| 1 | ACVR1, GDF11, MRPL53, RORA, SHH
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| Variant Analyses of Candidate Genes in Orofacial Clefts in Multi-Ethnic Populations.
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| Li M, Olotu J, Buxo-Martinez CJ, Mossey PA, Anand D, Busch T, Alade A, Gowans LJJ, Eshete M, Adeyemo WL, Naicker T, Awotoye WO, Gupta S, Adeleke C, Bravo V, Huang S, Adamson OO, Toraño AM, Bello CA, Soto M, Soto M, Ledesma R, Marquez M, Cordero JF, Lopez-Del Valle LM, Salcedo MI, Debs N, Petrin A, Malloy H, Elhadi K, James O, Ogunlewe MO, Abate F, Hailu A, Mohammed I, Gravem P, Deribew M, Gesses M, Hassan M, Pape J, Obiri-Yeboah S, Arthur FKN, Oti AA, Donkor P, Marazita ML, Lachke SA, Adeyemo AA, Murray JC, Butali A.
|
| Oral Dis. Jun 1. doi: 10.1111/odi.13932. Epub ahead of print. 2021
|
| 2 | IHH, SHH
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| Synergistic effects of Indian hedgehog and sonic hedgehog on chondrogenesis during cartilage repair.
|
| Chen L, Liu G, Li W, Wu X.
|
| J Mol Histol. Apr;52(2):407-418. doi: 10.1007/s10735-021-09964-2. Epub 2021 Feb 17 2021
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| 3 | FGF8, SHH
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| FGF8 and Shh promote the survival and maintenance of multipotent neural crest progenitors.
|
| da Costa MC, Trentin AG, Calloni GW.
|
| Mech Dev 154:251-258. doi: 10.1016/j.mod.2018.07.012. Epub 2018 Aug 1.
2018
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| 4 | NODAL, SHH, TGFB1, TGIF1, TGIF2
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| Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.
|
| Wotton D, Taniguchi K.
|
| Am J Med Genet C Semin Med Genet 178(2):128-139. doi: 10.1002/ajmg.c.31612. Epub 2018 May 11.
2018
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| 5 | IHH, SHH
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| The Hedgehog signalling pathway in bone formation.
|
| Yang J, Andre P, Ye L, Yang YZ.
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| Int J Oral Sci. Jun 26;7(2):73-9. doi: 10.1038/ijos.2015.14. 2015
|
| 6 | BMP7, SHH
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| Axon guidance effects of classical morphogens Shh and BMP7 in the hypothalamo-pituitary system.
|
| Liu F, Placzek M.
|
| Neurosci Lett 562:108-13. Erratum in: Neurosci Lett. 2014 Mar 6;562:107.
2014
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| 7 | GLI1, S100A14, SHH
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| Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells.
|
| Xu X, Su B, Xie C, Wei S, Zhou Y, Liu H, Dai W, Cheng P, Wang F, Xu X, Guo C.
|
| PLoS One 9(7):e96441. doi: 10.1371/journal.pone.0096441. eCollection 2014.
2014
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| 8 | HHIP, SHH
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| Single-nucleotide variants in two Hedgehog genes, SHH and HHIP, as genetic cause of combined pituitary hormone deficiency.
|
| Gorbenko del Blanco D, de Graaff LC, Visser TJ, Hokken-Koelega AC.
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| Clin Endocrinol (Oxf) 78(3):415-23. doi: 10.1111/cen.12000.
2013
|
| 9 | GREM1, SHH, TWIST2
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| Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.
|
| Wade C, Brinas I, Welfare M, Wicking C, Farlie PG.
|
| Dev Biol 370(1):145-53. doi: 10.1016/j.ydbio.2012.07.025. Epub 2012 Aug 1.
2012
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| 10 | SHH
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| Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.
|
| Hardy RY, Resh MD.
|
| J Biol Chem 287(51):42881-9. doi: 10.1074/jbc.M112.426833. Epub 2012 Oct 30.
2012
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| 11 | APP, PTCH1, SHH, TRI21
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| APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
|
| Trazzi S, Mitrugno VM, Valli E, Fuchs C, Rizzi S, Guidi S, Perini G, Bartesaghi R, Ciani E.
|
| Hum Mol Genet 20(8):1560-73. Epub 2011 Jan 25.
2011
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| 12 | SHH
|
| The regulation of tooth morphogenesis is associated with epithelial cell proliferation and the expression of Sonic hedgehog through epithelial-mesenchymal interactions.
|
| Ishida K, Murofushi M, Nakao K, Morita R, Ogawa M, Tsuji T.
|
| Biochem Biophys Res Commun 405(3):455-61. Epub 2011 Jan 19.
2011
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| 13 | SHH, VEGFA
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| Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.
|
| Chen W, Tang T, Eastham-Anderson J, Dunlap D, Alicke B, Nannini M, Gould S, Yauch R, Modrusan Z, DuPree KJ, Darbonne WC, Plowman G, de Sauvage FJ, Callahan CA.
|
| Proc Natl Acad Sci U S A 108(23):9589-94. Epub 2011 May 19.
2011
|
| 14 | GLI3, SHH
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| Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.
|
| Rash BG, Grove EA.
|
| Dev Biol. 359(2):242-50 2011
|
| 15 | MMDW, SHH
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| A specific mutation in the distant sonic hedgehog (SHH) cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZRS duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb.
|
| Wieczorek D, Pawlik B, Li Y, Akarsu NA, Caliebe A, May KJ, Schweiger B, Vargas FR, Balci S, Gillessen-Kaesbach G, Wollnik B.
|
| Hum Mutat 31(1):81-9.PMID: 19847792 2010
|
| 16 | HPE2, HPE3, HPE4, HPE5, SHH, SIX3, TGIF1, ZIC2
|
| Analysis of genotype-phenotype correlations in human holoprosencephaly.
|
| Solomon BD, Mercier S, Vélez JI, Pineda-Alvarez DE, Wyllie A, Zhou N, Dubourg C, David V, Odent S, Roessler E, Muenke M.
|
| Am J Med Genet C Semin Med Genet 154C(1):133-41. Review.PMID: 20104608 2010
|
| 17 | DEL7QD, SHH
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| Esophageal stenosis in a child presenting a de novo 7q terminal deletion.
|
| Zen PR, Riegel M, Rosa RF, Pinto LL, Graziadio C, Schwartz IV, Paskulin GA.
|
| Eur J Med Genet 53(5):333-6. Epub 2010 Jun 22.PMID: 20601258 2010
|
| 18 | SHH
|
| Hedgehog controls neural stem cells through p53-independent regulation of Nanog.
|
| Po A, Ferretti E, Miele E, De Smaele E, Paganelli A, Canettieri G, Coni S, Di Marcotullio L, Biffoni M, Massimi L, Di Rocco C, Screpanti I, Gulino A.
|
| EMBO J. 29(15):2646-58. 2010
|
| 19 | HPE2, HPE3, HPE4, HPE5, TGIF, shh, six3, zic2
|
| The unfolding clinical spectrum of holoprosencephaly due to mutations in SHH, ZIC2, SIX3 and TGIF genes.
|
| Paulussen AD, Schrander-Stumpel CT, Tserpelis DC, Spee MK, Stegmann AP, Mancini GM, Brooks AS, Collée M, Maat-Kievit A, Simon ME, van Bever Y, Stolte-Dijkstra I, Kerstjens-Frederikse WS, Herkert JC, van Essen AJ, Lichtenbelt KD, van Haeringen A, Kwee ML, Lachmeijer AM, Tan-Sindhunata GM, van Maarle MC, Arens YH, Smeets EE, de Die-Smulders CE, Engelen JJ, Smeets HJ, Herbergs J.
|
| Eur J Hum Genet 18(9):999-1005.
2010
|
| 20 | ARRB1, SHH
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| β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors.
|
| Parathath SR, Mainwaring LA, Fernandez-L A, Guldal CG, Nahlé Z, Kenney AM.
|
| Cell Cycle 9(19):4013-24. Epub 2010 Oct 11.
2010
|
| 21 | IHH, SHH
|
| Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.
|
| Fu X, Deng H, Zhao L, Li J, Zhou Y, Zhang Y.
|
| Mol Cell Biochem 337(1-2):185-92. doi: 10.1007/s11010-009-0298-8. Epub 2009 Oct 24.
2010
|
| 22 | HPE3, SHH
|
| Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner.
|
| Singh S, Tokhunts R, Baubet V, Goetz JA, Huang ZJ, Schilling NS, Black KE, MacKenzie TA, Dahmane N, Robbins DJ.
|
| Hum Genet 125(1):95-103. Epub 2008 Dec 5.
2009
|
| 23 | BDA1, IHH, SHH
|
| A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.
|
| Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KS, Chan D.
|
| Nature 458(7242):1196-200. Epub 2009 Mar 1.
2009
|
| 24 | PTCH1, SCUBE2, SHH
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| Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans.
|
| Tsai MT, Cheng CJ, Lin YC, Chen CC, Wu AR, Wu MT, Hsu CC, Yang RB.
|
| Biochem J 422(1):119-28.
2009
|
| 25 | APR3, HPE1, HPE10, HPE12, HPE13, HPE14, HPE15, HPE16, HPE17, HPE2, HPE3, HPE4, HPE5, HPE6, HPE7, HPE8, HPE9, SHH, SIX3, TGIF, ZIC2
|
| Array-CGH analysis indicates a high prevalence of genomic rearrangements in holoprosencephaly: an updated map of candidate loci.
|
| Bendavid C, Rochard L, Dubourg C, Seguin J, Gicquel I, Pasquier L, Vigneron J, Laquerrière A, Marcorelles P, Jeanne-Pasquier C, Rouleau C, Jaillard S, Mosser J, Odent S, David V.
|
| Hum Mutat 30(8):1175-82. 2009
|
| 26 | ABCG2, SHH
|
| Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.
|
| Kim JE, Singh RR, Cho-Vega JH, Drakos E, Davuluri Y, Khokhar FA, Fayad L, Medeiros LJ, Vega F.
|
| Mod Pathol 22(10):1312-20. Epub 2009 Jul 10.PMID: 19593328 2009
|
| 27 | SHH
|
| The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts.
|
| Shaw A, Gipp J, Bushman W.
|
| Oncogene 28(50):4480-90. Epub 2009 Sep 28.PMID: 19784071 2009
|
| 28 | SHH
|
| Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia.
|
| Rink JC, Gurley KA, Elliott SA, Sánchez Alvarado A.
|
| Science. 326(5958):1406-10. 2009
|
| 29 | DUP3PD, HPE13, SHH
|
| Sonic Hedgehog deletion and distal trisomy 3p in a patient with microphthalmia and microcephaly, lacking cerebral anomalies typical of holoprosencephaly.
|
| Ginocchio VM, De Brasi D, Genesio R, Ciccone R, Gimelli S, Fimiani F, de Berardinis T, Nitsch L, Banfi S, Magli A, Della Casa R.
|
| Eur J Med Genet ur J Med Genet. 2008 Aug 13. [Epub ahead of print]
2008
|
| 30 | SHH, TPT
|
| A microduplication of the long range SHH limb regulator (ZRS) is associated with triphalangeal thumb-polysyndactyly syndrome.
|
| Klopocki E, Ott CE, Benatar N, Ullmann R, Mundlos S, Lehmann K.
|
| J Med Genet 45(6):370-375. Epub 2008 Jan 4. 2008
|
| 31 | SHH, TPT
|
| A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb.
|
| Furniss D, Lettice LA, Taylor IB, Critchley PS, Giele H, Hill RE, Wilkie AO.
|
| Hum Mol Genet 17(16):2417-23. Epub 2008 May 7. 2008
|
| 32 | AIRE, ATR, BCOR, CCD, COL1A1, COL1A2, CRDAI, CYP27B1, DLX", FTC1, GALNT3, HPC3, NHS, OFCD, OI1A, OI1B, PCNT, PDDR, PGA1, RUNX2, SCKL, SCKL1, SCKL2, SCKL3, SHH, SIOD, SMARCAL1, TDOS, VDDR2, VDR, WHS
|
| The genetic basis of inherited anomalies of the teeth. Part 2: syndromes with significant dental involvement.
|
| Bailleul-Forestier I, Berdal A, Vinckier F, de Ravel T, Fryns JP, Verloes A.
|
| Eur J Med Genet 51(5):383-408. Epub 2008 May 23. Review. 2008
|
| 33 | HPE2, SHH, SIX3
|
| Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.
|
| Jeong Y, Leskow FC, El-Jaick K, Roessler E, Muenke M, Yocum A, Dubourg C, Li X, Geng X, Oliver G, Epstein DJ.
|
| Nat Genet 40(11):1348-53. Epub 2008 Oct 5.
2008
|
| 34 | SHH, TPT
|
| Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer.
|
| Sun M, Ma F, Zeng X, Liu Q, Zhao XL, Wu FX, Wu GP, Zhang ZF, Gu B, Zhao YF, Tian SH, Lin B, Kong XY, Zhang XL, Yang W, Lo WH, Zhang X.
|
| J Med Genet 45(9):589-95. Epub 2008 Apr 16.
2008
|
| 35 | PTCH1, SHH
|
| Patched1 regulates hedgehog signaling at the primary cilium.
|
| Rohatgi R, Milenkovic L, Scott MP.
|
| Science 317(5836):372-6. 2007
|
| 36 | HPE 3, HPE4, SHH, TGIF1, HPE10, HPE1, HPE9
|
| MLPA screening reveals novel subtelomeric rearrangements in holoprosencephaly.
|
| Bendavid C, Dubourg C, Pasquier L, Gicquel I, Le Gallou S, Mottier S, Durou MR, Henry C, Odent S, David V.
|
| Hum Mutat 28(12):1189-1197. 2007
|
| 37 | SHH
|
| Sonic hedgehog promotes stem-cell potential of MŸller glia in the mammalian retina.
|
| Wan J, Zheng H, Xiao HL, She ZJ, Zhou GM.
|
| Biochem Biophys Res Commun 363(2):347-54. Epub 2007 Sep 10. 2007
|
| 38 | PTCH1, SHH
|
| Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling.
|
| Shimokawa T, Svärd J, Heby-Henricson K, Teglund S, Toftgård R, Zaphiropoulos PG.
|
| Oncogene 26(34):4889-96. Epub 2007 Feb 19.
2007
|
| 39 | SHH
|
| Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation.
|
| Rowbotham NJ, Hager-Theodorides AL, Cebecauer M, Shah DK, Drakopoulou E, Dyson J, Outram SV, Crompton T.
|
| Blood. 109(9):3757-66. 2007
|
| 40 | SHH
|
| Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly.
|
| Huang X, Litingtung Y, Chiang C.
|
| Hum. Molec. Genet. 16(12):1454-68. 2007
|
| 41 | HPE3, HPE2, HPE4, HPE5, SHH, SIX3, TGIF1, ZIC2
|
| Molecular evaluation of foetuses with holoprosencephaly shows high incidence of microdeletions in the HPE genes.
|
| Bendavid C, Dubourg C, Gicquel I, Pasquier L, Saugier-Veber P, Durou MR, Jaillard S, Frebourg T, Haddad BR, Henry C, Odent S, David V.
|
| Hum Genet 119(1-2):1-8. Epub 2005 Dec 2. 2006
|
| 42 | SHH, HPE3
|
| Identification of a submicroscopic deletion of SHH associated with the holoprosencephaly spectrum by array-based CGH.
|
| Huang J, Hoffman JD, Zhang Y, Maisenbacher MK, Zackai EH, Weber BL, Ming JE.
|
| Clin Genet 69(4):367-9. No abstract available. 2006
|
| 43 | SHH, HPE3
|
| Language skills and neuropsychological performance in patients with SHH mutations and a holoprosencephaly-like phenotype.
|
| Santiago G, Abramides DV, De-Vitto LP, Ribeiro LA, Meira SG Jr, Richieri-Costa A.
|
| Am J Med Genet A 140(19):2085-90. 2006
|
| 44 | SHH, FGF9
|
| FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.
|
| White AC, Xu J, Yin Y, Smith C, Schmid G, Ornitz DM.
|
| Development 133(8):1507-17. Epub 2006 Mar 15. 2006
|
| 45 | BTRC, CREBBP, CSRP2, FKBP8, GAS1, GSK3B, HHAT, HHIP, IFT88, KIF27, KIF3A, KIF7, RAB23, SHH, STIL, STK36, SUFU, VTN
|
| Hedgehog signaling and congenital malformations.
|
| Nieuwenhuis E, Hui CC.
|
| Clin Genet 67(3):193-208. 2005
|
| 46 | CCD, HPE3, SHH, RUNX2
|
| Holoprosencephaly and cleidocranial dysplasia in a patient due to two position-effect mutations: case report and review of the literature.
|
| Fernandez BA, Siegel-Bartelt J, Herbrick JA, Teshima I, Scherer SW.
|
| Clin Genet 68(4):349-59. 2005
|
| 47 | HOXB8, SHH
|
| The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development.
|
| Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ.
|
| Nature 438(7068):671-4. 2005
|
| 48 | SHH, CRH, GLI1
|
| Sonic hedgehog regulates CRH signal transduction in the adult pituitary.
|
| Vila G, Papazoglou M, Stalla J, Theodoropoulou M, Stalla GK, Holsboer F, Paez-Pereda M.
|
| FASEB J 19(2):281-3. Epub 2004 Nov 30. 2005
|
| 49 | SHH
|
| Hedgehog signaling and cell cycle control in differentiating erythroid progenitors.
|
| Detmer K, Thompson AJ, Garner RE, Walker AN, Gaffield W, Dannawi H.
|
| Blood Cells Mol Dis 34(1):60-70. 2005
|
| 50 | SHH
|
| An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression.
|
| Niedermaier M, Schwabe GC, Fees S, Helmrich A, Brieske N, Seemann P, Hecht J, Seitz V, Stricker S, Leschik G, Schrock E, Selby PB, Mundlos S.
|
| J Clin Invest. 115(4):900-9. 2005
|
| 51 | SHH, IHH
|
| Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
|
| Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA.
|
| Nature 431(7009):707-12. Epub 2004 Sep 12. 2004
|
| 52 | HPE3, SCRA, MNX1, SHH, DEL7Q36
|
| Minimal clinical expression of the holoprosencephaly spectrum and of Currarino syndrome due to different cytogenetic rearrangements deleting the Sonic Hedgehog gene and the HLXB9 gene at 7q36.3.
|
| Horn D, Tonnies H, Neitzel H, Wahl D, Hinkel GK, von Moers A, Bartsch O.
|
| Am J Med Genet A 128(1):85-92. 2004
|
| 53 | SHH, ZIC2, SIX3, TGIF1, HPE3, HPE5, HPE2, HPE4
|
| Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations.
|
| Dubourg C, Lazaro L, Pasquier L, Bendavid C, Blayau M, Le Duff F, Durou MR, Odent S, David V.
|
| Hum Mutat 24(1):43-51. 2004
|
| 54 | SHH
|
| Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.
|
| Rice R, Spencer-Dene B, Connor EC, Gritli-Linde A, McMahon AP, Dickson C, Thesleff I, Rice DP.
|
| J Clin Invest. 113(12):1676-8. 2004
|
| 55 | SHH
|
| Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
|
| Wilbanks AM, Fralish GB, Kirby ML, Barak LS, Li YX, Caron MG.
|
| Science. 306(5705):2264-7. 2004
|
| 56 | SHH
|
| Hedgehog signalling controls eye degeneration in blind cavefish.
|
| Yamamoto Y, Stock DW, Jeffery WR.
|
| Nature. 431(7010):844-7. 2004
|
| 57 | NSOC, SHH
|
| Novel mutation in sonic hedgehog in non-syndromic colobomatous microphthalmia
|
| Schimmenti LA, De La Cruz J, Lewis RA, Karkera JD, Manligas GS, Roessler E, Muenke M.
|
| Am J Med Genet 116(3):215-21. 2003
|
| 58 | HPE3, SHH
|
| Previously undescribed nonsense mutation in SHH caused autosomal dominant holoprosencephaly with wide intrafamilial variability.
|
| Marini M, Cusano R, De Biasio P, Caroli F, Lerone M, Silengo M, Ravazzolo R, Seri M, Camera G.
|
| Am J Med Genet 117A(2):112-5. 2003
|
| 59 | NTN1, SHH
|
| The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.
|
| Charron F, Stein E, Jeong J, McMahon AP, Tessier-Lavigne M.
|
| Cell 113(1):11-23. 2003
|
| 60 | DHH, IHH, SHH, SMO
|
| A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
|
| Cooper MK, Wassif CA, Krakowiak PA, Taipale J, Gong R, Kelley RI, Porter FD, Beachy PA.
|
| Nat Genet 33(4):508-13. Erratum in: Nat Genet. 2003 May;34(1):113. 2003
|
| 61 | IHH, SHH
|
| Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling.
|
| Gofflot F, Hars C, Illien F, Chevy F, Wolf C, Picard JJ, Roux C.
|
| Hum Mol Genet 12(10):1187-98. 2003
|
| 62 | SHH
|
| SONIC HEDGEHOG mutations causing human holoprosencephaly impair neural patterning activity.
|
| Schell-Apacik C, Rivero M, Knepper JL, Roessler E, Muenke M, Ming JE.
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| Hum Genet 113(2):170-7. Epub 2003 Apr 23. 2003
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| 63 | SHH
|
| A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly.
|
| Lettice LA, Heaney SJ, Purdie LA, Li L, de Beer P, Oostra BA, Goode D, Elgar G, Hill RE, de Graaff E.
|
| Hum Mol Genet 12(14):1725-35. 2003
|
| 64 | SHH
|
| Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
|
| Thayer SP, Di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernandez-Del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M.
|
| Nature 425(6960):851-6. Epub 2003 Sep 14. 2003
|
| 65 | SHH
|
| Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.
|
| Mill P, Mo R, Fu H, Grachtchouk M, Kim PC, Dlugosz AA, Hui CC.
|
| Genes Dev. 17(2):282-94. 2003
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| 66 | SHH
|
| Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo.
|
| Lai K, Kaspar BK, Gage FH, Schaffer DV.
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| Nat Neurosci. 6(1):21-7. 2003
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| 67 | SHH
|
| Teratogenesis of holoprosencephaly.
|
| Cohen MM Jr, Shiota K.
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| Am J Med Genet 109(1):1-15. 2002
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| 68 | GLI3, SHH
|
| Gli and hedgehog in cancer: tumours, embryos and stem cells.
|
| Ruiz i Altaba A, Sanchez P, Dahmane N.
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| Nat Rev Cancer 2(5):361-72. Review. 2002
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| 69 | GLI3, SHH
|
| Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.
|
| Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C.
|
| Nature 418(6901):979-83. 2002
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| 70 | SHH
|
| Sonic hedgehog is required early in pancreatic islet development.
|
| diIorio PJ, Moss JB, Sbrogna JL, Karlstrom RO, Moss LG.
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| Dev Biol 244(1):75-84. 2002
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| 71 | SHH, LRP2
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| Megalin functions as an endocytic sonic hedgehog receptor.
|
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| 83 | SCRA, SHH
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| 84 | HPE3, SHH
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| 85 | SHH
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| Essential role for Sonic hedgehog during hair follicle morphogenesis.
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| 86 | SHH
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| 87 | PTCH2, SHH
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| Characterization of two patched receptors for the vertebrate hedgehog protein family.
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| 88 | SHH, PAX3
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| Sonic hedgehog induces proliferation of committed skeletal muscle cells in the chick limb.
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| 89 | PAX1, SHH
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| Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages.
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| 90 | SHH
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| 91 | IHH, SHH
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| Identification of a palmitic acid-modified form of human Sonic hedgehog.
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| 92 | SHH, HPE3, DEL7Q36
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| Cytogenetic rearrangements involving the loss of the sonic hedgehog gene at 7q36 cause holoprosencephaly.
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| 93 | HPE3, SHH
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| Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly.
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| 94 | GLI3, SHH
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| Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
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| Development 124 : 113-123. 1997
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| 95 | HOXD12, SHH
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| Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop.
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| 96 | SHH
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| 97 | SHH, HPE3
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| 98 | HPE3, SHH, SLOS
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| 99 | SHH
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| Hedgehog patterning activity : role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
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| Cell 86 : 21-34. 1996
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| 100 | SHH
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| Cholesterol modification of hedgehog signaling proteins in animal development.
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| 101 | SHH
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| Cell 86(1):21-34 1996
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| 102 | SHH
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| 103 | IHH, SHH
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| 104 | BMP2, FGF4, SHH
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