| 1 | CACNA1A, EIEE41, EIEE42, EIEE43, GABRB3, SLC1A2
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| De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies.
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| Epi4K Consortium.
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| Am J Hum Genet 99(2):287-98. doi: 10.1016/j.ajhg.2016.06.003. Epub 2016 Jul 28. 2016
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| 2 | SLC1A2
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| SLC1A2 rs3794087 are associated with susceptibility to Parkinson's disease, but not essential tremor, amyotrophic lateral sclerosis or multiple system atrophy in a Chinese population.
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| Xu Y, Cao B, Chen Y, Ou R, Wei Q, Yang J, Zhao B, Song W, Shang HF.
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| J Neurol Sci 365:96-100. doi: 10.1016/j.jns.2016.04.003. Epub 2016 Apr 8.
2016
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| 3 | CAV1, SLC1A1, SLC1A2, SLC1A3, SLC1A6
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| Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.
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| Abousaab A, Warsi J, Elvira B, Lang F.
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| J Membr Biol 249(3):239-49. doi: 10.1007/s00232-015-9863-0. Epub 2015 Dec 21.
2016
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| 4 | KL, SLC1A2, SLC1A3
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| Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho.
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| Warsi J, Abousaab A, Lang F.
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| Neurosignals 23(1):59-70. doi: 10.1159/000442604. Epub 2015 Dec 19.
2015
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| 5 | SLC1A2
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| Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII.
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| Underhill SM, Wheeler DS, Amara SG.
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| J Neurosci 35(13):5260-70. doi: 10.1523/JNEUROSCI.4365-14.2015.
2015
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| 6 | SLC1A2
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| Decreased EAAT2 protein expression in the essential tremor cerebellar cortex.
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| Lee M, Cheng MM, Lin CY, Louis ED, Faust PL, Kuo SH.
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| Acta Neuropathol Commun 2:157. doi: 10.1186/s40478-014-0157-z.
2014
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| 7 | SLC1A2
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| SLC1A2 rs3794087 variant and risk for migraine.
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| García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ.
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| J Neurol Sci 338(1-2):92-5. doi: 10.1016/j.jns.2013.12.022. Epub 2013 Dec 18.
2014
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| 8 | SLC1A2
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| Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
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| Tse DY, Chung I, Wu SM.
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| Vision Res 103:49-62. doi: 10.1016/j.visres.2014.07.020. Epub 2014 Aug 22.
2014
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| 9 | PICK1, SLC1A2
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| Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1.
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| Sogaard R, Borre L, Braunstein TH, Madsen KL, MacAulay N.
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| J Biol Chem 288(28):20195-207. doi: 10.1074/jbc.M113.471128. Epub 2013 May 22.
2013
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| 10 | SLC1A2, SLC1A3
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| Functional and morphological characterization of glutamate transporters in the rat locus coeruleus.
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| Medrano MC, Gerrikagoitia I, Martínez-Millán L, Mendiguren A, Pineda J.
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| Br J Pharmacol 169(8):1781-94. doi: 10.1111/bph.12235.
2013
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| 11 | EIEE41, SLC1A2
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| De novo mutations in epileptic encephalopathies.
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| Epi4K Consortium.
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| Nature 501(7466):217-21. doi: 10.1038/nature12439.
2013
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| 12 | SLC1A2
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| Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.
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| Thier S, Lorenz D, Nothnagel M, Poremba C, Papengut F, Appenzeller S, Paschen S, Hofschulte F, Hussl AC, Hering S, Poewe W, Asmus F, Gasser T, Schöls L, Christensen K, Nebel A, Schreiber S, Klebe S, Deuschl G, Kuhlenbäumer G.
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| Neurology 79(3):243-8. doi: 10.1212/WNL.0b013e31825fdeed. Epub 2012 Jul 3.
2012
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| 13 | SLC1A2
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| Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development.
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| DeSilva TM, Borenstein NS, Volpe JJ, Kinney HC, Rosenberg PA.
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| J Comp Neurol 520(17):3912-32. doi: 10.1002/cne.23130.
2012
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| 14 | SLC1A2
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| Differential expression of the glutamate transporter GLT-1 in pancreas.
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| Meabon JS, Lee A, Meeker KD, Bekris LM, Fujimura RK, Yu CE, Watson GS, Pow DV, Sweet IR, Cook DG.
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| J Histochem Cytochem 60(2):139-51. doi: 10.1369/0022155411430095. Epub 2011 Nov 22.
2012
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| 15 | ADORA1, SLC1A2
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| Regulation of ethanol-sensitive EAAT2 expression through adenosine A1 receptor in astrocytes.
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| Wu J, Lee MR, Kim T, Johng S, Rohrback S, Kang N, Choi DS.
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| Biochem Biophys Res Commun 406(1):47-52. Epub 2011 Feb 1.
2011
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| 16 | SLC1A2, SLC1A3
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| Excitatory amino acid transporter 2 and excitatory amino acid transporter 1 negatively regulate calcium-dependent proliferation of hippocampal neural progenitor cells and are persistently upregulated after injury.
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| Gilley JA, Kernie SG.
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| Eur J Neurosci 34(11):1712-23. doi: 10.1111/j.1460-9568.2011.07888.x. Epub 2011 Nov 17.
2011
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| 17 | SLC1A2
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| Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.
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| Gebhardt FM, Mitrovic AD, Gilbert DF, Vandenberg RJ, Lynch JW, Dodd PR.
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| J Biol Chem 285(41):31313-24. Epub 2010 Aug 5.
2010
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| 18 | SLC1A2, SLC1A3
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| Excitatory amino acid transporters EAAT-1 and EAAT-2 in temporal lobe and hippocampus in intractable temporal lobe epilepsy.
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| Sarac S, Afzal S, Broholm H, Madsen FF, Ploug T, Laursen H.
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| APMIS 117(4):291-301.
2009
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| 19 | SLC1A2
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| Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
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| Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, Kosik KS, Tanaka S, Hattori N.
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| FEBS Lett 583(13):2194-200. Epub 2009 Jun 13.PMID: 19527721 2009
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| 20 | SLC1A2
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| Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice.
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| Lin Y, Tian G, Roman K, Handy C, Travers JB, Lin CL, Stephens RL Jr.
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| Am J Physiol Gastrointest Liver Physiol 296(1):G129-34. Epub 2008 Nov 20.PMID: 19023027 2009
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| 21 | PIKFYVE, SLC1A2
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| Regulation of the glutamate transporter EAAT2 by PIKfyve.
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| Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.
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| Cell Physiol Biochem 24(5-6):361-8. doi: 10.1159/000257428. Epub 2009 Nov 4.
2009
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| 22 | SLC1A2
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| Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2.
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| Qu S, Kanner BI.
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| J Biol Chem 283(39):26391-400. Epub 2008 Jul 25.PMID: 18658151 2008
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| 23 | SLC1A2
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| Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes.
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| Lee SG, Su ZZ, Emdad L, Gupta P, Sarkar D, Borjabad A, Volsky DJ, Fisher PB.
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| J Biol Chem 283(19):13116-23. Epub 2008 Mar 7.PMID: 18326497 2008
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| 24 | PAX6, PRRG4, SLC1A2
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| Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism.
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| Xu S, Han JC, Morales A, Menzie CM, Williams K, Fan YS.
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| Cytogenet Genome Res 122(2):181-7. doi: 10.1159/000172086. Epub 2008 Dec 18. Erratum in: Cytogenet Genome Res. 2009;124(1):112.
2008
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| 25 | SLC1A2, PRRG4
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| New insights into autism from a comprehensive genetic map.
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| Katzov H.
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| Clin Genet 72(3):186-7. 2007
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| 26 | SLC1A2, SLC1A3
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| From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.
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| Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K.
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| Proc Natl Acad Sci U S A 103(32):12161-6. Epub 2006 Jul 31. 2006
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| 27 | SLC1A2
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| Thrombin-stimulated glutamate uptake in human platelets is predominantly mediated by the glial glutamate transporter EAAT2.
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| Hoogland G, Bos IW, Kupper F, van Willigen G, Spierenburg HA, van Nieuwenhuizen O, de Graan PN.
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| Neurochem Int 47(7):499-506. 2005
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| 28 | SLC1A2, GRM3
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| Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.
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| Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR.
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| Proc Natl Acad Sci U S A 101(34):12604-9. Epub 2004 Aug 13. 2004
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| 29 | ALS1, ALS2, ALS3, ALS4, ALS5, ALS6, ALS7, ALS8, NEFH, VEGFA, SMN1, SMN2, SLC1A2, GRIA2
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| Complex genetics of amyotrophic lateral sclerosis.
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| Kunst CB.
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| Am J Hum Genet 75(6):933-47. Epub 2004 Oct 11. No abstract available. 2004
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| 30 | SLC1A2, SLC1A7
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| A new GLT1 splice variant: cloning and immunolocalization of GLT1c in the mammalian retina and brain.
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| Rauen T, Wiessner M, Sullivan R, Lee A, Pow DV.
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| Neurochem Int 45(7):1095-106. 2004
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| 31 | SLC1A2
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| Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
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| Su ZZ, Leszczyniecka M, Kang DC, Sarkar D, Chao W, Volsky DJ, Fisher PB.
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| Proc Natl Acad Sci U S A 100(4):1955-60. 2003
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| 32 | SLC1A2
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| The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba.
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| Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D.
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| Mol Cell Neurosci 19(2):152-64. 2002
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| 33 | SLC1A2
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| Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission.
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| Tozaki H, Kanno T, Nomura T, Kondoh T, Kodama N, Saito N, Aihara H, Nagata T, Matsumoto S, Ohta K, Nagai K, Yajima Y, Nishizaki T.
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| Brain Res Mol Brain Res 97(1):7-12. 2001
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| 34 | SLC1A2
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| Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy.
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| Sander T, Berlin W, Ostapowicz A, Samochowiec J, Gscheidel N, Hoehe MR.
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| Epilepsy Res 41(1):75-81. 2000
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| 35 | SLC1A2
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| Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain.
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| Munch C, Schwalenstocker B, Hermann C, Cirovic S, Stamm S, Ludolph A, Meyer T.
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| Brain Res Mol Brain Res 80(2):244-51. 2000
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| 36 | SLC1A1, SLC1A2, SLC1A3
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| Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal.
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| O'Kane RL, Martinez-Lopez I, DeJoseph MR, Vina JR, Hawkins RA.
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| J Biol Chem 274(45):31891-5 1999
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| 37 | CHH, SLC1A2
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| Cartilage-hair hypoplasia syndrome: increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2.
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| Yel L, Aggarwal S, Gupta S.
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| J Clin Immunol 19(6):428-34. 1999
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| 38 | SLC1A2
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| 5'-heterogeneity of the human excitatory amino acid transporter cDNA EAAT2 (GLT-1).
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| Munch C, et al.
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| Neuroreport 9 : 1295-1297. 1998
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| 39 | SLC1A1, SLC1A2
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| Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2.
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| Mitrovic AD, et al.
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| J Biol Chem 273 : 14698-14706. 1998
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| 40 | SLC1A2
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| The EAAT2 (GLT-1) gene in motor neuron disease : absence of mutations in amyotrophic lateral sclerosis and a point mutation in patients with hereditary spastic paraplegia.
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| Meyer T, Munch C, Volkel H, Booms P, Ludolph AC.
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| J Neurol Neurosurg Psychiatry 65 : 594-596. 1998
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| 41 | SLC1A2
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| Localization of the gene encoding the human L-glutamate transporter (GLT-1) to 11p11.2-p13 by fluorescence in situ hybridization.
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| Takai S, et al.
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| Hum Genet 97 : 387-389. 1996
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| 42 | SLC1A1, SLC1A2, SLC1A3, SLC1A4, SLC1A5
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| Membrane topology of the high-affinity L-glutamate transporter (GLAST-1) of the central nervous system.
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| Wahle S, Stoffel W.
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| J Cell Biol 135 : 1867-1877. 1996
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| 43 | SLC1A1, SLC1A2
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| Membrane topology of the C-terminal half of the neuronal, glial, and bacterial glutamate transporter family.
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| Slotboom DJ, Lolkema JS, Konings WN.
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| J Biol Chem 271 : 31317-31321. 1996
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| 44 | SLC1A2
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| Assignment of the gene SLC1A2 coding for the human glutamate transporter EAAT2 to human chromosome 11 bands p13-p12.
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| Li X, et al.
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| Cytogenet Cell Genet 71 : 212-213. 1995
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| 45 | SLC1A2
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| Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas.
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| Manfras BJ, et al.
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| Biochim Biophys Acta 1195 : 185-188. 1994
|