Citations for
1SLIT2
Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer.
Göhrig A, Detjen KM, Hilfenhaus G, Körner JL, Welzel M, Arsenic R, Schmuck R, Bahra M, Wu JY, Wiedenmann B, Fischer C.
Cancer Res 74(5):1529-40. doi: 10.1158/0008-5472.CAN-13-1012. Epub 2014 Jan 21. 2014
2SLIT2
Reduced expression of Slit2 in renal cell carcinoma.
Ma WJ, Zhou Y, Lu D, Dong D, Tian XJ, Wen JX, Zhang J.
Med Oncol 31(1):768. doi: 10.1007/s12032-013-0768-4. Epub 2013 Nov 15. 2014
3ROBO1, ROBO2, SLIT1, SLIT2, SLIT3
Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.
Yang YH, Manning Fox JE, Zhang KL, MacDonald PE, Johnson JD.
Proc Natl Acad Sci U S A 110(41):16480-5. doi: 10.1073/pnas.1214312110. Epub 2013 Sep 24. 2013
4SLIT2
Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.
Beggs AD, Jones A, Shepherd N, Arnaout A, Finlayson C, Abulafi AM, Morton DG, Matthews GM, Hodgson SV, Tomlinson IP.
PLoS Genet 9(5):e1003488. doi: 10.1371/journal.pgen.1003488. Epub 2013 May 9. 2013
5ROBO3, SLIT2
Slit2 and Robo3 modulate the migration of GnRH-secreting neurons.
Cariboni A, Andrews WD, Memi F, Ypsilanti AR, Zelina P, Chedotal A, Parnavelas JG.
Development 139(18):3326-31. doi: 10.1242/dev.079418. 2012
6SLIT2
The cell motility modulator Slit2 is a potent inhibitor of platelet function.
Patel S, Huang YW, Reheman A, Pluthero FG, Chaturvedi S, Mukovozov IM, Tole S, Liu GY, Li L, Durocher Y, Ni H, Kahr WH, Robinson LA.
Circulation 126(11):1385-95. doi: 10.1161/CIRCULATIONAHA.112.105452. Epub 2012 Aug 3. 2012
7FZD3, SLIT2
Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon.
Hofmeister W, Devine CA, Rothnagel JA, Key B.
Mech Dev 129(5-8):109-24. doi: 10.1016/j.mod.2012.05.004. Epub 2012 May 17. 2012
8FYN, RHOA, SLIT2
Slit2 regulates the dispersal of oligodendrocyte precursor cells via Fyn/RhoA signaling.
Liu X, Lu Y, Zhang Y, Li Y, Zhou J, Yuan Y, Gao X, Su Z, He C.
J Biol Chem 287(21):17503-16. doi: 10.1074/jbc.M111.317610. Epub 2012 Mar 20. 2012
9SLIT1, SLIT2, SLIT3
The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.
Guijarro-Muñoz I, Cuesta AM, Alvarez-Cienfuegos A, Geng JG, Alvarez-Vallina L, Sanz L.
Exp Cell Res 318(4):371-8. doi: 10.1016/j.yexcr.2011.12.005. Epub 2011 Dec 14. 2012
10NEUROD1, SLIT2
The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma.
Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K.
Cancer Res 71(8):2938-48. Epub 2011 Feb 24. 2011
11SLIT2
SLIT2 is epigenetically silenced in ovarian cancers and suppresses growth when activated.
Qiu H, Zhu J, Yu J, Pu H, Dong R.
Asian Pac J Cancer Prev 12(3):791-5. 2011
12EPHA1, SLIT2
Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.
Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM.
Mol Cell Biol 31(3):404-16. doi: 10.1128/MCB.00667-10. Epub 2010 Dec 6. 2011
13EZH2, SLIT2
The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.
Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM.
Oncogene 29(39):5370-80. Epub 2010 Jul 12. 2010
14SLIT2
Epigenetic inactivation of SLIT2 in human hepatocellular carcinomas.
Jin J, You H, Yu B, Deng Y, Tang N, Yao G, Shu H, Yang S, Qin W.
Biochem Biophys Res Commun 379(1):86-91. Epub 2008 Dec 17. 2009
15SLIT2
Structure and functional relevance of the Slit2 homodimerization domain.
Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA.
EMBO Rep 10(7):736-41. Epub 2009 Jun 5.PMID: 19498462 2009
16ROBO2, SLIT1, SLIT2
Robo2 is required for Slit-mediated intraretinal axon guidance.
Thompson H, Andrews W, Parnavelas JG, Erskine L.
Dev Biol 335(2):418-26. Epub 2009 Sep 25. 2009
17CXCL12, CXCR4, SLIT1, SLIT2
SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.
Marlow R, Strickland P, Lee JS, Wu X, Pebenito M, Binnewies M, Le EK, Moran A, Macias H, Cardiff RD, Sukumar S, Hinck L.
Cancer Res 68(19):7819-27. 2008
18SLIT2
Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells.
Prasad A, Paruchuri V, Preet A, Latif F, Ganju RK.
J Biol Chem 283(39):26624-33. Epub 2008 Jul 8. 2008
19ROBO1, ROBO2, SLIT2, SLIT3
Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women.
Dickinson RE, Myers M, Duncan WC.
Endocrinology 149(10):5024-34. Epub 2008 Jun 19.PMID: 18566128 2008
20SLIT2
Structural insights into the Slit-Robo complex.
Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA.
Proc Natl Acad Sci U S A 104(38):14923-8. Epub 2007 Sep 11. 2007
21SLIT1, SLIT2, SLIT3
Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs.
Katoh Y, Katoh M.
Oncol Rep 14(5):1351-5.PMID: 16211308 2005
22SLIT2
Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration.
Xu HT, Yuan XB, Guan CB, Duan S, Wu CP, Feng L.
Proc Natl Acad Sci U S A 101(12):4296-301. Epub 2004 Mar 12. 2004
23SLIT2
SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma.
Astuti D, Da Silva NF, Dallol A, Gentle D, Martinsson T, Kogner P, Grundy R, Kishida T, Yao M, Latif F, Maher ER.
Br J Cancer 90(2):515-21. 2004
24ROBO1, ROBO2, ROBO3, SLIT1, SLIT2, SLIT3
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
Bagri A, Marin O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M.
Neuron 33(2):233-48. 2002
25SLIT2
SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.
Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER, Latif F.
Cancer Res 62(20):5874-80. 2002
26SLIT1, SLIT2, SLIT3
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.
Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Zh, Zhang Xc, Rao Y.
Nature 410(6831):948-52. 2001
27SLIT1, SLIT2, SLIT3
Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein.
Little MH, Wilkinson L, Brown DL, Piper M, Yamada T, Stow JL.
Am J Physiol Cell Physiol 281(2):C486-95.PMID: 11443047 2001
28SLIT2
Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2.
Georgas K, et al.
Cytogenet Cell Genet 86(3-4):246-247. No abstract available 1999
29SLIT2, SLIT1, SLIT2, SLIT3
Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching.
Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M.
Cell 96(6):771-84. 1999
30SLIT1, SLIT2, SLIT3
Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.
Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y.
Cell 96(6):807-18. 1999
31ROBO1, ROBO2, ROBO3, SLIT1, SLIT2, SLIT3
Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T.
Cell 96(6):795-806. 1999
32SLIT1, SLIT2, SLIT3
Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.
Itoh A, et al.
Brain Res Mol Brain Res 62(2):175-86 1998