| 1 | SLC22A2
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| Organic cation transporter 2 (SLC22A2), a low-affinity and high-capacity choline transporter, is preferentially enriched on synaptic vesicles in cholinergic neurons.
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| Nakata T, Matsui T, Kobayashi K, Kobayashi Y, Anzai N.
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| Neuroscience euroscience. 2013 Aug 16. doi:pii: S0306-4522(13)00689-1. 10.1016/j.neuroscience.2013.08.011. [Epub ahead of print]
2013
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| 2 | DDAH1, SLC22A2, SLC47A1, SLC7A2
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| Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).
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| Strobel J, Müller F, Zolk O, Endreß B, König J, Fromm MF, Maas R.
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| Amino Acids 45(4):989-1002. doi: 10.1007/s00726-013-1556-3. Epub 2013 Jul 18.
2013
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| 3 | SLC22A2, SLC22A8, SLC47A1, SLC47A2, SLC722A6
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| Precise comparison of protein localization among OCT, OAT, and MATE in human kidney.
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| Motohashi H, Nakao Y, Masuda S, Katsura T, Kamba T, Ogawa O, Inui K.
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| J Pharm Sci 102(9):3302-8. doi: 10.1002/jps.23567. Epub 2013 Apr 29.
2013
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| 4 | SLC22A2
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| Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.
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| Ciarimboli G, Lancaster CS, Schlatter E, Franke RM, Sprowl JA, Pavenstädt H, Massmann V, Guckel D, Mathijssen RH, Yang W, Pui CH, Relling MV, Herrmann E, Sparreboom A.
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| Clin Cancer Res 18(4):1101-8. doi: 10.1158/1078-0432.CCR-11-2503. Epub 2012 Jan 5.
2012
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| 5 | SLC22A2
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| The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization.
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| Brast S, Grabner A, Sucic S, Sitte HH, Hermann E, Pavenstädt H, Schlatter E, Ciarimboli G.
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| FASEB J 26(3):976-86. doi: 10.1096/fj.11-180679. Epub 2011 Nov 15.
2012
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| 6 | SLC22A2
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| Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response.
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| Bacq A, Balasse L, Biala G, Guiard B, Gardier AM, Schinkel A, Louis F, Vialou V, Martres MP, Chevarin C, Hamon M, Giros B, Gautron S.
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| Mol Psychiatry 17(9):926-39. doi: 10.1038/mp.2011.87. Epub 2011 Jul 19.
2012
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| 7 | LAPTM4A, SLC22A2
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| LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.
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| Grabner A, Brast S, Sucic S, Bierer S, Hirsch B, Pavenstädt H, Sitte HH, Schlatter E, Ciarimboli G.
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| Cell Mol Life Sci 68(24):4079-90. doi: 10.1007/s00018-011-0694-6. Epub 2011 May 8.
2011
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| 8 | SLC22A2, SLC47A1
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| OCT2 and MATE1 provide bidirectional agmatine transport.
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| Winter TN, Elmquist WF, Fairbanks CA.
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| Mol Pharm 8(1):133-42. doi: 10.1021/mp100180a. Epub 2010 Dec 3.
2011
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| 9 | ALMS1, BCAS3, C17orf82, CEP89, DUSP11, FAAP24, GATM, MYH9, NAT8, SHROOM3, SLC22A2, SLC7A9, TBX2, TPRKB, UMOD
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| Genetic loci influencing kidney function and chronic kidney disease.
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| Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Melander O, Munroe PB, Nordfors L, Parsa A, Peltonen L, Penninx BW, Perucha E, Pouta A, Prokopenko I, Roderick PJ, Ruokonen A, Samani NJ, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Shuldiner AR, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS.
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| Nat Genet 42(5):373-5. Epub 2010 Apr 11. 2010
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| 10 | SLC22A2
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| Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2).
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| Burger H, Zoumaro-Djayoon A, Boersma AW, Helleman J, Berns EM, Mathijssen RH, Loos WJ, Wiemer EA.
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| Br J Pharmacol 159(4):898-908. doi: 10.1111/j.1476-5381.2009.00569.x. Epub 2010 Jan 8.
2010
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| 11 | SLC22A2, SLC47A1
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| Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.
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| Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB.
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| Am J Physiol Renal Physiol 298(4):F997-F1005. doi: 10.1152/ajprenal.00431.2009. Epub 2010 Jan 6.
2010
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| 12 | SLC22A2, SLC47A1
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| Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.
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| Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB.
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| Am J Physiol Renal Physiol 298(4):F997-F1005. doi: 10.1152/ajprenal.00431.2009. Epub 2010 Jan 6.
2010
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| 13 | SLC22A1, SLC22A11, SLC22A2, SLC22A3, SLC22A4, SLC22A6, SLC22A7, SLC22A8
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| Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.
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| Ogasawara K, Terada T, Motohashi H, Asaka J, Aoki M, Katsura T, Kamba T, Ogawa O, Inui K.
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| J Hum Genet 53(7):607-14. Epub 2008 Apr 15. 2008
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| 14 | SLC22A2
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| Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation.
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| Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, Katsura T, Inui K.
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| Am J Physiol Renal Physiol 295(1):F165-70. doi: 10.1152/ajprenal.90257.2008. Epub 2008 May 28.
2008
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| 15 | SLC22A1, SLC22A2, SLC22A3, SLC29A4
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| The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.
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| Bottalico B, Noskova V, Pilka R, Larsson I, Domanski H, Casslén B, Hansson SR.
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| Mol Reprod Dev 74(10):1303-11.
2007
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| 16 | SLC22A1, SLC22A2, SLC22A3
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| Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.
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| Bottalico B, Larsson I, Brodszki J, Hernandez-Andrade E, Casslén B, Marsál K, Hansson SR.
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| Placenta 25(6):518-29.
2004
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| 17 | SLC22A2
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| cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
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| Urakami Y, Akazawa M, Saito H, Okuda M, Inui K.
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| J Am Soc Nephrol 13(7):1703-10. 2002
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| 18 | SLC22A2, SLC22A3
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| Gene structures of the human non-neuronal monoamine transporters EMT and OCT2.
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| Grundemann D, Schomig E.
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| Hum Genet 106(6):627-35. 2000
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| 19 | SLC22A1, SLC22A2
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| The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.
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| Koehler MR, et al.
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| Cytogenet Cell Genet 79 : 198-200. 1997
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| 20 | SLC22A1, SLC22A2
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| Cloning and characterization of two human polyspecific organic cation transporters.
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| Gorboulev V, et al.
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| DNA Cell Biol 16 : 871-881. 1997
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| 21 | SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5
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| Molecular cloning and characterization of a novel liver-specific transport protein.
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| Simonson GD, Vincent AC, Roberg KJ, Huang Y, Iwanij V.
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| J Cell Sci 107 ( Pt 4):1065-72. 1994
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