| 1 | MRAS, NS11, PPP1CB, SHOC2
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| SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
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| Young LC, Hartig N, Boned Del Río I, Sari S, Ringham-Terry B, Wainwright JR, Jones GG, McCormick F, Rodriguez-Viciana P.
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| Proc Natl Acad Sci U S A. Nov 6;115(45):E10576-E10585. doi: 10.1073/pnas.1720352115. Epub 2018 Oct 22 2018
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| 2 | MRAS, NS11, SHOC2
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| Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy
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| Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ
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| JCI Insight Mar 9;2(5):e91225. doi: 10.1172/jci.insight.91225. 2017
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| 3 | ERBIN, SHOC2
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| Erbin is a negative modulator of cardiac hypertrophy.
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| Rachmin I, Tshori S, Smith Y, Oppenheim A, Marchetto S, Kay G, Foo RS, Dagan N, Golomb E, Gilon D, Borg JP, Razin E.
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| Proc Natl Acad Sci U S A 111(16):5902-7. doi: 10.1073/pnas.1320350111.
2014
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| 4 | NLLAH, SHOC2
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| Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies.
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| Komatsuzaki S, Aoki Y, Niihori T, Okamoto N, Hennekam RC, Hopman S, Ohashi H, Mizuno S, Watanabe Y, Kamasaki H, Kondo I, Moriyama N, Kurosawa K, Kawame H, Okuyama R, Imaizumi M, Rikiishi T, Tsuchiya S, Kure S, Matsubara Y.
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| J Hum Genet 55(12):801-9. Epub 2010 Sep 30.
2010
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| 5 | NLLAH, SHOC2
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| Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
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| Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M.
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| Nat Genet 41(9):1022-6. Epub 2009 Aug 16.PMID: 19684605 2009
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| 6 | SHOC2
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| A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
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| Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F.
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| Mol Cell 22(2):217-30.PMID: 16630891 2006
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| 7 | ERBIN, SHOC2
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| Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.
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| Dai P, Xiong WC, Mei L.
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| J Biol Chem 281(2):927-33. Epub 2005 Nov 21.PMID: 16301319 2006
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| 8 | SHOC2
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| soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
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| Selfors LM, et al.
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| Proc Natl Acad Sci U S A 95 : 6903-6908. 1998
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| 9 | SHOC2
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| SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
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| Sieburth DS, Sun Q, Han M.
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| Cell 94(1):119-30.PMID: 9674433 1998
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