Citations for
1BCL2L12, EMD, KLK10, LMNA, MYO1C, SMAD2
Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus.
Ranade D, Pradhan R, Jayakrishnan M, Hegde S, Sengupta K.
BMC Mol Cell Biol 20(1):11. doi: 10.1186/s12860-019-0192-5. 2019
2SMAD2, SMAD4, TGFB1, TGIF1
TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.
Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ.
Nucleic Acids Res 46(17):9220-9235. doi: 10.1093/nar/gky680. 2018
3SMAD2, TRIM33
Trim33 mediates the proinflammatory function of Th17 cells.
Tanaka S, Jiang Y, Martinez GJ, Tanaka K, Yan X, Kurosaki T, Kaartinen V, Feng XH, Tian Q, Wang X, Dong C.
J Exp Med 215(7):1853-1868. doi: 10.1084/jem.20170779. Epub 2018 Jun 21. 2018
4SMAD2, SMAD3, SMAD4, ZFYVE16, ZFYVE9
Zfyve16 regulates the proliferation of B-lymphoid cells.
Zhao X, Li D, Qiu Q, Jiao B, Zhang R, Liu P, Ren R.
Front Med 12(5):559-565. doi: 10.1007/s11684-017-0562-3. Epub 2017 Dec 16. 2018
5SENP1, SMAD2
SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2.
Wu L, Qiu W, Sun J, Wang J.
Biochem Biophys Res Commun 495(1):755-760. doi: 10.1016/j.bbrc.2017.11.047. Epub 2017 Nov 8. 2018
6LEMD3, SMAD2, SMAD3
Structural basis for receptor-regulated SMAD recognition by MAN1.
Miyazono KI, Ohno Y, Wada H, Ito T, Fukatsu Y, Kurisaki A, Asashima M, Tanokura M.
Nucleic Acids Res 46(22):12139-12153. doi: 10.1093/nar/gky925. 2018
7MFN2, RIN1, SMAD2
Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.
Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY.
Mol Cell 62(4):520-31. doi: 10.1016/j.molcel.2016.04.010. Epub 2016 May 12. 2016
8SMAD2
Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2.
Koo JH, Lee HJ, Kim W, Kim SG.
Gastroenterology 150(1):181-193.e8. doi: 10.1053/j.gastro.2015.09.039. Epub 2015 Oct 3. 2016
9FSTL1, SMAD2, SMAD3
Follistatin-like 1 attenuates differentiation and survival of erythroid cells through Smad2/3 signaling.
Wu J, Dong Y, Teng X, Cheng M, Shen Z, Chen W.
Biochem Biophys Res Commun 466(4):711-6. doi: 10.1016/j.bbrc.2015.09.044. Epub 2015 Sep 10. 2015
10ENG, SMAD2
Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy.
Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY.
J Biol Chem 290(24):14884-92. doi: 10.1074/jbc.M114.630178. Epub 2015 Apr 30. 2015
11SMAD2, SMAD3, TCF3
E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation.
Wills AE, Baker JC.
Dev Cell 32(3):345-57. doi: 10.1016/j.devcel.2014.11.034. 2015
12SMAD2, SMAD3, TGFB1
Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis.
Zhang L, Liu C, Meng XM, Huang C, Xu F, Li J.
Mol Cell Biochem 400(1-2):17-28. doi: 10.1007/s11010-014-2258-1. Epub 2014 Oct 29. 2015
13SMAD2, SMAD3
Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells.
Li H, Yuan X, Li J, Tang X.
Curr Eye Res 40(4):386-97. doi: 10.3109/02713683.2014.925932. Epub 2014 Jun 9. 2015
14SH3KBP1, SMAD2
CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.
Yakymovych I, Yakymovych M, Zang G, Mu Y, Bergh A, Landström M, Heldin CH.
J Cell Biol 210(2):319-32. doi: 10.1083/jcb.201411025. 2015
15CTNNB1, SMAD2
Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and β-catenin signaling.
Xu H, Tsang KS, Wang Y, Chan JC, Xu G, Gao WQ.
J Biol Chem 289(38):26290-301. doi: 10.1074/jbc.M114.572560. Epub 2014 Aug 4. 2014
16CDKN1B, CDKN2B, RB1, SMAD2
Smad2 overexpression reduces the proliferation of the junctional epithelium.
Alotaibi MK, Kitase Y, Shuler CF.
J Dent Res 93(9):898-903. doi: 10.1177/0022034514543016. Epub 2014 Jul 14. 2014
17SMAD2
Prostaglandin E2 modifies SMAD2 and promotes SMAD2-SMAD4 complex formation.
Yang C, Chen C, Sorokin A.
Prostaglandins Leukot Essent Fatty Acids 90(5):145-9. doi: 10.1016/j.plefa.2014.02.004. Epub 2014 Feb 26. 2014
18SMAD2, SMAD3, SMAD7
Smad signaling pathways regulate pancreatic endocrine development.
El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G.
Dev Biol 378(2):83-93. doi: 10.1016/j.ydbio.2013.04.003. Epub 2013 Apr 17. 2013
19SMAD2, TGFB1
Calcium-sensing receptor inhibits TGF-β-signaling by decreasing Smad2 phosphorylation.
Organista-Juárez D, Carretero-Ortega J, Vicente-Fermín O, Vázquez-Victorio G, Sosa-Garrocho M, Vázquez-Prado J, Macías-Silva M, Reyes-Cruz G.
IUBMB Life 65(12):1035-42. doi: 10.1002/iub.1232. Epub 2013 Nov 24. 2013
20SMAD2, SMAD3
Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis.
Míguez DG, Gil-Guiñón E, Pons S, Martí E.
J Cell Sci 126(Pt 23):5335-43. doi: 10.1242/jcs.130435. Epub 2013 Oct 8. 2013
21IRF4, SMAD2, SMAD3
Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, Honma K, Yui K, Matsuyama T, Nakao T, Fukuyama S, Inoue H, Nomura M, Yoshimura A.
J Immunol 191(5):2360-71. doi: 10.4049/jimmunol.1301276. Epub 2013 Aug 2. 2013
22SMAD2
Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells.
Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY.
Circ Res 113(8):e76-86. doi: 10.1161/CIRCRESAHA.113.301921. Epub 2013 Jul 1. 2013
23SMAD2
Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state.
Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R.
J Biol Chem 288(25):18546-60. doi: 10.1074/jbc.M112.446591. Epub 2013 May 6. 2013
24SMAD2
Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.
Peterson AJ, O'Connor MB.
Development 140(3):649-59. doi: 10.1242/dev.085605. 2013
25ADAMTS5, SMAD2, VCAN
Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.
Dupuis LE, Osinska H, Weinstein MB, Hinton RB, Kern CB.
J Mol Cell Cardiol 60:50-9. doi: 10.1016/j.yjmcc.2013.03.010. Epub 2013 Mar 24. 2013
26LEMD3, PPM1A, SMAD2, SMAD3
Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.
Bourgeois B, Gilquin B, Tellier-Lebègue C, Östlund C, Wu W, Pérez J, El Hage P, Lallemand F, Worman HJ, Zinn-Justin S.
Sci Signal 6(280):ra49. doi: 10.1126/scisignal.2003411. 2013
27NPNT, SMAD2, TGFBR1
Nephronectin expression is regulated by SMAD signaling in osteoblast-like MC3T3-E1 cells.
Tsukasaki M, Yamada A, Yoshimura K, Miyazono A, Yamamoto M, Takami M, Miyamoto Y, Morimura N, Kamijo R.
Biochem Biophys Res Commun 425(2):390-2. doi: 10.1016/j.bbrc.2012.07.106. Epub 2012 Jul 27. 2012
28SMAD2, SMAD3, SMURF2, TRIB3
TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.
Hua F, Mu R, Liu J, Xue J, Wang Z, Lin H, Yang H, Chen X, Hu Z.
J Cell Sci 124(Pt 19):3235-46. doi: 10.1242/jcs.082875. Epub 2011 Sep 6. 2011
29POP1, SMAD2
Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia.
Glazov EA, Zankl A, Donskoi M, Kenna TJ, Thomas GP, Clark GR, Duncan EL, Brown MA.
PLoS Genet 7(3):e1002027. doi: 10.1371/journal.pgen.1002027. Epub 2011 Mar 24. 2011
30PIN1, SMAD2, SMAD3
Pin1 promotes transforming growth factor-beta-induced migration and invasion.
Matsuura I, Chiang KN, Lai CY, He D, Wang G, Ramkumar R, Uchida T, Ryo A, Lu K, Liu F.
J Biol Chem 285(3):1754-64. Epub 2009 Nov 17.PMID: 19920136 2010
31PARP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6
PARP-1 attenuates Smad-mediated transcription.
Lönn P, van der Heide LP, Dahl M, Hellman U, Heldin CH, Moustakas A.
Mol Cell 40(4):521-32. 2010
32SMAD2, SMAD4, SMAD6, TGFBR1
Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin.
Yu H, Mrowietz U, Seifert O.
Acta Derm Venereol 89(4):351-6. 2009
33RANBP3, SMAD2, SMAD3
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.
Dai F, Lin X, Chang C, Feng XH.
Dev Cell 16(3):345-57. 2009
34EOMES, SMAD2
Eomesodermin requires transforming growth factor-beta/activin signaling and binds Smad2 to activate mesodermal genes.
Picozzi P, Wang F, Cronk K, Ryan K.
J Biol Chem 284(4):2397-408. Epub 2008 Nov 26. 2009
35SMAD2, SMAD3, ZFYVE9
Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype.
Runyan CE, Hayashida T, Hubchak S, Curley JF, Schnaper HW.
J Biol Chem 284(37):25181-9. Epub 2009 Jul 20.PMID: 19620243 2009
36CLU, SMAD2, SMAD3
Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability.
Lee KB, Jeon JH, Choi I, Kwon OY, Yu K, You KH.
Biochem Biophys Res Commun 366(4):905-9. Epub 2007 Dec 17. 2008
37SMAD2, SMAD3
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.
Brown KA, Ham AJ, Clark CN, Meller N, Law BK, Chytil A, Cheng N, Pietenpol JA, Moses HL.
J Cell Biochem 105(2):596-611. 2008
38SMAD1, SMAD2, SMAD3, SMAD4, SMAD5
Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.
Langenfeld EM, Kong Y, Langenfeld J.
Oncogene 25(5):685-92. 2006
39SH2D2A, SMAD2, SMAD3
TSAd interacts with Smad2 and Smad3.
Richard KC, Bertolesi GE, Dunfield LD, McMaster CR, Nachtigal MW.
Biochem Biophys Res Commun 347(1):266-72. Epub 2006 Jun 21. 2006
40LMNA, SMAD2, RB, PPP2R3B, TGFB1
A-type lamins are essential for TGF-{beta}1 induced PP2A to dephosphorylate transcription factors.
Van Berlo JH, Voncken JW, Kubben N, Broers JL, Duisters R, van Leeuwen RE, Crijns HJ, Ramaekers FC, Hutchison CJ, Pinto YM.
Hum Mol Genet 14(19):2839-49. Epub 2005 Aug 22. 2005
41ZFYVE9, SMAD2
The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells.
Runyan CE, Schnaper HW, Poncelet AC.
J Biol Chem 280(9):8300-8. Epub 2004 Dec 21. 2005
42SMAD4, SMAD1, SMAD2, SMAD3, ESR1
Smad4 as a transcription corepressor for estrogen receptor alpha.
Wu L, Wu Y, Gathings B, Wan M, Li X, Grizzle W, Liu Z, Lu C, Mao Z, Cao X.
J Biol Chem 278(17):15192-200. Epub 2003 Feb 07. 2003
43SMAD2, SMAD4
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer.
Maliekal TT, Antony ML, Nair A, Paulmurugan R, Karunagaran D.
Oncogene 22(31):4889-97. 2003
44CREB1, MAPK8, SKI, JUN, SMAD2
c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.
Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A.
J Biol Chem 277(32):29094-100. 2002
45SMAD2
Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression.
Saura M, Zaragoza C, Cao W, Bao C, Rodriguez-Puyol M, Rodriguez-Puyol D, Lowenstein CJ.
Circ Res 91(9):806-13. 2002
46TGFBR2, SMAD2, SMAD3
The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals.
Watanabe R, et al.
Biochem Biophys Res Commun 254(3):707-12. 1999
47MAP3K1, SMAD2
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells.
Brown JD, et al.
J Biol Chem 274(13):8797-805. 1999
48SMAD2
Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion.
Prunier C, Mazars A, Noe V, Bruyneel E, Mareel M, Gespach C, Atfi A.
J Biol Chem 274(33):22919-22 1999
49SMAD2
Expression and mutational analysis of the MADR2/Smad2 gene in human prostate cancer.
Latil A, Pesche S, Valeri A, Fournier G, Cussenot O, Lidereau R.
Prostate 40(4):225-31 1999
50SMAD2, SMAD4
Smad2 and Smad4 gene mutations in hepatocellular carcinoma.
Yakicier MC, Irmak MB, Romano A, Kew M, Ozturk M.
Oncogene 18(34):4879-83 1999
51SMAD2
Characterization of the MADH2/Smad2 gene, a human mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway.
Takenoshita S, Mogi A, Nagashima M, Yang K, Yagi K, Hanyu A, Nagamachi Y, Miyazono K, Hagiwara K.
Genomics 48(1):1-11. 1998
52SMAD2
Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers.
Takenoshita S, et al.
Carcinogenesis 19 : 803-807. 1998
53CREBBP, SMAD2, SMAD4
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.
Topper JN, et al.
Proc Natl Acad Sci U S A 95 : 9506-9511. 1998
54SMAD2, SMAD4
MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma.
Maesawa C, Tamura G, Nishizuka S, Iwaya T, Ogasawara S, Ishida K, Sakata K, Sato N, Ikeda K, Kimura Y, Saito K, Satodate R.
Jpn J Cancer Res 88(4):340-3. 1997
55SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6
Frequency of Smad gene mutations in human cancers.
Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S.
Cancer Res 57(13):2578-80. 1997
56SMAD1, SMAD5, SMAD3, SMAD6, SMAD2
Mad-related genes in the human.
Riggins GJ, et al.
Nat Genet 13 : 347-349. 1996
57SMAD2
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Eppert K, et al.
Cell 86 : 543-552. 1996
58SMAD2, LOH18CR1
Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers.
Uchida K, et al.
Cancer Res 56 : 5583-5585. 1996