 Jan 4. 2008
37SMAD1, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9
SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.
Itman C, Loveland KL.
Dev Dyn 237(1):97-111.PMID: 18069690 2008
38HOXC9, SMAD4
MH1 domain of SMAD4 binds N-terminal residues of the homeodomain of Hoxc9.
Zhou B, Chen L, Wu X, Wang J, Yin Y, Zhu G.
Biochim Biophys Acta 1784(5):747-52. Epub 2008 Feb 20.PMID: 18339330 2008
39ENG, SMAD4, JPS4
ENG mutations in MADH4/BMPR1A mutation negative patients with juvenile polyposis.
Howe JR, Haidle JL, Lal G, Bair J, Song C, Pechman B, Chinnathambi S, Lynch HT.
Clin Genet 71(1):91-2. No abstract available. 2007
40JPS, JPS2, JPS3, JPHT, HMPS2, SMAD4, BMPR1A, PTEN
High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome.
Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, Back W, Kaufmann A, Keller KM, Blaas SH, Siebert R, Vogt S, Spranger S, Holinski-Feder E, Sunde L, Propping P, Friedl W.
J Med Genet 44(11):702-9. Epub 2007 Sep 14. 2007
41LAMA5, SMAD4
Basement membrane component laminin-5 is a target of the tumor suppressor Smad4.
Zapatka M, Zboralski D, Radacz Y, Böckmann M, Arnold C, Schöneck A, Hoppe S, Tannapfel A, Schmiegel W, Simon-Assmann P, Schwarte-Waldhoff I.
Oncogene 26(10):1417-27. Epub 2006 Sep 4. 2007
42SMAD4
Essential role of endothelial Smad4 in vascular remodeling and integrity.
Lan Y, Liu B, Yao H, Li F, Weng T, Yang G, Li W, Cheng X, Mao N, Yang X.
Mol Cell Biol 27(21):7683-92. Epub 2007 Aug 27.PMID: 17724086 2007
43ENG, ORW1, ORW2, ACVRL1, JPS, SMAD4
Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease.
Abdalla SA, Letarte M.
J Med Genet 43(2):97-110. Epub 2005 May 6. 2006
44SMAD4, JPHT
SMAD4 mutations found in unselected HHT patients.
Gallione CJ, Richards JA, Letteboer TG, Rushlow D, Prigoda NL, Leedom TP, Ganguly A, Castells A, Ploos van Amstel JK, Westermann CJ, Pyeritz RE, Marchuk DA.
J Med Genet 43(10):793-7. Epub 2006 Apr 13. 2006
45JPS, JPS2, JPS3, BMPR1A, SMAD4
Mutation screening in juvenile polyposis syndrome.
Pyatt RE, Pilarski R, Prior TW.
J Mol Diagn 8(1):84-8. 2006
46SMAD1, SMAD2, SMAD3, SMAD4, SMAD5
Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.
Langenfeld EM, Kong Y, Langenfeld J.
Oncogene 25(5):685-92. 2006
47SMAD4, BMPR1A
Vessels' morphology in SMAD4 and BMPR1A-related juvenile polyposis.
Handra-Luca A, Condroyer C, de Moncuit C, Tepper M, Flejou JF, Thomas G, Olschwang S.
Am J Med Genet A 138(2):113-7. 2005
48SMAD4, JPS, BMPR1A, JPS3
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.
Howe JR, Sayed MG, Ahmed AF, Ringold J, Larsen-Haidle J, Merg A, Mitros FA, Vaccaro CA, Petersen GM, Giardiello FM, Tinley ST, Aaltonen LA, Lynch HT.
J Med Genet 41(7):484-91. 2004
49BMPR1A, SMAD4, PTEN
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L.
Nat Genet 36(10):1117-21. Epub 2004 Sep 19. 2004
50SMAD4
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
De Bosscher K, Hill CS, Nicolas FJ.
Biochem J 379(Pt 1):209-16. 2004
51JPHT, JPS, SMAD4
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).
Gallione CJ, Repetto GM, Legius E, Rustgi AK, Schelley SL, Tejpar S, Mitchell G, Drouin E, Westermann CJ, Marchuk DA.
Lancet 363(9412):852-9. 2004
52JPS, JPS2, JPS3, PTEN, BMPR1A, SMAD4
Genetic conditions associated with intestinal juvenile polyps.
Merg A, Howe JR.
Am J Med Genet C Semin Med Genet 129(1):44-55. Review. 2004
53SMAD4, SMAD1, SMAD2, SMAD3, ESR1
Smad4 as a transcription corepressor for estrogen receptor alpha.
Wu L, Wu Y, Gathings B, Wan M, Li X, Grizzle W, Liu Z, Lu C, Mao Z, Cao X.
J Biol Chem 278(17):15192-200. Epub 2003 Feb 07. 2003
54SMAD4
Role of Smad4 (DPC4) inactivation in human cancer.
Miyaki M, Kuroki T.
Biochem Biophys Res Commun 306(4):799-804. Review. 2003
55SMAD2, SMAD4
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer.
Maliekal TT, Antony ML, Nair A, Paulmurugan R, Karunagaran D.
Oncogene 22(31):4889-97. 2003
56UBE2I, SMAD4
SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.
Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH.
J Biol Chem 278(33):31043-8. Epub 2003 Jun 17. 2003
57JPS, SMAD4
Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot.
Howe JR, Shellnut J, Wagner B, Ringold JC, Sayed MG, Ahmed AF, Lynch PM, Amos CI, Sistonen P, Aaltonen LA.
Am J Hum Genet 70(5):1357-62. 2002
58SMAD4
Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers.
Friedl W, Uhlhaas S, Schulmann K, Stolte M, Loff S, Back W, Mangold E, Stern M, Knaebel HP, Sutter C, Weber RG, Pistorius S, Burger B, Propping P.
Hum Genet 111(1):108-11. 2002
59JPS, SMAD4
Novel de novo mutation of MADH4/SMAD4 in a patient with juvenile polyposis.
Burger B, Uhlhaas S, Mangold E, Propping P, Friedl W, Jenne D, Dockter G, Back W.
Am J Med Genet 110(3):289-91. No abstract available. 2002
60SMAD4
Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene.
Blaker H, von Herbay A, Penzel R, Gross S, Otto HF.
Oncogene 21(1):158-64. 2002
61SMAD4
Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis.
Imai Y, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa S, Chiba S, Mitani K, Hirai H.
Oncogene 20(1):88-96. 2001
62STK11IP, SMAD4, STK11
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
Smith DP, Rayter SI, Niederlander C, Spicer J, Jones CM, Ashworth A.
Hum Mol Genet 10(25):2869-77. 2001
63SMAD4
Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer.
Had ija MP, Kapitanovic S, Radosevic S, Cacev T, Mirt M, Kovacevic D, Cacev T, Hadzija M, Spaventi R, Pavelic K.
J Mol Med 79(2-3):128-32. 2001
64SMAD1, SMAD4
Structural basis of Smad1 activation by receptor kinase phosphorylation.
Qin BY, Chacko BM, Lam SS, de Caestecker MP, Correia JJ, Lin K.
Mol Cell 8(6):1303-12. 2001
65DCC, SMAD4
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.
Hilgers W, Song JJ, Haye M, Hruban RR, Kern SE, Fearon ER.
Genes Chromosomes Cancer 27(4):353-7. 2000
66SMAD4
Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4.
Jones JB, Kern SE.
Nucleic Acids Res 28(12):2363-8. 2000
67SMAD4
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis.
Schwarte-Waldhoff I, Volpert OV, Bouck NP, Sipos B, Hahn SA, Klein-Scory S, Luttges J, Kloppel G, Graeven U, Eilert-Micus C, Hintelmann A, Schmiegel W.
Proc Natl Acad Sci U S A 97(17):9624-9. 2000
68SMAD4
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.
Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, Yeo CJ, Kern SE, Hruban RH.
Cancer Res 60(7):2002-6. 2000
69SMAD3, SMAD4, SMAD7
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta.
von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Bottinger EP.
J Biol Chem 275(15):11320-6. 2000
70SMAD4, SMAD7
Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer.
Jonson T, et al.
Genes Chromosomes Cancer 24 : 62-71. 1999
71SMAD4, LOH18CR1
Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers.
Takakura S, et al.
Genes Chromosomes Cancer 24 : 264-271. 1999
72SMAD4
Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients.
Friedl W, et al.
Genes Chromosomes Cancer 25(4):403-6. 1999
73SMAD4
Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors.
Bartsch D, et al.
Oncogene 18(14):2367-71. 1999
74JPS, SMAD4
SMAD genes in juvenile polyposis.
Roth S, et al.
Genes Chromosomes Cancer 26(1):54-61. 1999
75SMAD4, JPS
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis.
Miyaki M, et al.
Oncogene 18(20):3098-103. 1999
76SMAD2, SMAD4
Smad2 and Smad4 gene mutations in hepatocellular carcinoma.
Yakicier MC, Irmak MB, Romano A, Kew M, Ozturk M.
Oncogene 18(34):4879-83 1999
77JUNB, SMAD3, SMAD4
Smads bind directly to the Jun family of AP-1 transcription factors.
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF.
Proc Natl Acad Sci U S A. 96(9):4844-9. 1999
78JPS, SMAD4
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Howe JR, et al.
Science 280 : 1086-1088. 1998
79SMAD3, SMAD4
Human Smad3 and Smad4 are sequence-specific transcription activators.
Zawel L, et al.
Mol Cell 1 : 611-617. 1998
80BZS, JPS, SMAD4, MHAM, PTEN
PTEN and inherited hamartoma-cancer syndromes.
Eng C, et al.
Nat Genet 19 : 223. 1998
81SMAD4, CITED1
Transcriptional activating activity of Smad4 : roles of SMAd hetero-oligomerization and enhancement by an associating transactivator.
Shioda T, et al.
Proc Natl Acad Sci U S A 95 : 9785-9790. 1998
82CREBBP, SMAD2, SMAD4
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.
Topper JN, et al.
Proc Natl Acad Sci U S A 95 : 9506-9511. 1998
83JPS, SMAD4
Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Houlston R, et al.
Hum Mol Genet 7 : 1907-1912. 1998
84SMAD3, SMAD4
Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter.
Song CZ, Siok TE, Gelehrter TD.
J Biol Chem 273 : 29287-29290. 1998
85SMAD4
Overexpression of the tumor suppressor gene Smad4/DPC4 induces p21waf1 expression and growth inhibition in human carcinoma cells.
Hunt KK, et al.
Cancer Res 58 : 5656-5661. 1998
86SMAD4
Smad4 (DPC4)--a potent tumour suppressor ?
Duff EK, et al.
Br J Cancer 78 : 1615-1619. 1998
87SMAD4
Analysis of 5'-flanking region of human Smad4 (DPC4) gene.
Minami R, et al.
Biochim Biophys Acta 1443(1-2):182-5. 1998
88COL7A1, SMAD4
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
Vindevoghel L, et al.
Proc Natl Acad Sci U S A 95(25):14769-74. 1998
89SMAD4
DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells.
de Winter JP, Roelen BA, ten Dijke P, van der Burg B, van den Eijnden-van Raaij AJ.
Oncogene 14(16):1891-9. 1997
90SMAD2, SMAD4
MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma.
Maesawa C, Tamura G, Nishizuka S, Iwaya T, Ogasawara S, Ishida K, Sakata K, Sato N, Ikeda K, Kimura Y, Saito K, Satodate R.
Jpn J Cancer Res 88(4):340-3. 1997
91SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6
Frequency of Smad gene mutations in human cancers.
Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S.
Cancer Res 57(13):2578-80. 1997
92SMAD4
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.
Yingling JM, Datto MB, Wong C, Frederick JP, Liberati NT, Wang XF.
Mol Cell Biol 17(12):7019-28. 1997
93SMAD4
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
Hahn SA, et al.
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94LOH18CR1, SMAD4
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95SMAD4
DPC4, a candidate tumor suppressor gene, is altered infrequently in headand neck squamous cell carcinoma.
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96SMAD4, LOH18CR1
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97LOH18CR1, DCC, SMAD4
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98SMAD4, LOH18CR1
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99SMAD4
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100SMAD4, TSG9A, TSG17A, LOH18CR1
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101SMAD4, JPHT
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