Citations for
1SIX1, SIX2, SIX4
Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development.
Garcez RC, Le Douarin NM, Creuzet SE.
Cell Mol Life Sci 71(11):2149-64. doi: 10.1007/s00018-013-1477-z. Epub 2013 Sep 24. 2014
2EYA2, SIX1
Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R.
Nat Struct Mol Biol 20(4):447-53. doi: 10.1038/nsmb.2505. Epub 2013 Feb 24. 2013
3SIX1
Inhibition of Six1 promotes apoptosis, suppresses proliferation, and migration of osteosarcoma cells.
Hua L, Fan L, Aichun W, Yongjin Z, Qingqing C, Xiaojian W.
Tumour Biol umour Biol. 2013 Oct 11. [Epub ahead of print] 2013
4SIX1
The homoeobox gene SIX1 alters myosin heavy chain isoform expression in mouse skeletal muscle.
Hetzler KL, Collins BC, Shanely RA, Sue H, Kostek MC.
Acta Physiol (Oxf) cta Physiol (Oxf). 2013 Sep 18. doi: 10.1111/apha.12168. [Epub ahead of print] 2013
5SIX1, SIX4
Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R.
Dev Cell 26(4):416-30. doi: 10.1016/j.devcel.2013.06.018. 2013
6MYOD1, SIX1
Six1 regulates MyoD expression in adult muscle progenitor cells.
Liu Y, Chakroun I, Yang D, Horner E, Liang J, Aziz A, Chu A, De Repentigny Y, Dilworth FJ, Kothary R, Blais A.
PLoS One 8(6):e67762. doi: 10.1371/journal.pone.0067762. Print 2013. 2013
7EZH2, SIX1
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG.
Nat Genet 44(3):343-7. doi: 10.1038/ng.1068. 2012
8EYA2, SIX1
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties.
Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R, Ford HL.
Oncogene 31(5):552-62. doi: 10.1038/onc.2011.259. Epub 2011 Jun 27. 2012
9EYA2, MTOR, SIX1
Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy.
Lee SH, Kim J, Ryu JY, Lee S, Yang DK, Jeong D, Kim J, Lee SH, Kim JM, Hajjar RJ, Park WJ.
J Mol Cell Cardiol 52(3):718-26. doi: 10.1016/j.yjmcc.2011.12.002. Epub 2011 Dec 14. 2012
10SIX1
Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration.
Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, Maillet M, Pagès G, Rudnicki M, Tajbakhsh S, Maire P.
J Cell Biol 198(5):815-32. doi: 10.1083/jcb.201201050. 2012
11EYA1, NEUROD1, NEUROG1, SIX1
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Ahmed M, Xu J, Xu PX.
Development 139(11):1965-77. doi: 10.1242/dev.071670. Epub 2012 Apr 18. 2012
12GREM1, SIX1
Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis.
Nie X, Xu J, El-Hashash A, Xu PX.
Dev Biol 352(1):141-51. Epub 2011 Jan 31. 2011
13SIX1
Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.
El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D.
Dev Biol 353(2):242-58. Epub 2011 Mar 6. 2011
14EYA1, SIX1
Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development.
Wang C, Gargollo P, Guo C, Tang T, Mingin G, Sun Y, Li X.
Dev Biol 360(1):186-94. doi: 10.1016/j.ydbio.2011.09.020. Epub 2011 Sep 24. 2011
15SIX1, SIX4
Development of gustatory papillae in the absence of Six1 and Six4.
Suzuki Y, Ikeda K, Kawakami K.
J Anat 219(6):710-21. doi: 10.1111/j.1469-7580.2011.01435.x. Epub 2011 Oct 7. 2011
16SIX1, SIX4
Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P.
Dev Biol 359(2):303-20. doi: 10.1016/j.ydbio.2011.08.010. Epub 2011 Aug 22. 2011
17SIX1, TBX18
SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.
Nie X, Sun J, Gordon RE, Cai CL, Xu PX.
Development 137(5):755-65. Epub 2010 Jan 28. 2010
18BOR3, BOS3, SIX1
Biochemical and Functional Characterization of Six SIX1 Branchio-oto-renal Syndrome Mutations.
Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL.
J Biol Chem 284(31):20781-90. Epub 2009 Jun 4. 2009
19GBX2, SIX1, ZIC1
The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction.
Li B, Kuriyama S, Moreno M, Mayor R.
Development 136(19):3267-78. 2009
20SIX1, SIX4
Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4.
Chen B, Kim EH, Xu PX.
Dev Biol 326(1):75-85. doi: 10.1016/j.ydbio.2008.10.039. Epub 2008 Nov 7. 2009
21BOR3, BOS3, SIX1
SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR.
Kochhar A, Orten DJ, Sorensen JL, Fischer SM, Cremers CW, Kimberling WJ, Smith RJ.
Hum Mutat 29(4):565. 2008
22OTX2, SIX1, SIX6
Branchiootorenal syndrome and oculoauriculovertebral spectrum features associated with duplication of SIX1, SIX6, and OTX2 resulting from a complex chromosomal rearrangement.
Ou Z, Martin DM, Bedoyan JK, Cooper ML, Chinault AC, Stankiewicz P, Cheung SW.
Am J Med Genet A 146A(19):2480-9. 2008
23EYA1, BOR1, SIX1, BOS3
Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses.
Sanggaard KM, Rendtorff ND, Kjaer KW, Eiberg H, Johnsen T, Gimsing S, Dyrmose J, Nielsen KO, Lage K, Tranebjaerg L.
Eur J Hum Genet 15(11):1121-31. Epub 2007 Jul 18. 2007
24GDNF, SIX1, SIX4
Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.
Kobayashi H, Kawakami K, Asashima M, Nishinakamura R.
Mech Dev 124(4):290-303. Epub 2007 Jan 11. 2007
25SALL1,SIX1
Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development.
Chai L, Yang J, Di C, Cui W, Kawakami K, Lai R, Ma Y.
J Biol Chem 281(28):18918-26. Epub 2006 May 2. 2006
26SIX1
Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma.
Ng KT, Man K, Sun CK, Lee TK, Poon RT, Lo CM, Fan ST.
Br J Cancer 95(8):1050-5. Epub 2006 Sep 26. 2006
27SIX1, SIX4, SLC12A2
Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
Ando Z, Sato S, Ikeda K, Kawakami K.
FEBS J 272(12):3026-41. 2005
28SIX1, SIX4
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.
Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P.
Development 132(9):2235-49. Epub 2005 Mar 23. 2005
29SIX1, EZR
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
Nat Med 10(2):175-81. Epub 2004 Jan 04. 2004
30BOR3, BOS3, DFNA23, EYA1, SIX1
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.
Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM Jr, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F.
Proc Natl Acad Sci U S A 101(21):8090-5. Epub 2004 May 12. 2004
31EYA1, DACH1, SIX1
Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.
Ikeda K, Watanabe Y, Ohto H, Kawakami K.
Mol Cell Biol 22(19):6759-66. 2002
32SIX1
Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein.
Ford HL, Landesman-Bollag E, Dacwag CS, Stukenberg PT, Pardee AB, Seldin DC.
J Biol Chem 275(29):22245-54. 2000
33SIX1
Cloning of the human SIX1 gene and its assignment to chromosome 14.
Boucher CA, et al.
Genomics 33 : 140-142. 1996