| 1 | EYA1, SIX1
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| The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.
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| Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA.
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| Dev Cell 33(1):22-35. doi: 10.1016/j.devcel.2015.01.033. Epub 2015 Mar 26.
2015
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| 2 | SIX1, SIX2, SIX4
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| Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development.
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| Garcez RC, Le Douarin NM, Creuzet SE.
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| Cell Mol Life Sci 71(11):2149-64. doi: 10.1007/s00018-013-1477-z. Epub 2013 Sep 24.
2014
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| 3 | HDAC5, SIX1
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| HDAC5 promotes cell proliferation in human hepatocellular carcinoma by up-regulating Six1 expression.
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| Feng GW, Dong LD, Shang WJ, Pang XL, Li JF, Liu L, Wang Y.
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| Eur Rev Med Pharmacol Sci 18(6):811-6.
2014
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| 4 | EYA2, SIX1
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| Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
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| Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R.
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| Nat Struct Mol Biol 20(4):447-53. doi: 10.1038/nsmb.2505. Epub 2013 Feb 24.
2013
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| 5 | SIX1
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| Inhibition of Six1 promotes apoptosis, suppresses proliferation, and migration of osteosarcoma cells.
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| Hua L, Fan L, Aichun W, Yongjin Z, Qingqing C, Xiaojian W.
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| Tumour Biol umour Biol. 2013 Oct 11. [Epub ahead of print]
2013
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| 6 | SIX1
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| The homoeobox gene SIX1 alters myosin heavy chain isoform expression in mouse skeletal muscle.
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| Hetzler KL, Collins BC, Shanely RA, Sue H, Kostek MC.
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| Acta Physiol (Oxf) cta Physiol (Oxf). 2013 Sep 18. doi: 10.1111/apha.12168. [Epub ahead of print]
2013
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| 7 | SIX1, SIX4
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| Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
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| Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R.
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| Dev Cell 26(4):416-30. doi: 10.1016/j.devcel.2013.06.018.
2013
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| 8 | MYOD1, SIX1
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| Six1 regulates MyoD expression in adult muscle progenitor cells.
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| Liu Y, Chakroun I, Yang D, Horner E, Liang J, Aziz A, Chu A, De Repentigny Y, Dilworth FJ, Kothary R, Blais A.
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| PLoS One 8(6):e67762. doi: 10.1371/journal.pone.0067762. Print 2013.
2013
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| 9 | EZH2, SIX1
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| Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
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| Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG.
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| Nat Genet 44(3):343-7. doi: 10.1038/ng.1068.
2012
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| 10 | EYA2, SIX1
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| Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties.
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| Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R, Ford HL.
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| Oncogene 31(5):552-62. doi: 10.1038/onc.2011.259. Epub 2011 Jun 27.
2012
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| 11 | EYA2, MTOR, SIX1
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| Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy.
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| Lee SH, Kim J, Ryu JY, Lee S, Yang DK, Jeong D, Kim J, Lee SH, Kim JM, Hajjar RJ, Park WJ.
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| J Mol Cell Cardiol 52(3):718-26. doi: 10.1016/j.yjmcc.2011.12.002. Epub 2011 Dec 14.
2012
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| 12 | SIX1
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| Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration.
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| Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, Maillet M, Pagès G, Rudnicki M, Tajbakhsh S, Maire P.
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| J Cell Biol 198(5):815-32. doi: 10.1083/jcb.201201050.
2012
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| 13 | EYA1, NEUROD1, NEUROG1, SIX1
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| EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
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| Ahmed M, Xu J, Xu PX.
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| Development 139(11):1965-77. doi: 10.1242/dev.071670. Epub 2012 Apr 18.
2012
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| 14 | GREM1, SIX1
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| Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis.
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| Nie X, Xu J, El-Hashash A, Xu PX.
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| Dev Biol 352(1):141-51. Epub 2011 Jan 31.
2011
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| 15 | SIX1
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| Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.
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| El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D.
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| Dev Biol 353(2):242-58. Epub 2011 Mar 6.
2011
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| 16 | EYA1, SIX1
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| Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development.
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| Wang C, Gargollo P, Guo C, Tang T, Mingin G, Sun Y, Li X.
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| Dev Biol 360(1):186-94. doi: 10.1016/j.ydbio.2011.09.020. Epub 2011 Sep 24.
2011
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| 17 | SIX1, SIX4
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| Development of gustatory papillae in the absence of Six1 and Six4.
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| Suzuki Y, Ikeda K, Kawakami K.
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| J Anat 219(6):710-21. doi: 10.1111/j.1469-7580.2011.01435.x. Epub 2011 Oct 7.
2011
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| 18 | SIX1, SIX4
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| Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
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| Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P.
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| Dev Biol 359(2):303-20. doi: 10.1016/j.ydbio.2011.08.010. Epub 2011 Aug 22.
2011
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| 19 | SIX1, TBX18
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| SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.
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| Nie X, Sun J, Gordon RE, Cai CL, Xu PX.
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| Development 137(5):755-65. Epub 2010 Jan 28.
2010
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| 20 | EYA3, SIX1, TSHB
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| Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism.
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| Masumoto KH, Ukai-Tadenuma M, Kasukawa T, Nagano M, Uno KD, Tsujino K, Horikawa K, Shigeyoshi Y, Ueda HR.
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| Curr Biol 20(24):2199-206. doi: 10.1016/j.cub.2010.11.038. Epub 2010 Dec 2.
2010
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| 21 | BOR3, BOS3, SIX1
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| Biochemical and Functional Characterization of Six SIX1 Branchio-oto-renal Syndrome Mutations.
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| Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL.
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| J Biol Chem 284(31):20781-90. Epub 2009 Jun 4. 2009
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| 22 | GBX2, SIX1, ZIC1
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| The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction.
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| Li B, Kuriyama S, Moreno M, Mayor R.
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| Development 136(19):3267-78.
2009
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| 23 | SIX1, SIX4
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| Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4.
|
| Chen B, Kim EH, Xu PX.
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| Dev Biol 326(1):75-85. doi: 10.1016/j.ydbio.2008.10.039. Epub 2008 Nov 7.
2009
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| 24 | EYA3, MYOG, SIX1, SKI
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| Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.
|
| Zhang H, Stavnezer E.
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| J Biol Chem 284(5):2867-79. doi: 10.1074/jbc.M807526200. Epub 2008 Nov 12.
2009
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| 25 | BOR3, BOS3, SIX1
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| SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR.
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| Kochhar A, Orten DJ, Sorensen JL, Fischer SM, Cremers CW, Kimberling WJ, Smith RJ.
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| Hum Mutat 29(4):565. 2008
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| 26 | OTX2, SIX1, SIX6
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| Branchiootorenal syndrome and oculoauriculovertebral spectrum features associated with duplication of SIX1, SIX6, and OTX2 resulting from a complex chromosomal rearrangement.
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| Ou Z, Martin DM, Bedoyan JK, Cooper ML, Chinault AC, Stankiewicz P, Cheung SW.
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| Am J Med Genet A 146A(19):2480-9.
2008
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| 27 | EYA1, BOR1, SIX1, BOS3
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| Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses.
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| Sanggaard KM, Rendtorff ND, Kjaer KW, Eiberg H, Johnsen T, Gimsing S, Dyrmose J, Nielsen KO, Lage K, Tranebjaerg L.
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| Eur J Hum Genet 15(11):1121-31. Epub 2007 Jul 18. 2007
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| 28 | GDNF, SIX1, SIX4
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| Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.
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| Kobayashi H, Kawakami K, Asashima M, Nishinakamura R.
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| Mech Dev 124(4):290-303. Epub 2007 Jan 11.
2007
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| 29 | SALL1,SIX1
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| Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development.
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| Chai L, Yang J, Di C, Cui W, Kawakami K, Lai R, Ma Y.
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| J Biol Chem 281(28):18918-26. Epub 2006 May 2. 2006
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| 30 | SIX1
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| Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma.
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| Ng KT, Man K, Sun CK, Lee TK, Poon RT, Lo CM, Fan ST.
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| Br J Cancer 95(8):1050-5. Epub 2006 Sep 26. 2006
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| 31 | SIX1, SIX4, SLC12A2
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| Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
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| Ando Z, Sato S, Ikeda K, Kawakami K.
|
| FEBS J 272(12):3026-41.
2005
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| 32 | SIX1, SIX4
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| Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.
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| Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P.
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| Development 132(9):2235-49. Epub 2005 Mar 23.
2005
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| 33 | SIX1, EZR
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| Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
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| Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
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| Nat Med 10(2):175-81. Epub 2004 Jan 04. 2004
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| 34 | BOR3, BOS3, DFNA23, EYA1, SIX1
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| SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.
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| Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM Jr, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F.
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| Proc Natl Acad Sci U S A 101(21):8090-5. Epub 2004 May 12. 2004
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| 35 | EYA1, DACH1, SIX1
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| Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.
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| Ikeda K, Watanabe Y, Ohto H, Kawakami K.
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| Mol Cell Biol 22(19):6759-66. 2002
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| 36 | SIX1
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| Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein.
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| Ford HL, Landesman-Bollag E, Dacwag CS, Stukenberg PT, Pardee AB, Seldin DC.
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| J Biol Chem 275(29):22245-54.
2000
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| 37 | SIX1
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| Cloning of the human SIX1 gene and its assignment to chromosome 14.
|
| Boucher CA, et al.
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| Genomics 33 : 140-142. 1996
|