| 1 | SLC1A5, SLC6A4
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| Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2.
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| Seyer P, Vandermoere F, Cassier E, Bockaert J, Marin P.
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| Biochem J 473(13):1953-65. doi: 10.1042/BCJ20160315. Epub 2016 May 3.
2016
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| 2 | HDAC1, SLC6A4
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| Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells.
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| Phi van DK, Mühlbauer E, Phi-van L.
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| Biochim Biophys Acta 1849(8):909-18. doi: 10.1016/j.bbagrm.2015.05.008. Epub 2015 May 27.
2015
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| 3 | SLC6A4, STX3, TGFB1
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| Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways.
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| Nazir S, Kumar A, Chatterjee I, Anbazhagan AN, Gujral T, Priyamvada S, Saksena S, Alrefai WA, Dudeja PK, Gill RK.
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| PLoS One 10(5):e0120447. doi: 10.1371/journal.pone.0120447. eCollection 2015.
2015
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| 4 | SLC6A4
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| Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.
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| Rannversson H, Wilson P, Kristensen KB, Sinning S, Kristensen AS, Strømgaard K, Andersen J.
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| J Biol Chem 290(23):14582-94. doi: 10.1074/jbc.M114.629071. Epub 2015 Apr 22.
2015
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| 5 | SLC6A4
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| Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.
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| Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, Forrest LR.
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| Biochemistry 53(33):5444-60. doi: 10.1021/bi500637f. Epub 2014 Aug 15.
2014
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| 6 | SLC6A4
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| The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation.
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| Rahbek-Clemmensen T, Bay T, Eriksen J, Gether U, Jørgensen TN.
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| J Biol Chem 289(33):23004-19. doi: 10.1074/jbc.M113.495754. Epub 2014 Jun 27.
2014
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| 7 | SLC6A4
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| Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells.
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| Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW.
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| J Biol Chem 289(15):10466-75. doi: 10.1074/jbc.M113.482299. Epub 2014 Feb 25.
2014
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| 8 | SLC6A4
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| Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane.
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| Anderluh A, Klotzsch E, Reismann AW, Brameshuber M, Kudlacek O, Newman AH, Sitte HH, Schütz GJ.
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| J Biol Chem 289(7):4387-94. doi: 10.1074/jbc.M113.531632. Epub 2014 Jan 6.
2014
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| 9 | SLC6A4
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| The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport.
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| Felts B, Pramod AB, Sandtner W, Burbach N, Bulling S, Sitte HH, Henry LK.
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| J Biol Chem 289(3):1825-40. doi: 10.1074/jbc.M113.504654. Epub 2013 Nov 29.
2014
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| 10 | ITGB3, SLC6A4
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| Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain.
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| Whyte A, Jessen T, Varney S, Carneiro AM.
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| Neurochem Int 73:122-6. doi: 10.1016/j.neuint.2013.09.014. Epub 2013 Sep 29.
2014
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| 11 | PPP3CA, SLC6A4
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| Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake.
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| Seimandi M, Seyer P, Park CS, Vandermoere F, Chanrion B, Bockaert J, Mansuy IM, Marin P.
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| J Neurosci 33(41):16189-99. doi: 10.1523/JNEUROSCI.0076-13.2013.
2013
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| 12 | SLC6A4
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| Lack of serotonin transporter alters BDNF expression in the rat brain during early postnatal development.
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| Calabrese F, Guidotti G, Middelman A, Racagni G, Homberg J, Riva MA.
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| Mol Neurobiol 48(1):244-56. doi: 10.1007/s12035-013-8449-z. Epub 2013 Apr 9.
2013
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| 13 | SLC6A4
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| Stress-induced anhedonia correlates with lower hippocampal serotonin transporter protein expression.
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| Tang M, Lei J, Sun X, Liu G, Zhao S.
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| Brain Res 1513:127-34. doi: 10.1016/j.brainres.2013.03.042. Epub 2013 Apr 1.
2013
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| 14 | IL10, SLC6A4
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| IL-10 modulates serotonin transporter activity and molecular expression in intestinal epithelial cells.
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| Latorre E, Mendoza C, Matheus N, Castro M, Grasa L, Mesonero JE, Alcalde AI.
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| Cytokine 61(3):778-84. doi: 10.1016/j.cyto.2013.01.012. Epub 2013 Feb 12.
2013
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| 15 | HDAC2, SLC6A4
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| Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2.
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| Gill RK, Kumar A, Malhotra P, Maher D, Singh V, Dudeja PK, Alrefai W, Saksena S.
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| Am J Physiol Cell Physiol 304(4):C334-41. doi: 10.1152/ajpcell.00361.2012. Epub 2012 Nov 28.
2013
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| 16 | ERO1A, ERP44, SLC6A4
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| The role of ERp44 in maturation of serotonin transporter protein.
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| Freyaldenhoven S, Li Y, Kocabas AM, Ziu E, Ucer S, Ramanagoudr-Bhojappa R, Miller GP, Kilic F.
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| J Biol Chem 287(21):17801-11. doi: 10.1074/jbc.M112.345058. Epub 2012 Mar 26.
2012
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| 17 | SEC24C, SEC24D, SLC6A4
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| The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.
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| Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M.
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| J Biol Chem 286(18):16482-90. Epub 2011 Mar 17.
2011
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| 18 | SCAMP2, SCAMP5, SLC6A2, SLC6A3, SLC6A4
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| Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2.
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| Fjorback AW, Müller HK, Haase J, Raarup MK, Wiborg O.
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| Biochem Biophys Res Commun 406(2):165-70. Epub 2011 Feb 3.
2011
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| 19 | PDGFRB, SLC6A4
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| Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells.
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| Ren W, Watts SW, Fanburg BL.
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| Am J Physiol Lung Cell Mol Physiol 300(3):L486-97. doi: 10.1152/ajplung.00237.2010. Epub 2010 Dec 24.
2011
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| 20 | ITGB3, SLC6A4
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| Association and gene-gene interaction of SLC6A4 and ITGB3 in autism.
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| Ma DQ, Rabionet R, Konidari I, Jaworski J, Cukier HN, Wright HH, Abramson RK, Gilbert JR, Cuccaro ML, Pericak-Vance MA, Martin ER.
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| Am J Med Genet B Neuropsychiatr Genet 153B(2):477-83.PMID: 19588468 2010
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| 21 | SLC6A4, ZIC2
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| Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.
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| García-Frigola C, Herrera E.
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| EMBO J 29(18):3170-83. Epub 2010 Jul 30.PMID: 20676059 2010
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| 22 | SEC24D, SLC6A4
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| Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.
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| El-Kasaby A, Just H, Malle E, Stolt-Bergner PC, Sitte HH, Freissmuth M, Kudlacek O.
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| J Biol Chem 285(50):39201-10. Epub 2010 Oct 2.
2010
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| 23 | PTEN, SLC6A4
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| Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.
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| Page DT, Kuti OJ, Prestia C, Sur M.
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| Proc Natl Acad Sci U S A 106(6):1989-94.
2009
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| 24 | SLC6A4, PDS
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| Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.
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| Palos F, Garc’a-Rendueles ME, Araujo-Vilar D, Obregon MJ, Calvo RM, Cameselle-Teijeiro J, Bravo SB, Perez-Guerra O, Loidi L, Czarnocka B, Alvarez P, Refetoff S, Dominguez-Gerpe L, Alvarez CV, Lado-Abeal J.
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| J Clin Endocrinol Metab 93(1):267-77. Epub 2007 Oct 16. 2008
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| 25 | SLC6A4
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| A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.
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| Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL.
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| Hum Mol Genet 17(5):717-23. Epub 2007 Nov 30. 2008
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| 26 | SLC6A4
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| Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome.
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| Nonnis Marzano F, Maldini M, Filonzi L, Lavezzi AM, Parmigiani S, Magnani C, Bevilacqua G, Matturri L.
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| Genomics 91(6):485-91. Epub 2008 Apr 2. 2008
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| 27 | APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SCZD23, SLC6A4, TP53, TPH1
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| Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
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| Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L.
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| Nat Genet 40(7):827-34. 2008
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| 28 | ROBO1, ROBO2, SLC6A4
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| Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.
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| Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N.
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| Am J Med Genet B Neuropsychiatr Genet 147B(7):1019-27.
2008
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| 29 | SLC6A4
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| Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT.
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| Pavone LM, Spina A, Lo Muto R, Santoro D, Mastellone V, Avallone L.
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| Biochem Biophys Res Commun 377(2):419-22. Epub 2008 Oct 12.
2008
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| 30 | HTR5A, SLC6A4, ITGB3
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| Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.
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| Coutinho AM, Sousa I, Martins M, Correia C, Morgadinho T, Bento C, Marques C, Ataide A, Miguel TS, Moore JH, Oliveira G, Vicente AM.
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| Hum Genet 121(2):243-56. Epub 2007 Jan 3. 2007
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| 31 | SLC6A4
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| Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
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| Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D.
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| Am J Hum Genet 78(5):815-26. Epub 2006 Mar 28. 2006
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| 32 | SLC6A4
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| 3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: Haplotype analysis.
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| Maher BS, Marazita ML, Rand C, Zhou L, Berry-Kravis EM, Weese-Mayer DE.
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| Am J Med Genet A 140(13):1453-7. No abstract available. 2006
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| 33 | SCAMP2, SLC6A4
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| Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2.
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| Muller HK, Wiborg O, Haase J.
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| J Biol Chem 281(39):28901-9. Epub 2006 Jul 26. 2006
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| 34 | SLC6A4
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| Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors.
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| Sutcliffe JS, Delahanty RJ, Prasad HC, McCauley JL, Han Q, Jiang L, Li C, Folstein SE, Blakely RD.
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| Am J Hum Genet 77(2):265-79. Epub 2005 Jul 1. 2005
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| 35 | ADHD, DRD4, DRD5, SLC6A3, SLC6A4, SNAP25
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| The genetics of attention deficit hyperactivity disorder.
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| Thapar A, O'Donovan M, Owen MJ.
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| Hum Mol Genet 14 Spec No. 2:R275-82. 2005
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| 36 | SLC6A4
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| Sudden infant death syndrome: Association with a promoter polymorphism of the serotonin transporter gene.
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| Weese-Mayer DE, Berry-Kravis EM, Maher BS, Silvestri JM, Curran ME, Marazita ML.
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| Am J Med Genet 117A(3):268-74. 2003
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| 37 | SLC6A4
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| Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
|
| Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R.
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| Science 301(5631):386-9. 2003
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| 38 | SLC6A4
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| Association of the serotonin transporter gene with sudden infant death syndrome: a haplotype analysis.
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| Weese-Mayer DE, Zhou L, Berry-Kravis EM, Maher BS, Silvestri JM, Marazita ML.
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| Am J Med Genet 122A(3):238-45. 2003
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| 39 | SLC6A4
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| Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder.
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| Betancur C, Corbex M, Spielewoy C, Philippe A, Laplanche JL, Launay JM, Gillberg C, Mouren-Simeoni MC, Hamon M, Giros B, Nosten-Bertrand M, Leboyer M.
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| Mol Psychiatry 7(1):67-71. 2002
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| 40 | SLC6A4
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| A gender-specific association between the serotonin transporter gene and suicide attempts.
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| Baca-Garcia E, Vaquero C, Diaz-Sastre C, Saiz-Ruiz J, Fernandez-Piqueras J, de Leon J.
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| Neuropsychopharmacology 26(5):692-5. 2002
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| 41 | SLC6A4
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| A putative three-dimensional arrangement of the human serotonin transporter transmembrane helices: a tool to aid experimental studies.
|
| Ravna AW, Edvardsen O.
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| J Mol Graph Model 20(2):133-44. 2001
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| 42 | NF1, SLC6A4
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| Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes.
|
| Shen S, Battersby S, Weaver M, Clark E, Stephens K, Harmar AJ.
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| Eur J Hum Genet 8(1):75-8. 2000
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| 43 | SLC6A4
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| Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample.
|
| Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL.
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| Am J Med Genet 96(2):202-16. 2000
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| 44 | SLC6A4
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| Association of the serotonin transporter gene with serum cholesterol levels and heart disease.
|
| Comings DE, et al.
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| Mol Genet Metab 67(3):248-53. 1999
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| 45 | SLC6A4
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| Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders.
|
| Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES, Easton DF, Rubinsztein DC.
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| Am J Med Genet 81(1):58-63. 1998
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| 46 | SLC6A4
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| Serotonin transporter (5-HTT) gene and bipolar affective disorder.
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| Esterling LE, Yoshikawa T, Turner G, Badner JA, Bengel D, Gershon ES, Berrettini WH, Detera-Wadleigh SD.
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| Am J Med Genet 81(1):37-40. 1998
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| 47 | SLC6A4
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| Variability in the serotonin transporter gene and increased risk for major depression with melancholia.
|
| GutiŽrrez B, et al.
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| Hum Genet 103 : 319-322. 1998
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| 48 | SLC6A4
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| Serotonin transporter (5-HTT) gene variants associated with autism?
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| Klauck SM, Poustka F, Benner A, Lesch KP, Poustka A.
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| Hum Mol Genet 6(13):2233-8. 1997
|
| 49 | SLC6A4
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| Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects.
|
| Gelernter J, Kranzler H, Cubells JF.
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| Hum Genet 101(2):243-6. 1997
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| 50 | SLC6A4
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| A novel allelic variant of the human serotonin transporter gene regulatory polymorphism.
|
| DelbrŸck SJW, et al.
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| Cytogenet Cell Genet 79 : 214-220. 1997
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| 51 | SLC6A4
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| Polymorphism in serotonin transporter gene associated with susceptibility to major depression.
|
| Ogilvie AD, et al.
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| Lancet 347 : 731-733. 1996
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| 52 | SLC6A4
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| Genetic linkage study of bipolar disorder and the serotonin transporter.
|
| Kelsoe JR, et al.
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| Am J Med Genet 67 : 215-217. 1996
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| 53 | SLC6A4
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| Systematic screening for mutations in the coding region of the human serotonin transporter (5-HTT) gene using PCR and DGGE.
|
| Di Bella D, et al.
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| Am J Med Genet 67 : 541-545. 1996
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| 54 | SLC6A4
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| A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.
|
| Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Muller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP.
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| Mol Psychiatry 1(6):453-60. 1996
|
| 55 | SLC6A4
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| Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.
|
| Lesch KP, et al.
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| Science 274 : 1527-1531. 1996
|
| 56 | SLC6A4
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| Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17.
|
| Gelernter J, et al.
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| Hum Genet 95 : 677-680. 1995
|
| 57 | SLC6A4
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| Pstl RFLP at the SERT locus.
|
| Gelernter J, et al.
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| Hum Mol Genet 3 : 383. 1994
|
| 58 | SLC6A4
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| Antidepressant -and cocaine- sensitive human serotonin transporter : molecular cloning, expression and chromosomal localization.
|
| Ramamoorthy S, et al.
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| Proc Natl Acad Sci U S A 90 : 2542-2546. 1993
|
| 59 | MDRE, ABCB1, ABCB4, SLC5A1, SLC5A2, SLC6A1, SLC6A2, SLC6A4, SLC6A6, SLC6A8, SLC6A9
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| Molecular characterization of neurotransmitter transporters.
|
| Shafqat S, et al.
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| Mol Endocrinol 7 : 1517-1529. 1993
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| 60 | SLC6A4, SLC6A2
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| Linkage mapping of norepinephrine transporter protein and serotonin transporter protein genes.
|
| Gelernter J, et al.
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| Am J Hum Genet 53 : 1003. 1993
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| 61 | SLC6A4
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| Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
|
| Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD.
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| Proc Natl Acad Sci U S A 90(6):2542-6. 1993
|