1 | AP1AR, SHARPIN
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| Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.
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| Maritzen T, Zech T, Schmidt MR, Krause E, Machesky LM, Haucke V.
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| Proc Natl Acad Sci U S A 109(26):10382-7. doi: 10.1073/pnas.1206468109. Epub 2012 Jun 11.
2012
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2 | RBCK1, RNF31, SHARPIN
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| Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.
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| Stieglitz B, Haire LF, Dikic I, Rittinger K.
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| J Biol Chem 287(25):20823-9. doi: 10.1074/jbc.M112.359547. Epub 2012 May 1.
2012
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3 | SHARPIN
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| SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes.
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| Liang Y, Sundberg JP.
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| J Dermatol Sci Dermatol Sci. 2011 May 7. [Epub ahead of print]
2011
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4 | RNF31, SHARPIN
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| SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
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| Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.
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| Nature 471(7340):637-41. 2011
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5 | SHARPIN
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| SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.
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| Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K.
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| Nature 471(7340):633-6.
2011
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6 | SHARPIN
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| Loss-of-function of SHARPIN causes an osteopenic phenotype in mice.
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| Xia T, Liang Y, Ma J, Li M, Gong M, Yu X.
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| Endocrine 39(2):104-12. Epub 2010 Nov 11.
2011
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7 | SHARPIN
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| Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.
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| Liang Y, Seymour RE, Sundberg JP.
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| J Invest Dermatol 131(1):141-9. Epub 2010 Sep 2.
2011
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8 | SHARPIN
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| Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.
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| Zak DE, Schmitz F, Gold ES, Diercks AH, Peschon JJ, Valvo JS, Niemistö A, Podolsky I, Fallen SG, Suen R, Stolyar T, Johnson CD, Kennedy KA, Hamilton MK, Siggs OM, Beutler B, Aderem A.
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| Proc Natl Acad Sci U S A 108(28):11536-41. Epub 2011 Jun 27.
2011
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9 | SHARPIN
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| SHARPIN is an endogenous inhibitor of β1-integrin activation.
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| Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, Potter CS, Duffy T, Sundberg JP, Kallioniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J.
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| Nat Cell Biol. 13(11):1315-24. 2011
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10 | RBCK1, RNF31, SHARPIN
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| Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex.
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| Sato Y, Fujita H, Yoshikawa A, Yamashita M, Yamagata A, Kaiser SE, Iwai K, Fukai S.
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| Proc Natl Acad Sci U S A 108(51):20520-5. doi: 10.1073/pnas.1109088108. Epub 2011 Dec 2.
2011
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11 | RBCK1, RNF31, SHARPIN
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| SHARPIN negatively associates with TRAF2-mediated NFκB activation.
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| Liang Y.
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| PLoS One 6(7):e21696. doi: 10.1371/journal.pone.0021696. Epub 2011 Jul 29.
2011
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12 | RBCK1, SHARPIN
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| Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.
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| Landgraf K, Bollig F, Trowe MO, Besenbeck B, Ebert C, Kruspe D, Kispert A, Hänel F, Englert C.
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| Mol Cell Biol 30(24):5764-75. Epub 2010 Oct 18.
2010
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13 | SHARPIN
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| Newly identified tumor-associated role of human Sharpin.
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| Jung J, Kim JM, Park B, Cheon Y, Lee B, Choo SH, Koh SS, Lee S.
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| Mol Cell Biochem 340(1-2):161-7. Epub 2010 Feb 24.
2010
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14 | SHARPIN
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| Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.
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| He L, Ingram A, Rybak AP, Tang D.
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| J Clin Invest. 120(6):2094-108. 2010
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15 | SHARPIN
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| Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.
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| Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP.
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| Genes Immun 8(5):416-21. Epub 2007 May 31.
2007
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16 | SHARPIN
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| Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/W(v) mouse.
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| Daigo, Y., Takayama, I., Ward, S. M., Sanders, K. M., Fujino, M. A.
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| J. Gastroenterol. Hepatol. 18: 712-718 2003
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17 | SHANK1, SHANK2, SHANK3, SHARPIN
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| Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins.
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| Lim S, Sala C, Yoon J, Park S, Kuroda S, Sheng M, Kim E.
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| Mol Cell Neurosci 17(2):385-97. 2001
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