Citations for
1LRP1, PID1, SLC2A4
PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.
Fischer AW, Albers K, Schlein C, Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J
Biochim Biophys Acta Mol Basis Dis. Jun 1;1865(6):1592-1603. doi: 10.1016/j.bbadis.2019.03.010. Epub 2019 Mar 21. 2019
2SLC2A4
The first intracellular loop of GLUT4 contains a retention motif.
Talantikite M, Berenguer M, Gonzalez T, Alessi MC, Poggi M, Peiretti F, Govers R.
J Cell Sci 129(11):2273-84. doi: 10.1242/jcs.183525. Epub 2016 Apr 27. 2016
3SLC2A4
Single nucleotide polymorphisms in 5'-UTR of the SLC2A4 gene regulate solute carrier family 2 member 4 gene expression in visceral adipose tissue.
Malodobra-Mazur M, Bednarska-Chabowska D, Olewinski R, Chmielecki Z, Adamiec R, Dobosz T.
Gene 576(1 Pt 3):499-504. doi: 10.1016/j.gene.2015.10.067. Epub 2015 Oct 31. 2016
4RAB10, SLC2A4
Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation.
Brewer PD, Habtemichael EN, Romenskaia I, Mastick CC, Coster AC.
J Biol Chem 291(2):773-89. doi: 10.1074/jbc.M115.694919. Epub 2015 Nov 2. 2016
5RAB10, SEC16A, SLC2A4
SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.
Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw TE.
J Cell Biol 214(1):61-76. doi: 10.1083/jcb.201509052. Epub 2016 Jun 27. 2016
6ACTN4, MICALL2, RAB13, SLC2A4
A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis
Sun Y, Jaldin-Fincati J, Liu Z, Bilan PJ, Klip A.
Mol Biol Cell. Jan 1;27(1):75-89. doi: 10.1091/mbc.E15-05-0319. Epub 2015 Nov 4. 2016
7CRTC2, CRTC3, HDAC4, SIK2, SLC2A4
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.
Henriksson E, Säll J, Gormand A, Wasserstrom S, Morrice NA, Fritzen AM, Foretz M, Campbell DG, Sakamoto K, Ekelund M, Degerman E, Stenkula KG, Göransson O.
J Cell Sci 128(3):472-86. 2015
8SLC2A4, TBC1D4
Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.
Di Chiara M, Glaudemans B, Loffing-Cueni D, Odermatt A, Al-Hasani H, Devuyst O, Faresse N, Loffing J.
Am J Physiol Renal Physiol 309(9):F779-90. doi: 10.1152/ajprenal.00139.2015. Epub 2015 Sep 2. 2015
9DOC2B, DYNLT2B, SLC2A4, STX4
Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake.
Shimoda Y, Okada S, Yamada E, Pessin JE, Yamada M.
Endocrinology 156(10):3548-58. doi: 10.1210/en.2015-1120. Epub 2015 Jul 22. 2015
10CD74, MEF2A, PLAGL1, SLC2A4
Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
Liang Y, Yuan W, Zhu W, Zhu J, Lin Q, Zou X, Deng C, Fu Y, Zheng X, Yang M, Wu S, Yu X, Shan Z.
Metabolism 64(12):1682-93. doi: 10.1016/j.metabol.2015.09.007. Epub 2015 Sep 12. 2015
11SLC2A4, ZNF407
Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.
Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR.
J Biol Chem 290(10):6376-86. doi: 10.1074/jbc.M114.623736. Epub 2015 Jan 16. 2015
12SLC2A4, SLC2A8
Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria.
Maria Z, Campolo AR, Lacombe VA.
PLoS One 10(12):e0146033. doi: 10.1371/journal.pone.0146033. eCollection 2015. 2015
13RAB5A, SLC2A4
Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: a potential mechanism for development of insulin resistance.
Tessneer KL, Jackson RM, Griesel BA, Olson AL.
Endocrinology 155(9):3315-28. doi: 10.1210/en.2013-2148. Epub 2014 Jun 16. 2014
14SLC2A4
Ca˛⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.
Li Q, Zhu X, Ishikura S, Zhang D, Gao J, Sun Y, Contreras-Ferrat A, Foley KP, Lavandero S, Yao Z, Bilan PJ, Klip A, Niu W.
Am J Physiol Endocrinol Metab 307(2):E209-24. doi: 10.1152/ajpendo.00045.2014. Epub 2014 Jun 3. 2014
15SLC2A4
Molecular mechanisms of GLUT4 regulation in adipocytes.
Govers R.
Diabetes Metab 40(6):400-10. doi: 10.1016/j.diabet.2014.01.005. Epub 2014 Mar 20. Review. 2014
16AKT2, SLC2A4, TMOD3
Tropomodulin3 as the link between insulin-activated AKT2 and cortical actin remodeling in preparation of GLUT4 exocytosis.
Lim CY, Han W.
Bioarchitecture 4(6):210-4. doi: 10.1080/19490992.2015.1031949. Epub 2015 Aug 17. 2014
17BCAR3, SLC2A4
Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation.
Oh MJ, Yi SJ, Kim HS, Kim JH, Jeong YH, van Agthoven T, Jhun BH.
Biochem Biophys Res Commun 441(4):911-6. doi: 10.1016/j.bbrc.2013.10.161. Epub 2013 Nov 9. 2013
18DNAJC5, SLC2A4
Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane.
Jambaldorj B, Terada E, Hosaka T, Kishuku Y, Tomioka Y, Iwashima K, Hirata Y, Teshigawara K, Thi Kim Le C, Nakagawa T, Harada N, Sakai T, Sakaue H, Matsumoto T, Funaki M, Takahashi A, Nakaya Y.
J Med Invest 60(3-4):197-204. 2013
19SLC2A4
SLC2A4gene: a promising target for pharmacogenomics of insulin resistance.
Corręa-Giannella ML, Machado UF.
Pharmacogenomics 14(8):847-50. doi: 10.2217/pgs.13.45. No abstract available. 2013
20MFN2, SLC2A4
Overexpression of mitofusin 2 improves translocation of glucose transporter 4 in skeletal muscle of high‑fat diet‑fed rats through AMP‑activated protein kinase signaling.
Kong D, Song G, Wang C, Ma H, Ren L, Nie Q, Zhang X, Gan K.
Mol Med Rep 8(1):205-10. doi: 10.3892/mmr.2013.1457. Epub 2013 May 2. 2013
21SLC2A4
Insulin regulates Glut4 confinement in plasma membrane clusters in adipose cells.
Lizunov VA, Stenkula K, Troy A, Cushman SW, Zimmerberg J.
PLoS One 8(3):e57559. doi: 10.1371/journal.pone.0057559. Epub 2013 Mar 8. 2013
22SLC2A4
Identification of nuclear factor-κB sites in the Slc2a4 gene promoter.
Furuya DT, Neri EA, Poletto AC, Anhę GF, Freitas HS, Campello RS, Rebouças NA, Machado UF.
Mol Cell Endocrinol 370(1-2):87-95. doi: 10.1016/j.mce.2013.01.019. Epub 2013 Feb 24. 2013
23CLTCL1, SLC2A4
The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.
Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM.
PLoS One 8(10):e77787. doi: 10.1371/journal.pone.0077787. eCollection 2013. 2013
24SLC2A12, SLC2A4
GLUT12 functions as a basal and insulin-independent glucose transporter in the heart.
Waller AP, George M, Kalyanasundaram A, Kang C, Periasamy M, Hu K, Lacombe VA.
Biochim Biophys Acta 1832(1):121-7. doi: 10.1016/j.bbadis.2012.09.013. Epub 2012 Oct 4. 2013
25MYO1C, SLC2A4
Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.
Boguslavsky S, Chiu T, Foley KP, Osorio-Fuentealba C, Antonescu CN, Bayer KU, Bilan PJ, Klip A.
Mol Biol Cell 23(20):4065-78. doi: 10.1091/mbc.E12-04-0263. Epub 2012 Aug 23. 2012
26AXIN1, KIF3A, SLC2A4, TNKS2
The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.
Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC.
Cell Res 22(8):1246-57. doi: 10.1038/cr.2012.52. Epub 2012 Apr 3. 2012
27NGFR, RAB31, RAB5A, SLC2A4
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.
Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K.
Proc Natl Acad Sci U S A 109(15):5838-43. doi: 10.1073/pnas.1103638109. Epub 2012 Mar 28. 2012
28SLC2A4
Insulin stimulated-glucose transporter Glut 4 is expressed in the retina.
Sánchez-Chávez G, Peńa-Rangel MT, Riesgo-Escovar JR, Martínez-Martínez A, Salceda R.
PLoS One 7(12):e52959. doi: 10.1371/journal.pone.0052959. Epub 2012 Dec 21. 2012
29SLC2A4, TBC1D4
The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.
Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, Stöckli J, James DE.
Mol Cell Biol 32(24):4946-59. doi: 10.1128/MCB.00761-12. Epub 2012 Oct 8. 2012
30CD36, SLC2A4, VAMP3
Overexpression of vesicle-associated membrane protein (VAMP) 3, but not VAMP2, protects glucose transporter (GLUT) 4 protein translocation in an in vitro model of cardiac insulin resistance.
Schwenk RW, Angin Y, Steinbusch LK, Dirkx E, Hoebers N, Coumans WA, Bonen A, Broers JL, van Eys GJ, Glatz JF, Luiken JJ.
J Biol Chem 287(44):37530-9. doi: 10.1074/jbc.M112.363630. Epub 2012 Aug 30. 2012
31SLC2A11, SLC2A4, SLC2A8
Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.
McBrayer SK, Cheng JC, Singhal S, Krett NL, Rosen ST, Shanmugam M.
Blood 119(20):4686-97. doi: 10.1182/blood-2011-09-377846. Epub 2012 Mar 27. 2012
32SLC2A4
Endocytosis, recycling, and regulated exocytosis of glucose transporter 4.
Foley K, Boguslavsky S, Klip A.
Biochemistry 50(15):3048-61. Epub 2011 Mar 25. Review. 2011
33SLC2A4, TBC1D4
Molecular basis of insulin-responsive GLUT4 trafficking systems revealed by single molecule imaging.
Hatakeyama H, Kanzaki M.
Traffic 12(12):1805-20. doi: 10.1111/j.1600-0854.2011.01279.x. Epub 2011 Oct 9. 2011
34PLAGL1, SLC2A4
Regulation of cardiomyocyte Glut4 expression by ZAC1.
Czubryt MP, Lamoureux L, Ramjiawan A, Abrenica B, Jangamreddy J, Swan K.
J Biol Chem 285(22):16942-50. Epub 2010 Apr 2. 2010
35SLC2A3, SLC2A4, SLC2A8
Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex.
Gómez O, Ballester-Lurbe B, Poch E, Mesonero JE, Terrado J.
J Anat Anat. 2010 Aug 30. [Epub ahead of print]PMID: 20819112 2010
36ARFRP1, GOLGA4, SLC2A4
Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.
Hesse D, Hommel A, Jaschke A, Moser M, Bernhardt U, Zahn C, Kluge R, Wittschen P, Gruber AD, Al-Hasani H, Joost HG, Schürmann A.
Biochem Biophys Res Commun 394(4):896-903. doi: 10.1016/j.bbrc.2010.03.059. Epub 2010 Mar 15. 2010
37GDI1, RAB10, SLC2A4
GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.
Chen Y, Deng Y, Zhang J, Yang L, Xie X, Xu T.
Biochem J 422(2):229-35. 2009
38RAB4A, RAB4B, SLC2A4
Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.
Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M.
PLoS One 4(4):e5257.PMID: 19590752 2009
39SLC2A4
The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles.
Li LV, Bakirtzi K, Watson RT, Pessin JE, Kandror KV.
Biochem J 419(1):105-12, 1 p following 112. 2009
40SLC2A4, VAMP2, VAMP4, VAMP8
Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes.
Williams D, Pessin JE.
J Cell Biol 180(2):375-87.PMID: 18227281 2008
41PRKD1, SLC2A4
Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.
Luiken JJ, Vertommen D, Coort SL, Habets DD, El Hasnaoui M, Pelsers MM, Viollet B, Bonen A, Hue L, Rider MH, Glatz JF.
Cell Signal 20(3):543-56. Epub 2007 Nov 26.PMID: 18164589 2008
42LNPEP, SLC2A4
The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?
Fernando RN, Albiston AL, Chai SY.
Eur J Neurosci 28(3):588-98. doi: 10.1111/j.1460-9568.2008.06347.x. 2008
43SLC2A1, SLC2A4, SGK1
Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.
Jeyaraj S, Boehmer C, Lang F, Palmada M.
Biochem Biophys Res Commun 356(3):629-35. Epub 2007 Mar 12. 2007
44TBC1D4, SLC2A4
A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.
Ramm G, Larance M, Guilhaus M, James DE.
J Biol Chem 281(39):29174-80. Epub 2006 Jul 31. 2006
45SLC2A4, SREBF1
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes.
Im SS, Kwon SK, Kang SY, Kim TH, Kim HI, Hur MW, Kim KS, Ahn YH.
Biochem J 399(1):131-9. 2006
46RUFY1, SLC2A4
The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
Mari M, Monzo P, Kaddai V, Keslair F, Gonzalez T, Le Marchand-Brustel Y, Cormont M.
J Cell Sci 119(Pt 7):1297-306. Epub 2006 Mar 7.PMID: 16522682 2006
47SLC2A4
Overexpression of anion exchanger 2 in human hepatocellular carcinoma.
Wu TT, Hsieh YH, Wu CC, Tsai JH, Hsieh YS, Huang CY, Liu JY.
Chin J Physiol 49(4):192-8. 2006
48SLC2A12, SLC2A4, SLC2A5
Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle.
Stuart CA, Yin D, Howell ME, Dykes RJ, Laffan JJ, Ferrando AA.
Am J Physiol Endocrinol Metab 291(5):E1067-73. Epub 2006 Jun 27. 2006
49SLC2A4, RBP4
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB.
Nature 436(7049):356-62. 2005
50LNPEP, SLC2A4
Expression of glucose transporter 4 in the human pancreatic islet of Langerhans.
Kobayashi H, Mitsui T, Nomura S, Ohno Y, Kadomatsu K, Muramatsu T, Nagasaka T, Mizutani S.
Biochem Biophys Res Commun 314(4):1121-5. 2004
51SLC2A11, SLC2A4
GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern.
Gaster M, Handberg A, Schürmann A, Joost HG, Beck-Nielsen H, Schrřder HD.
Pflugers Arch 448(1):105-13. Epub 2003 Dec 24. 2004
52ASPSCR1, SLC2A4
Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking.
Bogan JS, Hendon N, McKee AE, Tsao TS, Lodish HF.
Nature 425(6959):727-33. 2003
53SLC2A4, MEF2A
Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.
Knight JB, Eyster CA, Griesel BA, Olson AL.
Proc Natl Acad Sci U S A 100(25):14725-30. Epub 2003 Nov 20. 2003
54CAPN10, SLC2A4
Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes.
Paul DS, Harmon AW, Winston CP, Patel YM.
Biochem J 376(Pt 3):625-32. 2003
55INPP5K, SLC2A4
SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.
Ijuin T, Takenawa T.
Mol Cell Biol 23(4):1209-20. 2003
56SLC2A4
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB.
Nature 409(6821):729-33. 2001
57ACADVL, AIPL1, ALOX12, ATP1B1, CACP, CD68, CLDN7, DLG4, EIF4A1, GABARAP, RABEP1, SHBG, SLC2A4
A physical and expression map of the D17S1810-D17S1353 region spanning the central areolar choroidal dystrophy locus.
Lichanska AM, McGibbon D, Silvestri G, Hughes AE.
Cytogenet Cell Genet 93(1-2):43-7. 2001
58RHOQ, SLC2A4, SORBS1
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10.
Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, Saltiel AR.
Nature 410(6831):944-8. 2001
59SLC2A4,SYNGR2
Cellugyrin is a marker for a distinct population of intracellular Glut4-containing vesicles.
Kupriyanova TA, Kandror KV.
J Biol Chem 275(46):36263-8. 2000
60SLC2A4
Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.
Shepherd PR, Kahn BB.
N Engl J Med 341(4):248-57. Review. No abstract available. 1999
61SLC2A4, TNF
Insulin resistance in cancer patients is associated with enhanced tumor necrosis factor-alpha expression in skeletal muscle.
Noguchi Y, et al.
Biochem Biophys Res Commun 253(3):887-92. 1998
62SLC2A1, SLC2A2, SLC2A3, SLC2A4, SLC2A5, SLC2A6
Structure, function and biosynthesis of GLUT1.
Mueckler M, Hresko RC, Sato M.
Biochem Soc Trans 25(3):951-4. Review. No abstract available. 1997
63SLC2A1, SLC2A4
Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations.
Pontirolli AE, et al.
Acta Diabetol 33 : 193-197. 1996
64SLC2A4
Human SLC2A4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
Buse JB, et al.
Diabetes 41 : 1436-1445. 1992
65SLC2A4
Polymorphism in exon 4a of the human SLC2A4/muscle-fat facilitative glucose transporter gene detected by SSCP.
Muraoka A, et al.
Nucleic Acids Res 19 : 4313. 1991
66SLC2A1, SLC2A2, SLC2A3, SLC2A3P1, SLC2A4, SLC2A5
Facilitative glucose transporters : an expanding family.
Gould GW, et al.
Trends Biochem Sci 15 : 18-23. 1990
67SLC2A1, SLC2A2, SLC2A3, SLC2A3P1, SLC2A4, SLC2A5
Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).
Kayano T, et al.
J Biol Chem 265 : 13276-13282. 1990
68SLC2A4
A KpnI polymorphism for the human insulin-responsive glucose transporter gene (GLUT4) on chromosome 17.
Leysens N, et al.
Nucleic Acids Res 17 : 3621. 1989
69SLC2A4, SLC2A5, SLC2A3P1
Assignment of genes encoding three human glucose transporter/transporter-like proteins (SLC2A4, SLC2A5 and SLC2A6) to chromosomes 17, 1 and 5, respectively.
Fan YS, et al.
(HGM10) Cytogenet Cell Genet 51 : 997. 1989