| 1 | NANOS1, NANOS3, SIAH1
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| PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues
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| Sajek M, Janecki DM, Smialek MJ, Ginter-Matuszewska B, Spik A, Oczkowski S, Ilaslan E, Kusz-Zamelczyk K, Kotecki M, Blazewicz J, Jaruzelska J
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| Cell Mol Life Sci. Jan;76(1):147-161. doi: 10.1007/s00018-018-2926-5. Epub 2018 Sep 29. 2019
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| 2 | SIAH1, SIAH2, USP19
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| The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.
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| Zhang Q, Wang Z, Hou F, Harding R, Huang X, Dong A, Walker JR, Tong Y.
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| Biochim Biophys Acta Gen Subj 1861(1 Pt A):3095-3105. doi: 10.1016/j.bbagen.2016.10.019. Epub 2016 Oct 21.
2017
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| 3 | GAPDH, SIAH1
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| High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1.
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| Suarez S, McCollum GW, Jayagopal A, Penn JS.
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| J Biol Chem 290(47):28311-20. doi: 10.1074/jbc.M115.682385. Epub 2015 Oct 5.
2015
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| 4 | SIAH1, SIAH2
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| The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.
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| Knauer SK, Mahendrarajah N, Roos WP, Krämer OH.
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| Cytokine Growth Factor Rev 26(4):405-13. doi: 10.1016/j.cytogfr.2015.04.002. Epub 2015 May 12.
2015
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| 5 | CDK2, KLF10, SIAH1
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| CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1.
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| Lin CH, Lin SY, Chang HW, Ko LJ, Tseng YS, Chang VH, Yu WC.
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| Biochim Biophys Acta 1853(5):1174-81. doi: 10.1016/j.bbamcr.2015.02.018. Epub 2015 Feb 26.
2015
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| 6 | GAPDH, MAP3K5, SIAH1
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| Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade.
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| Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A.
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| J Biol Chem 290(1):56-64. doi: 10.1074/jbc.M114.596205. Epub 2014 Nov 12.
2015
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| 7 | SIAH1
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| glucose and hypoxia.
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| Zhao Y, Li Q, Jin A, Cui M, Liu X.
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| Am J Transl Res 7(1):15-27. eCollection 2015.
2015
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| 8 | SIAH1, SIAH2
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| Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.
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| Gopalsamy A, Hagen T, Swaminathan K.
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| PLoS One 9(9):e106547. doi: 10.1371/journal.pone.0106547. eCollection 2014.
2014
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| 9 | COPS5, CTNNB1, SIAH1
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| The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells.
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| Jumpertz S, Hennes T, Asare Y, Vervoorts J, Bernhagen J, Schütz AK.
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| Cell Signal 26(9):2051-9. doi: 10.1016/j.cellsig.2014.05.013. Epub 2014 May 29.
2014
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| 10 | CDKN1B, COPS5, EXOC3, SIAH1
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| Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1.
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| Tanaka T, Iino M.
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| Cell Signal 26(10):2071-85. doi: 10.1016/j.cellsig.2014.06.003. Epub 2014 Jun 18.
2014
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| 11 | SIAH1, TNK2
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| SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.
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| Buchwald M, Pietschmann K, Brand P, Günther A, Mahajan NP, Heinzel T, Krämer OH.
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| Oncogene 32(41):4913-20. doi: 10.1038/onc.2012.515. Epub 2012 Dec 3.
2013
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| 12 | SIAH1
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| Two high-resolution structures of the human E3 ubiquitin ligase Siah1.
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| Rimsa V, Eadsforth TC, Hunter WN.
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| Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 12):1339-43. doi: 10.1107/S1744309113031448. Epub 2013 Nov 28.
2013
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| 13 | SIAH1, SIAH2, USP19
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| An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.
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| Velasco K, Zhao B, Callegari S, Altun M, Liu H, Hassink G, Masucci MG, Lindsten K.
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| Biochem Biophys Res Commun 433(4):390-5. doi: 10.1016/j.bbrc.2013.02.094. Epub 2013 Mar 13.
2013
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| 14 | ELL2, SIAH1
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| The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.
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| Liu M, Hsu J, Chan C, Li Z, Zhou Q.
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| Mol Cell 46(3):325-34. doi: 10.1016/j.molcel.2012.03.007. Epub 2012 Apr 5.
2012
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| 15 | GAPDH, NPM1, RILPL1, SIAH1
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| S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade.
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| Lee SB, Kim CK, Lee KH, Ahn JY.
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| J Cell Biol 199(1):65-76. doi: 10.1083/jcb.201205015.
2012
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| 16 | SEPTIN4, SIAH1
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| ARTS and Siah collaborate in a pathway for XIAP degradation.
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| Garrison JB, Correa RG, Gerlic M, Yip KW, Krieg A, Tamble CM, Shi R, Welsh K, Duggineni S, Huang Z, Ren K, Du C, Reed JC.
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| Mol Cell 41(1):107-16. Epub 2010 Dec 23. 2011
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| 17 | EEF1D, SIAH1
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| Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.
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| Wu H, Shi Y, Lin Y, Qian W, Yu Y, Huo K.
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| Mol Cell Biochem 357(1-2):209-15. doi: 10.1007/s11010-011-0891-5. Epub 2011 Jun 3.
2011
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| 18 | GAPDH, SIAH1
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| siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller cells.
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| Yego EC, Mohr S.
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| J Biol Chem 285(5):3181-90. Epub 2009 Nov 23.PMID: 19940145 2010
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| 19 | PARD3, SIAH1
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| Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
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| Famulski JK, Trivedi N, Howell D, Yang Y, Tong Y, Gilbertson R, Solecki DJ.
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| Science 330(6012):1834-8. Epub 2010 Nov 25.
2010
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| 20 | SIAH1
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| SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells.
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| Wen YY, Yang ZQ, Song M, Li BL, Zhu JJ, Wang EH.
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| Cancer Sci 101(1):73-9. Epub 2009 Sep 2.
2010
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| 21 | PHC2, SIAH1
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| SIAH-1 interacts with mammalian polyhomeotic homologues HPH2 and affects its stability via the ubiquitin-proteasome pathway.
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| Wu H, Lin Y, Shi Y, Qian W, Tian Z, Yu Y, Huo K.
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| Biochem Biophys Res Commun 397(3):391-6. doi: 10.1016/j.bbrc.2010.05.024. Epub 2010 May 22.
2010
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| 22 | KIF22, SIAH1
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| Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes.
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| Bruzzoni-Giovanelli H, Fernandez P, Veiga L, Podgorniak MP, Powell DJ, Candeias MM, Mourah S, Calvo F, Marín M.
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| J Exp Clin Cancer Res 29:10. doi: 10.1186/1756-9966-29-10.
2010
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| 23 | SIAH1
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| Inhibition of Siah ubiquitin ligase function.
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| Möller A, House CM, Wong CS, Scanlon DB, Liu MC, Ronai Z, Bowtell DD.
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| Oncogene 28(2):289-96. Epub 2008 Oct 13.
2009
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| 24 | SIAH1, SNCA
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| Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.
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| Lee JT, Wheeler TC, Li L, Chin LS.
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| Hum Mol Genet 17(6):906-17. Epub 2007 Dec 7. 2008
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| 25 | SIAH1, TRIB3
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| E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.
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| Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F.
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| Cell Signal 20(5):942-8. Epub 2008 Jan 24.PMID: 18276110 2008
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| 26 | HIF1AN, SIAH1
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| Abundance of aspargynyl-hydroxylase FIH is regulated by Siah-1 under normoxic conditions.
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| Fukuba H, Takahashi T, Jin HG, Kohriyama T, Matsumoto M.
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| Neurosci Lett 433(3):209-14. Epub 2008 Jan 20.
2008
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| 27 | SIAH1
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| Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin.
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| Mei Y, Xie C, Xie W, Wu Z, Wu M.
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| Oncogene 26(43):6319-31. Epub 2007 Apr 9. 2007
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| 28 | SIAH1, SH3RF1
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| Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.
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| Xu Z, Sproul A, Wang W, Kukekov N, Greene LA.
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| J Biol Chem 281(1):303-12. Epub 2005 Oct 17. 2006
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| 29 | SNCA, SNCAIP, SIAH1, SIAH2
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| Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.
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| Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.
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| Proc Natl Acad Sci U S A 101(15):5500-5. Epub 2004 Apr 02. 2004
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| 30 | KHDRBS3, SIAH1
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| SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome.
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| Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, Sette C, Jones KT, Elliott DJ.
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| Hum Mol Genet 13(14):1525-34. Epub 2004 May 26. 2004
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| 31 | SIAH1, SIAH2, AFF2, AFF1
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| Mediation of Af4 protein function in the cerebellum by Siah proteins.
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| Oliver PL, Bitoun E, Clark J, Jones EL, Davies KE.
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| Proc Natl Acad Sci U S A 101(41):14901-6. Epub 2004 Sep 30. 2004
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| 32 | SIAH1
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| Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner.
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| Iwai A, Marusawa H, Matsuzawa S, Fukushima T, Hijikata M, Reed JC, Shimotohno K, Chiba T.
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| Oncogene 23(45):7593-600. 2004
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| 33 | SIAH1
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| SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas.
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| Matsuo K, Satoh S, Okabe H, Nomura A, Maeda T, Yamaoka Y, Ikai I.
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| Genes Chromosomes Cancer 36(3):283-91. 2003
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| 34 | SIAH1, RBBP8
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| SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.
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| Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H.
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| Oncogene 22(55):8845-51. 2003
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| 35 | SIAH1
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| The characterization of the human Siah-1 promoter(1).
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| Maeda A, Yoshida T, Kusuzaki K, Sakai T.
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| FEBS Lett 512(1-3):223-6. 2002
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| 36 | POU2AF1, SIAH1
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| The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.
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| Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P.
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| EMBO J 20(15):4143-52. 2001
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| 37 | POU2AF1, SIAH1, SIAH2
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| Regulation of BOB.1/OBF.1 stability by SIAH.
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| Boehm J, He Y, Greiner A, Staudt L, Wirth T.
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| EMBO J 20(15):4153-62. 2001
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| 38 | SIAH1
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| SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21 (Waf1).
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| Roperch JP, et al.
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| Proc Natl Acad Sci U S A 96(14):8070-3. 1999
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| 39 | BRCA1, MKRN1, MKRN2, MKRN3, MKRNP1, MKRNP2, MKRNP3, MKRNP4, MKRNP5, MKRNP6, RNF139, SIAH1, SIAH2
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| RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.
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| Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM.
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| Proc Natl Acad Sci U S A 96(20):11364-9 1999
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| 40 | SIAH1, SIAH2
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| Characterization of human homologs of the Drosophila seven in absentia (sina) gene.
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| Hu G, Chung YL, Glover T, Valentine V, Look AT, Fearon ER.
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| Genomics 46(1):103-11. 1997
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| 41 | SIAH1
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| Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.
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| Nemani M, et al.
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| Proc Natl Acad Sci U S A 93 : 9039-9042. 1996
|