| 1 | SLC16A4
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| Monocarboxylate Transporter 4 (MCT4) Overexpression Is Correlated with Poor Prognosis of Osteosarcoma.
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| Liu Y, Sun X, Huo C, Sun C, Zhu J.
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| Med Sci Monit 25:4278-4284. doi: 10.12659/MSM.912272.
2019
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| 2 | SLC16A1, SLC16A4
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| Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4).
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| Futagi Y, Kobayashi M, Narumi K, Furugen A, Iseki K.
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| Cell Mol Life Sci 76(24):4905-4921. doi: 10.1007/s00018-019-03151-z. Epub 2019 May 17.
2019
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| 3 | SLC16A1, SLC16A4
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| Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
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| Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN.
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| Cell Rep 25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043.
2018
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| 4 | BSG, SLC16A4, TMPRSS11B
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| Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
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| Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA.
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| Cell Rep 25(8):2223-2233.e6. doi: 10.1016/j.celrep.2018.10.100.
2018
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| 5 | SLC16A4
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| Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer.
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| Todenhöfer T, Seiler R, Stewart C, Moskalev I, Gao J, Ladhar S, Kamjabi A, Al Nakouzi N, Hayashi T, Choi S, Wang Y, Frees S, Daugaard M, Oo HZ, Fisel P, Schwab M, Schaeffeler E, Douglas J, Hennenlotter J, Bedke J, Gibb EA, Fazli L, Stenzl A, Black PC.
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| Mol Cancer Ther 17(12):2746-2755. doi: 10.1158/1535-7163.MCT-18-0107. Epub 2018 Sep 27.
2018
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| 6 | SLC16A4
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| MCT4 Expression Is a Potential Therapeutic Target in Colorectal Cancer with Peritoneal Carcinomatosis.
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| Kim HK, Lee I, Bang H, Kim HC, Lee WY, Yun SH, Lee J, Lee SJ, Park YS, Kim KM, Kang WK.
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| Mol Cancer Ther 17(4):838-848. doi: 10.1158/1535-7163.MCT-17-0535. Epub 2018 Feb 26.
2018
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| 7 | SLC16A1, SLC16A4
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| The flexible cytoplasmic loop 3 contributes to the substrate affinity of human monocarboxylate transporters.
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| Futagi Y, Sasaki S, Kobayashi M, Narumi K, Furugen A, Iseki K.
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| Biochim Biophys Acta Biomembr 1859(10):1790-1795. doi: 10.1016/j.bbamem.2017.05.014. Epub 2017 May 27.
2017
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| 8 | SLC16A1, SLC16A4
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| The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4.
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| Pinheiro C, Miranda-Gonçalves V, Longatto-Filho A, Vicente AL, Berardinelli GN, Scapulatempo-Neto C, Costa RF, Viana CR, Reis RM, Baltazar F, Vazquez VL.
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| Cell Cycle 15(11):1462-70. doi: 10.1080/15384101.2016.1175258. Epub 2016 Apr 22.
2016
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| 9 | SLC16A1, SLC16A4
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| Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis.
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| Bovenzi CD, Hamilton J, Tassone P, Johnson J, Cognetti DM, Luginbuhl A, Keane WM, Zhan T, Tuluc M, Bar-Ad V, Martinez-Outschoorn U, Curry JM.
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| Biomed Res Int 2015:242437. doi: 10.1155/2015/242437. Epub 2015 Dec 8. Review.
2015
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| 10 | SLC16A4
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| MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma.
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| Fisel P, Stühler V, Bedke J, Winter S, Rausch S, Hennenlotter J, Nies AT, Stenzl A, Scharpf M, Fend F, Kruck S, Schwab M, Schaeffeler E.
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| Oncotarget 6(31):30615-27. doi: 10.18632/oncotarget.5593.
2015
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| 11 | SLC16A1, SLC16A4
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| Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.
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| Domènech-Estévez E, Baloui H, Repond C, Rosafio K, Médard JJ, Tricaud N, Pellerin L, Chrast R.
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| J Neurosci 35(10):4151-6. doi: 10.1523/JNEUROSCI.3534-14.2015.
2015
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| 12 | SLC16A4
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| The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.
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| Tan Z, Xie N, Banerjee S, Cui H, Fu M, Thannickal VJ, Liu G.
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| J Biol Chem 290(1):46-55. doi: 10.1074/jbc.M114.603589. Epub 2014 Nov 18.
2015
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| 13 | BSG, SLC16A1, SLC16A4
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| CD147 required for corneal endothelial lactate transport.
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| Li S, Nguyen TT, Bonanno JA.
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| Invest Ophthalmol Vis Sci 55(7):4673-81. doi: 10.1167/iovs.14-14386.
2014
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| 14 | SLC16A4
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| Monocarboxylate transporter 4 facilitates cell proliferation and migration and is associated with poor prognosis in oral squamous cell carcinoma patients.
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| Zhu J, Wu YN, Zhang W, Zhang XM, Ding X, Li HQ, Geng M, Xie ZQ, Wu HM.
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| PLoS One 9(1):e87904. doi: 10.1371/journal.pone.0087904. eCollection 2014.
2014
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| 15 | SLC16A4, SLC1A3
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| Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy.
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| Liu B, Niu L, Shen MZ, Gao L, Wang C, Li J, Song LJ, Tao Y, Meng Q, Yang QL, Gao GD, Zhang H.
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| Mol Neurobiol 50(2):327-38. doi: 10.1007/s12035-013-8619-z. Epub 2014 Jan 25.
2014
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| 16 | SLC16A4
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| Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4).
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| Sasaki S, Kobayashi M, Futagi Y, Ogura J, Yamaguchi H, Takahashi N, Iseki K.
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| PLoS One 8(7):e67690. doi: 10.1371/journal.pone.0067690. Print 2013.
2013
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| 17 | SLC16A1, SLC16A4
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| Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
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| Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F.
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| Neuro Oncol 15(2):172-88. doi: 10.1093/neuonc/nos298. Epub 2012 Dec 20.
2013
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| 18 | BSG, SLC16A1, SLC16A4
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| CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
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| Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J.
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| Proc Natl Acad Sci U S A 108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20166. 2011
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| 19 | BSG, SLC16A4
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| Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.
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| Pértega-Gomes N, Vizcaíno JR, Miranda-Gonçalves V, Pinheiro C, Silva J, Pereira H, Monteiro P, Henrique RM, Reis RM, Lopes C, Baltazar F.
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| BMC Cancer 11:312. doi: 10.1186/1471-2407-11-312.
2011
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| 20 | SLC16A1, SLC16A4
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| Monocarboxylate transport in human corneal epithelium and cell lines.
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| Vellonen KS, Häkli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A.
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| Eur J Pharm Sci 39(4):241-7. doi: 10.1016/j.ejps.2009.12.006. Epub 2009 Dec 24.
2010
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| 21 | SLC16A1, SLC16A2, SLC16A4
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| Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
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| Pérez de Heredia F, Wood IS, Trayhurn P.
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| Pflugers Arch 459(3):509-18. doi: 10.1007/s00424-009-0750-3. Epub 2009 Oct 30.
2010
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| 22 | SLC16A4
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| Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration.
|
| Gallagher SM, Castorino JJ, Philp NJ.
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| Am J Physiol Cell Physiol 296(3):C414-21. doi: 10.1152/ajpcell.00430.2008. Epub 2008 Dec 10.
2009
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| 23 | SLC16A1, SLC16A2, SLC16A4
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| Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
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| Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L.
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| J Physiol 583(Pt 2):469-86. Epub 2007 Jun 28.
2007
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| 24 | SLC16A4
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| The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.
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| Ullah MS, Davies AJ, Halestrap AP.
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| J Biol Chem 281(14):9030-7. Epub 2006 Feb 1. 2006
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| 25 | SLC16A1, SLC16A10, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8
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| The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
|
| Halestrap AP, Price NT.
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| Biochem J 343 Pt 2:281-99. Review. 1999
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| 26 | SLC16A10, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8
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| Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.
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| Price NT, Jackson VN, Halestrap AP.
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| Biochem J 329 ( Pt 2):321-8. 1998
|