Citations for
ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome.
Oh AR, Sohn S, Lee J, Park JM, Nam KT, Hahm KB, Kim YB, Lee HJ, Cha JY.
Metabolism 85:286-297. doi: 10.1016/j.metabol.2018.04.006. Epub 2018 Apr 15. 2018
SLC9A3 Protein Is Critical for Acrosomal Formation in Postmeiotic Male Germ Cells.
Wang YY, Chiang HS, Cheng CY, Wu YN, Lin YC, Liu HC, Tsai WK, Chen YL, Lin YH.
Int J Mol Sci 19(1). pii: E103. doi: 10.3390/ijms19010103. 2017
Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis.
Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Dominguez Rieg JA, Rieg T.
Kidney Int 92(2):397-414. doi: 10.1016/j.kint.2017.02.001. Epub 2017 Apr 3. 2017
Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.
Wang YY, Lin YH, Wu YN, Chen YL, Lin YC, Cheng CY, Chiang HS.
PLoS Genet 13(4):e1006715. doi: 10.1371/journal.pgen.1006715. eCollection 2017 Apr. 2017
Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats.
Linz B, Hohl M, Reil JC, Böhm M, Linz D.
J Cardiovasc Pharmacol 67(3):225-31. doi: 10.1097/FJC.0000000000000336. 2016
Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.
Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, Müller T.
Hum Mol Genet 24(23):6614-23. doi: 10.1093/hmg/ddv367. Epub 2015 Sep 10. 2015
Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.
Solocinski K, Richards J, All S, Cheng KY, Khundmiri SJ, Gumz ML.
Am J Physiol Renal Physiol 309(11):F933-42. doi: 10.1152/ajprenal.00197.2014. Epub 2015 Sep 16. 2015
Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.
No YR, He P, Yoo BK, Yun CC.
Am J Physiol Cell Physiol 309(1):C14-21. doi: 10.1152/ajpcell.00067.2015. Epub 2015 Apr 8. 2015
Expression and subcellular localization of NHE₃ in the human gallbladder epithelium.
Chen Y, Kong J, Wu S.
Int J Clin Exp Pathol 7(12):8791-6. eCollection 2014. 2014
Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule.
Brasen JC, Burford JL, McDonough AA, Holstein-Rathlou NH, Peti-Peterdi J.
Am J Physiol Renal Physiol 307(11):F1249-62. doi: 10.1152/ajprenal.00174.2014. Epub 2014 Oct 8. 2014
11MYO6, SLC9A3
Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.
Chen T, Hubbard A, Murtazina R, Price J, Yang J, Cha B, Sarker R, Donowitz M.
J Cell Sci 127(Pt 16):3535-45. doi: 10.1242/jcs.149930. Epub 2014 Jun 13. 2014
Phospho-NHE3 forms membrane patches and interacts with beta-actin to sense and maintain constant direction during cell migration.
Perike S, Özkucur N, Sharma P, Staroske W, Bläsche R, Barth K, Funk RH.
Exp Cell Res 324(1):13-29. doi: 10.1016/j.yexcr.2014.03.005. Epub 2014 Mar 19. Erratum in: Exp Cell Res. 2014 Aug 1;326(1):185. 2014
Sodium/proton exchanger 3 (NHE3) and sudden infant death syndrome (SIDS).
Studer J, Bartsch C, Haas C.
Int J Legal Med 128(6):939-43. doi: 10.1007/s00414-014-0978-0. Epub 2014 Mar 4. 2014
IRBIT plays an important role in NHE3-mediated pHi regulation in HSG cells.
Tran TM, Park MY, Lee J, Bae JS, Hwang SM, Choi SY, Mikoshiba K, Park K.
Biochem Biophys Res Commun 437(1):18-22. doi: 10.1016/j.bbrc.2013.06.010. Epub 2013 Jun 13. 2013
Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.
Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U.
Cell Physiol Biochem 32(5):1386-402. 2013
Proximal tubule specific knockout of the Na⁺/H⁺ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion.
Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M.
J Mol Med (Berl) 91(8):951-63. doi: 10.1007/s00109-013-1015-3. Epub 2013 Mar 19. 2013
Gene expression of solute carrier family 9 (sodium/hydrogen exchanger) 3, (SLC9A3) is downregulated in patients with ulcerative colitis.
Fonseca-Camarillo G, Yamamoto-Furusho JK.
Inflamm Bowel Dis 18(6):1197-8. doi: 10.1002/ibd.22968. Epub 2012 Mar 22. No abstract available. 2012
18SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, SLC9A6, SLC9A7, SLC9C1
Role of the Na(+)/H(+) exchanger on the development of diabetes mellitus and its chronic complications.
Sun YM, Su Y, Li J, Tian Y, Wang LF.
Biochem Biophys Res Commun 427(2):229-31. doi: 10.1016/j.bbrc.2012.09.050. Epub 2012 Sep 18. Review. 2012
19SGK3, SLC9A3
Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.
He P, Lee SJ, Lin S, Seidler U, Lang F, Fejes-Toth G, Naray-Fejes-Toth A, Yun CC.
Mol Biol Cell 22(20):3812-25. doi: 10.1091/mbc.E11-04-0328. Epub 2011 Aug 24. 2011
Role of Na+ /H+ exchanger 3 in the acidification of the male reproductive tract and male fertility.
Pholpramool C, Borwornpinyo S, Dinudom A.
Clin Exp Pharmacol Physiol 38(7):403-9. doi: 10.1111/j.1440-1681.2011.05525.x. Review. 2011
21SLC9A1, SLC9A3
High sodium intake increases HCO(3)- absorption in medullary thick ascending limb through adaptations in basolateral and apical Na+/H+ exchangers.
Good DW, George T, Watts BA 3rd.
Am J Physiol Renal Physiol 301(2):F334-43. doi: 10.1152/ajprenal.00106.2011. Epub 2011 May 25. 2011
Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis.
Dorfman R, Taylor C, Lin F, Sun L, Sandford A, Paré P, Berthiaume Y, Corey M, Durie P, Zielenski J; Members of Canadian Consortium for CF Genetic Studies.
Pediatr Pulmonol 46(4):385-92. doi: 10.1002/ppul.21372. Epub 2010 Oct 21. 2011
23SLC9A3, SLC9A3R1, SLC9A3R2
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.
Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M.
Am J Physiol Cell Physiol 300(4):C771-82. doi: 10.1152/ajpcell.00119.2010. Epub 2010 Dec 29. 2011
BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction.
Lee JS, Lee YM, Kim JY, Park HW, Grinstein S, Orlowski J, Kim E, Kim KH, Lee MG.
J Biol Chem 285(11):8104-13. Epub 2010 Jan 14.PMID: 20080968 2010
25SLC9A2, SLC9A3, SLC9A8
Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5.
Xu H, Zhang B, Li J, Chen H, Wang C, Ghishan FK.
Am J Physiol Gastrointest Liver Physiol m J Physiol Gastrointest Liver Physiol. 2010 Jul 29. [Epub ahead of print]PMID: 20671194 2010
26SGK2, SLC9A3
Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.
Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D.
Am J Physiol Renal Physiol 299(6):F1496-506. doi: 10.1152/ajprenal.00075.2010. Epub 2010 Oct 6. 2010
Genetic variation in solute carrier genes is associated with preeclampsia.
Morrison AC, Srinivas SK, Elovitz MA, Puschett JB.
Am J Obstet Gynecol 203(5):491.e1-491.e13. doi: 10.1016/j.ajog.2010.06.004. Epub 2010 Aug 5. 2010
28SLC9A3, SYT1
Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.
Musch MW, Arvans DL, Wang Y, Nakagawa Y, Solomaha E, Chang EB.
Am J Physiol Gastrointest Liver Physiol 298(2):G203-11. doi: 10.1152/ajpgi.00379.2009. Epub 2009 Nov 19. 2010
Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
He P, Klein J, Yun CC.
J Biol Chem 285(36):27869-78. doi: 10.1074/jbc.M110.133066. Epub 2010 Jun 28. 2010
Transcriptional regulation of the human Na+/H+ exchanger NHE3 by serotonin in intestinal epithelial cells.
Amin MR, Ghannad L, Othman A, Gill RK, Dudeja PK, Ramaswamy K, Malakooti J.
Biochem Biophys Res Commun 382(3):620-5. Epub 2009 Mar 20.PMID: 19303862 2009
31SLC9A2, SLC9A3
Induction of intestinalization in human esophageal keratinocytes is a multistep process.
Kong J, Nakagawa H, Isariyawongse BK, Funakoshi S, Silberg DG, Rustgi AK, Lynch JP.
Carcinogenesis 30(1):122-30. Epub 2008 Oct 8.PMID: 18845559 2009
NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.
Zachos NC, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee LJ, Li M, de Jonge H, Donowitz M.
J Biol Chem 284(35):23708-18. Epub 2009 Jun 17. 2009
NHE3 in the human brainstem: implication for the pathogenesis of the sudden infant death syndrome (SIDS)?
Wiemann M, Frede S, Tschentscher F, Kiwull-Schšne H, Kiwull P, Bingmann D, Brinkmann B, Bajanowski T.
Adv Exp Med Biol 605:508-13. 2008
Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer.
Kang JU, Koo SH, Kwon KC, Park JW, Kim JM.
Cancer Genet Cytogenet 182(1):1-11.PMID: 18328944 2008
35SLC9A3, SLC9A8
Effect of thyroid hormone on the postnatal renal expression of NHE8.
Gattineni J, Sas D, Dagan A, Dwarakanath V, Baum M.
Am J Physiol Renal Physiol 294(1):F198-204. Epub 2007 Oct 31.PMID: 17977906 2008
Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1.
Malakooti J, Sandoval R, Amin MR, Clark J, Dudeja PK, Ramaswamy K.
Biochem J 396(2):327-36. 2006
Expression of SLC26A3, CFTR and NHE3 in the human male reproductive tract: role in male subfertility caused by congenital chloride diarrhoea.
Hihnala S, Kujala M, Toppari J, Kere J, Holmberg C, Hšglund P.
Mol Hum Reprod 12(2):107-11. Epub 2006 Jan 18. 2006
Shank2 associates with and regulates Na+/H+ exchanger 3.
Han W, Kim KH, Jo MJ, Lee JH, Yang J, Doctor RB, Moe OW, Lee J, Kim E, Lee MG.
J Biol Chem 281(3):1461-9. Epub 2005 Nov 17.PMID: 16293618 2006
39SLC9A3, SLC9A8
Na+/H+ exchangers in renal regulation of acid-base balance.
Bobulescu IA, Moe OW.
Semin Nephrol 26(5):334-44. Review.PMID: 17071327 2006
Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.
Zhao H, Shiue H, Palkon S, Wang Y, Cullinan P, Burkhardt JK, Musch MW, Chang EB, Turner JR.
Proc Natl Acad Sci U S A 101(25):9485-90. Epub 2004 Jun 14. 2004
A NHE3-related pseudogene is on human chromosome 10; the functional genemaps to 5p15.3.
Kokke FTM, et al.
Mamm Genome 7 : 235-236. 1996
42SLC9A1, SLC9A2, SLC9A3
Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.
Dudeja PK, Rao DD, Syed I, Joshi V, Dahdal RY, Gardner C, Risk MC, Schmidt L, Bavishi D, Kim KE, Harig JM, Goldstein JL, Layden TJ, Ramaswamy K.
Am J Physiol 271(3 Pt 1):G483-93.PMID: 8843774 1996
Chromosomal assignment of four genes encoding Na/H exchanger isoforms inhuman and rat.
Szpirer C, et al.
Mamm Genome 5 : 153-159. 1994