| 1 | GABBR1, SLC12A5
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| Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex.
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| Wright R, Newey SE, Ilie A, Wefelmeyer W, Raimondo JV, Ginham R, Mcllhinney RAJ, Akerman CJ.
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| J Neurosci 37(22):5447-5462. doi: 10.1523/JNEUROSCI.2164-16.2017. Epub 2017 Apr 27.
2017
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| 2 | PACSIN1, SLC12A5
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| Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition.
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| Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Uvarov P, Kwan J, Bagshaw RD, Pawson T, Emili A, De Koninck Y, Anggono V, Airaksinen M, Woodin MA.
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| Elife 6. pii: e28270. doi: 10.7554/eLife.28270.
2017
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| 3 | SLC12A5, WNK1
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| WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
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| Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I.
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| Sci Signal 8(383):ra65. doi: 10.1126/scisignal.aaa0354.
2015
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| 4 | EIEE34, SLC12A5
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| Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.
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| Stödberg T, McTague A, Ruiz AJ, Hirata H, Zhen J, Long P, Farabella I, Meyer E, Kawahara A, Vassallo G, Stivaros SM, Bjursell MK, Stranneheim H, Tigerschiöld S, Persson B, Bangash I, Das K, Hughes D, Lesko N, Lundeberg J, Scott RC, Poduri A, Scheffer IE, Smith H, Gissen P, Schorge S, Reith ME, Topf M, Kullmann DM, Harvey RJ, Wedell A, Kurian MA.
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| Nat Commun 6:8038. doi: 10.1038/ncomms9038.
2015
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| 5 | SLC12A5
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| A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.
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| Puskarjov M, Seja P, Heron SE, Williams TC, Ahmad F, Iona X, Oliver KL, Grinton BE, Vutskits L, Scheffer IE, Petrou S, Blaesse P, Dibbens LM, Berkovic SF, Kaila K.
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| EMBO Rep 15(6):723-9. doi: 10.1002/embr.201438749. Epub 2014 Mar 24.
2014
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| 6 | HTR2A, SLC12A5
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| Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2.
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| Bos R, Sadlaoud K, Boulenguez P, Buttigieg D, Liabeuf S, Brocard C, Haase G, Bras H, Vinay L.
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| Proc Natl Acad Sci U S A 110(1):348-53. doi: 10.1073/pnas.1213680110. Epub 2012 Dec 17.
2013
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| 7 | SLC12A2, SLC12A5
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| Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett syndrome.
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| Duarte ST, Armstrong J, Roche A, Ortez C, Pérez A, O'Callaghan Mdel M, Pereira A, Sanmartí F, Ormazábal A, Artuch R, Pineda M, García-Cazorla A.
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| PLoS One 8(7):e68851. doi: 10.1371/journal.pone.0068851. Print 2013.
2013
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| 8 | NLGN2, SLC12A5
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| An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch.
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| Sun C, Zhang L, Chen G.
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| Mol Brain 6:23. doi: 10.1186/1756-6606-6-23.
2013
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| 9 | NETO2, SLC12A5
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| Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons.
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| Ivakine EA, Acton BA, Mahadevan V, Ormond J, Tang M, Pressey JC, Huang MY, Ng D, Delpire E, Salter MW, Woodin MA, McInnes RR.
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| Proc Natl Acad Sci U S A 110(9):3561-6. doi: 10.1073/pnas.1212907110. Epub 2013 Feb 11.
2013
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| 10 | SLC12A5
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| An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo.
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| Fiumelli H, Briner A, Puskarjov M, Blaesse P, Belem BJ, Dayer AG, Kaila K, Martin JL, Vutskits L.
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| Cereb Cortex 23(2):378-88. doi: 10.1093/cercor/bhs027. Epub 2012 Feb 17.
2013
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| 11 | SLC12A5
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| Vesicular uptake and exocytosis of L-aspartate is independent of sialin.
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| Morland C, Nordengen K, Larsson M, Prolo LM, Farzampour Z, Reimer RJ, Gundersen V.
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| FASEB J 27(3):1264-74. doi: 10.1096/fj.12-206300. Epub 2012 Dec 6.
2013
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| 12 | SLC12A5
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| KCC2 transport activity requires the highly conserved L₆₇₅ in the C-terminal β1 strand.
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| Döding A, Hartmann AM, Beyer T, Nothwang HG.
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| Biochem Biophys Res Commun 420(3):492-7. doi: 10.1016/j.bbrc.2012.02.147. Epub 2012 Mar 3.
2012
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| 13 | SLC12A5
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| Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders.
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| Tao R, Li C, Newburn EN, Ye T, Lipska BK, Herman MM, Weinberger DR, Kleinman JE, Hyde TM.
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| J Neurosci 32(15):5216-22. doi: 10.1523/JNEUROSCI.4626-11.2012.
2012
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| 14 | SLC12A5
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| Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders.
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| Tao R, Li C, Newburn EN, Ye T, Lipska BK, Herman MM, Weinberger DR, Kleinman JE, Hyde TM.
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| J Neurosci 32(15):5216-22. doi: 10.1523/JNEUROSCI.4626-11.2012.
2012
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| 15 | SLC12A5
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| Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain.
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| Acton BA, Mahadevan V, Mercado A, Uvarov P, Ding Y, Pressey J, Airaksinen MS, Mount DB, Woodin MA.
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| J Neurosci 32(25):8746-51. doi: 10.1523/JNEUROSCI.6089-11.2012.
2012
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| 16 | SLC12A5
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| The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines.
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| Gauvain G, Chamma I, Chevy Q, Cabezas C, Irinopoulou T, Bodrug N, Carnaud M, Lévi S, Poncer JC.
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| Proc Natl Acad Sci U S A 108(37):15474-9. Epub 2011 Aug 30.
2011
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| 17 | EGR4, SLC12A5
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| Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription.
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| Ludwig A, Uvarov P, Soni S, Thomas-Crusells J, Airaksinen MS, Rivera C.
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| J Neurosci 31(2):644-9. doi: 10.1523/JNEUROSCI.2006-10.2011.
2011
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| 18 | SLC12A5
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| Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2.
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| Lee HH, Jurd R, Moss SJ.
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| Mol Cell Neurosci 45(2):173-9. doi: 10.1016/j.mcn.2010.06.008. Epub 2010 Jun 20.
2010
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| 19 | SLC12A5
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| Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.
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| Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD.
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| Proc Natl Acad Sci U S A 106(13):5383-8. Epub 2009 Mar 11.
2009
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| 20 | SLC12A5, SLC12A9
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| CIP1 is an activator of the K+-Cl- cotransporter KCC2.
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| Wenz M, Hartmann AM, Friauf E, Nothwang HG.
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| Biochem Biophys Res Commun 381(3):388-92. Epub 2009 Feb 20.
2009
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| 21 | SLC12A4, SLC12A5, SLC12A6, SLC12A7
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| Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells.
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| Fujii T, Takahashi Y, Ikari A, Morii M, Tabuchi Y, Tsukada K, Takeguchi N, Sakai H.
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| J Biol Chem 284(1):619-29. Epub 2008 Nov 4. 2009
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| 22 | SLC12A4, SLC12A5, SLC12A6, SLC12A7, WNK3
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| Renal and brain isoforms of WNK3 have opposite effects on NCCT expression.
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| Glover M, Zuber AM, O'Shaughnessy KM.
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| J Am Soc Nephrol 20(6):1314-22. Epub 2009 May 21.
2009
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| 23 | SLC12A5
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| Neurogenic role of the depolarizing chloride gradient revealed by global overexpression of KCC2 from the onset of development.
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| Reynolds A, Brustein E, Liao M, Mercado A, Babilonia E, Mount DB, Drapeau P.
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| J Neurosci 28(7):1588-97.PMID: 18272680 2008
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| 24 | SLC12A5
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| Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.
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| Lee HH, Walker JA, Williams JR, Goodier RJ, Payne JA, Moss SJ.
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| J Biol Chem 282(41):29777-84. Epub 2007 Aug 10. 2007
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| 25 | SLC12A5
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| A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.
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| Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS.
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| J Biol Chem 282(42):30570-6. Epub 2007 Aug 22. 2007
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| 26 | IGF1, SLC12A4, SLC12A5, SLC12A6, SLC12A7
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| IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.
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| Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR.
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| J Cell Physiol 210(3):626-36.
2007
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| 27 | SLC12A4, SLC12A5, SLC12A6, SLC12A7
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| K-Cl cotransport function and its potential contribution to cardiovascular disease.
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| Adragna NC, Lauf PK.
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| Pathophysiology 14(3-4):135-46. Epub 2007 Oct 18.PMID: 17949953 2007
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| 28 | SLC12A5
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| KCC2 interacts with the dendritic cytoskeleton to promote spine development.
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| Li H, Khirug S, Cai C, Ludwig A, Blaesse P, Kolikova J, Afzalov R, Coleman SK, Lauri S, Airaksinen MS, Keinänen K, Khiroug L, Saarma M, Kaila K, Rivera C.
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| Neuron 56(6):1019-33.PMID: 18093524 2007
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| 29 | SLC12A5
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| A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.
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| Mercado A, Broumand V, Zandi-Nejad K, Enck AH, Mount DB.
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| J Biol Chem 281(2):1016-26. Epub 2005 Nov 16. 2006
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| 30 | SLC12A4, SLC12A5, SLC12A6, SLC12A7
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| KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts.
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| Misri S, Chimote AA, Adragna NC, Warwar R, Brown TL, Lauf PK.
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| Exp Eye Res 83(5):1287-94. Epub 2006 Sep 1.
2006
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| 31 | SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9
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| Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.
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| Hebert SC, Mount DB, Gamba G.
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| Pflugers Arch 447(5):580-93. Epub 2003 May 9. Review. 2004
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| 32 | SLC12A5
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| Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.
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| Song L, Mercado A, Vazquez N, Xie Q, Desai R, George AL Jr, Gamba G, Mount DB.
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| Brain Res Mol Brain Res 103(1-2):91-105. 2002
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| 33 | SLC12A5
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| Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology.
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| Sallinen R, Tornberg J, Putkiranta M, Horelli-Kuitunen N, Airaksinen MS, Wessman M.
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| Cytogenet Cell Genet 94(1-2):67-70. 2001
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