Citations for
1FBXO45, NMNAT2, SKP1
PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.
Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B.
J Biol Chem 293(36):13897-13909. doi: 10.1074/jbc.RA118.002176. Epub 2018 Jul 11. 2018
2SKP1, SUGT1
The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores.
Willhoft O, Kerr R, Patel D, Zhang W, Al-Jassar C, Daviter T, Millson SH, Thalassinos K, Vaughan CK.
Sci Rep 7:41626. doi: 10.1038/srep41626. 2017
3SKP1
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Yumimoto K, Muneoka T, Tsuboi T, Nakayama KI.
J Biol Chem 288(45):32766-76. doi: 10.1074/jbc.M113.511303. Epub 2013 Sep 30. 2013
4CUL1, SF3B3, SKP1, SKP2
Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130).
Cordero-Espinoza L, Hagen T.
Biol Open 2(8):838-44. doi: 10.1242/bio.20134374. eCollection 2013 Aug 15. 2013
5FBXO7, SKP1
Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease.
Mandel SA, Fishman-Jacob T, Youdim MB.
Neurodegener Dis 10(1-4):220-3. doi: 10.1159/000333223. Epub 2011 Dec 23. Review. 2012
6SKP1
Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease.
Mandel SA, Fishman-Jacob T, Youdim MB.
Parkinsonism Relat Disord 18 Suppl 1:S177-9. doi: 10.1016/S1353-8020(11)70055-4. 2012
7BRCA1, FBXO44, SKP1
The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.
Lu Y, Li J, Cheng D, Parameswaran B, Zhang S, Jiang Z, Yew PR, Peng J, Ye Q, Hu Y.
J Biol Chem 287(49):41014-22. doi: 10.1074/jbc.M112.407106. Epub 2012 Oct 18. 2012
8CUL1, DRG2, SKP1
SKP1-CULLIN1-F-box (SCF)-mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells.
Chen J, Shen BY, Deng XX, Zhan Q, Peng CH.
Biochem Biophys Res Commun 420(3):651-5. doi: 10.1016/j.bbrc.2012.03.058. Epub 2012 Mar 17. 2012
9FBXO2, FBXO6, SKP1
Skp1 stabilizes the conformation of F-box proteins.
Yoshida Y, Murakami A, Tanaka K.
Biochem Biophys Res Commun 410(1):24-8. doi: 10.1016/j.bbrc.2011.05.098. Epub 2011 May 24. 2011
10FBXO7, SKP1, XPO1
A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins.
Nelson DE, Laman H.
J Biol Chem 286(22):19804-15. doi: 10.1074/jbc.M111.220079. Epub 2011 Mar 4. 2011
11MIS12, SKP1
Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites.
Davies AE, Kaplan KB.
J Cell Biol 189(2):261-74. doi: 10.1083/jcb.200910036. 2010
12FBXO2, FBXO44, SKP1
Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.
Kumanomidou T, Nakagawa T, Mizushima T, Suzuki A, Tokunaga F, Iwai K, Yoshida Y, Tanaka K, Yamane T.
Acta Crystallogr Sect F Struct Biol Cryst Commun 66(Pt 1):95-8. doi: 10.1107/S1744309109050581. Epub 2009 Dec 25. 2010
13SKP1
A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A.
Fishman-Jacob T, Reznichenko L, Youdim MB, Mandel SA.
J Biol Chem 284(47):32835-45. Epub 2009 Sep 11.PMID: 19748892 2009
14CUL7, FBXW8, SKP1
The cullin7 E3 ubiquitin ligase: a novel player in growth control.
Sarikas A, Xu X, Field LJ, Pan ZQ.
Cell Cycle 7(20):3154-61. Epub 2008 Oct 4. Review.PMID: 18927510 2008
15CUL7, IRS1, SKP1
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
Xu X, Sarikas A, Dias-Santagata DC, Dolios G, Lafontant PJ, Tsai SC, Zhu W, Nakajima H, Nakajima HO, Field LJ, Wang R, Pan ZQ.
Mol Cell 30(4):403-14.PMID: 18498745 2008
16FBXO2, SKP1
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.
Nelson RF, Glenn KA, Zhang Y, Wen H, Knutson T, Gouvion CM, Robinson BK, Zhou Z, Yang B, Smith RJ, Paulson HL.
J Neurosci 27(19):5163-71. 2007
17CENPE, SKP1
Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis.
Liu D, Zhang N, Du J, Cai X, Zhu M, Jin C, Dou Z, Feng C, Yang Y, Liu L, Takeyasu K, Xie W, Yao X.
Biochem Biophys Res Commun 345(1):394-402. Epub 2006 Apr 25. 2006
18SKP1
Involvement of the SCF complex in the control of Cdh1 degradation in S-phase.
Benmaamar R, Pagano M.
Cell Cycle 4(9):1230-2. Epub 2005 Sep 20. 2005
19OCP1, SKP1
The cochlear F-box protein OCP1 associates with OCP2 and connexin 26.
Henzl MT, Thalmann I, Larson JD, Ignatova EG, Thalmann R.
Hear Res 191(1-2):101-9. 2004
20ELOC, SKP1
Identification of Elongin C and Skp1 sequences that determine Cullin selection.
Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW.
J Biol Chem 279(41):43019-26. Epub 2004 Jul 27. 2004
21FBXO2, SKP1
The cochlear F-box protein OCP1 associates with OCP2 and connexin 26.
Henzl MT, Thalmann I, Larson JD, Ignatova EG, Thalmann R.
Hear Res 191(1-2):101-9. 2004
22CDCA3, SKP1, WEE1
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW.
Cell 113(1):101-13. 2003
23CUL1, SKP1
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Piva R, Liu J, Chiarle R, Podda A, Pagano M, Inghirami G.
Mol Cell Biol 22(23):8375-87. 2002
24CUL1, RBX1, SKP1, SKP1B, SKP2
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.
Nature 416(6882):703-9. 2002
25SKP1, SKP1B, SKP2
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP.
Nature 408(6810):381-6. 2000
26CCNF, FBXL12, FBXL6, FBXO10, FBXO11, FBXO18, FBXO2, FBXO3, FBXO4, FBXO8, FBXW5, FBXW5, FBXW7, FBXW8, KDM2A, SHFM3P1, SKP1, TSPAN17
A family of mammalian F-box proteins.
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW.
Curr Biol 9(20):1180-2. 1999
27SKP1, SKP1B, SKP2
Characterization of the cullin and F-box protein partner Skp1.
Ng RW, Arooz T, Yam CH, Chan IW, Lau AW, Poon RY.
FEBS Lett 438 : 183-189. 1998
28SKP1, SKP1B, SKP2
Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2).
Demetrick DJ, et al.
Cytogenet Cell Genet 73 : 104-107. 1996
29SKP1, SKP1B, SKP2
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Bai C, et al.
Cell 86(2):263-74 1996
30SKP1, SKP1B, SKP2
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
Zhang H, Kobayashi R, Galaktionov K, Beach D.
Cell 82(6):915-25. 1995