| 1 | SIRT3, SIRT4, SIRT5
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| Mitochondrial Sirtuins in Skin and Skin Cancers.
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| Su S, Ndiaye M, Singh CK, Ahmad N.
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| Photochem Photobiol hotochem Photobiol. 2020 Mar 3. doi: 10.1111/php.13254. [Epub ahead of print] Review.
2020
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| 2 | SIRT3, SIRT4, SIRT5
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| Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.
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| Sejour R, Sanguino RA, Mikolajczak M, Ahmadi W, Villa-Cuesta E.
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| G3 (Bethesda) 10(5):1599-1612. doi: 10.1534/g3.120.401174.
2020
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| 3 | MIPEP, SIRT3
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| Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.
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| Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y.
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| FEBS Lett 591(24):4067-4073. doi: 10.1002/1873-3468.12914. Epub 2017 Nov 28.
2017
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| 4 | GOT2, SIRT3
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| SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
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| Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan KL, Xiong Y, Ye D.
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| EMBO J 34(8):1110-25. doi: 10.15252/embj.201591041. Epub 2015 Mar 9.
2015
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| 5 | HSPE1, SIRT3
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| Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.
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| Lu Z, Chen Y, Aponte AM, Battaglia V, Gucek M, Sack MN.
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| J Biol Chem 290(4):2466-76. doi: 10.1074/jbc.M114.606228. Epub 2014 Dec 12.
2015
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| 6 | SIRT3
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| Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis.
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| Dai SH, Chen T, Wang YH, Zhu J, Luo P, Rao W, Yang YF, Fei Z, Jiang XF.
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| Int J Mol Sci 15(8):14591-609. doi: 10.3390/ijms150814591.
2014
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| 7 | FOXO3, SIRT3
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| SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia.
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| Tseng AH, Wu LH, Shieh SS, Wang DL.
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| Biochem J iochem J. 2014 Aug 27. [Epub ahead of print]
2014
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| 8 | LONP1, SIRT3
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| Sirtuin 3 interacts with Lon protease and regulates its acetylation status.
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| Gibellini L, Pinti M, Beretti F, Pierri CL, Onofrio A, Riccio M, Carnevale G, De Biasi S, Nasi M, Torelli F, Boraldi F, De Pol A, Cossarizza A.
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| Mitochondrion itochondrion. 2014 Aug 13. pii: S1567-7249(14)00116-0. doi: 10.1016/j.mito.2014.08.001. [Epub ahead of print]
2014
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| 9 | SIRT3
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| Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.
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| Chen Y, Fu LL, Wen X, Wang XY, Liu J, Cheng Y, Huang J.
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| Cell Death Dis 5:e1047. doi: 10.1038/cddis.2014.14. Review.
2014
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| 10 | SIRT3
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| Sirt3 controls chromosome alignment by regulating spindle dynamics during mitosis.
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| Choi BS, Park JE, Jang CY.
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| Biochem Biophys Res Commun 444(4):662-9. doi: 10.1016/j.bbrc.2014.01.124. Epub 2014 Feb 1.
2014
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| 11 | FOXO3, SIRT3
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| SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.
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| Tseng AH, Shieh SS, Wang DL.
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| Free Radic Biol Med 63:222-34. doi: 10.1016/j.freeradbiomed.2013.05.002. Epub 2013 May 7.
2013
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| 12 | SIRT3
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| The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation.
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| Bause AS, Matsui MS, Haigis MC.
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| J Biol Chem 288(51):36484-91. doi: 10.1074/jbc.M113.472324. Epub 2013 Nov 5.
2013
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| 13 | OGG1, SIRT3
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| Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.
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| Cheng Y, Ren X, Gowda AS, Shan Y, Zhang L, Yuan YS, Patel R, Wu H, Huber-Keener K, Yang JW, Liu D, Spratt TE, Yang JM.
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| Cell Death Dis 4:e731. doi: 10.1038/cddis.2013.254.
2013
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| 14 | SIRT3
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| Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.
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| Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR.
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| Diabetes 62(10):3404-17. doi: 10.2337/db12-1650. Epub 2013 Jul 8.
2013
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| 15 | IDH2, SIRT3
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| SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
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| Yu W, Dittenhafer-Reed KE, Denu JM.
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| J Biol Chem 287(17):14078-86. doi: 10.1074/jbc.M112.355206. Epub 2012 Mar 13.
2012
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| 16 | SIRT3
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| SIRT3 functions in the nucleus in the control of stress-related gene expression.
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| Iwahara T, Bonasio R, Narendra V, Reinberg D.
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| Mol Cell Biol 32(24):5022-34. doi: 10.1128/MCB.00822-12. Epub 2012 Oct 8.
2012
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| 17 | SIRT3
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| SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.
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| D'Aquila P, Rose G, Panno ML, Passarino G, Bellizzi D.
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| Gene 497(2):323-9. doi: 10.1016/j.gene.2012.01.042. Epub 2012 Jan 27.
2012
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| 18 | SIRT3
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| Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
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| Wagner GR, Pride PM, Babbey CM, Payne RM.
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| Hum Mol Genet 21(12):2688-97. doi: 10.1093/hmg/dds095. Epub 2012 Mar 6.
2012
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| 19 | SIRT3
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| Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
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| Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR.
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| Biochem J 433(3):505-14.
2011
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| 20 | SIRT3
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| SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.
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| Bell EL, Emerling BM, Ricoult SJ, Guarente L.
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| Oncogene 30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28.
2011
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| 21 | SIRT3
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| SIRT3 deacetylase: the Jekyll and Hyde sirtuin.
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| Silberman DM, Mostoslavsky R.
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| EMBO Rep 12(8):746-7. doi: 10.1038/embor.2011.147. No abstract available.
2011
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| 22 | SIRT3
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| Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
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| Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR.
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| Proc Natl Acad Sci U S A 108(35):14608-13. Epub 2011 Aug 22.
2011
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| 23 | SIRT3
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| Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.
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| Yoshino J, Imai S.
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| Mol Cell 44(2):170-1. doi: 10.1016/j.molcel.2011.10.005.
2011
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| 24 | SIRT3
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| SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
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| Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, Verdin E.
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| Mol Cell 44(2):177-90. doi: 10.1016/j.molcel.2011.07.019.
2011
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| 25 | SIRT3, SOD2
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| Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.
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| Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, Xiong Y.
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| EMBO Rep 12(6):534-41. doi: 10.1038/embor.2011.65. Epub 2011 May 13.
2011
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| 26 | SDHA, SDHB, SIRT3
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| Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.
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| Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC.
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| PLoS One 6(8):e23295. doi: 10.1371/journal.pone.0023295. Epub 2011 Aug 17.
2011
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| 27 | SDHA, SIRT3
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| Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria.
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| Cimen H, Han MJ, Yang Y, Tong Q, Koc H, Koc EC.
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| Biochemistry 49(2):304-11.PMID: 20000467 2010
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| 28 | SIRT3
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| SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.
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| Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D.
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| Cancer Cell 17(1):41-52.PMID: 20129246 2010
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| 29 | MRPL10, SIRT3, SIRT4
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| NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.
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| Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC.
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| J Biol Chem 285(10):7417-29. Epub 2009 Dec 30.PMID: 20042612 2010
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| 30 | IDH2, SIRT3
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| Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
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| Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA.
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| Cell 143(5):802-12.
2010
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| 31 | SIRT3, SOD2
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| Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
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| Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D.
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| Mol Cell 40(6):893-904. doi: 10.1016/j.molcel.2010.12.013.
2010
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| 32 | SIRT1, SIRT3
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| Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
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| Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y.
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| Proteomics 9(9):2444-56.PMID: 19343720 2009
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| 33 | SIRT3, SIRT4, SIRT5
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| Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
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| Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C.
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| J Mol Biol 382(3):790-801. Epub 2008 Jul 25.
2008
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| 34 | SIRT3, SIRT4, SIRT5
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| Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
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| Nakamura Y, Ogura M, Tanaka D, Inagaki N.
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| Biochem Biophys Res Commun 366(1):174-9. Epub 2007 Dec 3.
2008
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| 35 | FOXO3A, SIRT3
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| SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.
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| Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D.
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| Int J Biol Sci 4(5):291-9.PMID: 18781224 2008
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| 36 | SIRT3, XRCC6
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| SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
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| Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP.
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| Mol Cell Biol 28(20):6384-401. Epub 2008 Aug 18.PMID: 18710944 2008
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| 37 | SIRT3
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| The human SIRT3 protein deacetylase is exclusively mitochondrial.
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| Cooper HM, Spelbrink JN.
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| Biochem J 411(2):279-85.PMID: 18215119 2008
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| 38 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7, SIRT8
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| Sirtuins: critical regulators at the crossroads between cancer and aging.
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| Saunders LR, Verdin E.
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| Oncogene 26(37):5489-504. Review.
2007
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| 39 | SIRT3
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| Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
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| Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B.
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| Mol Cell Biol 27(24):8807-14. Epub 2007 Oct 8.PMID: 17923681 2007
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| 40 | SIRT3
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| A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.
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| Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, Greco V, Maggiolini M, Feraco E, Mari V, Franceschi C, Passarino G, De Benedictis G.
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| Genomics 85(2):258-63. 2005
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| 41 | SIRT3
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| SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes.
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| Shi T, Wang F, Stieren E, Tong Q.
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| J Biol Chem 280(14):13560-7. Epub 2005 Jan 14. 2005
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| 42 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
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| Araki T, Sasaki Y, Milbrandt J.
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| Science 305(5686):1010-3. 2004
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| 43 | SIRT3
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| SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
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| Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP.
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| Proc Natl Acad Sci U S A 99(21):13653-8. 2002
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| 44 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
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| Frye RA.
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| Biochem Biophys Res Commun 273(2):793-8. 2000
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| 45 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
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| Frye RA.
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| Biochem Biophys Res Commun 260(1):273-9. 1999
|