1 | SLC22A1
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| Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.
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| Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ.
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| Am J Hum Genet 101(4):489-502. doi: 10.1016/j.ajhg.2017.08.008. Epub 2017 Sep 21.
2017
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2 | SLC22A1
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| Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation.
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| Hyrsova L, Smutny T, Trejtnar F, Pavek P.
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| Drug Metab Rev 48(2):139-58. doi: 10.1080/03602532.2016.1188936.
2016
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3 | SLC22A1
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| Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes.
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| Dujic T, Causevic A, Bego T, Malenica M, Velija-Asimi Z, Pearson ER, Semiz S.
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| Diabet Med 33(4):511-4. doi: 10.1111/dme.13040.
2016
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4 | SLC22A1
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| Functional characterization of the organic cation transporters (OCTs) in human airway pulmonary epithelial cells.
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| Ingoglia F, Visigalli R, Rotoli BM, Barilli A, Riccardi B, Puccini P, Dall'Asta V.
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| Biochim Biophys Acta 1848(7):1563-72. doi: 10.1016/j.bbamem.2015.04.001.
2015
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5 | SLC22A1
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| Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake.
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| Boxberger KH, Hagenbuch B, Lampe JN.
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| Drug Metab Dispos 42(6):990-5. doi: 10.1124/dmd.113.055095.
2014
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6 | HNF4A, NR3C1, SLC22A1
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| Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.
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| Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P.
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| Pharmacol Rep 65(5):1322-35.
2013
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7 | SLC22A1
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| A common novel splice variant of SLC22A1 (OCT1) is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia.
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| Grinfeld J, Gerrard G, Alikian M, Alonso-Dominguez J, Ale S, Valgańon M, Nteliopoulos G, White D, Marin D, Hedgley C, O'Brien S, Clark R, Goldman JM, Milojkovic D, Apperley JF, Foroni L.
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| Br J Haematol 163(5):631-9. doi: 10.1111/bjh.12591.
2013
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8 | HNF1A, SLC22A1
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| Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene.
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| O'Brien VP, Bokelmann K, Ramírez J, Jobst K, Ratain MJ, Brockmöller J, Tzvetkov MV.
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| J Pharmacol Exp Ther 347(1):181-92. doi: 10.1124/jpet.113.206359.
2013
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9 | SLC22A1
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| A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.
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| Egenberger B, Gorboulev V, Keller T, Gorbunov D, Gottlieb N, Geiger D, Mueller TD, Koepsell H.
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| J Biol Chem 287(37):31561-73. doi: 10.1074/jbc.M112.388793.
2012
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10 | SLC22A1
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| Transcription factor Oct1 is a somatic and cancer stem cell determinant.
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| Maddox J, Shakya A, South S, Shelton D, Andersen JN, Chidester S, Kang J, Gligorich KM, Jones DA, Spangrude GJ, Welm BE, Tantin D.
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| PLoS Genet 8(11):e1003048. doi: 10.1371/journal.pgen.1003048.
2012
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11 | SLC22A1, SLC22A6, SLC22A8
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| Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule.
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| Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam SK.
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| PLoS One 7(7):e40796. doi: 10.1371/journal.pone.0040796.
2012
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12 | SLC22A1
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| The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
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| Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dötsch V, Hunte C, Sitte HH, Koepsell H.
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| J Biol Chem 286(43):37874-86. doi: 10.1074/jbc.M111.289330.
2011
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13 | GFI1B, SLC22A1
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| Human promoter mutations unveil Oct-1 and GATA-1 opposite action on Gfi1b regulation.
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| Hernández A, Villegas A, Anguita E.
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| Ann Hematol 89(8):759-65. doi: 10.1007/s00277-009-0900-x.
2010
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14 | SLC22A1, SLC47A1
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| Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.
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| Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH.
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| Pharmacogenet Genomics 20(1):38-44. doi: 10.1097/FPC.0b013e328333bb11.
2010
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15 | SLC22A1, SLC22A3
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| Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.
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| Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E.
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| Hepatology 50(4):1227-40. doi: 10.1002/hep.23103.
2009
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16 | SLC22A1, SLC22A11, SLC22A2, SLC22A3, SLC22A4, SLC22A6, SLC22A7, SLC22A8
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| Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.
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| Ogasawara K, Terada T, Motohashi H, Asaka J, Aoki M, Katsura T, Kamba T, Ogawa O, Inui K.
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| J Hum Genet 53(7):607-14. Epub 2008 Apr 15. 2008
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17 | SLC22A1
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| Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
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| Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM.
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| Clin Pharmacol Ther 83(2):273-80. Epub 2007 Jul 4.
2008
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18 | SLC22A1, SLC22A2, SLC22A3, SLC29A4
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| The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.
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| Bottalico B, Noskova V, Pilka R, Larsson I, Domanski H, Casslén B, Hansson SR.
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| Mol Reprod Dev 74(10):1303-11.
2007
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19 | SLC22A1
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| Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats.
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| Umehara KI, Iwatsubo T, Noguchi K, Kamimura H.
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| Xenobiotica 37(8):818-31.
2007
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20 | SLC22A1, SLC22A2, SLC22A3
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| Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.
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| Bottalico B, Larsson I, Brodszki J, Hernandez-Andrade E, Casslén B, Marsál K, Hansson SR.
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| Placenta 25(6):518-29.
2004
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21 | SLC22A1
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| Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
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| Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators.
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| Proc Natl Acad Sci U S A 100(10):5902-7. Epub 2003 Apr 28. 2003
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22 | SLC22A1
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| Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
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| Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators.
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| Proc Natl Acad Sci U S A 100(10):5896-901. Epub 2003 Apr 28. 2003
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23 | SLC22A1
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| Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter.
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| Hayer M, Bnisch H, Brss M.
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| Ann Hum Genet 63 : 473-482. 1999
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24 | SLC22A1, SLC22A2
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| The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.
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| Koehler MR, et al.
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| Cytogenet Cell Genet 79 : 198-200. 1997
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25 | SLC22A1
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| Cloning and functional expression of a human liver organic cation transporter.
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| Zhang L, et al.
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| Mol Pharmacol 51 : 913-921. 1997
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26 | SLC22A1, SLC22A2
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| Cloning and characterization of two human polyspecific organic cation transporters.
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| Gorboulev V, et al.
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| DNA Cell Biol 16 : 871-881. 1997
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27 | SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5
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| Molecular cloning and characterization of a novel liver-specific transport protein.
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| Simonson GD, Vincent AC, Roberg KJ, Huang Y, Iwanij V.
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| J Cell Sci 107 ( Pt 4):1065-72. 1994
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