1 | SIGMAR1
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| Characterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactions.
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| Ortega-Roldan JL, Ossa F, Schnell JR.
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| J Biol Chem 288(29):21448-57. doi: 10.1074/jbc.M113.450379. Epub 2013 Jun 12.
2013
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2 | IL24, SIGMAR1
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| Sigma 1 Receptor plays a prominent role in IL-24-induced cancer-specific apoptosis.
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| Do W, Herrera C, Mighty J, Shumskaya M, Redenti SM, Sauane M.
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| Biochem Biophys Res Commun 439(2):215-20. doi: 10.1016/j.bbrc.2013.08.057. Epub 2013 Aug 26.
2013
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3 | SIGMAR1
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| Lack of sigma-1 receptor exacerbates ALS progression in mice.
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| Mavlyutov TA, Epstein ML, Verbny YI, Huerta MS, Zaitoun I, Ziskind-Conhaim L, Ruoho AE.
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| Neuroscience 240:129-34. doi: 10.1016/j.neuroscience.2013.02.035. Epub 2013 Feb 28.
2013
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4 | ALS16, SIGMAR1
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| Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis.
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| Prause J, Goswami A, Katona I, Roos A, Schnizler M, Bushuven E, Dreier A, Buchkremer S, Johann S, Beyer C, Deschauer M, Troost D, Weis J.
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| Hum Mol Genet 22(8):1581-600. doi: 10.1093/hmg/ddt008. Epub 2013 Jan 11.
2013
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5 | SIGMAR1
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| The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.
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| Pal A, Fontanilla D, Gopalakrishnan A, Chae YK, Markley JL, Ruoho AE.
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| Eur J Pharmacol 682(1-3):12-20. doi: 10.1016/j.ejphar.2012.01.030. Epub 2012 Feb 22.
2012
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6 | ADAM10, ADAM17, SIGMAR1
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| Overexpression of sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro.
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| Li J, Liu B, Gao X, Ma Z, CaoSong T, Mei YA, Zheng Y.
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| Protein Cell 3(2):153-9. doi: 10.1007/s13238-012-2006-9. Epub 2012 Feb 9. Erratum in: Protein Cell. 2012 May;3(5):400.
2012
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7 | SIGMAR1
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| Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis.
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| Shioda N, Ishikawa K, Tagashira H, Ishizuka T, Yawo H, Fukunaga K.
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| J Biol Chem 287(28):23318-31. doi: 10.1074/jbc.M112.349142. Epub 2012 May 22.
2012
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8 | ALS16, SIGMAR1
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| A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.
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| Al-Saif A, Al-Mohanna F, Bohlega S.
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| Ann Neurol 70(6):913-9. doi: 10.1002/ana.22534. Epub 2011 Aug 12.
2011
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9 | ALS16, SIGMAR1
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| SIGMAR1 mutations, genetic heterogeneity at the chromosome 9p locus, and the expanding etiological diversity of amyotrophic lateral sclerosis.
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| Fecto F, Siddique T.
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| Ann Neurol 70(6):867-70. doi: 10.1002/ana.22648. No abstract available.
2011
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10 | SIGMAR1
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| Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).
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| Ha Y, Saul A, Tawfik A, Williams C, Bollinger K, Smith R, Tachikawa M, Zorrilla E, Ganapathy V, Smith SB.
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| Invest Ophthalmol Vis Sci 52(10):7749-60. doi: 10.1167/iovs.11-8169.
2011
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11 | HSPA5, SIGMAR1, SRR
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| Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.
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| Ha Y, Dun Y, Thangaraju M, Duplantier J, Dong Z, Liu K, Ganapathy V, Smith SB.
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| Invest Ophthalmol Vis Sci 52(1):527-40. doi: 10.1167/iovs.10-5731. Print 2011 Jan. 2011
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12 | SIGMAR1
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| Expression of sigma receptor 1 mRNA and protein in rat retina.
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| Liu LL, Wang L, Zhong YM, Yang XL.
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| Neuroscience 167(4):1151-9. doi: 10.1016/j.neuroscience.2010.03.006. Epub 2010 Mar 9.
2010
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13 | DRD1, SIGMAR1
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| Sigma-1 receptors amplify dopamine D1 receptor signaling at presynaptic sites in the prelimbic cortex.
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| Fu Y, Zhao Y, Luan W, Dong LY, Dong Y, Lai B, Zhu Y, Zheng P.
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| Biochim Biophys Acta 1803(12):1396-408. doi: 10.1016/j.bbamcr.2010.08.005. Epub 2010 Aug 20.
2010
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14 | SIGMAR1
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| Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction.
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| Tchedre KT, Huang RQ, Dibas A, Krishnamoorthy RR, Dillon GH, Yorio T.
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| Invest Ophthalmol Vis Sci 49(11):4993-5002. doi: 10.1167/iovs.08-1867. Epub 2008 Jul 18.
2008
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15 | SIGMAR1
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| Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
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| Hayashi T, Su TP.
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| Cell 131(3):596-610.
2007
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16 | SIGMAR1
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| Silencing of sigma-1 receptor induces cell death in human lens cells.
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| Wang L, Duncan G.
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| Exp Cell Res 312(8):1439-46. Epub 2006 Feb 9.
2006
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17 | SIGMAR1
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| Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system.
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| Palacios G, Muro A, Vela JM, Molina-Holgado E, Guitart X, Ovalle S, Zamanillo D.
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| Brain Res 961(1):92-9.
2003
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18 | SIGMAR1
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| Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina
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| Shamsul Ola M, Moore P, El-Sherbeny A, Roon P, Agarwal N, Sarthy VP, Casellas P, Ganapathy V, Smith SB.
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| Brain Res Mol Brain Res 95(1-2):86-95. 2001
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19 | DEL3PD, SIGMAR1
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| Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene
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| Prasad PD, Li HW, Fei YJ, Ganapathy ME, Fujita T, Plumley LH, Yang-Feng TL, Leibach FH, Ganapathy V.
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| J Neurochem 70(2):443-51. 1998
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20 | SIGMAR1
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| Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)
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| Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V.
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| Biochem Biophys Res Commun 229(2):553-8. 1996
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21 | SIGMAR1
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| 41.
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| The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex.
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| Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Ta hi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Tak
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